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Tài liệu Báo cáo khóa học: Quantitative analysis, using MALDI-TOF mass spectrometry, of the N-terminal hydrolysis and cyclization reactions of the activation 2 process of onconase pdf
... evaluating the influence of Table 2. Thermodynamic parameters of the thermal denaturaturation of the different onconase (ONC) variants at 25 C and pH 2.0. (CGdm/HCl)ẵ13,midpoint of guanidinium ... hydrogen bonded to the e-amino group of the Lys9 side-chain, which simultaneouslyinteracts with the main phosphate of the substrate [32]. The closer positioning of the N-terminus to the mainprotein ... immunogenicity.Acknowledgements The authors thank Professor Ron Raines for the generous gift of the genes encoding onconase and the variant. We are also indebted toDr Francesc Canals for his help in the mass spectra...
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Tài liệu Euphorion Being Studies of the Antique and the Mediaeval in the Renaissance - Vol. II pot
... a hierarchy attending to the business of factory or counting-house under the orders of the father of the family, and to the economy of the house-under the superintendence of the mother; a manner ... mythical meaning had been lost in the several centuries of Christianity,was very decayed and obscure; and the fact of the blood on the lance being that of a murdered kinsman of Peredur, and of the ... land of bliss. And there is in the very sensuousness and love of beauty -of these men a vagueness and melancholy, a constant: sense of the fleeting and of the eternal, as in that passage,translated...
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Báo cáo Y học: Identification of residues critical for activity of the wound-induced leucine aminopeptidase (LAP-A) of tomato pptx
... caused changes in the conformation of the tomato L AP-A enzyme did not reveal any correlationwith the n ature of t he residue in the mutant His6–LAP-Aenzyme.X-ray structures of the unliganded ... important for LAP catalysis and coordination of the two zinc io ns in the a ctive site. The i mpact of the mutations on the tomato LAP enzyme must be viewed in the context o f these data. The most ... (Lys342), and the N-terminal amine of the P1 residue of the peptide substrate. A water moleculethat bridges Zn1 and Zn2 is the sixth ligand. In addition to the zinc-bridging water molecule and the...
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Structure of the S15,S6,S18-rRNA Complex:Assembly of the 30S Ribosome Central Domain
... birefringencestudies, and the conformation of the boundjunction is clearly seen in the structure of the Tth T4 RNP (Fig. 2C) and in the structure of the 30S subunit (1).Biochemical studies of the S15-rRNA ... helix 23a, and to the folded RNA backbone (Figs. 2C and 5). The S6binding site for S18 is a concave surface made of one strand of the  sheet, the loop between2 and 3, and the extended COOH-terminalcoil. ... in the loop region be-tween helices ␣1 and ␣2 and in the COOH-terminal end of helix ␣3 interact with the RNAbackbone of the lower three-helix junction andwith adjacent nucleotides in the...
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Báo cáo khoa học: The propeptide of cruzipain ) a potent selective inhibitor of the trypanosomal enzymes cruzipain and brucipain, and of the human enzyme cathepsin F ppt
... loop in the primed side of the binding sitegroove. Although the prodomains of cathepsins F andW share the same degree of similarity to the prodo-main of cruzipain, the similarity of the mature ... in the micromolar range. The potency of PCZ as an inhibitor of cruzipainand brucipain decreased moderately at the more acidicpH value of 5 (Table 1), but remained in the subnano-molar range. ... tag at the N-terminus. This type of N-terminal tag was previ-ously used for the expression of the propeptide of human cathepsin K, and it did not interfere with the inhibitory activity of the protein...
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Báo cáo Y học: Amino acids 3–13 and amino acids in and flanking the 23FxxLF27 motif modulate the interaction between the N-terminal and ligand-binding domain of the androgen receptor pdf
... Rotterdam, the Netherlands The N-terminal domain (NTD) and the ligand-bindingdomain (LBD) of the androgen receptor (AR) exhibit aligand–dependent interaction (N/C interaction). Aminoacids 3–36 in the ... detection of androgen receptorN/C interaction The ligand-dependent interaction between AR NTD andAR LBD, N/C interaction, was studied in yeast andmammalian in vivo protein interaction systems, and ... K., Trapman, J. &Brinkmann, A.O. (1998) Functional interactions of the AF-2activation domain core region of the human androgen receptorwith the amino-terminal domain and with the transcriptionalcoactivator...
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Báo cáo khoa học: Determination of the redox potentials and electron transfer properties of the FAD- and FMN-binding domains of the human oxidoreductase NR1 doc
... transfer electrons from the FAD/NADPH domain to the FMN domain, and (b) the thermodynamic properties of the FMN domain in CPR andnitric oxide synthase. Despite overall structural resemblance of ... to CPRand NOS, the rate of hydride transfer in NR1 (% 1s)1)issubstantially less than the rates in CPR (% 200 s)1[24]); andNOS (% 200 s)1for the first hydride transfer reaction in the FAD-FMN ... a role in the metabolic activation of bioreductive drugs. The lack of amembrane anchor in NR1 suggests that reduction of the P450 enzymes attached to the endoplasmic reticulum is an unlikely...
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Báo cáo khoa học: Internalization of the human CRF receptor 1 is independent of classical phosphorylation sites and of b-arrestin 1 recruitment potx
... stimulation with agonist (Fig. 1). The change is characterized by shrinkage of the cells anddetachment from the surface of the culture dish. A similarchange in the shape of the cell following agonist ... with the Substance P receptor [25]. Detachment of the cells from the surface of the culture dish could r eflectdisassembly of the actin cytoskeleton in the me mbraneregions as a consequence of ... forseveral GPCRs [29]. The function of b-arrestin is to uncouple the receptor f rom the G-protein, thereby mediating recepto rdesensitization, and furthermore to couple the receptor to the endocytic...
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Báo cáo khoa học: Expression, purification and characterization of the second Kunitz-type protease inhibitor domain of the human WFIKKN protein pot
... (JASCO).Fig. 3. Alignment of the sequences of the second Kunitz-modules of the human and fugu WFIKKN proteins (wfikkn_hu_2; wfikkn_fugu_2) with the second Kunitz-domains of the human and the two fugu WFIKKNRP ... [8–10]). Thermal unfolding of the proteinwas monitored at 203 nm at a heating rate of 60 Cặh)1.Effect of the recombinant protein on the activity of proteases The activity of the proteases on synthetic ... of the second Kunitz–typeprotease inhibitor module of human WFIKKN. The solid line indicates the spectrum of the recombinant protein, the dotted line indicates the CDPro-predicted spectrum of...
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The Education Of The Negro Prior To 1861 - A History of the Education of the Colored People of the United States from the Beginning of Slavery to the Civil War pdf
... if the circumstances of the Negroes werechanged, they would equal, if not excel, the rest of the human family "in majesty of intellect, elegance of manners, purity of morals, and ardor of ... colonists, to the mutual aid resulting from the proximity of the communities, and to the coöperation of the Canadians. The previous experience of most of theseadventurers as sojourners in the free ... Christian teachers of the Negro race, and the prevention of the immigration of workers from the Northern States rendered the blackshelpless and dependent upon a few benevolent white ministers of the...
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Báo cáo hóa học: " Comparison of the self-administered and interviewer-administered modes of the child-OIDP" ppt
... participated in the study designand led the writing of the manuscript, EB carried out the data analysis and participated in writing the manuscript,KOB participated in the study design and criticallyreviewed ... frommost other studies on Child-OIDP and some of the asso-ciations between the Child-OIDP and proxy measureswere not significant. While the low value of alpha isaffected by the nature of the Child-OIDP ... criticallyreviewed the manuscript, AS conceived of the study andcritically reviewed the manuscript, CO participated in the study design, carried out the data collection and partici-pated in writing the manuscript....
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báo cáo hóa học:" The occurrence of osteoarthritis at a minimum of ten years after reconstruction of the anterior cruciate ligament" pdf
... necessity for repeated operations, mayincrease the risk of developing OA. Another factor of pos-sible importance might be the required tension of the graft and the post-operative rehabilitation ... meniscal tears and degenerative changes. Dis-ruption of the ACL often leads to significant disabilitywhich can lead to changes in lifestyle. Although bothoperative and non-operative treatments ... in 55% of the patientsA (1–2 mm), in 29 % of the patients B (3–5 mm) and in16% of the patients C (6–10 mm) stability.Looking at the osteoarthritis rate of the operated knee, 55% of the patients...
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báo cáo hóa học:" Revision hip replacement for recurrent Hydatid disease of the pelvis: a case report and review of the literature" doc
... along the lateral side of rectus femoris and the other one deep to gluteus medius on 25/10/99. The operation was covered with Praziquental and Albenda-zole and she was discharge d home on Albendazole. ... disease of the pelvis: a case report and review of the literature. Journal of Orthopaedic Surgery and Research 2010 5:17.Submit your next manuscript to BioMed Centraland take full advantage of: ... thus ending up inremote organs. Due to their physiologic role as capillaryfilters and their vast capillary volume, the liver and lungare most often affected. The brain, the muscle s or the bones...
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báo cáo hóa học:" Repositioning and stabilization of the radial styloid process in comminuted fractures of the distal radius using a single approach: the radio-volar double plating technique" pot
... drafting of the manuscript.GK participated in the design of the study and coordination and helped todraft the manuscript. All authors read and approved the final manuscript.Competing interestsThere ... release of the distal osseousinsertion of the brachioradialis tendon [4]. This permitsbetter manipulation of the fracture fragments because the brachioradialis tendon is known to be an importantdeforming ... postoperatively and at 24 months for both groups 7.5°(±3.5/range 0-12). Preoperative loss of radial length was6.3 mm (± 3.7/range 2-12) and was equal postopera-tively and at 2 4 months...
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