new findings in the diagnosis and prevention of colorectal cancer in ibd

Is Lactobacillus GG Helpful in Children With Crohn’s Disease? Results of a Preliminary, Open-Label Study docx

Ngày tải lên : 05/03/2014, 12:20

... index including subjective reporting of abdominal pain, general well-being, and diarrhea and physical findings, including linear growth and laboratory parameters (hematocrit, serum albumin, and ... important role in the initiation and perpetuation of the disease(13,14) It has been hypothesized that the intestinal inflammatory response is the result of an exaggerated intestinal host immune ... preliminary investigation to address the question of underlying mechanisms of action of this probiotic in Crohn’s disease In conclusion, and fully acknowledging the limitations of an open-label study in...

5
511
0

Infliximab therapy in pediatric Crohn’s disease: a review docx

Ngày tải lên : 22/03/2014, 10:20

... been measured in the lamina propria of the bowel of patients with CD21 and increased concentration of TNF has also been found in the stool of children with CD.22 At the Clinical and Experimental ... to normal after months of discontinuing infliximab.56 In a study of 6290 adult patients on maintenance infliximab therapy, there was no increased risk of malignancy in the infliximab group compared ... histologic and endoscopic disease activity and in inducing and maintaining remission in patients with active CD ACCENT I was a multicenter randomized double-blind international trial studying retreatment...

7
380
0

Báo cáo Y học: Structural study on lipid A and the O-speciﬁc polysaccharide of the lipopolysaccharide from a clinical isolate of Bacteroides vulgatus from a patient with Crohn’s disease ppt

Ngày tải lên : 31/03/2014, 23:20

... active moiety of LPS in the induction of cytokines, including tumor necrosis factor, and the phosphate residue at the 4¢-position is a critical site for the activity [24] Therefore, the monophosphoryl ... OPS chain Taking these observations into account, the structure of the OPS moiety was deduced to be that shown in Fig 5C In the Bacteroides group, the structure of the polysaccharide part of LPS ... further analyzed as the main component of lipid A The structure of the lipid A component was established by NMR and MS The 1H NMR signals of the isolated lipid A were assigned using DQF-COSY and...

7
437
0

CROHN''''S DISEASE pdf

Ngày tải lên : 27/06/2014, 16:20

... of the epithelium are located in the lower ⅔ of the small intestinal crypts and the lower ½ of the colonic glands The functional cells of these renewing units are located on the villus and the ... conditions In the normal small intestine (left), laminins LM-322 and LM-511 are found in the BM of the villus epithelial cells while laminin LM-211, is found in the BM of crypt epithelial cells Tenascin-C ... epithelial cell and myofibroblast susceptibility to proinflammatory cytokines in the crypt region Epithelial BM molecules in the normal human intestine The epithelial BM of the human intestine...

222
519
0

Báo cáo sinh học: "Mycobacterium avium subsp. paratuberculosis linked to Crohn''''s Disease and Paratuberculosis" pot

Ngày tải lên : 08/08/2014, 19:20

... streptomycin the MIC range was of 0,5-2 μg/ml in both animal and human strains, for ciprofloxacin it was at 0.5–16 μg/ml, independently of the source of isolation, while rifampin produced a MIC of 0.5–1 ... μg/ml in human and bovine strains and of >2 μg/ml for bovine and animal isolate Rifabutin MIC was very similar to rifampin Also ethambutol generated a MIC of 2–8 μg/ml in human strains and 4–16 ... measuring the change in the daily GI (DGI) for the drug-containing vials compared with the GI for the control vials, where they report a lower MIC of 0.5–4 μg/ml, probably due to differences in the...

3
273
0

Báo cáo y học: "Adalimumab - an effective and promising treatment for patients with fistulizing Crohn’s disease: a case series" pdf

Ngày tải lên : 11/08/2014, 00:23

... significant and complete healing of draining fistulas in active FCD Furthermore, the long-term healing of draining fistulas was maintained over two years from the baseline of the CHARM study, while in the ... coordination EIE participated in the design of the study, the acquisition and interpretation of the data and the drafting of the manuscript PZ participated in the sequence alignment and the drafting ... efficacious and safe in all of the three cases Page of Remission of active luminal and fistulizing disease was achieved soon after the initiation of adalimumab and sustained thereafter with maintenance...

6
350
0

Báo cáo y học: "Perforated Meckel’s diverticulum presenting with combined bowel and urinary obstruction and mimicking Crohn’s disease: a case report" pps

Ngày tải lên : 11/08/2014, 03:21

... with surrounding inflammation and fibrosis Given the inability to repair the defect in the terminal ileum from the fistulous opening, resection of a segment of the terminal ileum and cecum was ... weight loss in the past month, anorexia, a decrease in stool caliber, fatigue, and painful urination, in addition to the presenting complaints He denied having a fever, but did complain of night ... rather than malignancy A fine-needle aspirate of the abscess fluid also lacked malignant cytology Endoscopically, there were no ulcerations or gross findings to support a diagnosis of IBD, and...

5
277
0

Báo cáo y học: "Perforated Meckel’s diverticulum presenting with combined bowel and urinary obstruction and mimicking Crohn’s disease: a case report" doc

Ngày tải lên : 11/08/2014, 07:20

... with surrounding inflammation and fibrosis Given the inability to repair the defect in the terminal ileum from the fistulous opening, resection of a segment of the terminal ileum and cecum was ... weight loss in the past month, anorexia, a decrease in stool caliber, fatigue, and painful urination, in addition to the presenting complaints He denied having a fever, but did complain of night ... rather than malignancy A fine-needle aspirate of the abscess fluid also lacked malignant cytology Endoscopically, there were no ulcerations or gross findings to support a diagnosis of IBD, and...

5
308
0

Báo cáo y học: "Acute panuveitis with hypopyon in Crohn''''s disease secondary to medical therapy: a case report." pptx

Ngày tải lên : 11/08/2014, 10:22

... when combining rifabutin and clarithromycin leading to an increase in rifabutin levels, resulting in an increase frequency of uveitis, this could explain the acute onset of uveitis in our case[10] ... hypopyon often occurs several months after starting rifabutin In this case the presence of hypopyon, and rapid initial improvement following withdrawal of rifabutin, suggest rifabutin as the underlying ... days, the hypopyon had reduced to mm and the vision had improved to 6/9 in the right eye; a reducing course of dexamethasone was instituted One week after discontinuing rifabutin and clarithromycin,...

3
461
0

Báo cáo y học: "Association of the T allele of an intronic single nucleotide polymorphism in the colony stimulating factor 1 receptor with Crohn''''s disease: a case-control study" ppt

Ngày tải lên : 11/08/2014, 10:23

... occurred in the terminal web of the epithelial cell and in the lateral junctions of the cells The localization of CSF1R in actin-rich areas of the cell is not surprising in view of data from in vitro ... deletions in the CSF1R gene [25-27] There is a paucity of literature regarding the expression of the CSF1R protein in the intestine despite documentation of its presence in the epithelium of a variety ... (green arrow) B Staining of the superficial epithelium of the colon C Staining of the superficial epithelium of the ileum with an epithelial cell being sloughed off into the lumen (green arrow)...

8
294
0

Báo cáo y học: "Granulomatous cheilitis associated with exacerbations of Crohn''''s disease: a case report" potx

Ngày tải lên : 11/08/2014, 11:20

... course of the patient was the fact that during the exacerbations of CD, the enlargement of the lip was more evident, returning to almost normal during the periods of remission and that the administration ... symptoms but also in diminishment of the size of the lip swelling Another point of interest was the fact that granulomatous cheilitis was the only extraintestinal manifestation in our patient, ... manifesting as a significant swelling of the lower lip could be the first clinical sign of CD This lesion could well be correlated with the activity of the intestinal disease, being quite prominent in...

4
333
0

Báo cáo y học: "Colonic adenocarcinoma revealing Crohn''''s disease: a case report Case report" pdf

Ngày tải lên : 11/08/2014, 12:20

... recognized the occult nature of intestinal cancer in Crohn's disease They found that 59% of all cancers and 33% of colorectal carcinomas complicating Crohn's disease were discovered only at operation Therefore, ... patient and in formulating the diagnostic strategy All authors participated in writing and revising the manuscript All authors read and approved the final manuscript Acknowledgements The authors ... Written informed consent was obtained from the patient for publication of this case report and any accompanying images A copy of the written consent is available for review by the Editor -in- Chief of...

3
324
0

báo cáo khoa học: " Musings on genome medicine: Crohn’s disease" potx

Ngày tải lên : 11/08/2014, 12:20

... result of the interaction between the genetic hand that is drawn and the bacteria residing in the gut In this model, CD is seen as a disorder arising from both the environment (including micro-organisms, ... again detected, including NOD2 (nuclearbinding oligomerization domain containing 2; usually associated with structuring disease), IL23R (receptor for interleukin 23) and PTPN2 (protein tyrosine ... by the sum of all 32 of these alleles, strongly suggesting that other risk alleles will be detected in the future Indeed, the sum of these alleles contributes only a factor of to sibling relative...

3
188
0

Báo cáo y học: "A 47-year-old man with neuro-Sweet syndrome in association with Crohn’s disease: a case report" ppsx

Ngày tải lên : 11/08/2014, 14:20

... from these lesions Histology on the specimens revealed severe papillary edema The dermis contained an infiltrate of neutrophils and nuclear dust was also present These findings supported the clinical ... from the patient for publication of this case report and accompanying images A copy of the written consent is available for review by the Editor -in- Chief of this journal Competing interests The ... Second-line agents include indomethacin, cyclosporine and dapsone Conclusion This is a case of aseptic meningitis secondary to neuroSweet disease in a patient with Crohn’s disease The association of...

4
267
0

Báo cáo y học: "Sweet''''s syndrome in a patient with Crohn''''s disease: a case report" pot

Ngày tải lên : 11/08/2014, 21:22

... procedures and therapy Competing interests The authors declare that they have no competing interests Authors' contributions NM was involved in the management of the patient while in hospital, wrote the ... data, and finalized the manuscript for submission to the journal, ML was involved in giving intellectual advice and reviewing the manuscript Consent Written informed consent was obtained from the ... steroids are tapered too quickly In recurrent disease, therapy with colchicine, potassium iodide, dapsone, doxycycline, indomethacin, clofazimine, isotretinoin and cyclosporine have all been described...

4
351
0

Báo cáo y học: " Takayasu''''s arteritis associated with Crohn''''s disease: a case report" pot

Ngày tải lên : 11/08/2014, 23:21

... showed no lesion in the oesophagus, stomach, or small intestine including the terminal ileum and cecum Abdominal CT scan showed thickening of the abdominal aorta (4 mm) and narrowing of renal arteries ... be clinically silent [2] Due to the involvement of the aorta and its vasculature, TA may present with gastrointestinal bleeding [6] Since most of these features may also be present in CD, there ... complicating the diagnosis and perhaps exacerbating the clinical course of patients with IBD [6] Conclusion Takayasu's arteritis affects the aorta and its vasculature and may compromise intestinal...

4
562
0

Báo cáo y học: "Chronic cough associated with Crohn’s disease" pdf

Ngày tải lên : 13/08/2014, 10:20

... manifestations of IBD are uncommon [2,3] Any part of the lung and its vasculature may be involved in association with IBD Large airways disease is the commonest site of lung involvement in IBD In a recent ... that they have no competing interests Authors’ contributions AHM and SF were the clinicians and GA the radiologist managing the case SF drafted the initial manuscript All authors have read and ... showed evidence of inflammation which is the most prevalent involvement in IBD [5] The location of stenosis in the medium size bronchi lead to the unique radiological picture of dilated, fluid...

4
247
0

báo cáo hóa học: " Identification of symptom domains in ulcerative colitis that occur frequently during flares and are responsive to changes in disease activity" ppt

Ngày tải lên : 18/06/2014, 19:20

... trials, including molecules targeting interleukin 12, interleukin 17, and endothelial integrins The efficacy of UC therapies in clinical trials is assessed with disease activity indices that typically ... benchmark for determining the clinical efficacy of new UC therapies An ideal index for the measurement of disease activity in UC would include the symptom domains important to patients and would focus ... used in the questionnaire to rate the three criteria for each of the 28 symptom domains mean of 60, and a standard deviation of 18 points on the 0–100 scale With an alpha of 0.05, and a power of...

12
382
1

Báo cáo khoa hoc:" Complicated Crohn''''s-like colitis, associated with Hermansky-Pudlak syndrome, treated with Infliximab: a case report and brief review of the literature" pot

Ngày tải lên : 11/08/2014, 10:22

... Improvement of ileitis, healing of ulcers (after wk of the initial dose of infliximab) Improvement of ileitis, healing of ulcers (after wk of the initial dose of infliximab) However, a review of the ... Improvement of edema and healing of linear ulcers in sigmoid colon (8 weeks after the initial dose of infliximab) Improvement of edema and healing of linear ulcers in sigmoid colon (8 weeks after the initial ... hallmark findings of HPS presented to the University Hospital of Alexandropoulos in 2005 complaining of an 10-month history of recurrent episodes of abdominal pain worse with defecation and intermittent...

7
380
0

The Use of Selected Medicinal Herbs for Chemoprevention and Treatment of Cancer, Parkinson’s Disease, Heart Disease, and Depression

Ngày tải lên : 25/10/2013, 05:20

... downregulation of the expression of calmolulin-dependent kinases, cdk4 and cdk6, cyclin D1 and cyclin D3 Approximately half of the berries evaluated, including those of Vaccinium, signiﬁcantly inhibited the ... increase in mortality due to the use of digoxin During the 1980s, interest in using digoxin was renewed with a decrease in cases of digoxin intoxication, newer heart failure drugs demonstrating poorer ... mediated through norepinephrine and the renin-angiotensin system originating in the kidneys (both neurohormonal deactivating effects), and the slowing of the heart rate and decreased nerve impulse...

57
683
0