nucleus replacement of the intervertebral disc
Báo cáo y học: "Degeneration of the intervertebral disc" pptx
... to the vertebral bodies, with the fibres continuing into the disc [8] A schematic view of a spinal segment and the intervertebral disc The figure shows the organization of the disc with the nucleus ... and 20% of the dry weight of the annulus and nucleus, respectively [23], provides tensile strength to the disc and anchors the tissue to the bone Aggrecan, the major proteoglycan of the disc [24], ... lead to degeneration of the disc Nutritional pathways to disc degeneration One of the primary causes of disc degeneration is thought to be failure of the nutrient supply to the disc cells [65] Like...
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Báo cáo khoa học: "Calcification of the Intervertebral Discs and Curvature of the Radius and Ulna: A Radiographic Survey of Finnish Miniature" potx
... number of calcifications within a single dog The presence of calcification was not related to sex or age in either breed nor was the age related to the number of calcified discs The median number of ... (Antisedan® mg/ml) 0.1 mg/kg IM to reverse the sedation The authors evaluated the radiographs together The number of calcified discs was calculated and their location in the vertebral column was recorded ... defined as the length of a divided by the length of b Teaching Hospital of Helsinki University for a radiographic survey of the spine and front legs For the radiographic examination the dogs were...
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Báo cáo y học: "The role of interleukin-1 in the pathogenesis of human Intervertebral disc degeneration" pdf
... Despite these data, there is no clear evidence that IL-1 is synthesized by native human disc cells (as opposed to cells within herniated disc tissue) or whether it can induce the altered synthesis of ... discs (Fig 1) Staining was particularly prominent in the cytoplasm of the chondrocyte-like cells of the NP and IAF No significant difference was observed between the proportions of cells in the ... observed in the matrix of the IVDs or in blood vessels, with the exception of immunopositivity for ICE, which showed some staining in the matrix and blood vessels of the most degenerate discs (histological...
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Báo cáo y học: "Action of fibroblast growth factor-2 on the intervertebral disc" docx
... actions of FGF2 in intervertebral disc of of Schematic of the regulationcells catabolic and anti-anabolic actions of FGF2 in intervertebral disc cells Fibroblast growth factor (FGF2) activates the ... synthesis, reducing the amount of PG synthesized per cell by 40% A similar finding was noted in the case of AF cells FGF2-mediated reduction in PG accumulation in the CM is therefore, in part, the ... pathogenesis of painful intervertebral disc degeneration Spine 2006, 31:560-566 Doita M, Kanatani T, Harada T, Mizuno K: Immunohistologic study of the ruptured intervertebral disc of the lumbar...
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The laws of the fifth discipline
... pushing on its bow? The leverage lies in going to the stern and pushing the tail end of the tanker to the right, in order to turn the front to the left This, of course, is the job of the rudder But ... illustration of leverage that also served as his metaphor for the principle of leverage the "trim tab." A trim tab is a small "rudder on the rudder" of a ship It is only a fraction the size of the rudder ... easier to turn the rudder, which, then, makes it easier to turn the ship The larger the ship, the more important is the trim tab because a large volume of water flowing around the rudder can...
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Tài liệu The Formular of the National Discourse in Vietnam, 1940-1945 - Nguyễn Thế Anh pdf
... superficially in the face of French rule A new generation of Vietnamese grew up within a context characterized by the decline of the long-held superiority of the white man, 14 The Formulation of the National ... on the notion that their lives would be entirely changed for the better, in order to nurture the ‘subjective’ factor of the revolutionary will of the people as a whole 22 The Formulation of the ... conclude that the outcome of the Revolution of August 1945, the crest of a conquering, irresistible swell, depended upon the strengths of the leadership and local organization of the Việt Minh,...
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Báo cáo y học: "Transcriptional profiling of bovine intervertebral disc cells: implications for identification of normal and degenerate human intervertebral disc cell phenotypes" pdf
... with their presence identifying an adaptation of the cells to the unique environment of the IVD [19-21] This suggests that the challenging environment of the IVD contributes to defining the cells ... During development the perichordal disc, forerunner of the IVD and endplates, forms by segmentation of the mesenchymal column that surrounds the developing notochord (NC) The notochordal segments ... component analysis The results of the PCA of the microarray data showed that the three replicates for each cell type clustered closely together validating our ability to separate the cell types by...
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benston et al - following the money; the enron failure and the state of the corporate disclosure (2003)
... widespread public and of cial concern about the usefulness of current disclosures by corporations than the failure of Enron in the fall of 2001 and the subsequent disclosures of misconduct by its ... a very real interest in the information that corporations disclose, the trustworthiness of the disclosure, and how and when they disclose it The Enron affair and the other accounting episodes ... reported is the value of the building as of the date of the financial statement, which cannot be the investor’s decision date Worse yet, the values of most assets cannot be determined from the market...
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Báo cáo y học: "Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration" ppt
... Interestingly, the MTL differed according to the degree of degeneration in two discs from the same individual (grade disc: MTL 8.56; grade disc: MTL 7.7), and following the statistical correction of results ... study, performed the majority of the laboratory work and analysis, and drafted the manuscript AJF participated in the design of the study and interpretation of data JAH conceived the study, secured ... M, Antoniou J: The role of proteoglycans in aging, degeneration and repair of the intervertebral disc Biochem Soc Trans 2002, 30:869-874 Roughley PJ: Biology of intervertebral disc aging and...
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Báo cáo y học: "The influence of serum, glucose and oxygen on intervertebral disc cell growth in vitro: implications for degenerative disc disease" potx
... degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration Arthritis Res Ther 2007, 9:R45 Urban JP, Smith S, Fairbank JC: Nutrition of the intervertebral disc ... extents These areas warrant further investigation, as the actions of individual growth and survival factors that may enter the disc from the vascular supply or that may be synthesised by IVD cells themselves ... intervertebral disc: cellularity and diffusion of glucose in vitro J Anat 1975, 120:113-130 Gruber HE, Hanley EN Jr: Analysis of aging and degeneration of the human intervertebral disc Comparison of surgical...
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Báo cáo y học: "Expression and regulation of neurotrophins in the nondegenerate and degenerate human intervertebral disc" pdf
... participated in the design of the study, performed the majority of the laboratory work and analysis, and drafted the manuscript AJF helped to secure funding, participated in the design of the study ... who have demonstrated innervation of both the perianular region of the IVD as well as the central region of endplate above the nucleus pulposus (NP) [10] Within the degenerate IVD, however, nerves ... structure of the extracellular matrix Up to a total of 400 cells were counted in each region of the IVD, and the number of positively stained cells was expressed as a percentage of the total...
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Báo cáo y học: "Regulation of catabolic gene expression in normal and degenerate human intervertebral disc cells: implications for the pathogenesis of intervertebral disc degeneration" ppt
... that the lack of TNF-R1 does not affect the incidence or severity of collagen-induced arthritis in the joints [27] Repeated injections of TNF-α into the joints of TNF-R1 knockout mice enhanced the ... inhibition of 23 24 25 intervertebral disc degeneration Int J Exp Pathol 2006, 87:17-28 Le Maitre CL, Freemont AJ, Hoyland JA: The role of interleukin-1 in the pathogenesis of human intervertebral disc ... Analysis of tissue distribution of TNF-alpha, TNF-alphareceptors, and the activating TNF-alpha-converting enzyme suggests activation of the TNF-alpha system in the aging intervertebral disc Ann...
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Báo cáo y học: " Increased expression of matrix metalloproteinase-10, nerve growth factor and substance P in the painful degenerate intervertebral disc" pot
... role in the activation of a number of other members of the MMP family in a range of cell types, including articular chondrocytes [19,20,32] The activation of MMP by other members of the MMP family ... within the NP of the degenerate IVD [12,17], which correlates with our observations regarding MMP-10 localisation to the NP The wide substrate specificity of MMP-10, coupled with the activity of other ... time, this results in the breakdown of matrix until the disc loses both height and function, and in a large proportion of cases, there is innervation and initiation of the pain response which...
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Báo cáo y học: "Expression of cartilage-derived morphogenetic protein in human intervertebral discs and its effect on matrix synthesis in degenerate human nucleus pulposus cells" potx
... stimulate the synthesis of these important matrix molecules this would be of benefit for regenerating the degenerate disc Previous studies investigating the effect of CDMP1 on rabbit disc cells ... loss in disc height, de-stabilisation of the motion segment and the ingrowth of blood vessels and nerves resulting in generation of Here we demonstrate the synthesis and localisation of CDMP ... Images are of nucleus pulposus of grade non-degenerate discs (column 1), the nucleus pulposus of grade 10 degenerate discs (column 2) and IgG controls for each antibody Bars = 570 μm Page of 10 (page...
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Báo cáo y học: "Effect of small interference RNA (siRNA) for ADAMTS5 on intervertebral disc degeneration in the rabbit anular needle-puncture model" pptx
... saline (PBS) per disc) The timing of injection was earlier than that used in other studies [17,18] to reveal the effect of an injection of ADAMTS5 siRNA during the acute phase of disc degeneration ... cleaves the core protein of aggrecan, may significantly contribute to the loss of water content of the NP after anular puncture However, the reason that the disc height loss was not reversed by the ... gene therapy for the inhibition of intervertebral disc degeneration Int J Exp Pathol 2006, 87:17-28 Le Maitre CL, Freemont AJ, Hoyland JA: The role of interleukin-1 in the pathogenesis of human intervertebral...
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Báo cáo khoa hoc:" Human MMP28 expression is unresponsive to inflammatory stimuli and does not correlate to the grade of intervertebral disc degeneration" doc
... model of nucleus pulposus tissue degeneration Matrix Biol 2006, 25(7):409-418 Le Maitre CL, Freemont AJ, Hoyland JA: The role of interleukin-1 in the pathogenesis of human intervertebral disc ... Herniation L4/5 61 M Disc Herniation L3/4 50 M Disc Herniation L5/S1 46 F Disc Herniation L5/S1 51 M Symptomatic Disc Disease L4/5 50 F Disc Herniation L3/4 51 F Disc Herniation L4/5 47 M Disc Herniation ... 14 37 F Disc Herniation L4/5 15 66 M Disc Herniation L5/S1 16 70 F Disc Herniation L5/S1 17 40 F Disc Herniation L4/5 18 55 F Disc Herniation L4/5 19 26 M Disc Herniation L5/S1 20 57 M Disc Herniation...
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Báo cáo y học: "Intradiscal transplantation of synovial mesenchymal stem cells prevents intervertebral disc degeneration through suppression of matrix metalloproteinase-related genes in nucleus pulposus cells in rabbits" potx
... analyses for discs The disc height index was defined as the ratio of disc height to vertebral body height by lateral radiographs of the spine (Figure 3a) The disc height index in the degeneration ... selected only if the raw values of the ‘signal’ were more than the lower limit of the confidence interval Expression of the gene was judged to be ‘present’ by the GeneChip Operating Software version ... transplantation of synovial MSCs After aspiration of the nucleus pulposus, intervertebral disc space rapidly decreases Synovial MSCs injected into the nucleus pulposus space promote synthesis of type...
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Báo cáo y học: "The efficacy of Link N as a mediator of repair in a rabbit model of intervertebral disc degeneration" ppt
... date, however, there have been no reports on the effect of Link N on the IVD in vivo The purpose of the present study was to determine the effect of intradiscally administered Link N on disc cell ... rodents because of the small size and volume of their discs In addition, the NPs cells remain notochordal in the adult, unlike the human and many large animal models On the other hand, larger ... N stimulating the proteoglycan content when it is administered to the degenerate rabbit disc in vivo This stimulation occurs in both the NP and AF of the disc and in the absence of any effect...
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Báo cáo khoa học: " Calcification of intervertebral discs in the dachshund: a radiographic and histopathologic study of 20 dogs" ppsx
... (62.5%) of the dogs, while in a radiographic study of 327 one-year old dachshunds Stigen [7] found calcified discs in 79 (24.2%) of the dogs On the assumption that most of the dogs in the former ... transitional zone between the nucleus pulposus and the annulus fibrosus, or - distinct calcification of a larger part of the nucleus pulposus, or - indistinct calcification of the entire nucleus pulposus ... of calcified discs in each dog ranged from one (dog no 19) to 24 (dog no 17) The individual number and location of calcified discs together with the degree of calcification of each affected disc, ...
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Cambridge.University.Press.Gender.Race.and.the.Writing.of.Empire.Public.Discourse.and.the.Boer.War.Sep.1999.pdf
... food stocks, and the mood of the garrison The tactics of the Daily Mail captured the attention of the nation; the newspaper dramatized the situation of the town by emphasizing the danger that ... approached the particulars of the Boer War with the eye of a journalist, concerned with the specifics on the spot, such as the role of the Boer police in the Witwatersrand or the analysis of the parts ... the interest of the British public very decisively The press followed the events of the war in such detail that Haggard decided by the end of the war to give up the idea of writing a series of...
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