notch jagged signaling in neoplasia

Jagged notch signaling in zebrafish pronephros development

Ngày tải lên : 14/09/2015, 10:29

... Hong et al., 2006) 1.4 Notch Signaling: Regulation of Notch Signaling and Function in Kidney 1.4.1 Notch Signaling: Lateral Inhibition and Lateral Induction Notch signaling is an evolutionarily ... this process, since it interacts with Jagged2 a and facilitates Jagged2 a internalization In summary, our findings indicate a new function of Notch signaling in cell differentiation within a zebrafish ... and the inner ear, and that of Delta -Notch signaling in neural tissue, the inner ear and the intestine In all these cases, the blockage of Notch signaling leads to a failure in lateral inhibition...

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Tài liệu Báo cáo khoa học: Osmotic stress sensing and signaling in ﬁshes doc

Ngày tải lên : 18/02/2014, 16:20

... place in the order of minutes to hours and involves many hormones, including arginine vasopressin, angiotensin II, natriuretic peptides, vasoactive intestinal peptide, urotensin II, insulin and ... (within h) induced by hyperosmotic stress, indicating a role of this mitogenactivated protein kinase kinase kinase interacting protein for osmosensory signal transduction in ﬁsh 14-3-3 proteins ... of MAPK cascades, mitogen-activated protein kinase kinase kinase interacting protein (TAK binding protein ¼ TAB 2), as an IEG during hyperosmotic stress in tilapia gill epithelium [26] This gene...

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Tài liệu Báo cáo khoa học: Osmosensing and signaling in the regulation of mammalian cell function docx

Ngày tải lên : 18/02/2014, 16:20

... Thus, integrin-dependent cell volume sensing and signaling integrates into the overall context of insulin signaling Similarly, sensing of glutamine-induced hepatocyte swelling by integrins feeds into ... Osmosensing and signaling in mammalian cell function F Schliess et al [7] On the other hand, hyperosmotic shrinkage prevents insulin-induced hepatocyte swelling and proteolysis inhibition, indicating ... R, vom Dahl S & Haussinger D (2004) Involvement of integrins and Src ¨ in insulin signaling towards autophagic proteolysis in rat liver J Biol Chem 279, 21294–21301 15 Reinehr R, Becker S, Braun...

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Tài liệu Báo cáo khoa học: Dual P2Y12 receptor signaling in thrombin-stimulated platelets – involvement of phosphoinositide 3-kinase b but not c isoform in Ca2+ mobilization and procoagulant activity pdf

Ngày tải lên : 18/02/2014, 16:20

... work investigating the interaction of P2Y12 with P2Y1 signaling [25,40] We ﬁnd that P2Y12 enhances the thrombin-induced Ca2+ response in a way not only involving adenylyl cyclase ⁄ PKA inhibition, ... (1993) ADP- and thapsigargin-evoked Ca2+ entry and protein-tyrosine phosphorylation are inhibited by the tyrosine kinase inhibitors genistein and methyl-2,5-dihydroxycinnamate in fura-2-loaded human ... where thrombin is generated in situ We ﬁnd that (autocrine) ADP, acting via P2Y12, enhances and extends the thrombin-induced platelet activation by increasing Ca2+ mobilization from internal stores,...

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Tài liệu Báo cáo khoa học: Bone morphogenetic protein signaling in stem cells ) one signal, many consequences pptx

Ngày tải lên : 19/02/2014, 00:20

... chemical inhibitor SB-431542 to block activin ⁄ TGF-b signaling in murine stem cell cultures Both experiments resulted in a strong growth inhibition of the stem cells but, fascinatingly, did not interfere ... cells into astrocytes, by binding and hyper activating the promoter of glial ﬁbrillary acidic protein (GFAP) In parallel, BMP signals lead to enhanced expression of ID proteins, which in turn bind ... and BMP signaling cascades including Lefty1, ID1 and ID2 These data already indicate negative transcriptional regulation between LIF ⁄ STAT3 signaling on one end, and TGF-b ⁄ BMP signaling on...

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Báo cáo khoa học: Proteomic analysis reveals Hrs ubiquitin-interacting motif-mediated ubiquitin signaling in multiple cellular processes ppt

Ngày tải lên : 07/03/2014, 03:20

... protein interactions In order to gain insight into the role of Hrs UIM-mediated ubiquitin signaling in cells, we performed a proteomic screen for Hrs UIM-interacting ubiquitinated proteins in human ... to bind clathrin via its C-terminal clathrin box motif and regulate clathrin-coated vesicle trafﬁcking [57] Interestingly, Hrs also contains a C-terminal clathrin box motif that binds clathrin, ... ubiquitin binding of the ubiquitin-interacting motif J Biol Chem 278, 28976–28984 12 Miller SL, Malotky E & O’Bryan JP (2004) Analysis of the role of ubiquitin-interacting motifs in ubiquitin binding...

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Báo cáo khoa học: Gonadotropin-releasing hormone: GnRH receptor signaling in extrapituitary tissues docx

Ngày tải lên : 16/03/2014, 04:20

... (NF-jB) signaling The GnRH-induced signaling pathways in extrapituitary tissues are shown schematically in Fig Fig Schematic representation of GnRHR signaling in extrapituitary tissues Binding of ... adhesion kinase (FAK) and proline-rich tyrosine kinase (Pyk2) are the predominant mediators of integrin signaling GnRHR has been shown to signal through these molecules, suggesting a role for GnRH in ... are involved in cell growth, metastasis, or survival Arr, b-arrestin; CREB, cAMP response element-binding protein; FGFR, ﬁbroblast growth factor receptor; HB-EGF, heparin-binding EGF; IjB, inhibitory...

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Báo cáo khoa học: Intrabodies against the EVH1 domain of Wiskott–Aldrich syndrome protein inhibit T cell receptor signaling in transgenic mice T cells potx

Ngày tải lên : 16/03/2014, 14:20

... products were mixed in the following combinations: 18SVH–linker and linker) 18VL, 18VH–linker and linker)18VL, 21SVH–linker and linker)21VL, 21VH–linker and linker)21VL and singlechain antibodies, ... protein kinases and regulatory molecules into the membrane-receptor complexes, resulting in the correct initiation and amplification of the signaling reaction WASP is an adaptor molecule containing ... blotting, immunostaining, immunoprecipitation and blocking of protein function Therefore, if intrabodies retain their specificity and high-affinity binding properties, they may be useful tools for inhibition...

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Báo cáo khoa học: Liver receptor homolog-1 localization in the nuclear body is regulated by sumoylation and cAMP signaling in rat granulosa cells docx

Ngày tải lên : 23/03/2014, 06:20

... and Sox9 Mol Endocrinol 18, 2451–2462 39 Kim YH, Choi CY & Kim Y (1999) Covalent modiﬁcation of the homeodomain-interacting protein kinase (HIPK2) by the ubiquitin-like protein SUMO-1 Proc Natl ... Billig H (2004) Inhibition of small ubiquitin-related modiﬁer-1 expression by luteinizing hormone receptor stimulation is linked to induction of progesterone receptor during ovulation in mouse granulosa ... by inserting the corresponding fragments into pcDNA-Tag3A (Stratagene, La Jolla, CA, USA) cleaved with EcoRI and HindIII The BsrGI-BamHI fragment from pEGFP-LRH1-K213 ⁄ 289R was inserted into...

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Báo cáo khóa học: Glutamate signaling in peripheral tissues ppt

Ngày tải lên : 30/03/2014, 13:20

... distribution Brain, retina, testis, bone Brain, retina, liver Brain, intestine, kidney, retina, liver, heart Brain, placenta Retina, liver Vesicular glutamate transporter subtypes VGLUT1 560 Brain, bone ... both glucagon and insulin in pancreatic islets Insulin secretion is stimulated by AMPA, KA and NMDA in MIN6 cells derived from insulin-secreting pancreatic b cells [58], and also induced by both ... a single dose of morphine decreases NR1 mRNA in adrenal glands but not in hippocampus [137] The prior systemic administration of NMDA prevents the marked increase in adrenal AP1 DNA binding induced...

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Báo cáo hóa học: "Involvement of aryl hydrocarbon receptor signaling in the development of small cell lung cancer induced by HPV E6/E7 oncoproteins" ppt

Ngày tải lên : 18/06/2014, 16:20

... lines indicate protein-protein binding interactions, and arrows refer to “acts on” interactions such as proteolysis, expression, and protein-protein interactions Genes up regulated are shown in ... from in situ to invasive carcinoma and in a minor percentage brain, liver and pancreas metastases were observed Inactivation of p53 and pRB occurs in the majority of neuroendocrine lung carcinomas ... subsequently leading to progression of the cell into the S-phase [14] Furthermore, E7 binds to inhibitors of cyclin-dependent kinases (p16, p21), increasing the level of phosphorylated pRb In this way,...

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báo cáo hóa học: " Treatment with gelsolin reduces brain inflammation and apoptotic signaling in mice following thermal injury" potx

Ngày tải lên : 19/06/2014, 22:20

... implying that there might be no T cell infiltration in brain secondary to acute burns Similarly, there was no expression of anti-inflammatory cytokines, including IL-10 mRNA, induced by gelsolin infusion ... The ERK1/2 blotting displayed equal loading between wells Kinetic changes in plasma gelsolin concentrations To evaluate kinetic changes in circulating gelsolin in various groups in the study, we ... expression in brain during the entire observation period, suggesting that administration of gelsolin only inhibits proinflammatory cytokine transcription, without augmenting expression of anti-inflammatory...

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báo cáo hóa học:" BMP-2 signaling in ovarian cancer and its association with poor prognosis" pot

Ngày tải lên : 20/06/2014, 07:20

... using diaminobenzidine containing 0.3% H2O2 as a substrate for peroxidase and nuclei were counterstained with diluted hematoxylin Epithelial zones were scored according to the intensity of staining ... recombinant BMP-2 protein was examined The ability of BMP-2 to induce signaling pathways and expression of target genes was investigated Functional assays were also performed to determine the in ... stimulation with BMP-2 To determine whether the BMP-2 signaling pathways were functional in these cell lines, we examined the effect of BMP-2 treatment on three main signaling pathways We first stimulated...

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Báo cáo hóa học: " Resveratrol engages AMPK to attenuate ERK and mTOR signaling in sensory neurons and inhibits incision-induced acute and chronic pain" pptx

Ngày tải lên : 21/06/2014, 19:20

... ERK and eIF4E in TG cultures (Figure 5) These findings indicate that resveratrol blocks IL6-induced signaling in sensory neurons Figure Resveratrol blocks IL-6 induced signaling in sensory neurons ... efficaciously inhibits ERK and mTOR signaling in sensory neurons in vitro The mTOR [39-42] and ERK pathways [43] have been linked to pathology in multiple preclinical pain models and our previous findings ... IL-6-mediated signaling via the ERK/eIF4E pathway and IL-6induced allodynia These findings suggest that resveratrol may be an efficacious compound for use in pain conditions linked to IL-6 signaling, ...

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Báo cáo sinh học: "Compound developmental eye disorders following inactivation of TGF signaling in neural-crest stem cells" doc

Ngày tải lên : 06/08/2014, 18:21

... cultured in DMEM:F12 medium (Gibco/Invitrogen, Carlsbad, USA) containing 10% fetal bovine serum (Sigma) Following a 60 incubation in DMEM:F12 medium containing 0.1% bovine serum albumin at 37°C, ... suggesting that both transcription factors are involved in mediating TGF␤ signaling in ocular cells during development Interestingly, a report of a family suffering from both Axenfeld-Rieger’s anomaly ... defines distinct layers of the developing retina in control eyes (Figure 5h) In Tgfbr2-mutant mice, however, patterning into cell layers was disturbed, and the thickness of the retina was increased...

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Báo cáo sinh học: "Imp-L2, a putative homolog of vertebrate IGF-binding protein 7, counteracts insulin signaling in Drosophila and is essential for starvation resistance" ppt

Ngày tải lên : 06/08/2014, 18:21

... for insulin [6] Interestingly, Imp-L2 has been shown to bind human insulin, IGF-I, IGF-II and proinsulin, and its homolog in the moth Spodoptera frugiperda, Sf-IBP, can inhibit insulin signaling ... with insulin for binding to the insulin receptor (InR) and inhibit the autophosphorylation of InR [6] Furthermore, IGFBP-7 is suspected to be a tumor suppressor in a variety of human organs, including ... levels in vivo [24] The amount of membrane-bound tGPH reflects signaling activity in the phosphoinositide 3-kinase/protein kinase B (PI 3-kinase/ PKB) pathway Overexpression of dInR resulted in a...

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Báo cáo y học: "Antigen receptor signaling in the rheumatic diseases" doc

Ngày tải lên : 09/08/2014, 01:22

... dephosphorylates the inhibitory tyrosine of Lck [54] Pep cooperatively inhibits TCR signaling by binding Csk and this association in turn is mediated by a proline-rich sequence in the C-terminal region ... discussed above include quantitative and perhaps qualitative impairments in a single critical molecule, ZAP-70, involved in TCR signal transduction What of perturbations in distinct signaling pathways ... antigen receptor signaling Both single and double knockouts (dKOs) have been generated, revealing overlapping as well as developmentally distinct roles in antigen receptor signaling [35] The T-cell-specific...

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Báo cáo y học: "Reduced transforming growth factor-beta signaling in cartilage of old mice: role in impaired repair capacity" ppsx

Ngày tải lên : 09/08/2014, 07:20

... transforming growth factor (TGF)-beta signaling Staining ofin cartilage molecules in cartilage Paraffin sections of knee joints of young and old mice were stained with antibodies against (a,c) ... The intensity of the staining was not taken into account as no obvious differences were observed in staining intensities in the different experimental groups: young/old or -IL-1/+IL-1 The obtained ... W, Dunander C, Heingard D: Inhibition of interleukin-1alphainduced cartilage oligomeric matrix protein degradation in bovine articular cartilage by matrix metalloproteinase inhibitors: potential...

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Báo cáo y học: " Aging, osteoarthritis and transforming growth factor-β signaling in cartilage" pps

Ngày tải lên : 09/08/2014, 07:20

... conserved Mad homology domains (MH in the amino terminus and MH in the carboxy terminus) References Binding of the TGF-β isoforms to the TGF-β receptors (TGF-βRs) results in the recruitment and phosphorylation ... morphogenetic proteins to body morphogenetic proteins Cytokine Growth Factor Rev 2005, 16: 249-250 Lories RJU, Luyten FP: Bone morphogenetic protein signaling in joint homeostasis and disease Cytokine Growth ... transforming growth factor-beta signaling in cartilage of old mice: role in impaired repair capacity Arthritis Res Ther 2005, 7:R1338-R1347 β ten Dijike P, Hill CS: New insights into TGF-β–Smad signaling...

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Báo cáo y học: "Targeting Toll-like receptor signaling in plasmacytoid dendritic cells and autoreactive B cells as a therapy for lupus" pps

Ngày tải lên : 09/08/2014, 07:20

... IgG3 in mice; IgG1 and IgG3 in humans) This suggests that T cells and BAFF-producing antigen-presenting cells may play an indispensable role in lupus pathogenesis Interestingly, IFN priming induces ... is lacking [82] Interestingly, some mainly circumstantial evidence suggests a role for chronic Epstein–Barr virus infection in the pathogenesis of SLE [83] However, instead of considering lupus ... suggesting aviditydriven competition for binding to a common receptor structure, probably TLR9 Indeed, one particular INH-ODN, named 2114, binds to recombinant TLR9–immunoglobulin fusion protein...

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