parental conflict of interest theory of genomic imprinting
POTENTIAL CONFLICT OF INTEREST IN THE PRODUCTION OF DRUG COMPENDIA doc
Ngày tải lên :
09/03/2014, 00:20
... for conflict of interest, or components thereof, that might pertain to conflict of interest in compendia; and (2) published reports of conflict- of- interest issues with regard to the writing of ... 4.1.1 Conflict of interest in evidence sources .20 4.1.2 Conflict of interest in data availability 23 4.1.3 Conflict of interest in selection of indications and evidence .24 4.1.4 Conflict ... meticulous conflict- of- interest policies Unfortunately, due to the largely subjective nature of conflict of interest, the presence or extent of (a) biased review, (b) conflict of interest, and...
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Conflict of Interest in the Professions pdf
Ngày tải lên :
16/03/2014, 05:20
... embezzle" is part of common sense There is a conflict of interests here, that is, a conflict between one of your interests and one of your employer's, but no conflict of interest Conflicting interests ... Regulating the Conflict of Interest of Government Officials Kathleen Clark 49 Conflict of Interest as Risk Analysis Kevin McMunigal II 23 61 PROFESSIONS WITHIN BUSINESSES Conflict of Interest in ... "apparent conflicts of interest" or "merely apparent conflicts of interest. " The term "apparent conflict of interest" need not be wasted in this way On the standard view, a conflict of interest...
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Conflict of Interest within Public Accounting Firms Caused by Horizontal Integration pdf
Ngày tải lên :
23/03/2014, 00:20
... M (2004) Conflict of Interest and the Case of Auditor Independence www.people.hbs.edu/mbazerman/Papers/Conflicts%2 0of% 2 0Interest. pdf#search=%22public %20accounting%2 0conflict% 2 0of% 20interests%22 ... accusations that the provision of non-audit services creates a conflict of interest, the public accounting industry argues that the two services are capable of remaining independent of one another Firms ... ensure the integrity of their audits and avoid a conflict of interest, while also competing in the consulting industry The SEC, however, is reluctant to bestow such a high degree of ethical responsibility...
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Role of RNA directed DNA methylation in controlling genomic imprinting in arabidopsis thaliana
Ngày tải lên :
11/09/2015, 10:14
... doses of the maternal genome and one dose of the paternal genome This specific parental genomic dosage attracted interest in early studies of plant reproduction, which led to the discovery of imprinting ... allele-dependent imprinting is still not understood 1.1.2 The impact of interploid crosses on imprinting discovery Evidence for parental genomic imprinting also came from the study of the seeds developing ... evolution of imprinting 3.1 Parental conflict Imprinting arose independently in plants and mammals, which are both characterized by a mode of reproduction involving maternal nutrition of the developing...
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Diffusion and Use of Genomic Innovations in Health and Medicine: Workshop Summary pot
Ngày tải lên :
14/03/2014, 23:20
... for Cost of Illness of Pharmacogenomics, 74 5-2 Criteria for Cost-Effectiveness of Pharmacogenomics, 75 Copyright © National Academy of Sciences All rights reserved Diffusion and Use of Genomic ... conclusion of the meeting Burke offered a summary of the day’s presentations While various types of genomic innovation were discussed, a number of presentations focused primarily on genomic testing ... John Allen Hollingsworth Professor of Ethics, Professor of Medical Education and Director, Institute for Practical Ethics, Department of Religious Studies, University of Virginia, Charlottesville...
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Conflict of Norms in Public International Law How WTO Law Relates to other Rules of International Law doc
Ngày tải lên :
30/03/2014, 10:20
... University of Cambridge John S Bell FBA Professor of Law, Faculty of Law, University of Cambridge Editorial Board Professor Professor Professor Professor Professor Professor Professor Professor Professor ... y n is Associate Professor of Law at Duke University School of Law His areas of interest are public international law and the law of the WTO He was previously Legal Affairs Of cer for the WTO ... Professor Professor Advisory Committee Professor D W Bowett QC Judge Rosalyn Higgins QC Professor Sir Robert Jennings QC Professor J A Jolowicz QC Professor Sir Elihu Lauterpacht CBE QC Professor...
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Báo cáo hóa học: " Research Article A Hybrid Technique for the Periodicity Characterization of Genomic Sequence Data" ppt
Ngày tải lên :
22/06/2014, 00:20
... a symbol (or pattern of symbols) is simply the count of the number of instances of that symbol at a spacing of ρ Consider now a sequence containing a symbol (or pattern of symbols) Sm that repeats ... notion of periodicity in the Fourier sense is described in terms of the frequencies of those basis functions onto which the projections of x[n] are the largest in magnitude That is, the magnitude of ... period estimate often contained the common factors of two or more of the true periodic components, an artifact attributable to the superposition of harmonic spectra reinforcing multiples of the individual...
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Báo cáo khoa học: "Localisation of genomic regions controlling microdensitometric parameters of wood characteristics in hybrid larches" pps
Ngày tải lên :
08/08/2014, 14:20
... Analysis of a microdensitometric profile from a single ring, with the description of basic parameters assessed specific gravity (ld), maximal density of the ring (Md), minimal density of the ring ... the phenotypic value, Mj the effect of male parent j, Bk the effect of block k and eijk the residual error of phenotypic value of progeny ijk The effects of the genotype at the 68 tested markers ... heterogeneity Two values of density contrast across rings were calculated: RC as the mean value of density contrast of each ring, and DC as the difference between the extreme values of wood specific...
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Báo cáo y học: " Short distance movement of genomic negative strands in a host and nonhost for Sugarcane mosaic virus (SCMV)" docx
Ngày tải lên :
11/08/2014, 21:21
... the involvement of proteins on the local and systemic Page of translocation of the negative viral strand and even fewer dealing with its plant protein interactions [18] The aim of this study was ... restriction in the long distance movement of genomic negative and positive strands in both types of resistant hosts Results After SCMV-VER1 inoculation of the susceptible maize plants, mosaic symptoms ... import mechanism is different of cell-to-cell movement in potyvirus We present evidence of the presence of SCMV virions in maize stems This suggests that SCMV is capable of long distance spread in...
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Báo cáo sinh học: "A stitch in time: Efficient computation of genomic DNA melting bubbles" potx
Ngày tải lên :
12/08/2014, 17:20
... necessary for many genomic applications Conclusion The fast algorithm described in this article enables the computation of stitch profiles of genomic sequences Melting features of interest, such ... state A stitch profile thus provides some features, e.g bubbles, that would be of interest in genomic analyses However, the previously described algorithm for computing stitch profiles [29] has ... hours In some types of low temperature melting studies, the features of interest are the bubbles rather than the helical regions In such applications, switching off the computation of helix stitches...
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Báo cáo khoa học: "Patience and change: a conflict of interests" doc
Ngày tải lên :
13/08/2014, 03:20
... Risks and benefits of activated protein C treatment for severe sepsis N Engl J Med 2002, 347:1027-1030 Siegel JP: Assessing the use of activated protein C in the treatment of severe sepsis N ... management of severe sepsis and septic shock Crit Care Med 2004, 32:858873 Smith R, Roberts I: Patient safety requires a new way to publish clinical trials PLoS Clin Trials 2006, 1:e6 Page of (page...
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Báo cáo sinh học: " Effects of the number of markers per haplotype and clustering of haplotypes on the accuracy of QTL mapping and prediction of genomic breeding values" pot
Ngày tải lên :
14/08/2014, 13:21
... animals of generation 1001 on average had 20 offspring, whereas parents of previous generations on average had two offspring The generation 1002 produced one more generation of 1000 offspring ... identification of all pairs of base haplotypes with an IBD probability among them of > limitIBD; 2) clustering of all pairs of haplotypes identified in step 1, summing the mutual off-diagonal elements ... locus j, and Prj is the Definition of windows and clustering of related haplotypes Two types of haplotypes were considered: 1) the haplotypes of the first generation of genotyped animals (referred...
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Báo cáo sinh học: " Accuracy of genomic breeding values in multi-breed dairy cattle populations" pps
Ngày tải lên :
14/08/2014, 13:21
... accuracies of both sources of information Conclusion Predicting genomic breeding values using a genomic relationship matrix is an attractive approach to implement genomic selection, since accuracies of ... expected accuracies obtained as a function of elements of the inverse coefficient matrix when a genomic relationship matrix is used, with accuracies of GEBV obtained by correlating GEBV and breeding ... GBLUP approach, expected accuracies of breeding values are readily calculated from the diagonal elements of the inverse of the coefficient matrix In populations of Holstein and Jersey bulls genotyped...
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Báo cáo sinh học: "The nature, scope and impact of genomic prediction in beef cattle in the United States" pdf
Ngày tải lên :
14/08/2014, 13:21
... both of the animals in terms of exhibiting natural behaviors and being free of disease, suffering, and mortality, and of the labor in terms of worker safety In this context, the design of a beef ... Page of 11 recording Other genomic analyses that will not be considered in this review include correct assignment of parents, identification of genetic diseases, detection of signatures of selection, ... the collection of phenotypes on large cohorts will also be invaluable Page of 11 Conclusion Genomic prediction offers accuracies that exceed those of pedigree-based parent average of young selection...
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Báo cáo sinh học: " Impacts of both reference population size and inclusion of a residual polygenic effect on the accuracy of genomic prediction" potx
Ngày tải lên :
14/08/2014, 13:21
... bulls on the estimation of SNP effects and on direct genomic values (DGV) and (2) the impact of including an RPG effect on the accuracy of genomic prediction using EuroGenomics reference bulls ... German Holstein bulls Year of birth Data for routine genomic evaluation Nb of genotyped animals Nb of bulls in reference population Data for genomic validation study Nb of bulls with daughters Sum ... proportion of additive Results and discussion Genomic validation using German national data Table shows the results of genomic validation based on the national genomic and phenotypic data of German...
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Báo cáo sinh học: " Persistence of accuracy of genomic estimated breeding values over generations in layer chickens" pdf
Ngày tải lên :
14/08/2014, 13:21
... single-trait analyses (Figure 2) Persistency of accuracy across generations Method of estimation Effect of π and heritability Figure shows the accuracies of pedigree and genomic EBV per generation, averaged ... accuracy of genomic selection in Norwegian red cattle assessed by cross-validation Genetics 2009, 183:1119-1126 Goddard ME: Genomic selection: Prediction of accuracy and maximisation of long term ... to fitting average π), because in most of the methods π is not estimated The effect of differences between early versus late traits in terms of the number of phenotypes used for training (Table...
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Báo cáo y học: "Genome informatics: taming the avalanche of genomic data" pptx
Ngày tải lên :
14/08/2014, 14:21
... shift of focus from the proteincoding part of genomes to the functional non-protein-coding part The avalanche of genomic data will no doubt continue to grow and lead to more discoveries of how ... Probably only a few of them will survive, but those that will be of great value to the entire community Although genomics and bioinformatics have already generated vast amounts of new discoveries, ... tools as well as user-friendly web visualization tools for a wide range of genomic data Much of the annotation in a MOD consists of links to other databases, and it is vital to keep these up to date...
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Báo cáo y học: "Classification methods for the development of genomic signatures from high-dimensional data" potx
Ngày tải lên :
14/08/2014, 17:22
... evaluation of the performance of a classification algorithm The SN is the proportion of correct positive classifications out of the number of true positives The SP is the proportion of correct ... correct negative classifications out of the number of true negatives The accuracy is the total number of correct classifications out of the total number of samples The PPV is the probability ... of trees is generated using the default of ntree = 500 The number of features selected at each node in a tree is selected using the default value of floor(m1/2), where m is the total number of...
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Báo cáo y học: "Transcriptional features of genomic regulatory blocks" pdf
Ngày tải lên :
14/08/2014, 21:20
... 96th hour of differentiation For each probe, detection pvalues were computed by BeadStudio software (Illumina) For the expression profile comparison analysis, we used a pvalue cutoff of 0.05 for ... expression patterns of bystander genes are unrelated to those of the target gene, suggesting that they are unresponsive to the regulatory input of HCNEs [6,7,9] sponding target gene One of the fundamental ... segments of genome that are rich in CpG dinucleotides as opposed to general depletion of CpG dinucleotides in the rest of vertebrate genome sequence [11,12] These core promoters are of the 'broad'...
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Báo cáo y học: "Developmental roles of 21 Drosophila transcription factors are determined by quantitative differences in binding to an overlapping set of thousands of genomic regions" ppsx
Ngày tải lên :
14/08/2014, 21:20
... reasonable estimate of the relative number of factor molecules in direct contact with different genomic regions in vivo Binding to thousands of genomic regions over a relatively narrow range of occupancies ... SNA TWI 0.0 SNA TWI corellation of scores of peaks 301-600 with corresponding scores of each factor corellation of scores of peaks 1-300 with corresponding scores of each factor Heat maps showing ... at least one factor, and of this, 9.8 Mb is within 250 bp of a ChIP/chip peak At a 25% FDR, 32.2 Mb of the genome is within 250 bp of a ChIP/chip peak, which is 27% of the 118.4 Mb euchromatic...
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