padlock model of damage recognition by uvrb
Tài liệu Báo cáo Y học: Dynamic mechanism of nick recognition by DNA ligase ppt
... decrease of the degree of hydration of the bound DNA As a 5996 A V Cherepanov and S de Vries (Eur J Biochem 269) Ó FEBS 2002 Fig Illustration of the proposed mechanism of dynamic nick recognition by ... 5¢-phosphate of the nick and backwards in the 5¢-direction of the nicked strand Fig Illustration of the proposed mechanism of dynamic nick recognition by DNA ligase Positioning of the reacting ... at the 3¢-OH primer end of the dsDNA bound to DNA polymerase What could be the role of this transition in the DNA ligase catalysis? DYNAMIC MECHANISM OF NICK RECOGNITION BY DNA LIGASE – A HYPOTHESIS...
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Báo cáo khoa học: Mutational analysis of substrate recognition by human arginase type I ) agmatinase activity of the N130D variant pot
... understanding of the importance of Asn130 in substrate binding and recognition by arginase I, this residue was changed to aspartate by sitedirected mutagenesis, and the kinetic consequences of the mutation ... presence of agmatine were assayed by measuring the production of l-ornithine Urea was determined by a colorimetric method with a-isonitrosopropiophenone [28], and l-ornithine by the method of Chinard ... indicated by the numbers on the right side The migration of the protein markers is indicated by pencil marks on the membrane The arrow indicates the position of the wild-type and N130D variants of human...
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Dendritic cells respond differently to live and killed bacteria molecular mechanisms of pathogen recognition by dendritic cells and implications for vaccine development
... 1.3 Role of TLRs in the control of adaptive immunity TLRs sense the presence of infection through recognition of PAMPs (pathogen-associated molecular patterns) Recognition of PAMPs by Toll-like ... development of vaccines against E.coli infections a challenge Since, one of the criteria for an effective vaccine is the generation of long-lived immunological memory by the priming of both B and ... Immune System The generation of long-lived immunological memory by the priming of both B and T cells is part of the adaptive immune system This system is composed of highly specialized, systemic...
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A self organizing neural network model for a mechanism of pattern recognition unaffected by shift in position
... the neocognitron consists of a cascade connection of a number of modular structures preceded by an input layer U o Each of the modular structure is composed of two layers of cells connected in a ... the degree of saturation of C-cells Self-organization of the Network The self-organization of the neocognitron is performed by means of "learning without a teacher" During the process of self-organization, ... of self-organization, the network acquires a structure similar to the hierarchy model of the visual nervous system proposed by Hubel and Wiesel (1962, 1965) According to the hierarchy model by...
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Tài liệu Báo cáo khoa học: "Inducing Gazetteers for Named Entity Recognition by Large-scale Clustering of Dependency Relations" ppt
... “type”, or it ended with “name” followed by of This rule is for treating expressions like “ is one of the landlocked countries.” By applying this method of extraction to all the articles in Wikipedia, ... hidden Markov models and selected applications in speech recognition Proceedings of the IEEE, 77(2):257–286 E Riloff and R Jones 1999 Learning dictionaries for information extraction by multi-level ... are sorted on the basis of p(c|n) Stadium names are examples of multi-word nouns (word boundaries are indicated by “/”) and also include abbreviated expressions (marked by [abb.]) stage We have...
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Báo cáo khoa học: Structural and biological effects of a b2- or b3-amino acid insertion in a peptide Application to molecular recognition of substance P by the neurokinin-1 receptor ppt
... response of these agonists could be explained by the number of receptors to be occupied by these agonists to get activation of the second messenger cascade as reported [40] Enzymatic degradation of ... distance-dependent dielectric screening of 4Ær and no cut-off was used Minimum-energy conformers of b- and a-amino acids were generated by molecular dynamics at high temperature followed by energy minimization ... a-peptides (oligomers of a-amino acids) has recently been applied to the syntheses of linear tetrapeptides of somatostatin [20] and of cyclic tetrapeptide and pentapeptide analogues of the RGD sequence...
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Báo cáo Y học: The presence of a helix breaker in the hydrophobic core of signal sequences of secretory proteins prevents recognition by the signal-recognition particle in Escherichia coli doc
... overloading of the SRP pathway The re-routing of (G-10L)prePhoE to the Sec translocon via the SRP instead of the SecB pathway could be explained by the increased hydrophobicity of the hydrophobic core of ... dependency of the targeting of mutant prePhoE By the substitution of an a-helix-promoting residue (Leu, Ala or Cys) for the helix-breaking Gly)10 of the signal sequence of PhoE, the a-helix is expected ... radioactive labeling of the cells, the PhoE forms were immunoprecipitated and analyzed by SDS/PAGE (Fig 5) Depletion of 4.5S RNA did not result in the accumulation of precursors of either wild-type...
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Báo cáo khoa học: Methylene analogues of adenosine 5¢-tetraphosphate Their chemical synthesis and recognition by human and plant mononucleoside tetraphosphatases and dinucleoside tetraphosphatases pot
... brings into focus the possibility of direct recognition of the Pa–O–Pb bridge by the protein, a possibility that might be explored by the synthesis and use of the imino analogue, pppNHpA Do the ... methanol (70 : 30 v ⁄ v)] Table Comparison of the hydrolysis of ppppA and pppCH2pA by specific p4A-hydrolysing enzymes The velocities of conversion of the nucleoside tetraphosphates (0.5 mM) to ... Results and Discussion Comments on the synthesis of p4A analogues Recognition of p4A analogues as substrates by the p4A hydrolysing enzymes The preparation of intermediate ADP and ATP analogues followed...
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Báo cáo khóa học: Differential carbohydrate epitope recognition of globotriaosyl ceramide by verotoxins and a monoclonal antibody pdf
... pathogenesis of HUS or VT tissue targeting and pathology in animal models [33] We have shown previously the expression of Gb3 within the renal glomerulus, as monitored by the binding of fluorescein ... were externally calibrated with the molecular mass of a mixture of standard peptides Results Comparison of ligand/Gb3 binding by RELISA The binding of VT1, VT2, and mAb anti-Gb3 (38.13) to Gb3 was ... carbohydrate recognition epitopes of Gb3 for VT1, VT2, and mAb anti-Gb3, binding to a series of synthetic monodeoxyGb3 analogues was assayed by TLC overlay (Fig 2) The hydroxyl groups of the trisaccharide...
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Báo cáo khoa học: "A Model for Robust Processing of Spontaneous Speech by Integrating Viable Fragments*" ppt
... improving the selection of resuits by using a stochastic model of V1T sequence probabilities, on the extension of the rule set to cover more spontaneous speech phenomena of German, English and ... a greater length is preferred The coverage of an analysis is the sum of the lengths of the component analyses it consists of Note that the coverage of an analysis will be less than its length ... Analyses • speech recognition errors However, the parsers will usually be able to deliver a collection of partial analyses - - each covering a part of a path through the WHG The goal of the robust...
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Báo cáo khoa học: Substrate recognition and ®delity of strand joining by an archaeal DNA ligase docx
... effect of duplex DNA by LigTk Among the various steps in the reaction mechanism of LigTk, we have clari®ed the following: (a) substrate (nicked, duplex DNA) formation precedes recognition by LigTk; ... T.R (2000) Nick recognition by DNA ligases J Mol Biol 296, 43±56 32 Pritchard, C.E & Southern, E.M (1997) Eects of base mismatches on joining of short oligodeoxynucleotides by DNA ligases Nucleic ... consumption of the substrates, raising the possibility that LigTk could not turnover We addressed this possibility by examining the ligation reaction by LigTk with various amounts of template...
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Báo cáo khoa học: Substrate recognition by three family 13 yeast a-glucosidases Evaluation of deoxygenated and conformationally biased isomaltosides pptx
... Molecular recognition of isomaltosides is more similar for the yeast a-glucosidase and oligo-1,6-glucosidase of glycoside of hydrolase family 13 when compared to that of glucoamylase of glycoside ... NMR spectra of isomaltose before (Fig 2A) and after (Fig 2B,C) addition of the enzyme Fig Hydrolysis of isomaltose by baker's yeast a-glucosidase followed by 1H NMR (A) before addition of enzyme; ... representatives of two categories of yeast a-glucosidases The study strongly demonstrates the advantage offered by enzymes with simple speci®city for application of substrate analogs in elucidation of the...
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Báo cáo khoa học: "Paradigmatic Cascades: a Linguistically Sound Model of Pronunciation by Analogy" docx
... idea of our model is to take advantage of the internal structure of "natural" lexicons In fact, a lexicon is a very complex object, whose elements are intimately tied together by a number of fine-grained ... Pronunciation of Unknown Words Supose now that we wish to infer the pronunciation of a word x, which does not appear in the lexicon This goal is achieved by exploring the neighbourhood of x defined by A, ... rank the stack of analogs according to the expectation of the number of lexical derivatives a given analog may have This expectation is computed by summing up the productivities of all the alternations...
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báo cáo hóa học:" Rat model of metastatic breast cancer monitored by MRI at 3 tesla and bioluminescence imaging with histological correlation" ppt
... infusion of cells Region of interest from the head of group Page of 10 (page number not for citation purposes) Journal of Translational Medicine 2009, 7:88 MRI with histological correlation of group ... metastatic model in the nude rat Group consisted of 18 rats that received × 106 FEPro labeled 231BRL cells by IC injection Serial MRI and BLI studies were performed as part of a study and cohorts of ... ratio of FE:Pro of 100 μg/ml:6 μg/ml of media The cells were incubated for two hours followed by overnight incubation with complete media Labeled cells were washed times with 10 unit/ml of heparinized...
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Báo cáo hóa học: " Modulation of the major histocompatibility complex by neural stem cell-derived neurotrophic factors used for regenerative therapy in a rat model of stroke" ppt
... differentiation of forelimb foot faults (DOFFF) is the difference between the number of faults for the right and left forelimbs SOFFF and DOFFF were used as an index of motor deficit CSF aspiration 80 μL of ... 7, day 14 and day 28 by counting the number of foot faults in the left and right forelimbs The sum of foot faults (SOFFF) in the forelimbs is defined as the number of faults of right and left forelimbs, ... of the differentiation of forelimb and foot faults (DOFFF) derived from ischemic control mice over four weeks compared to the sham-operated normal control rats The DOFFF of the three groups of...
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Báo cáo sinh học: " Improvement of cardiac contractile function by peptide-based inhibition of NF-B in the utrophin/dystrophin-deficient murine model of muscular dystrophy" potx
... in cardiac histopathological features of this model Between eight and ten weeks -of- age, dko mice display myocardial damage followed by fibrotic scarring in damaged regions[13] Despite the robust ... improvement of contractile function The underlying cause of weakened contractile performance of the end-stage heart failing myocardium is often independent of the originating cause of heart failure ... et al.: Improvement of cardiac contractile function by peptide-based inhibition of NF-B in the utrophin/ dystrophin-deficient murine model of muscular dystrophy Journal of Translational Medicine...
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báo cáo hóa học: " Interleukin 1 receptor antagonist knockout mice show enhanced microglial activation and neuronal damage induced by intracerebroventricular infusion of human β-amyloid" pdf
... signaling because of the loss of the IL-1 receptor's physiological antagonist We induced AD-relevant neuroinflammation and neuronal damage by intracerebroventricular (ICV) infusion of human Aβ1–42 ... of Medicine All animal procedures were approved by the Animal Care and Use Committee at Northwestern University One of the biochemical responses of glia to both acute and chronic conditions of ... the two neuropathological hallmarks of AD This finding is complemented by the revelation that this overproduction of IL-1 closely corresponds to the level of neuropathology found in a given brain...
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báo cáo hóa học: " Inhibition of NF-κB activation by 5-lipoxygenase inhibitors protects brain against injury in a rat model of focal cerebral ischemia" docx
... expression of 5-LOX in the ipsilateral hemisphere of brain tissue sections at 24 h after reperfusion (Fig 1E, b), which was reduced by the administration of BW-B 70C (Fig 1E, c) The mechanisms of 5-LOX ... expression of NF-κB luciferase activity in BV2 microglial cells Because the activation of NF-κB is important for the induction of iNOS in glial cells [31], the effect of BW-B 70C on the activation of ... inhibition of NF-κB by BW-B 70C, we examined the effect of BW-B 70C on nuclear translocation of p50/p65 complex in LPS-treated primary microglial cells LPS stimulated the nuclear translocation of p65...
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báo cáo hóa học: " Anandamide inhibits Theiler’s virus induced VCAM-1 in brain endothelial cells and reduces leukocyte transmigration in a model of blood brain barrier by activation of CB1 receptors" pdf
... immunofluorescence microphotograps per level were analyzed using the Image J software designed by National Institutes of Health Results are presented as intensity of staining per vessel in case of ... transmigration in a model of blood brain barrier by activation of CB1 receptors Journal of Neuroinflammation 2011 8:102 Submit your next manuscript to BioMed Central and take full advantage of: • Convenient ... about the effects of endocannabinoids, and in particular of AEA, on the mechanisms involved in the control of leukocyte trafficking Advance in the knowledge of VCAM-1 regulation by endocannabinoids...
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