... define drug- deliverysystemsof a certain size range Reflecting this trend of size definition, NanoparticulateDrugDeliverySystems is a worthy attempt to bring together a wide range of drug- delivery ... the area ofnanoparticulate drug- deliverysystems The first chapter covers a complete overview of the nanoparticulate drugdelivery system, covering wide applications and evaluation of the nanoparticulate ... Epstein-Barash, and Gershon Golomb 16 OcularApplicationsofNanoparticulate Drug- DeliverySystems 271 Annick Ludwig 17 NanoparticulateSystems for Central Nervous System DrugDelivery 281 Jean-Christophe...
... surface of the polymer, resulting in a release rate that is proportional to the surface area of the drugdelivery system (See Figure 2.5b) a DrugDrug Drug- loaded biodegradable particles b DrugDrug ... application of SBA-15 in the deliveryof the small molecule model drugof ibuprofen (IBU), with emphasis on the influence of the different functional methods on the adsorption and release of IBU Chapter ... sustained release of the large protein model drugof bovine serum albumin (BSA) on SBA-15 Chapter covers the factors affecting stability of the released BSA in fabrication ofdrugdelivery systems, including...
... stability Chemical Aspects ofDrugDeliverySystems Table Routes of administration and general classification ofdrugdeliverysystems ROUTES OF ADMINISTRATION DRUGDELIVERY CLASS ORAL SOLIDS ... imposed by the nature of the various routes of administration available for drugdelivery ROUTES OF ADMINISTRATION AND CLASSIFICATION OFDRUGDELIVERYSYSTEMS The principal routes of administration ... Aspects ofDrugDeliverySystems Table Mechanisms and properties influencing drug release from particle carrier systems* MECHANISM OFDRUG RELEASE PROPERTIES INFLUENC~NG DRUG DIFFUSION DRUG RELEASE...
... A4: series of multiple doses of a conventional drugdelivery system B: ideal drug concentration profile PRODRUG What is a prodrug? Prodrug is an inactive precursor of a drug Prodrug reconversion ... Targeted drugdelivery systems: deliver drug to a desired body location, organ, tissue, specific cells… Controlled-release drugdelivery systems: preprogramed drug release By the route of delivery: ... Society of Chemistry, American Chemical Society, Wiley InterScience journals… CONTENTS Generalities ofdrugdelivery Liposomes as drugdeliverysystems Polymers and polymeric systems for drug delivery...
... construction ofdrugdeliverysystems in not too long a time The functionalization of CNTs used in the construction ofdrugdeliverysystems will be discussed in later sections In vivo behavior of functionalized ... application of CNTs as the molecular transporter in drugdelivery Page 14 of 22 Drugdelivery targeted to lymphatic system Many cancers metastasize through lymphatic canal The drugdeliverysystems ... schematic illustration of the strategy for the preparation of the CNT-based drugdeliverysystems Figure The modification of CNTs Schematic illustration of modification of CNTs with various molecules...
... for DrugDeliverySystemsDrugdeliverysystems modify the kinetics or the location of the escape of the drug from the medicine Tables 15.1 and 15.2 provide generic reasons for using drugdelivery ... types of protein drug [21–23] 15.6 Examples of Biodegradable Polymer DrugDeliverySystems Under Development 15.6.1 Polyketals Polyketal-based drugdeliverysystems are under development for applications ... polymer applications Zoladex is the most successful (in terms of duration of clinical use and Table 15.1 Use of a drugdelivery system for kinetic control Dissolution ofdrug is too slow Drug and/or...
... http://www.molecular-cancer.com/content/10/1/3 Page of 20 Figure Live/non-live deliverysystems Live or biological gene deliverysystems include viral and/or bacterial vectors Non-live or nonbiological deliverysystems mainly include ... induction of greater immune responses compared with those elicited by other routes ofdelivery However, the results of vaccination via the skin, have sometimes been conflicting, due to the lack ofdelivery ... advanced class ofdrugdelivery systems, with several formulations in clinical trials Over the past 20 years, a variety of techniques have been developed for encapsulating both conventional drugs (such...
... application of nanodelivery systems in medicine Design of nanotechnology – based drugdeliverySystems Nanoparticles can be used in targeted drugdelivery at the site of disease to improve the uptake of ... therapy The effectiveness ofdrugdeliverysystems can be attributed to their small size, reduced drug toxicity, controlled time release of the drug and modification ofdrug pharmacokinetics and ... uptake of poorly soluble drugs [8,9], the targeting of drugs to a specific site, and drug bioavailability A schematic comparison of untargeted and targeted drugdeliverysystems is shown in Figure...
... the deliveryof DCU via intravenous (IV) infusion route was explored Similar to oral delivery, IV deliveryof DCU was limited by the poor aqueous solubility of DCU The poor aqueous solubility of ... [27] to estimate the amount ofdrug entering the small intestine as a function of time M = D e−Ke(t) where M is the mass of the drug remaining in the stomach, D is the drug dosed, Ke is the stomach ... SC drug depot should continuously provide a slow release ofdrug to the bloodstream providing a longer and sometimes steady drug supply Combined, both effects may result in a drug plasma profile...
... Preface A major goal of pharmacotherapeutics is the attainment of an effective drug concentration at the intended site of action for a desired length of time Efficient deliveryof a drug while minimizing ... Mitra 251 III DrugDeliverySystems A: Conventional SystemsOcular Penetration Enhancers Thomas Wai-Yip Lee and Joseph R Robinson 281 10 Corneal Collagen Shields for OcularDrugDelivery Shiro ... Overview ofOcularDrugDelivery Figure Miosis-time profiles: Plots of the average observed changes in pupillary diameter (ÁPD) as a function of time following the instillation of 25.0 mL of the...
... advantages of direct topical drug administration include targeted drugdelivery to the anterior segment of the eye and avoidance of systemic drug toxicity Many of the disadvantages of eyedrops, ... breakdown of ophthalmic drugs in the eye While this biotransformation usually results in loss of efficacy, the development of prodrugs takes advantage of the increased corneal permeability of the prodrug ... penetration and ocular bioavailability of drugs J Ocular Pharmacol., 1:309 Lee, V H L., and Robinson, J R (1986) Review: Topical oculardrug delivery: Recent developments and future challenges J Ocular...
... increased utility of the microdialysis approach in the study ofoculardrugdelivery and disposition Unique applicationsof the microdialysis approach in the examination ofdrugocular disposition ... delineation of the fundamental mechanisms of vitreal clearance and retinal uptake of drugs (12) More often, ocular pharmacokinetics are determined by obtaining single sample of the ocular fluids ... weight of the diffusing species, and CP represents the concentration of polymer (collagen and hyaluronic acid) in the hydrogel in units of grams of polymer per gram of hydrogel Using the sum of the...
... Routes of delivery: case studies (7) Oculardeliveryof peptide and protein drugs, Adv DrugDelivery Rev., 8:331–339 81 Chiou, G C Y (1994) Systemic deliveryof polypeptide drugs through ocular ... Noncorneal delivery is not a panacea and will probably have niche utility in oculardrugdelivery The greatest potential for the concept appears to be in the area of intraocular deliveryof polar ... basis ofdrug penetration via the noncorneal pathway The challenge for the future is to creatively apply the available knowledge to the practical design of drugs and drugdeliverysystems for ocular...
... their delivery via the ocular route may be viable However, one of the principal problems in the oculardeliveryof peptide and protein drugs is that of relatively low bioavailability to the ocular ... increase the ocular absorption of topically applied hydrophilic but not lipophilic drugs, while not affecting the systemic absorption of either type ofdrug In addition, the presence of sites beyond ... sodium taurocholate IV OCULARDELIVERYOF PEPTIDE AND PROTEIN DRUGS Peptides and proteins may be instilled into the eye for local/topical use Instillation of a topical dose of a drug to the eye leads...
... advantageous properties of several deliverysystems will enhance the use of gene therapy and provide flexibility in the treatment of many diseases Non Viral Vectors One of the greatest concerns ... therapeutically active drugs This is a fascinating technology that has the potential of being a tailor-made delivery system that will improve the therapeutic index of a number of drugs Another modification ... refers to a number of related inherited retinal diseases with an incidence of in 3000 An understanding of the genetic causes of retinitis pigmentosa could lead to deliveryof specific genes in...
... reviewed as a new drug product by the FDA’s Drug Center (CDER) V CLINICAL TESTING OF NEW OPHTHALMIC DRUGDELIVERYSYSTEMS A Human Versus Animal Testing Human drug products are often tested during ... regulation of food, drugs, devices, and cosmetics One of the major provisions of the Act was the reauthorization of PDUFA for years as described above A number of the reforms affecting drug products ... therapeutics: drugdelivery and targeting Adv DrugDelivery Rev., 18:115–131 167 J W Jaroszewski, and J S Cohen (1991) Cellular uptake of antisense oligodeoxynucleotides Adv DrugDelivery Rev.,...
... Preface A major goal of pharmacotherapeutics is the attainment of an effective drug concentration at the intended site of action for a desired length of time Efficient deliveryof a drug while minimizing ... Mitra 251 III DrugDeliverySystems A: Conventional SystemsOcular Penetration Enhancers Thomas Wai-Yip Lee and Joseph R Robinson 281 10 Corneal Collagen Shields for OcularDrugDelivery Shiro ... Overview ofOcularDrugDelivery Figure Miosis-time profiles: Plots of the average observed changes in pupillary diameter (ÁPD) as a function of time following the instillation of 25.0 mL of the...
... increased utility of the microdialysis approach in the study ofoculardrugdelivery and disposition Unique applicationsof the microdialysis approach in the examination ofdrugocular disposition ... delineation of the fundamental mechanisms of vitreal clearance and retinal uptake of drugs (12) More often, ocular pharmacokinetics are determined by obtaining single sample of the ocular fluids ... weight of the diffusing species, and CP represents the concentration of polymer (collagen and hyaluronic acid) in the hydrogel in units of grams of polymer per gram of hydrogel Using the sum of the...