overview of the animal research in psychiatricillness and substance abuse
Báo cáo khoa học: Recent insights into cerebral cavernous malformations: animal models of CCM and the human phenotype pptx
... on the biochemical interactions of the CCM proteins) Furthering the pursuit of genetic interactions, co-morpholino experiments were performed to examine the interactions between the CCM genes and ... Specifically, these defects are caused by the loss of Ccm3 interaction with the kinases serine ⁄ threonine kinase 25 (STK25) and mammalian sterile twenty-like (MST4), giving a hint to the signaling pathway ... failure in mice lacking Ccm2 The connections of the heart to the aorta, and the associated cranial portions of the dorsal aorta are narrowed in mice lacking Ccm2 The paired dorsal aortae in a wild-type...
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Báo cáo y học: " Characterization of protein tyrosine phosphatase H1 knockout mice in animal models of local and systemic inflammation" docx
... models of inflammation and inflammatory pain and it has a biphasic profile [27] Recent studies pointed out important roles for prostaglandins, nitric oxide and TNFα in the CARR-induced inflammatory ... activate the innate immune response CARR interacts with TLR4 leading to increased Bcl10, to NFκB pathway activation and IL8 production [25,26] CARR injection in the hind paw of the mouse is one of the ... processing of other cytokines and cytokine receptors [32-35] Interestingly, PTPH1 is known to inhibit TACE expression and activity in vitro [36] We therefore analyzed cytokines plasma levels in carrageenan-treated...
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Báo cáo khoa học: "Tree-ring characteristics of subalpine fir (Abies lasiocarpa (Hook.) Nutt.) in relation to elevation and climatic fluctuations" docx
... in tree-ring properties from the montane to subalpine forest However, it is not clear what will be the change in tree-ring properties of subalpine fir with increasing elevation, and whether the ... same area Considering the importance of density as an index of wood quality, the role of climate as the major determinant of tree growth, and the concerns about the impact of climatic change ... photosynthesis early in the growing season would result in early initiation of cambial activity and increased supply of photosynthates that, in turn, would benefit cell-wall thickening later in the...
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Báo cáo y học: " Dimensional and hierarchical models of depression using the Beck Depression Inventory-II in an Arab college student sample" pot
... this model within samples of students across cultures The loadings on the general factor of the bifactor model provide some insight into the nature of the specific domains of the BDI-II First, ... data The interpretation of these findings, according to the theory of bifactor models [46], is that, while the general factor of the bifactor model represents the common trait shared by all the ... (i) using the responses of a sample of Arab college students to the Beck Depression Inventory (BDI-II) in CFA, to compare the “goodness of fit” indices of the original dimensional three -and two-factor...
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Báo cáo khoa học: "Acute renal failure – definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group" doc
... planning, conducting and critically evaluating studies utilizing animal models Table summarizes these principles and other guidelines for the use of animal models in the study of ARF Despite their limitations, ... problems include the definition of ARF [3]; the choice, validity and relevance of animal models of ARF [4]; and the choice regarding appropriate physiological and clinical end-points for trials of ... definitions of ARF have common elements, including the use of serum creatinine and, often, urine output Although the kidney has numerous functions, these are the only functions that are routinely...
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Tài liệu Báo cáo khoa học: Animal models of amyloid-b-related pathologies in Alzheimer’s disease docx
... having sufficient power are therefore extremely important in minimizing the in uence of confounding factors arising from inherent problems associated with breeding APP transgenic mice and maintaining ... N-terminus of the Ab domain in APP It was identified in 1992 [47] and shown to increase Ab levels by six- to eightfold [4] These discoveries created intense interest in APP processing and paved the way ... line C3-3 [58] A chimeric cDNA clone encoding murine APP695 was used, in which the region in and around the murine Ab domain was replaced with the human Ab sequence and the Swedish mutation The...
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Tài liệu Báo cáo Y học: Short peptides are not reliable models of thermodynamic and kinetic properties of the N-terminal metal binding site in serum albumin doc
... albumins On the other hand, the direct thermodynamic and kinetic characterization of Ni(II) binding at site I in HSA and BSA was obtained These data can be very useful in further studies of the ... presumably providing metal binding at site II and the neighbouring His242) bind phosphate ions, thereby providing another level of competition for metal ion binding Kinetics of Ni(II) binding and Cu(II)/Ni(II) ... conformation of the chelate rings The characteristic alternate pattern of the dd bands in the CD spectra is dictated by the conformation of the sixmembered chelate ring involving the His residue...
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Báo cáo khoa học: "Corpus-Based Induction of Syntactic Structure: Models of Dependency and Constituency" pdf
... nouns to the left of the verb (usually subjects) There is another, subtle distinction: in the Paskin work, a canonical ordering of multiple attachments was fixed, while in the Carroll and Charniak ... which contain a matching terminal X Therefore, one can start with uniform rewrites and let the interaction between the data and the model structure break the initial symmetry If one recasts their ... dependent) pairs of words, but the score of a dependency can optionally condition on other characteristics of the structure, most often the direction of the dependency (whether the arrow points left...
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báo cáo hóa học:" Immunological considerations of modern animal models of malignant primary brain tumors" doc
... introduced by the use of germ line p53 inactivation alters immune system function in a number of significant ways in these animals, limiting the use of these models for evaluating the effect of anti-tumor ... the PDGF isoform, PDGF-B, and the receptor PDGF-R frequently occur in gliomas, suggesting the potential role of a malfunctioning autocrine signaling loop in the pathogenesis of some of these tumors ... that involve inducing gliomagenesis by mutating the germ line, and in so doing produce an immunologically flawed paradigm with limited value for pre-clinical testing immunotherapies p53 The tumor...
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báo cáo hóa học:" General anxiety, depression, and physical health in relation to symptoms of heart-focused anxietya cross sectional study among patients living with the risk of serious arrhythmias and sudden cardiac death" doc
... results, and in writing the first draft AH has been the corresponding author NØ participated in the preparation and conduct of the study and the editing of the article BR contributed to shaping of the ... of the article and the editing of the article GEE contributed to the statistical analyses and the editing of the manuscripts KN participated in preparation and the editing of the article All ... counseling setting it is interesting to analyze them together since they are very similar with regard to the risk they are living with, they share some common disease manifestations, and LQTS and...
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Báo cáo y học: " In vivo imaging approaches in animal models of rheumatoid arthritis" pot
... reduced the signs of inflammation The groundwork for further studies on the dynamics of lymphocyte interactions in the synovium has thus been established 168 Most of the work in intravital imaging of ... developed originally for microvascular research and then adapted for inflammation research A nonexhaustive list includes the brain, the liver, the lungs, the muscle, the spleen, the lymph nodes, the pancreas, ... leukocytes in inflamed vessels may correlate with the utility of these contrast agents in detecting active arthritis in the knee [23] The utility of ultrasound may be enhanced, and the mechanism of contract...
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Báo cáo y học: " Gene therapy in animal models of rheumatoid arthritis: are we ready for the patients" pdf
... effects in the injected joint, it is becoming increasingly clear that local treatment also affects arthritis in nearby joints This is an intriguing and general finding, which may expand the therapeutic ... to the lymphatic system In RA patients the draining lymph nodes of inflamed foot joints had higher levels of proinflammatory and anti-inflammatory cytokines than found in serum; furthermore, the ... rheumatoid factors in RA patients may form immune complexes with the immunoglobulin domain of the tgAAC94 fusion protein, thereby inactivating the therapeutic protein in the arthritic joint Moreover,...
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Báo cáo y học: "Role of fibroblast growth factor 8 (FGF8) in animal models of osteoarthritis" doc
... sterile saline was injected into the knee instead of MIA (saline) The synovial lavage was performed with saline days after the intraarticular injection of MIA into knee joints The content of sulfated ... promotes the degradation of the ECM of the articular cartilage and the release of S-GAG into synovial fluid Intraperitoneal administration of anti-FGF8 antibody significantly inhibited the increase in ... S-GAG in the joint by 42% (P = 0.0188; Figure 6) Discussion The present study provides new and interesting findings about the role of FGF8 in joint inflammation We analyzed the rabbit knee in a...
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Báo cáo y học: "Colony variability under the spotlight in animal models of arthritis" pps
... Arthritis Research & Therapy Vol 11 No Robinson same inbred strain of mouse, the universally studied BALB/c, which is the most susceptible to PGIA The goal of the research was to compare the incidence ... the incidence and severity of PGIA and proteoglycan-induced spondylitis and to determine expression patterns of a panel of relevant genes in a large number of distinct colonies of the susceptible ... affects the immune response and disease pathology In conclusion, the present report strengthens the validity of previous studies of the PGIA model in different laboratories, and throws down the gauntlet...
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Báo cáo y học: "Lessons from animal models of arthritis over the past decade" pot
... underly the dominance of joint pathology in these mice, although GPI is also abundant at other sites in the body This principle was already identified in AIA in mice, where antigen is planted in the ... selective inhibitor of the alternative complement pathway markedly reversed inflammation and bone destruction [45] Role of cytokines Findings on the involvement of TNF, IL-1, IL-6 and IL-17 in arthritis ... dominant early inflammatory cytokine in all models, it is the pivotal cytokine in inhibition of chondrocyte proteoglycan synthesis in the articular cartilage in all models studied so far and...
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Báo cáo sinh học: "Estimating variances and covariances for bivariate animal models using scaling and transformation" pot
... the formation of M, an augmented matrix of mixed-model coefficients and righthand sides of the form: = = = with log ICIassociated with the pivots Z, and involved in the Gaussian elimination of ... i and y are introduced This model has the general form: a with It should be noted that the range of maximization of o, bi is from minus infinity to infinity rather than to infinity in order to ... IAI,with the last term independent of the variance AS parameters a el and 2 ’; Differentiating this log-likelihood with respect to 0and Q noting ’;1 , e are independent of and and equating to zero...
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Báo cáo y học: " General and Specific Components of Depression and Anxiety in an Adolescent Population" pdf
... factor loadings [26] The standard errors of measurement were computed from the inverse of the square root of the information function and were plotted using graphics commands These graphs are important ... students invited Response rates for individual schools ranged from 18 % to 38 % resulting in 33 % of the adolescents taking part in the study (n = 1238; 46 % boys and 54 % girls) A total of 55 % of the ... confounding effect of the different response scales (an instrument “method” effect), we included orthogonal method factors for the MFQ and the RCMAS scales The goodness -of- fit indices and the factor...
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Báo cáo y học: " The development of a knowledge test of depression and its treatment for patients suffering from non-psychotic depression: a psychometric assessment" ppt
... testing the instruments with patients suffering from depression Three experts were invited for an informal panel discussion of the instrument, and reviewing the individual items in depth Each of ... discrimination between the high and the low performing groups Modifying the distracters to increase the difficulty level of these items can make these items more discriminating Alternatively, changing ... community clinics Also the instrument contains some very easy items leading to poor discriminating power for these items and the comparative lack of difficult items In future research the instrument...
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báo cáo khoa học: " Psychosocial and contextual correlates of opioid overdose risk among drug users in St. Petersburg, Russia" pot
... participated in developing the study design, helping to create the study instruments, performing data analyses, conducting the interviews, and writing the manuscript KB participated in developing the ... helping to create the study instruments, performing data analyses, conducting the interviews, and writing the manuscript EK supervised the conduct of the study at the Bekhterev Institute and ... in hospital-based treatment (BMC) reported injecting heroin in the past 30 days Almost three quarters of the sample reported injecting heroin at their most recent injection (74.6%) or injecting...
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Báo cáo y học: " First Siena International Conference on Animal Models of " pptx
... highlighting the time needed to produce lesions (up to 12 months in some species) and the importance of the choice of animal and strain Of people who smoke 15–20% develop COPD, and the lesions ... predictive of the human condition and userfriendly to the experimentalist Animal models that may be of great benefit to the study of the mechanisms involved in the development of COPD were described The ... smoke in the rat and mouse were compared That work revealed a greater inflammatory and emphysematous response in the B6C3F1 mouse than in the F344 rat These changes were seen in the mouse after and...
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