parkinson s disease and secondary parkinsonism
Tài liệu THERAPEUTICS of PARKINSON’S DISEASE and OTHER MOVEMENT DISORDERS docx
... degradation and PARKINSON S DISEASE AND PARKINSONISM PARKINSON S DISESASE Sporadic Autosomal Dominant SYN LRRK2 UCH-L1 GENES TOXIN Autosomal Recessive AGING PARKIN DJ-1 Protein O abnormal autophagy UPS ... McNaught, K .S and Jenner, P (2001) Proteasomal function is impaired in substantia nigra in Parkinson s disease Neuroscience Letters, 297 (3), 191 194 20 PARKINSON S DISEASE AND PARKINSONISM McNaught, ... Trojanowski, J.Q et al (2002) Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson s disease Science, 295, 865 868 16 PARKINSON S DISEASE AND PARKINSONISM Baba,...
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Tài liệu Parkinson’s Disease and Related Disorders docx
... L.: Sleep disturbances and excessive daytime sleepiness in Parkinson disease: an overview Arnulf, I.: Sleep and wakefulness disturbances in Parkinson s disease ... Disease and Parkinsonism seen at the Columbia-Presbyterian Medical Center from 1949 to 1964 Nearly 85% had classic Parkinson s Disease and 13% had post-encephalitic associated Parkinsonism This ... outstanding scientists and clinicians, Toshiharu Nagatsu, Yoshikuni Mizuno, Japan (Award of the WFN Research Group on Parkinsonism and Related Disorders), Saskia Biskup, Germany and Andrew B Singleton,...
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PARKINSON''''S DISEASE AND MOVEMENT DISORDERS: DIAGNOSIS AND TREATMENT GUIDELINES FOR THE PRACTICING PHYSICIAN potx
... these motor systems For example, in patients with atypical parkinsonism (so-called parkinsonism plus syndrome), the clinical diagnosis is based on the additional systems involved If signs of parkinsonism ... disorders On the island of Guam, amyotrophic lateral sclerosis, parkinsonism, and dementia occur in various combinations, perhaps as manifestations of the same disease process Outside Guam, the association ... PARKINSON' S DISEASE AND MOVEMENT DISORDERS: DIAGNOSIS AND TREATMENT GUIDELINES FOR THE PRACTICING PHYSICIAN CURRENT CLINICAL PRACTICE Parkinson s Disease and Movement Disorders: Diagnosis and...
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Surgical Treatment of Parkinson’s Disease and Other Movement Disorders pot
... disorders These diseases are conventionally categorized into either hypokinetic disorders, such as Parkinson s disease, or hyperkinetic disorders such as hemiballism or drug-induced dyskinesias ... disorders such as Huntington s disease (HD) or dystonia, which seem to cross the boundary between these diseases Another common misconception is that movement disorders are basal ganglia diseases ... pathophysiology of common human movement disorders such as Parkinson s and Huntington s diseases (PD/HD) These structures classically include: 1) the striatum, which comprises the caudate nucleus (CD),...
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An Atlas of PARKINSON’S DISEASE AND RELATED DISORDERS pdf
... index ISBN 1-85070-943-2 Extrapyramidal disorders Atlases Parkinsonism Atlases Movement disorders Atlases I Title II Series [DNLM: Parkinson Disease atlases Basal Ganglia Diseases atlases Movement ... Parkinson s disease ©2004 CRC Press LLC Figure 11 Posture in later-stage Parkinson s disease Figure 12 Parkinson s disease: Impaired fist clenching Figure 13 Parkinson s disease: Tremor illustrated ... Postencephalitic Parkinsonism Drug-induced Parkinsonism Cases of postencephalitic Parkinsonism still occur sporadically Besides the Parkinsonism, clinical features include oculogyric crises, behavioral disorders,...
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An Illustrated Pocketbook of Parkinson''''s Disease and Related Disorders pot
... PARKINSON S DISEASE Figure 16 Parkinson s disease: dystonic posturing of the big toe secondary to dopa therapy 15 16 AN ILLUSTRATED POCKETBOOK OF PARKINSON S DISEASE Figure 17 Parkinson s disease: ... Posture in later-stage Parkinson s disease AN ILLUSTRATED POCKETBOOK OF PARKINSON S DISEASE Figure 12 Parkinson s disease: impaired fist clenching 11 12 AN ILLUSTRATED POCKETBOOK OF PARKINSON S ... RD, Bakay RA Neurosurgical horizons in Parkinson s disease Neurology 1993;43:l–7 Parkinson' s disease Any discussion of the clinical characteristics of Parkinson s disease must take into account...
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báo cáo hóa học: " Gait dynamics in mouse models of Parkinson''''s disease and Huntington''''s disease" doc
... SOD1 G93A and wild-type control mice at age ~8 weeks, ~10 weeks, ~12 weeks, and ~13 weeks Discussion Gait disturbances are characteristic of Parkinson' s disease, Huntington 's disease, and amyotrophic ... image analyses The treadmill belt was wiped clean between studies if necessary Statistics Data are presented as means ± SE ANOVA was used to test for statistical differences among saline-treated, ... in Parkinson' s disease and Huntington 's disease Mov Disord 1998, 13:428-437 Blin O, Ferrandez AM, Serratrice G: Quantitative analysis of gait in Parkinson patients: increased variability of stride...
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PARKINSON’S DISEASE AND RELATED DISORDERS - PART 5 pot
... Figure 14 Positive glabellar tap Persistent blinking is a feature of Parkinson s disease, but is also seen in Alzheimer s disease Figure 15 6-[18F]-fluorodopa–PET scan appearance in a normal subject ... cells (astrocytes and macrophages) Debris and a few vascular channels can be seen (Luxol fast blue–H & E) Figure 24 CT of a patient with a Parkinsonian syndrome shows multiple lacunar infarcts ... Histological sections from Parkinson' s disease with dementia showing cortical Lewy bodies stained with ubiquitin (immunochemistry preparation, left; silver impregnation, right) Figure 28 Histology...
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PARKINSON’S DISEASE AND RELATED DISORDERS - PART 6 ppt
... normal subject (left) compared with that in Parkinson' s disease (middle) and in progressive supranuclear palsy (right) (11C-raclopride is a selective reversible antagonist of D2 receptors) Figure ... degeneration shows atrophy of the putamen with rarefaction and gliosis (H & E) Figure 35 Transverse section of midbrain in striatonigral degeneration shows pallor of the substantia nigra ©2004 CRC Press ... (lower) basis pontis secondary to olivopontocerebellar atrophy in multiple system atrophy Figure 38 Histological sections of basis pontis (arrowed) show the normal complement of pontine neurons in...
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PARKINSON’S DISEASE AND RELATED DISORDERS - PART 7 pot
... 45 Histological section of cerebral cortex in corticobasal degeneration shows severe gliosis and an achromatic neuron (H & E) Figure 46 Histological sections of cerebral cortex showing swollen ... proved responsive to botulinum toxin ©2004 CRC Press LLC Figure 55 Abnormal neck posture in a patient with spasmodic torticollis Figure 56 Mechanisms of actions of various botulinum toxins (BTX) ... copy three hand postures (A–C, lower), in each instance, the patient 's version was defective (A–C, upper) ©2004 CRC Press LLC Figure 50 In this patient with corticobasal degeneration, sagittal T1-weighted...
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PARKINSON’S DISEASE AND RELATED DISORDERS - PART 8 ppt
... Histology in Wilson 's disease shows atrophy and rarefaction of the putamen (black arrows) Loss of myelin bundles in the putamen contrasts with the more normal appearances in the globus pallidus ... Huntington 's disease is accompanied by DNA gels (lower) which indicate trinucleotide repeats of between 40 and 52 ©2004 CRC Press LLC Figure 68 Coronal section of brain in Huntington 's disease shows symmetrical ... fast blue) Figure 63 Histology of brain in Wilson 's disease shows a Bergmann type astrocyte within an atrophic putamen (H & E) ©2004 CRC Press LLC Figure 64 Histology of brain in Wilson 's disease...
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PARKINSON’S DISEASE: National clinical guideline for diagnosis and management in primary and secondary care ppt
... diagnosis at regular intervals (6–12 months) Throughout disease Diagnosis and early disease Disease progression Parkinson s disease algorithm Figure 3.1 Parkinson s disease algorithm: interventions ... or organisations: all healthcare professionals people with the disease and carers of these people patient support groups commissioning organisations service providers Parkinson s disease 2.4 Involvement ... Diagnosis is particularly highlighted This can be difficult, and while swift assessment by someone with appropriate expertise is important when suspicion of Parkinson s disease first arises, so...
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báo cáo hóa học: " Cyclooxygenase-2 mediates microglial activation and secondary dopaminergic cell death in the mouse MPTP model of Parkinson''''s disease" pptx
... drugs have shown protective effects in reducing the risk of neurodegenerative disease such as Alzheimer 's disease [8,18] and PD [19] In the present study, we tested the hypothesis that excessive ... oxide synthase [52] This suggests that microglial activation and release of toxic substances occurs before the secondary or progressive death of the dopaminergic neurons Our data as well as those ... TH-positive neurons than the WT mice (#p < 0.05 and ##p < 0.01, respectively) Nissl staining showed similar trends and statistical results (Fig 2C &2D), which indicates a true loss of the TH-positive...
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The Use of Selected Medicinal Herbs for Chemoprevention and Treatment of Cancer, Parkinson’s Disease, Heart Disease, and Depression
... 11.3 Parkinson s Disease Parkinson s disease (also known as Parkinson disease or PD) is a degenerative disorder of the central nervous system that often impairs the sufferer s motor skills and speech ... functions, neurotransmitter levels, emotional stress, and progression of neurodegenerative conditions such as Parkinson s and Alzheimer s diseases (Rahman et al., 2008) 11.4 Heart Disease 11.4.1 Case ... flesh, including essential fatty acids from seeds and seed oils, and fibers, such as microcrystalline cellulose, pectins, lignins, cutin-like polymers, and condensed tannins, have been suggested...
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Tài liệu Báo cáo khoa học: Proteomic analysis of dopamine and a-synuclein interplay in a cellular model of Parkinson’s disease pathogenesis docx
... biology and oxidative stress in Parkinson disease pathogenesis Nat Clin Pract Neurol 4, 600–609 Lesage S & Brice A (2009) Parkinson s disease: from monogenic forms to genetic susceptibility factors ... represent a valuable starting-point for focused investigations aiming to better understand the key issues of PD pathogenesis Materials and methods Cells Human neuroblastoma SH-SY5Y cells were cultured ... network, as well as statistically significant functional association with GO classifications [16] Western blotting Expression of a-synuclein and HSP70 was determined by western blotting Proteins (80...
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Báo cáo khoa học: High and complementary expression patterns of alcohol and aldehyde dehydrogenases in the gastrointestinal tract Implications for Parkinson’s disease docx
... nervous system neurons A recent study analyzed the enteric nervous system in PD and found that both Meissner s and Auerbach s plexuses were affected already in early stages of disease and terminal ... components Signal intensities were scored using a semiquantitative scale with five steps (–,+),+,++ and +++) Scores were based on several sections ⁄ animal and several animals ⁄ observation and confirmed ... large intestines Adh3 shows low and ubiquitous expression in all tissues and Aldh1 is observed at low to moderate levels in esophagus, stomach and jejunum, but not in rectum The apparent signal...
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