other natural products with a similar mechanism of action

Tài liệu Báo cáo Y học: Tissue factor pathway inhibitor A possible mechanism of action doc

Ngày tải lên : 22/02/2014, 04:20

... us k XaÀTFPI;VIIaÀTF ¼ k XaÀTFPI;VIIaÀTF þ k XaÀTFPI;VIIaÀTF Appara app a a1 ent values of k XaÀTFPI;VIIaÀTF and k TFPIÀXaÀVIIaÀTF are rather a d low So we assumed the true rate constants of the ... kinetics of factor X activation in the absence of factor Xa at the initiation point of the reaction Yet this mechanism based on the hypothesis of the interaction between TFPI and Xa–VIIa–TF cannot ... be added for the detection of the hypothetical reaction is deﬁned by the correlation: ½VIIa À TF0 / KXaÀVIIaÀTF ¼ D kXaÀVIIaÀTF d VIIaÀTF;Xa ka A2 2Þ In a similar fashion, the analysis of VIIa–TF...

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Tài liệu Báo cáo khoa học: Hypoxic resistance to articular chondrocyte apoptosis – a possible mechanism of maintaining homeostasis of normal articular cartilage pdf

Ngày tải lên : 18/02/2014, 14:20

... examination of the articular cartilage after experimentally induced OA Articular cartilage of the femoral condyles from the experimental joints was examined to assess any macroscopic damage caused ... progression of inflammation and may be detected in the synovial fluid These changes could be associated with a natural history of OA and may be beneficial in the detection of patients at risk of rapidly ... western blot analysis was performed It was shown that cotreatment of cells with ALLN and TRAIL increased caspase-8 activation and JNK phosphorylation However, both caspase-8 activation and JNK 7380...

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Báo cáo khoa học: A novel mechanism of V-type zinc inhibition of glutamate dehydrogenase results from disruption of subunit interactions necessary for efﬁcient catalysis doc

Ngày tải lên : 05/03/2014, 23:20

... conformational change that appears to be required for maximal activity of the enzyme, thus resulting in a potent inhibition of the overall maximum rate of the oxidative deamination of L-glutamate ... relative quantitation was achieved using the ratio of the height of the emerging peak to that of the undigested GDH For MALDI-TOF calibration purposes, BSA was used as a standard and was diluted ... (glutamate or norvaline) and zinc impact the overall stability and local ﬂexibility of the enzyme As shown in Table 4, the addition of zinc to enzyme alone causes a small increase in thermal stability...

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Estimating Inﬂation Expectations with a Limited Number of Inﬂation-Indexed Bonds ∗ doc

Ngày tải lên : 15/03/2014, 07:20

... ) and H2(xt )) are used to calculate a set of forecast observation points This set of points is used to estimate a mean and variance of the data forecasts • The mean and variance of the data ... obtain parameter estimates From the parameter estimates we use the Kalman filter to obtain estimates of the latent factors 3.3 Calculation of Model Estimates For a given set of model parameters and ... inflation expectations and inflation risk premia Due to a lack of data, we cannot this, and instead we estimate inflation forward rates as part of our model Vol No Estimating Inflation Expectations...

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Báo cáo khoa học: A novel mechanism of TGFb-induced actin reorganization mediated by Smad proteins and Rho GTPases docx

Ngày tải lên : 16/03/2014, 06:20

... GCGAAGCTTACCAGACCGTGGACTAACGA CCCACCGTCTTCGAGAACTA CTTCCTTGGTCTTGGCAGAG CCAGACTAGATGTAGTATTTTTTG ATTAGAGCCAGATGCTTAAGTCC ACCACAGTCCATGCCATCAC TCCACCACCCTGTTGCTGTA and then treated with TGFb1; alternatively cells ... antisense hRhoA sense hRhoA antisense GAPDH-F GAPDH-R Sequence (5¢- to 3¢) GGGATCAGAGTTCATAGTGAAAAGAG GCGAAGCTTCGGCCTAGCTCTCTCCCGGGTCTC GCGGGTACCAATGTGATGGGTGGACTGGT GCGAAGCTTACCAGACCGTGGACTAACGA ... change Cells appeared elongated or spindle-shaped, with a parallel arrangement of actin bundles (Fig 5J) Addition of TGFb did not cause any additional changes in actin cytoskeleton organization...

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Báo cáo khoa học: "Modeling Human Sentence Processing Data with a Statistical Parts-of-Speech Tagger" ppt

Ngày tải lên : 17/03/2014, 04:20

... Probability Decrease at the Disambiguating Region A total of 30 pairs of a garden-path sentence and its ambiguous, non-garden-path control were tested for a comparison of the probability decrease ... carry out simulations that compare the evolution of probabilities in the tagger with that in a theoretically more powerful model trained on the same data, such as an incremental statistical parser ... Journal of Memory and Language,, 47:50–68, 2002 C.D Manning and H Sch¨ tze Foundations of u Statistical Natural Language Processing The MIT Press, Cambridge, Massachusetts, 1999 B Roark Probabilistic...

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RESEARCH DISCUSSION PAPER: Estimating Inﬂ ation Expectations with a Limited Number of Inﬂ ation-indexed Bonds doc

Ngày tải lên : 22/03/2014, 20:20

... this paper are those of the authors and are not necessarily those of the Reserve Bank of Australia Author: finlayr at domain rba.gov.au Media Of ce: rbainfo@rba.gov.au Abstract We estimate inflation ... ) and H2(xt )) are used to calculate a set of forecast observation points This set of points is used to estimate a mean and variance of the data forecasts • The mean and variance of the data ... inflation expectations and inflation risk premia Due to a lack of data we cannot this and instead estimate inflation forward rates as part of our model 18 inflation, a low 2-year break-even inflation...

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Báo cáo Y học: Repression of FasL expression by retinoic acid involves a novel mechanism of inhibition of transactivation function of the nuclear factors of activated T-cells pptx

Ngày tải lên : 24/03/2014, 03:21

... total RNA using 100 ng random hexamer (Pharmacia, Uppsala, Sweden) The PCR primer sequences used were as follows FasL (forward: 5¢-ATGTTTCAGC TCTTCCACCTACAGAAGGA-3¢, reverse: 5¢-CAGAGA GAGCTCAGATACGTTGAC-3¢); ... 12-myristate 13-acetate (PMA) and CsA were purchased from Sigma Ionomycin was obtained from Calbiochem (La Jolla, CA, USA) All other chemicals used were of the purest grade available from Sigma RT-PCR ... substrate 4-methyl-lumbellifery-b-galactoside, and was normalized for protein content [30] A one-way analysis of variance was performed using GraphPad INSTATÒ (GraphPad Software, San Diego, CA, USA)...

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báo cáo sinh học:" Experience with a "social model" of capacity building: the Peoples-uni" ppt

Ngày tải lên : 18/06/2014, 17:20

... countries, mainly in Africa, with the largest numbers from Nigeria, Tanzania and Uganda Seventy-four were male and 43 female; their previous education and current occupation are shown in Table A fee of ... Lanka and Sudan A decision was made to use a competence-based educational model, and to develop modules that covered the "foundation sciences" of public health as well as those that tackled a variety ... will be charged for the academic transcript, although a similar amount will be charged in future before the start of the course (by means of an automated Page of (page number not for citation purposes)...

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Báo cáo sinh học: " Codon usage in vertebrates is associated with a low risk of acquiring nonsense mutations" doc

Ngày tải lên : 18/06/2014, 19:20

... the analysis software; WAF and PS analyzed and interpreted the data, and wrote the manuscript Both authors read and approved the final manuscript Schmid and Flegel Journal of Translational Medicine ... non-vertebrates A low risk of acquiring nonsense mutations may have Page of advantages for organisms with relatively long lifespans and small numbers of offspring Calculating F is a novel tool for addressing ... usage of a species Loss -of- function mutations, such as nonsense mutations, are the molecular basis of many recessive alleles, which can greatly affect the genome of an organism and are the cause...

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Báo cáo sinh học: "Functional characterization of human Cd33+ And Cd11b+ myeloid-derived suppressor cell subsets induced from peripheral blood mononuclear cells co-cultured with a diverse set of human tumor cell lines" docx

Ngày tải lên : 18/06/2014, 19:20

... Genetech, San Francisco, CA), anti-TNFa (Humira, Abbott, Abbott Park, IL), anti-IL-1b (clone AB-206-NA, Abcam, Cambridge, MA), anti-IL-6 (clone AB-201-NA, Abcam), anti-GM-CSF (clone BVD2), anti-TGFb ... 3:721-732 Matsusaka T, Fujikawa K, Nishio Y, Mukaida N, Matsushima K, Kishimoto T, Akira S: Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, ... MDSC samples (4-998 osteogenic sarcoma, DU 145 prostate carcinoma, CAKI-1 renal cell carcinoma, SKOV-3 ovarian carcinoma, and SW 608 and SW 732 colorectal adenocarcinoma cell lines), we analyzed...

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báo cáo hóa học: " The health-related quality of life in rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis: a comparison with a selected sample of healthy people" potx

Ngày tải lên : 18/06/2014, 19:20

... sedimentation rate, and a general health assessment on a visual analog scale (VAS) [23] Disease activity in patients with AS and axial PsA was measured with the BASDAI [24] The BASDAI consists of VAS ... RA SA Per PsA Ax PsA MH Controls RA SA Per PsA Ax PsA RE Controls RA SA Per PsA Ax PsA SF Controls RA SA Per PsA Ax PsA VT Controls RA SA Per PsA Ax PsA SF-36 PCS Controls RA SA Per PsA Ax PsA ... RA SA Per PsA Ax PsA GH Controls RA SA Per PsA Ax PsA MH Control RA SA Per PsA Ax PsA RE Controls RA SA Per PsA Ax PsA SF Controls RA SA Per PsA Ax PsA VT Controls RA SA Per PsA Ax PsA SF-36 PCS...

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Báo cáo hóa học: " Gait kinematic analysis in patients with a mild form of central cord syndrome" pdf

Ngày tải lên : 19/06/2014, 08:20

... Consejer a of Sanidad of the Junta of Comunidades of Castilla-La Mancha (Spain) and FISCAM PI 2006/44 (Spain) The authors thank Dr Antonio Sánchez-Ramos (Head of Department of Physical Medicine and ... was calculated as the average of the values obtained in the five trials considered A descriptive analysis was made of the clinical and functional variables by calculating the mean and standard ... results of our study reveal that not only patients with CCS walk at a slower speed but also, that they display a series of kinematic alterations such as a smaller range of movement in the sagittal...

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báo cáo hóa học:" Establishment of an animal model of a pasteurized bone graft, with a preliminary analysis of muscle coverage or FGF-2 administration to the graft" potx

Ngày tải lên : 20/06/2014, 04:20

... size of the bone formation was also quantitatively measured in the lateral view using Alpha Ease FC software (Alpha Innotech, San Leandro, CA, USA) The area was calculated in relation with that ... results was made and agreed upon by AS, TY and NT Tartrate-resistant acid phosphatase (TRAP) staining After radiographical examination, the femurs with the graft were decalcified with EDTA (ethylenediaminetetraacetic ... (ethylenediaminetetraacetic acid), and cut sagittally, then stained with hematoxylin and eosin and tartrate-resistant acid phosphatase (TRAP) staining in order to demonstrate the osteoclasts Deparaffinized...

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Báo cáo toán học: " General decay for a wave equation of Kirchhoff type with a boundary control of memory type" pdf

Ngày tải lên : 20/06/2014, 21:20

... nonlinear wave equations of Kirchhoff type with some dissipation Nonlinear Anal TMA 65, 243–264 (2006) doi:10.1016/j.na.2004.11.023 13 Yamada, Y: On some quasilinear wave equations with dissipative ... Soufyane, A: General decay of solutions of a wave equation with a boundary control of memory type Nonlinear Anal Real World Appl 11, 2896–2904 (2010) doi:10.1016/j.nonrwa.2009.10.013 18 Cavalcanti, ... the case where M(s) = 1, Cavalcanti et al [14] investigated the existence and uniform decay of strong solutions of wave equation (1.1) with a nonlinear boundary damping of memory type and a nonlinear...

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Báo cáo hóa học: " Application of Evolution Strategies to the Design of Tracking Filters with a Large Number of Speciﬁcations" potx

Ngày tải lên : 23/06/2014, 00:20

... he has been there as an Assistant Professor of automata theory and programming language translation His main research topics are evolutionary computation applications and network optimization ... conditions are classiﬁed with respect to radar and aircraft characteristics because of the very diﬀerent behavior of any tracker for varying input conditions Radar parameters represent the accuracy and ... respect to the radar (radial and tangential projection of velocity heading), magnitude of the transversal acceleration, and magnitude of the groundspeed change There are four quality parameters in...

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Engineering Concepts in Industrial Product Design With A Case Study of Bicycle Design

Ngày tải lên : 02/07/2014, 13:08

... ve araçlarına yaklaşımlarının karşılaştırılması gösterilmiştir Ayrıca, mühendislikte kullanılan tasarım metotları ve bunların tasarım aktivitesi sürecindeki avantajları da konunun daha net bir ... a ıklanabilmesi amacı ile belirlenmiştir Bu çalışma, tasarım sistemleri alanının bir parçasıdır ve sonuçta, tasarım sürecine ve bilgisine yönelik akılcı yaklaşımların belirlenmesini amaçlanmaktadır ... methods are stated and their advantages in design activity are revealed This study is a part of design systems area, with formal approaches to models of design processes and knowledge Finally, a case...

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With a big sum of money pdf

Ngày tải lên : 22/07/2014, 04:20

... be easy to make a good decision With some people, the latter one will be a choice without a hesitation for two main reasons The very first reason is that an enterprise can lead a person to a more ... bring confidence, happiness and wealth On the contrary, some bad ones may force you into a poor state that one must overcome; otherwise, there is a big failure afterwards Happy, sad, successful, ... to a better one where people live in good conditions Admittedly, it is no doubt that a good house can offer a shelter, senses of leisure and comfort to which people who are afraid of risk always...

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Báo cáo toán học: "An Asymptotic Expansion for the Number of Permutations with a Certain Number of Inversions" docx

Ngày tải lên : 07/08/2014, 06:20

... a substantially improved paper the electronic journal of combinatorics (2000), #R50 11 References [1] M Abramowitz and I .A Stegun, Eds., Handbook of Mathematical Functions with Formulas, Graphs ... Formulas, Graphs and Mathematical Tables, Dover Publications, New York, 1966 [2] E .A Bender, Central and Local Limit Theorems Applied to Asymptotic Enumeration, J Combinatorial Theory A 15 (1973), ... ≤ ln n and m is a fixed integer at least 2 Here, H2q are the Hermite polynomials defined before Theorem and the S2q are defined in Theorem In particular, we have a complete asymptotic expansion...

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