new insights into the assembly and metabolism of apob containing lipoproteins from in vivo kinet

Báo cáo khoa học: New insights into the functions and N-glycan structures of factor X activator from Russell’s viper venom pot

Ngày tải lên : 07/03/2014, 06:20

... investigate the binding speciﬁcity of RVV-X, several human coagulation factors containing the Gla 3946 Fig Analysis of the binding of RVV-X to Gla -containing plasma factors or proteins by far-western ... platelets and endothelial cells The important role of these glycans in pharmacokinetics has been demonstrated by the slower and smaller increment of FDP in vivo after the injection of desialylated ... sequences of the three subunits of RVV-X (Figs and 5) suggest the possible presence of three conformational Ca2+-binding sites in the heavy chain and none in LC1 and LC2, in accordance with the results...

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Tài liệu Báo cáo Y học: A Raman optical activity study of rheomorphism in caseins, synucleins and tau New insight into the structure and behaviour of natively unfolded proteins pot

Ngày tải lên : 21/02/2014, 15:20

... that the former is likely to be in the Cterminal half and the latter in the N-terminal half of the protein [29,48±51] Sequence-based structure prediction methods suggest that the caseins are of the ... form of b strand [18] The positive bands at » 1675 cm)1 in the amide I region of the ROA spectra of b- and j-casein, which originate mainly in the peptide C O stretch, are characteristic of disordered ... expressed in the adult human brain [54] They fall into two classes, depending on the number of microtubule-binding repeats Three isoforms have three repeats each and the other three isoforms have...

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báo cáo khoa học: " New insight into the structures and formation of anthocyanic vacuolar inclusions in flower petals" potx

Ngày tải lên : 12/08/2014, 05:20

... anthocyanin -containing pro-vacuolar vesicles being formed at the site of anthocyanin biosynthesis, which then bud off the ER and fuse with the tonoplast With regard to the fate of the anthocyanins ... (Fig 2A), clearly showing irregular-shaped anthocyanin -containing deposits of the AVI Interestingly, these AVI -containing protoplasts were rigid, tending to maintain their original cell shape No ... to the initiation of the project and was involved in design and supervision of the research and the writing of the manuscript Acknowledgements We are grateful for the assistance of Mr Ray Rains...

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X ray crystallographic study of yeast dcp1 and dcp2 proteins insights into the mechanism and regulation of eukaryotic mRNA decapping

Ngày tải lên : 14/09/2015, 12:28

... regulation, interacting with the actin binding protein WASP interacting protein, WIP A minimal 25 amino acids peptide containing the DLPPPEP motif found in WIP is required for interaction with WASP The ... has been retained with the Dcp2 protein on gel The deletion of the C-terminal region, containing Box B, in the hDcp2 protein abolishes the RNA binding capacity of protein truncated So the Box B ... machinery The proteins involved in the mRNA 5’ decay pathway aggregate to form the 5’ decay machinery, including the factors in RNA binding, RNA remodeling, complex scaffolding and catalysis The...

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Tài liệu Báo cáo khoa học: Solution structure of hirsutellin A – new insights into the active site and interacting interfaces of ribotoxins docx

Ngày tải lên : 18/02/2014, 08:20

... increasing its pKa value It is known that the presence of a cation–p interaction is crucial in determining the pKa of the histidine residue in the active site of RNases and consequently in determining ... with the other charged groups In the NMR structures, this side ˚ chain of D40 is a short distance (£ A) from the side chains of H42 and R95 Finally, the aromatic ring of F126, placed close to the ... Superposition of the active-site residues of the 20 conformers of the solution structure of HtA Catalytic groups E66 and H113 are shown in red, and side chains of other residues in their vicinity are...

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Tài liệu Báo cáo khóa học: Further insights into the assembly of the yeast cytochrome bc1 complex based on analysis of single and double deletion mutants lacking supernumerary subunits and cytochrome b pdf

Ngày tải lên : 19/02/2014, 12:20

... protein was detectable in the CKL57 strain We not know whether the lack of immunoreactivity in the latter strain was due to the inability of the truncated protein to insert into and be stable in the ... Interestingly, the absence of subunit also resulted in an increase in the ratio of intermediate to mature cytochrome c1 and a disappearance of the intermediate form of the Rieske protein At the ... in the case of the W303–1B q° strain (results not shown) In the mitochondrial membranes from this strain, the content of cytochrome c1 increased from 29 to 73%, and the amounts of core proteins...

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Click Here: The State of Online Advertising - New insights into the beliefs of consumers and professional marketers ppt

Ngày tải lên : 15/03/2014, 22:20

... Edelman Berland conducted an online survey of 1,250 adults, 18 years or older, including 1,000 general population and 250 Marketing Decision Makers, each in the U.S Interviewing took place from October ... liked on behalf of their favorite brands, but also wish there was a dislike button for social media 68% of consumers find online ads “annoying” and “distracting” and 54% say online banner ads ... popular form of online advertising Advertising/Marketing professionals considered in the bottom professions among consumers – along with actors and dancers; not highly regarded by marketing professionals...

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báo cáo khoa học: " Construction of a potato consensus map and QTL meta-analysis offer new insights into the genetic architecture of late blight resistance and plant maturity traits" pps

Ngày tải lên : 11/08/2014, 11:21

... confidence intervals of the individual QTLs onto the consensus map It is based on a scaling rule between the positions of the flanking markers of the QTLs on their original maps and the positions of these ... one of them is mandatory), the trait related to the QTL and the size of the QTL mapping population used for the QTL detection The statistical method implemented in the MetaQTL software hypothesizes ... all the input maps into a consensus map in a single step It takes into account the distances between adjacent markers from all individual maps rescaled in Haldane unit The size and type of the...

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Báo cáo khoa học: New insights into the P-glycoprotein-mediated efﬂuxes of rhodamines doc

Ngày tải lên : 08/03/2014, 08:20

... Relation among the resistance factor, kinetics of uptake, and kinetics of the P-glycoprotein-mediated efflux of doxorubicin, daunorubicin, 8-(S)-fluoroidarubicin, and idarubicin in multidrug-resistant ... to each other and to the efficiency of the P-gp-mediated efflux of anthracyclines This work represents the first report, using intact cells, of real-time measurements of the rate of rhodamine transport ... is the concentration of free internal rhodamine; CT, the total concentration of rhodamine added to the cells, and is equal to the concentration of rhodamine in the extracellular medium plus the...

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Báo cáo sinh học: "Making the jump: new insights into the mechanism of trans-translation" pdf

Ngày tải lên : 06/08/2014, 18:21

... precede the resume codon to the correct positioning of the MLD Identifying determinants of template switching One problem in determining the critical elements of transtranslation in vivo has ... structures of (a) tRNA, (b) mRNA and (c) tmRNA (a,c) The 3’ and 5’ termini, the amino acid acceptor stem (AC) and the anticodon (A), D and T arms are indicated (b,c) The Shine-Dalgarno sequence (SD), the ... permutations of the -1 triplet and determined their effect on survival in the kanamycin resistance assay They found that eight of the 18 codons that were prohibited according to the -1 hypothesis [12]...

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Báo cáo y học: "New insights into the pathogenesis of glucocorticoid-induced avascular necrosis: microarray analysis of gene expression in a rat model" potx

Ngày tải lên : 12/08/2014, 14:22

... than other endothelial cells in the body In keeping with the theory of endothelial cell activation having a role in ANFH, coagulation-related gene expression in particular serine (or cysteine) ... an overdose of ketamine/ xylazine at the age of 30 weeks Tissue samples were obtained from the proximal femur containing the femoral head Some samples were put in RNALater (QIAGEN Inc., Mississauga, ... identified on the luminal surface of endothelial cells in sections of normal human arteries and veins [44] A2M has also been implicated in hemostasis as a regulator of thrombin [45] and in the development...

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Thyroid and Parathyroid Diseases – New Insights into Some Old and Some New Issues Edited by Laura Sterian Ward pdf

Ngày tải lên : 30/03/2014, 23:20

... occurring within minutes; Binding of iodine, T3 and T4 hormone synthesis Secretion of thyroglobulin into colloid Taking colloid back into the cell with endocytos, Effects occurring within hours; ... erythropoiesis With the protein synthesis they caused to occur in these precursor cells, they provide the synthesis of enzymes at the beginning and at the end of hemoglobin synthesis (Dillmann, ... Diseases – New Insights into Some Old and Some New Issues with the size rather than with the nature of nodule of the thyroid gland, Tg is not used for the diagnosis of the thyroid cancer Routine preoperative...

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beer tap into the art and science of brewing mar 2003

Ngày tải lên : 11/06/2014, 10:32

... working either directly in the production, marketing, and selling of the product or indirectly in the industries that supply the Brewers, including farming, malting, and the production of packaging ... drinking beer by informing them about the myriad of biochemical and chemical reactions that are involved in the production of their favorite drink and by exposing them to the enormous reservoir of ... Breweries In truth the drinker is often not quite sure who owns the brand in her glass In Finland Carlsberg heavily influences the other major brewer, Sinebrychoff, as is the case for two of the three...

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state university of new york press the perils and promise of global transparency why the information revolution may not lead to security democracy or peace oct 2006

Ngày tải lên : 11/06/2014, 12:45

... data and reading the public materials of thousands of interest groups that influence decision making; and read newspapers, magazines, and websites The Complexity of Transparency produced by independent ... regimes exist in only a small number of issue areas and, even in those areas the high costs of collecting and reporting information limit their scope • The reach of information and communication ... politics and security Indeed, growing transparency affects the lives of citizens around the globe It affects the fundamental security of societies by influencing the likelihood of war and peace and influences...

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báo cáo hóa học:" Tuberculosis and HIVNeeded: A New Paradigm for the Control and Management of Linked Epidemics" pot

Ngày tải lên : 20/06/2014, 08:20

... ongoing In Rwanda, integration of TB and HIV services at a district hospital increased HIV counselling and testing of TB patients and improved TB screening and case detection in HIV-infected individuals ... developed;[9,10] how and if these tests can be used, and whether their associated cost will be prohibitive in these settings is yet to be determined Likewise, the treatment of HIV in the setting of active ... subtleties and added complexities of TB diagnosis and appropriate management, including the treatment of drug-resistant TB, in the context of HIV co-infection must be recognized and incorporated into...

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báo cáo hóa học:" Research Article A New Technique for the Digitization and Restoration of Deteriorated Photographic Negatives" pptx

Ngày tải lên : 21/06/2014, 20:20

... introduced into the normal map due to the prospective projection of the imaging system As the distance from the camera’s optical center increases, the angle of incidence on the surface also increases ... negative is printed using a standard light table These distortions are directly related to the nonplanar shape of the negative and are largely independent of the content of the emulsion In other words, ... normal and incident light, θt is the angle between outgoing light and the surface normal, φ0 is the phase function, Li is the incident light intensity, and τ is the material thickness The single-scatter...

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Báo cáo hóa học: " New Insights into the RLS Algorithm" pdf

Ngày tải lên : 23/06/2014, 01:20

... factors: the exponential window, the level of noise at the system output, and the condition number The closer the exponential window is to one, the better the misalignment is, but the tracking abilities ... noise, it is interesting to see how the misalignment will degrade by increasing the condition number of the input signal For example, by increasing the condition number from to 10, the misalignment ... to use E the interpolation formulation to better understand the link among all variables in the RLS algorithm, and especially to emphasize the role of the interpolation error energies since − tr[R−1...

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THYROID AND PARATHYROID DISEASES – NEW INSIGHTS INTO SOME OLD AND SOME NEW ISSUES ppt

Ngày tải lên : 27/06/2014, 10:20

... occurring within minutes; Binding of iodine, T3 and T4 hormone synthesis Secretion of thyroglobulin into colloid Taking colloid back into the cell with endocytos, Effects occurring within hours; ... erythropoiesis With the protein synthesis they caused to occur in these precursor cells, they provide the synthesis of enzymes at the beginning and at the end of hemoglobin synthesis (Dillmann, ... Diseases – New Insights into Some Old and Some New Issues with the size rather than with the nature of nodule of the thyroid gland, Tg is not used for the diagnosis of the thyroid cancer Routine preoperative...

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báo cáo khoa học: " Measuring cis-acting regulatory variants genome-wide: new insights into expression genetics and disease susceptibility" pdf

Ngày tải lên : 11/08/2014, 12:20

... of cis- and transregulatory variants and the type of polymorphisms involved in gene expression eQTL mapping and expression arrays give information about cis- and trans-acting variants, and this ... mRNA isoforms of dopamine receptor D2 [20] Two intronic SNPs were found to alter splicing and brain activity in vivo during cognitive processing in humans [20] SNPs residing in transcribed RNAs ... promoter SNP in VKORC1 (encoding vitamin K epoxide reductase complex subunit 1, the target of warfarin) affects expression only in the liver but not in the heart or lymphocytes [24] Studying the TPH2...

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Báo cáo y học: "Qualitative and quantitative research into the development and feasibility of a video-tailored physical activity intervention" pptx

Ngày tải lên : 14/08/2014, 08:20

... aims of the study One researcher moderated the session, which included explaining purpose and procedure of the focus group sessions, introducing the topic, leading the discussions, encouraging ... think of the concept of video-tailoring? After explaining the concept of ‘video-tailoring’ a large majority of focus group participants (26 out of 30) agreed that the concept was good and interesting; ... a case of people being unfamiliar with a new and unknown type of intervention (video), and preferring what they know best (text) As internet speed, number of broadband connections and new websites...

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