p63 cancer cells recapitulated prostate like primitive glandular structure formation in the metastatic loci
Báo cáo khoa học: Induction of PAI-1 expression by tumor necrosis factor a in endothelial cells is mediated by its responsive element located in the 4G/5G site ppt
... expression in vascular endothelial cells Expression of PAI-1 was analyzed at the level of protein synthesis (A) in the presence or absence of NAC (10 mM) The PAI-1 antigen was determined using the ELISA ... which these signaling pathways lead to the induction of PAI-1 in endothelial cells Interestingly, PAI-1 upregulation by TGF-b has also been shown to involve ROS production in mesangial cells ... PAI-1 in vascular smooth muscle cells and endothelial cells [39] Furthermore, NF-jB -like binding site in the PAI-1 promoter is responsible for IL-1-induced PAI-1 expression and this element is involved...
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Báo cáo y học: "B cells from rheumatoid arthritis patients show important alterations in the expression of CD86 and FcgRIIb, which are modulated by anti-tumor necrosis factor therapy" potx
... comparing the percentage of B cells in the lymphocytic population (mean percentage ± SD 7.5 ± 3.1 and ± 2.2, respectively) Furthermore, when we discriminated B cells in naïve cells, memory cells ... differentially regulated by Th1/Th2 cytokines, with interferon-gamma favoring the activator receptor and interleukin-4 favoring the inhibitory receptor [42] On the other hand, TNF downmodulates FcgRIIb ... sufficient to induce an increase in the expression of CD86 [38,39], whereas the overexpression of this receptor on murine B cells reverses the induction of CD86 triggered via BCR [9] However, in a multifactorial...
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Báo cáo y học: "High-Resolution Flow Cytometry: a Suitable Tool for Monitoring Aneuploid Prostate Cancer Cells after TMZ and TMZ-BioShuttle Treatment"
... arrest of diploid cells in the G1 phase, whereas the cells of the aneuploid fraction pass from the G1 into the S phase This finding is confirmed by the investigation of DU 145 cells in the S phase: ... dienophile compound in the DARinv It is connected via the ε-amino-coupling of the lysine spacer to the nuclear address sequence (NLS) At the right site of the table the CPP module in the single letter ... Combined therapy using siRNA targeting Bcl-xL and cisplatin against prostate cancer Int J Cancer 2009;125(12):2978-90 Cherry J, Karschner V, Jones H, and Pekala PH HuR, an RNA-binding protein, involved...
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Báo cáo y học: "Why are some children with early onset of asthma getting better over the years" -aneuploid-prostate-cancer-cells-after-tmz-tmz-bioshuttle-treatment.html#post143974
... Hospital, including PHC data of the statements made by the mid-wife in her records of the check-up of the mothers during the pregnancy (17) In the follow-up at the age of seven, n= 191 children of the ... neonatal death and those living outside the region, were included in the study At the age of seven, all of them still living in the region were included in a follow-up of their computerised medical ... findings regards the quality of the information given to the parents when the http://www.medsci.org Int J Med Sci 2009, clinical asthma diagnosis was made There might be a recall bias, but there...
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Báo cáo khoa học: Altered expression of tumor protein D52 regulates apoptosis and migration of prostate cancer cells potx
... [33], and integrins is important in determining the formation of metastatic cells [34,35] The expression of murine TPD52 in NIH3T3 cells induces the expression of several genes involved in the promotion ... attachment to the extracellular matrix proteins: vitronectin, fibronectin, fibrinogen, laminin, osteopontin, amongst others [38] Vitronectin can bind to avb5 and avb3 integrin receptors The expression ... of integrins Taken together, migration studies confirm the involvement of avb3 integrin in TPD52 mediated migration of LNCaP cells towards vitronectin Similar to breast cancer cells, prostate cancer...
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Báo cáo sinh học: " Downregulation of APOBEC3G by Xenotropic Murine Leukemia-Virus Related Virus (XMRV) in Prostate Cancer Cells docx
... protein XMRV is able to productively replicate in these cells Findings This report builds on and challenges the published data on the absence of A3G protein in prostate epithelial cells lines ... ribonucleoprotein complex in prostate epithelial cells It has been reported that A3G in resting CD4+ cells and monocytes are predominantly in its lowmolecular-mass (LMM) active form making these cells ... of infectious XMRV Virus infections were performed using cells plated day before infection Cells were at 50% confluency at the time of infection On the day of infection, fresh media containing...
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báo cáo hóa học:" Serous papillary adenocarcinoma possibly related to the presence of primitive oocyte-like cells in the adult ovarian surface epithelium: a case report" docx
... stem cells The analysis confirmed the presence of round, SSEA-4 and SOX-2-positive primitive oocyte -like cells in the ovarian surface epithelium These cells resembled primitive oocytes in the ... VASA-positive cells (arrows) in the ovarian surface epithelium and cortex (A, B) Smaller cells with diameters of to μm in the epithelium (C-F) Bigger cells with diameters of 10 μm in the epithelium ... surface epithelium as related to epithelial ovarian cancer These cells resembled primitive oocytes in the ovarian surface epithelium of fetal ovaries, and might have been involved in the manifestation...
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Báo cáo khoa học: "The Akt-inhibitor Erufosine induces apoptotic cell death in prostate cancer cells and increases the short term effects of ionizing radiation" pot
... that the Akt-inhibitor ErPC3 increases radiation-induced apoptosis in prostate cancer cells The most prominent combination effects were obtained in LNCaP cells that did not show any apoptosis in ... in PC3 and LNCaP prostate cancer cells Moreover, we compared the effects of ErPC3 to the effects of the PI3K inhibitor LY294002 LY294002 inhibits the upstream kinase PI3K thereby preventing the ... Apoptosis-induction by ErPC3 and ionizing radiation in prostate cancer cell lines The WST-1 assay mirrors just the number of viable cells at a specific time point, but does not indicate whether the therapy...
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Báo cáo khoa học: "The alkylphospholipid, perifosine, radiosensitizes prostate cancer cells both in vitro and in vivo" docx
... each individual treatment points We then investigated the in vivo radiosensitization effect of perifosine in a prostate cancer xenograft model in nude mice Perifosine treatment protocols in the ... Radiosensitization of perifosine in prostate cancer PC-3 cells Cells were irradiated in the absence (control) or in the presence of perifosine and the colony formation assay was conducted Shown are the means and ... phospho-Akt-S473 were observed in perifosine alone and the combination groups, indicating radiation combed with perifosine can increase the inhibitory effect of perifosine on Akt, resulting in a synergistic...
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Báo cáo khoa học: "In vitro studies on the modification of low-dose hyper-radiosensitivity in prostate cancer cells by incubation with genistein and estradiol" pot
... black bar In the controls 15% of the cells were in S-phase, 65% in G0/G1 and 20% in G2/M In the following, the S-phase was reduced to 5%, while G0/G1 increased to 73% The proportion of cells in G2/M ... 15% of the cells were in S-phase, 65% in G0/G1 and 20% in G2/M In the following, the S-phase was reduced to 5%, while G0/G1 increased to 73% The proportion of cells in G2/M was only minimal changes ... irradiation the cells were harvested and subjected to protein extraction The shown results represent one of three assays In controls incubated in FCS containing media and in controls incubated in media...
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Báo cáo y học: "Hedgehog overexpression leads to the formation of prostate cancer stem cells with metastatic property irrespective of androgen receptor expression in the mouse model" pps
... Hedgehog involvement in promotion of basal cell hyperplasia toward malignant transformation Metastatic P63+ cancer cells recapitulated prostate- like primitive glandular structure formation in the metastatic ... cancer (arrow-indicated respectively in (c) and (f)) (C) P63+ cancer cells recapitulated prostate- like glandular structure formation in the metastatic loci (arrowhead-indicated in (d), (f), (g), ... neuroendocrine cells The Hh-initiated P63+ basal/stem cells were characteristic of PCSCs, as they were able to form primitive prostate- like glandular structures in the metastatic loci Besides,...
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báo cáo khoa học: " XAF1 expression and regulatory effects of somatostatin on XAF1 in prostate cancer cells" docx
... mimic the development of prostate cancer clinically Understanding the regulating effects of XAF1 during the whole progression may help us find potential therapeutic strategies for prostate cancer ... somatostatin indicates a promising strategy for prostate cancer therapy Materials and methods Cell lines and cell culture A human prostate epithelial cell line (RWPE-1) and prostate cancer cell lines ... somatostatin and Octreotide in prostate cancer cell lines To examine the regulatory effects of somatostatin and Octreotide on XAF1 mRNA and protein expression, prostate cancer cell lines (LNCaP,...
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báo cáo khoa học: "Possible immunotherapeutic potentiation with D-Fraction in prostate cancer cells" pps
... http://www.jhoonline.org/content/1/1/25 Accordingly, we are interested in investigating whether the combination of IFN-α2b and PDF may have the potentiated growth inhibitory effects on prostatic cancer cells in vitro Such studies ... compared to those in controls (Fig 3) These results indicate that the IFN-α2b/PDF combination causes a blockage of cells entering from the G1 to the S phase, increasing cell number in the G1 phase ... regulation [21] These information further suggest that our IFN-α2b/PDF combination may affect certain protein kinase(s), triggering the specific cascade events (via the signal transduction) on the cell...
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Báo cáo y học: " Human lung cancer cells express functionally active Toll-like receptor 9" potx
... part of the study and was involved in the design of the study KD and PZ conducted the clinical part of the study and were involved in the design and coordination of the study TG performed the immunohistochemistry, ... lines and were involved in drafting the manuscript JG was involved in immunohistochemistry of cell lines and the design of the study DB conducted the surgical part of the study EV conducted the ... defense mechanisms against malignantly transforming cells While the first possibility seems unlikely in the light of our findings of a functionality of the receptor in various in vitro and ex vivo...
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EFFECTS OF CHOLINE KINASE ACTIVITY ON PHOSPHOLIPID METABOLISM AND MALIGNANT PHENOTYPE OF PROSTATE CANCER CELLS
... 1991) .The major pathway of choline incorporation into phosphatidylcholine in mammalian cells (other than liver and kidney) is via CDP-choline pathway Choline can also be retained in the cells in ... forms of the purified 13 yeast choline kinase increased in the presence of ATP With respect to regulation by ADP, the purified choline kinase was inhibited by ADP, the product of the reaction The ... choline in tumor as compared to normal cells Choline transport in cancer cells is at present not well understood due to limited data on choline transporter in cancer cells The identity of the...
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Tài liệu The Electrical Properties of Cancer Cells pptx
... ability to communicate information inside themselves and between other cells The coordination of information by the cells of the body is involved in the regulation and integration of cellular ... migrate into the ECM are involved in initiating the removal of old and damaged cells and in stimulating the growth of new cells Fibroblasts and fibrocytes are the main cells that produce the proteins ... proteins to each other and to cell membrane integrins The cell membranes contain proteins called integrins, which creates a continuum linking the internal liquid crystal cytoskeletal proteins...
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Tài liệu Báo cáo khoa học: EGF receptor in relation to tumor development: molecular basis of responsiveness of cancer cells to EGFR-targeting tyrosine kinase inhibitors docx
... erlotinib in intestinal epithelial cells [53] Furthermore, the expression of cIAP-1 and of X-linked IAP is reduced by AG1478 in squamous cell carcinoma cell lines NA and Ca9-22 [54] As small interfering ... to the progression, invasion and maintenance of the malignant phenotype In keratinocyte and cutaneous squamous cancer cells, gefitinib blocks EGF-induced cytoskeleton remodeling and in vitro invasiveness, ... in promoting the G1-to-S phase transition of the cell-cycle by phosphorylating the retinoblastoma (RB) protein Activation of cyclin–CDK complexes is counterbalanced by CDK inhibitors, including...
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Tài liệu Báo cáo khóa học: Suppression of b1,3galactosyltransferase b3Gal-T5 in cancer cells reduces sialyl-Lewis a and enhances poly N-acetyllactosamines and sialyl-Lewis x on O-glycans Lydia Mare and Marco Trinchera pdf
... using adaptors for the BstXI sites available in the vector Numbers in the b3Gal-T5 cassette refer to the cDNA sequence starting from the ATG translation initiation codon (indicated) Numbers in ... obtained by BioGel P-4 purification of the included volume of the column in (A), large O-glycans (j), obtained as the included volume of the column in (C), and small O-glycans (s), obtained as the ... E-selectin ligand [36] and may be involved in the metastatic spread of cancer cells, as suggested for other selectin ligands [37] Previous data indicate that b3Gal-T5 is the enzyme candidate for synthesis...
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Tài liệu Báo cáo khoa học: Enhanced expression of Mcm proteins in cancer cells derived from uterine cervix docx
... uterine cervical cancer by immunohistochemical techniques, and the results were compared with the findings obtained by hematoxylin and eosin staining We examined the expression of these proteins in ... detected in some of the cancer cells All these findings were also observed in cancer cells with deep invasion To further characterize the expression of Mcm4, PCNA and Ki67 in cancer cells, a section ... intense staining was observed in BrdU-positive WI-38 cells These data suggest that the level of Mcm4 protein was maximized at the S phase in WI-38 cells and that the Mcm4 expression in HeLa cells...
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