... MR, Childs R, Barrett AJ: Health-related quality of life in patients receiving reduced-intensity conditioning allogeneichematopoietic stem cell transplantation. Bone Marrow Transplant 2006, 38(2):101-109.13. ... research,including Spanish speakers, and individuals undergoingreduced intensity transplantation or receiving treat-ment for disease relapse following transplantation. Theknowledge gained from ... DN, Atlam N, Fowler DH,Pavletic SZ: Determinants of functional performance in long-termsurvivors ofallogeneichematopoieticstemcelltransplantation with chronic graft-versus-host disease (cGVHD)....
... neutropenic interval by4–6 days compared with the same dose of cyclophos-phamide without hematopoieticstemcell support, andalso to hasten stemcell regeneration of the immunesystem under ... dialysis is initiated. Pharma-cokinetics of drugs such as high cyclophosphamidemetabolites are poorly understood inpatientswith renalfailure. For this reason, inpatientswith either renal insuffi-ciency ... direct comparison of HSCT with cyclophosphamide andATG versus the Hopkins’ treatment protocol incorporatinghigh-dose cyclophosphamide without stemcell support.Competing interestsNone declared.References1....
... Comparison of regulatory T cell levels at baseline inpatientswith melanoma and healthy subjects.(A) Box plot showingbaseline regulatory T cell (Treg) levels in 22 patientswith melanoma prior to interferon-a ... CD8+cellsasaninternalcontrol.OnlyCD4+cells expressing CD25 with higher intensities thanthe CD8+cells were included in the gate for CD25high cell s. The gate for CD25low cell s was set to include cellsexpressing ... and was receiving a secondline of chemotherapy with fotemustine following thereappearance of liver and lung metastases. Of the 17 patients t reated with adjuvant IFN-a 2b, 4 patients had very...
... Effect of dose on immune response in patients vaccinated with an her-2/neu intracellular domain protein–basedvaccine. J Clin Oncol 2004, 22:1916-1925.44. Reilly RT, Machiels JP, Emens LA, Ercolini ... Vaccina tion with a plasmid DNAencoding HER-2/neu together with low doses of GM-CSF and IL-2 in patientswith metastatic breast carcinoma: a pilot clinical trial. Journal of Translational Medicine ... s.e.m.) binding activity ofpatients evaluable at all time points (patient #3,4, 8, pre, post and late). C. Binding activity in the serum of all patients at all available individual time points...
... identify-ing four and two individuals, respectively as cancer patients havin g tumor cell circulating in the blood flow.High CGB activity was found in blood of three patients with ovarian carcinoma ... indicatedthepresenceoftumorcellscirculatinginbloodof patients. The raw results of GNRH1 expression in blood of can-cer patients was fitted to three normal distributions.Two of these distributions corresponding ... distinguishing patients with tumor cells circulating in their blood andindicate the metastatic spread of these cells.AcknowledgementsThis study was supported by the Polish Ministry of Science...
... in four one-hour sessions of indi-vidual counselling with a diabetes nurse specialist, whohad a bachelor’s degree in education and was trained in motivational interviewing [19]. Using the patients ... recommendedlevel of 30 minutes of daily exercise. Over the sametime period, patients participated in three individualcounselling sessions with a dietician who was alsotrained in motivational interviewing ... differences in the SF-36 vitalityscale inpatientswith chronic conditions [29]. Patients suffering from a condition with a 5-point lower vital-ity score (compared withpatients without that...
... number ofpatients with percentages in parentheses*SPAP available in 39 subjectsFigure 1 Boxplot summary of BNP inpatientswith andwithout right ventricular (RV) dilatation. Median levels of ... different findingsmay be explained by the timingof measurementsobtained. Pulmonary hypertension with subsequent RVdilatation and dysfunction in mechanically ventilated patients with ALI is ... levels in ICU patients do not change signifi-cantly [11,41]. In summary, inpatientswith acute lung injury theplasma levels of BNP are increased, yet the reasons forthis increase remain unclear....
... 2).Twenty-eight patients had previously been treated with hepatic surgery, 54 with prior systemic chemotherapy,including FOLFOX in 35 patients, FOLFIRI in 15, Avastin in 37 patients, and other biologics in ... Survival ofpatients treated with Irinotecan drug eluting beads with liver dominant hepatic metastasis after fail-ing standard chemotherapy b) Overall Survival ofpatients treated with Irinotecan ... eluting beads with liver dominant hepatic metastasis after failing standard chemotherapyFigure 1a) Disease Free Survival ofpatients treated with Irinotecan drug eluting beads with liver dominant...
... along with JFV, in charge of most of the CVID patients gathered in this study and contributed tothe writing of the article. MA and FL were in charge of CVID patients and contributed to the writing ... deVries JE: Peripheral blood lymphocytes ofpatientswith com-mon variable immunodeficiency (CVI) produce reduced levels of interleukin-4, interleukin-2 and interferon-gamma, but pro-liferate normally ... role of IL-12 in dendritic cell- induced differentiation of naive B lymphocytes. J Immunol1998, 161:2223-2231.12. MacLennan I, Vinuesa C: Dendritic cells, BAFF, and APRIL:innate players in adaptive...
... CD8+CD28- T cells [38-40]. An increase of these cells inpatientswith SLE might thusconstitute an effort of counter-regulation within the disturbedimmune system of SLE patients. Surprisingly, ... pre-dominant IFNγ secretion.To gain more insight into the role of autoantigen specific Tcells in SLE, we investigated spontaneous T cell responses tohnRNP-A2 inpatientswith SLE and in healthy ... response,emphasizing the role of T cells in SLE [18,19]. The cellularaspect of the immune response to DNA in its various forms hasbeen extensively studied, including the characterization of Tcells inducing...
... tobe effective in treating a variety of inflammatory diseases. In combination with methotrexate, infliximab provides significantand sustained improvement in a majority ofpatientswith rheu-matoid ... which includes an overview of the studiesinvestigating autoantibody profile during treatment with inflixi-mab, ANAs were detected in between 4% and 17% of SpA patients before initiation of treatment. ... and13% ofpatientswith SpA developed infusion reactions (P =0.126). The OR for development of infusion reactions in RA patients with baseline ANA positivity alone was 2.1. Infliximabwithout...
... preferentially binds peptides containing thenon-standard amino acid citrulline (deiminated arginine) [11]. In addition, an abnormally increased function of the enzymepeptidylarginine deiminase 4 (PAD4; ... anti-CCPantibodies) to those inpatientswith RA. In addition, patients with rhupus display a clinical and serological profile indistin-guishable from patientswith SLE. Moreover, the presence of other coexistent ... similar in allgroups ofpatients (two patientswith rhupus, three patients with RA, and three patientswith SLE also had SS).We found high titers of anti-CCP antibodies in four of seven(57%) patients...
... of alloreactive Bcells inpatientswith early RA. Markers of B -cell activation,such as beta2-microglobulin, immunoglobulin levels, free lightchains (FLCs) of immunoglobulins, and BAFF (B -cell ... associated with early RA.Conclusions Markers of B -cell activation are elevated in patientswith early RA, compared with undifferentiated arthritis,independently of any systemic increase in BAFF ... higher in early RA than in UA. Some features of B -cell activation were nonethelessobserved inpatientswith UA, including BAFF levels that werehigher than in healthy donors, elevated IgG in 55% of...