nitrite and nitrate in cancer
Báo cáo y học: "yrosine kinase – Role and significance in Cancer"
Ngày tải lên :
03/11/2012, 09:57
... ATP binding site serves as a docking site for specific binding of cytoplasmic signaling proteins containing Src homology-2 (SH2) and protein tyrosine binding (PTB) domains These proteins in turn ... tyrosine kinase inhibitors Inhibiting the activity of tyrosine kinases by low molecular weight compounds capable of interfering with either ligand binding (in the case of receptor tyrosine kinases) ... carcinoma Bladder cancer Glioblastoma multiforme Autocrine-paracrine loop Glioma Autocrine-paracrine loop PDGFR and PDGF IGFR and IGF I and II Breast cancer Table Protein kinase inhibitors in clinical...
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Tài liệu Psychotherapy and Survival in Cancer: The Conflict Between Hope and Evidence pptx
Ngày tải lên :
15/02/2014, 05:20
... needed for conducting, reporting, and interpreting randomized clinical trials This knowledge cannot be inferred from an understanding of conventional experimental design in the social and behavioral ... randomization, introducing bias Forty patients were each initially randomized to intervention and control conditions In the intervention group, patient was excluded owing to death, owing to incomplete ... emphasized reducing denial while preserving hope, completing unfinished business, and taking an active role in treatment decisions, but “above all else, simply listening, understanding, and sometimes...
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The Use of Mushroom Glucans and Proteoglycans in Cancer Treatment potx
Ngày tải lên :
06/03/2014, 02:21
... 1-6 main chains and 1-4 branchings, and the more common 1-3 main chains and 1-6 branchings.18 This fraction also is highly active in vitro and in animal models of cancer, although activity in these ... predict anticancer efficacy in humans Maitake D-Fraction has been used in a few exploratory studies in cancer patients.17 In 1994, a group from China published in abstract form their findings from ... hospitals in Shanghai, Beijing, and other areas in China, with a total 189 patients The double-blind study used the same doses and test materials as the previous study, and examined PSP against the...
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Báo cáo y học: " Preparation of RGD-modified Long Circulating Liposome Loading Matrine, and its in vitro Anti-cancer Effects"
Ngày tải lên :
26/10/2012, 08:57
... (GIBCO, USA) containing 10% heat-inactivated fetal bovine serum (Nuoding, China), and the HT-29 cells were grown in DMEM medium (GIBCO, USA) also containing 10% heat-inactivated fetal bovine serum All ... Biology, Chinese Academy of Sciences (Shanghai, China) The breast cancer Bcap-37 and colon cancer HT-29 cell lines were maintained in our lab A375 cells and Bcap-37 cells were grown in RPMI1640 ... then evaluated by in vitro testing in human cancer cell lines We observed that 198 RGD-M-LCL had increased anti-proliferative activity and increased the induction of apoptosis in cancer cells compared...
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Tài liệu Area Socioeconomic Variations in Cancer Incidence and Stage at Diagnosis in New Jersey, 1996-2002 pdf
Ngày tải lên :
14/02/2014, 21:20
... the skin, non-Hodgkin lymphoma, oral (oral cavity and pharynx) cancer, ovarian cancer, pancreas cancer, prostate cancer, stomach cancer, thyroid cancer, and urinary bladder cancer To compare incidence ... Trends in Cancer Incidence and Mortality in New Jersey, 1979-2002; • Cancer Survival in New Jersey 1979-1997; • Cancer Prevalence in New Jersey on January 1, 2003; and • Childhood Cancer in New ... inactivity, and a diet high in saturated fat and/ or red meat and low in fruits and vegetables • The lower incidence for whites and blacks in the areas with low poverty may be due in part to increased...
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Tài liệu Nanotechnology in Cancer Treatment and Detection doc
Ngày tải lên :
15/02/2014, 05:20
... smaller than most human cells Cancer Nanotechnology research is interdisciplinary and incorporates Biology, Chemistry, Engineering, Medicine, and Physics Properties of Cancer Cells • Epidermal Growth ... trials reveal that a single intravenous nanoparticle injection eradicated 100 percent of tumors in mice when exposed to near-infrared light Most work is being done with near-infrared light, which ... affinity to Cancer cells than healthy cells (EGFR binding) White light and simple, inexpensive microscope is all that’s necessary for powerful ex vivo Cancer detection The scattering is so strong...
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Tài liệu Báo cáo khóa học: Suppression of b1,3galactosyltransferase b3Gal-T5 in cancer cells reduces sialyl-Lewis a and enhances poly N-acetyllactosamines and sialyl-Lewis x on O-glycans Lydia Mare and Marco Trinchera pdf
Ngày tải lên :
19/02/2014, 12:20
... cultured in Dulbecco’s modified Eagle’s medium containing 10% foetal bovine serum, 100 UÆmL)1 penicillin, 1.0 mgÆmL)1 streptomycin and mM L-Glu For treating BxPC3 cells and clones with drugs affecting ... formed in metabolically radiolabelled cells The main radioactive oligosaccharides formed in BxPC3 cells (j in lower part, and A, B, and C of upper part) and T5AS clone (h in lower part, and A, B, and ... elevated in the serum of patients with various abdominal illnesses [32] including cancers of the digestive tract [33–35] Moreover, it is an E-selectin ligand [36] and may be involved in the metastatic...
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Báo cáo khoa học: The dipeptidyl peptidase IV family in cancer and cell biology pot
Ngày tải lên :
06/03/2014, 09:22
... gastrointestinal tract, skin, lymph node, spleen, liver and lung, as well as in pancreatic acinar cells, adrenal gland, spermatogonia and spermatids of testis, and in Purkinje cells and in the ... cell line have revealed roles for DP9 in cell adhesion, in in vitro wound healing, in cell migration, and in proliferation and apoptosis, and roles for DP8 have been found in wound healing, in cell ... Cell-surface CD26 ⁄ DPIV interacts with adenosine deaminase, CARMA-1 and caveolin-1 Stimulation of CD26 causes IRAK-1 and Toll-interacting protein to disengage from caveolin-1, resulting in the phosphorylation...
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Báo cáo khoa học: 3 Cdt1 and geminin are down-regulated upon cell cycle exit and are over-expressed in cancer-derived cell lines potx
Ngày tải lên :
07/03/2014, 16:20
... recombinant full-length Cdt1 and geminin (HisT7-geminin and His-geminin, amount of recombinant protein run in each lane in ng is indicated) and immunoblotted with anti-Cdt1 and anti-geminin Ig ... differences in relative amounts of Cdt1 and its inhibitor in different cell lines It would be interesting to investigate whether geminin and/ or Cdt1 levels or the ratio of Cdt1 to its inhibitor geminin ... gastrointestinal tract, localizing mainly in the proliferating zone of the gut epithelium Cdt1 and geminin are over-expressed in cancer cells Given the correlation we observed between Cdt1 and geminin...
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Báo cáo khoa học: Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting pdf
Ngày tải lên :
15/03/2014, 00:20
... their main roles focus on ectodomain shedding and nonproteolytic functions, such as binding to adhesion molecules, integrins and interacting with phosphorylation sites for serine ⁄ threonine and ... such as angiostatin, tumstatin, endostatin and endorepellin MMPs also modulate the cell–cell and cell–ECM interactions by processing E-cadherin and integrins, respectively, affecting both cell phenotype ... [20] During cancer progression, increased shedding of the membrane-anchored ligands of EGFR, including heparin-binding EGF (HB-EGF), transforming growth factor (TGF)-a and amphiregulin, was observed...
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Báo cáo khoa học: A study of microRNAs in silico and in vivo: diagnostic and therapeutic applications in cancer pot
Ngày tải lên :
16/03/2014, 01:20
... lymphomagenesis in mice [44] The miRNA miR-21 is overexpressed in many solid tumors, including breast, colon, lung, prostate and stomach, and in endocrine pancreas tumors, glioblastomas and uterine leiomyomas ... examined to date [8,52], a feature that could be particularly useful in diagnosing incident cancers in otherwise normal tissues Indeed, this approach discriminates normal and neoplastic tissues in ... neoplastic tissues in various cancer types, including CLL, breast cancer, glioblastoma, thyroid papillary carcinoma, hepatocellular carcinoma, lung cancer, colon cancer and endocrine pancreatic tumors...
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Thuốc chống viêm ức chế lipooxygenase và cyclooxygenase dùng dự phòng và điều trị ung th- (LOX an COX - inhibitors as adjunctive therapies in the prevention and treatment of cancer) ppt
Ngày tải lên :
20/03/2014, 03:20
... ung th in vitro, thấy quercetin làm thoái giáng đột biến p53 - protein, làm ngừng chu kỳ tế bào giai đoạn G1 , ức chế tyrosin - kinase, ngăn chặn hoạt tính protein - ras In vitro, quercetin ức ... Curcumin có nhiều ảnh hởng đến sinh lý bệnh học tế bào ung th: in vitro, curcumin làm ngừng chu kỳ tế bào u, thúc đẩy chết theo chơng trình (apoptosis) Tuy nghiên cứu hạn chế, nhng thấy curcumin ... bào khác nhau, thấy quercetin làm tăng hiệu lực điều trị cisplatin, adriamycin, busulfan, cyclophosphamid làm tế bào ung th giảm đề kháng với gemcitabin topotecan Bromelain Là hỗn hợp protease chứa...
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Cancer Chemotherapy Rachel Airley Cancer Research Scientist and Lecturer in Pharmacology pot
Ngày tải lên :
22/03/2014, 21:20
... breast (77%) and cervix (61%) cancers; 10–50% survival, including colon (47% in males, 48% in females), renal (45% in males, 48% in females) and brain (12% in males, 15% in females); and cancers where ... Vascular disrupting agents 199 199 202 209 212 14 Tyrosine kinase inhibitors 14.1 Introduction 14.2 Tyrosine kinase inhibitors targeting angiogenesis 14.3 Non-receptor tyrosine kinase inhibitors 217 ... Whereas RIP kinase interacts homologously with death domain receptors via its C-terminal death domain, necroptosis is induced via its N-terminal serine/threonine kinase domain RIP kinase may effect...
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Cancer Incidence and Mortality in New Jersey 1999 - 2003 docx
Ngày tải lên :
28/03/2014, 23:20
... Only invasive cancers were included in the incidence data, except in situ bladder cancers were included Incidence and Mortality Coding Beginning with the year 2001, the coding scheme for incident ... categories of cancer and for all sites combined For the incidence counts and rates, in situ cancers are not included except for bladder cancer in situ cases, which are included with invasive urinary ... the Cancer Epidemiology Services office or on our website, http://nj.gov/health/ces/index.shtml, including: • • • • Trends in Cancer Incidence and Mortality in New Jersey 1979-2002; Cancer Incidence...
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Báo cáo khoa học: Death-associated protein kinase (DAPK) and signal transduction: regulation in cancer ppt
Ngày tải lên :
29/03/2014, 08:20
... tumours and are now being tested in combination therapies [47] Tyrosine kinase inhibitors are widely and successfully used in the treatment of cancer, and in the context of this review, may inhibit ... (BMS-354825) tyrosine kinase inhibitor suppresses invasion and induces cell cycle arrest and apoptosis of head and neck squamous cell carcinoma and non-small cell lung cancer cells Clin Cancer Res 11, ... death-associated protein kinase in lung cancers Clin Cancer Res 9, 3034–3041 Dansranjavin T, Mobius C, Tannapfel A, Bartels M, ¨ Wittekind C, Hauss J & Witzigmann H (2006) E-cadherin and DAP kinase in pancreatic...
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ONCOGENOMICS AND CANCER PROTEOMICS – NOVEL APPROACHES IN BIOMARKERS DISCOVERY AND THERAPEUTIC TARGETS IN CANCER pot
Ngày tải lên :
30/03/2014, 09:20
... Wnt/βcatenin and cadherin pathway genes including N-cadherin and P-cadherin but low E-cadherin protein expression This finding demonstrated the highgrade serous ovarian cancer contained messenchymal ... colorectal cancer, which will be discussed in details below a Chromosomal instability (CIN) Chromosomal instability lead to increase rate of losing or gaining chromosomes during cell division and accounts ... targets in cancer are also included Chapters in “Oncogenomics and Cancer Proteomics - Novel Approaches in Biomarkers Discovery and Therapeutic Targets in Cancer present comprehensive and expert...
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Báo cáo khoa học: Suppression of microtubule dynamics by benomyl decreases tension across kinetochore pairs and induces apoptosis in cancer cells potx
Ngày tải lên :
30/03/2014, 10:20
... K Rathinasamy and D Panda [10] The binding site of benomyl in tubulin is yet to be determined However, it has been suggested that benomyl binds to tubulin at a site that is distinct from ... the motor proteins and spindle checkpoint proteins [19] This reduction of checkpoint proteins is required for inactivating the spindle checkpoint signal and progression in the cell cycle [20] The ... beneficial in chemotherapy Similar to taxol and vinblastine, benomyl also induces apoptosis in HeLa cells, indicating that benomyl may be useful in combination with other potent anticancer drugs...
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báo cáo hóa học:" RAGE (Receptor for Advanced Glycation Endproducts), RAGE Ligands, and their role in Cancer and Inflammation" pptx
Ngày tải lên :
18/06/2014, 15:20
... propagates inflammatory responses and is a significant RAGE ligand in the setting of sepsis and acute inflammation HMGB1 is an apparent autocrine/paracrine regulator of monocyte invasion, involving ... upregulation of inflammation in this setting [181] Another RAGE ligand, AGE-CML, is present in endoneurial and epineurial mononuclear cells in chronic inflammatory demyelinating polyneuropathy and vasculitic ... has role in shuttling HIPK2 (homeodomaininteracting protein kinase 2) to the cytosol Abundantly expressed in undifferentiated and proliferating embryonic cells but usually undetectable in adult...
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Báo cáo hóa học: "A randomized phase II trial of mitoxantrone, estramustine and vinorelbine or bcl-2 modulation with 13-cis retinoic acid, interferon and paclitaxel in patients with metastatic castrate-resistant prostate cancer: ECOG 3899" pot
Ngày tải lên :
18/06/2014, 16:20
... combined navelbine and mitoxantrone, supporting the testing of combination therapy with estramustine, mitoxantrone, and vinorelbine in patients with CRPC One study demonstrated a potential clinical benefit ... with vinorelbine, mitoxantrone and estramustine yielded a response rate suggesting clinical activity in men with CRPC, and was well tolerated The combination of CRA/IFN and paclitaxel, in contrast, ... receptor tyrosine kinase inhibitor ZD1839 in non-small cell lung cancer and other solid tumors Clin Cancer Res., 9: 2040-2048, 2003 Clin Cancer Res 2003, 9:1990-1994 Jaeschke R, Singer J, Guyatt...
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