neutron capture therapy of cancer nanoparticles and high molecular weight boron delivery agents
nanotechnology for cancer therapy, 2007, p.810
... Therapy of Cancer: Nanoparticles and High Molecular Weight Boron Delivery Agents 77 Gong Wu, Rolf F Barth, Weilian Yang, Robert J Lee, Werner Tjarks, Marina V Backer, and Joseph ... implications for the systemic delivery of not only low -molecular- weight and macromolecular agents, but also particulate delivery vehicles Simply enhancing the plasma half-life of these agents (e.g., long-circulating ... nanotherapeutics, boron neutron capture therapy, and the discussion on nanotechnology characterization for cancer therapy, as well as guidance from the U.S Food and Drug Administration on approval of nanotechnology...
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báo cáo hóa học: " In vitro and in vivo pre-clinical analysis of a F(ab’)2 fragment of panitumumab for molecular imaging and therapy of HER1-positive cancers" pot
... article as: Wong et al.: In vitro and in vivo pre-clinical analysis of a F(ab’)2 fragment of panitumumab for molecular imaging and therapy of HER1-positive cancers EJNMMI Research 2011 1:1 Submit ... those of the F(ab’)2 fragment with a higher overall detection of tumor lesions The authors postulate that the success of these studies was the result of careful selection and matching of the ... μCi) of 86Y-CHX-A"-panitumumab F(ab’)2 and imaged and days post-injection of the RIC (c) Specificity was demonstrated by co-injecting 100 μg of panitumumab with the RIC and blocking uptake of the...
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Surface functionalization of superparamagnetic iron oxide nanoparticles for potential cell targeting, imaging, and cancer therapy applications
... Properties of PLMA-SPIONs Table 3-3 Properties of PLMA-1-PEG-SPIONs Table 3-4 Relaxivities of cell-associated and free nanoparticles Table 5-1 Properties of nanoparticles Table 6-1 Molecular weight ... magnetization curves of (a) ferromagnetic nanoparticles and (b) superparamagnetic nanoparticles Figure 2-3 In vivo behavior of nanoparticles in blood vessels The EPR effect of nanoparticles is ... spectra of (a) pristine SPIONs and (b) PLMA2-SPIONs. Figure 3-6 Schematic representation of the synthesis of PLMA-1-PEGSPIONs Site and extent of amide band formation between H2NPEG and PLMA-1...
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Molecular Imaging: An Essential Tool in Preclinical Research, Diagnostic Imaging, and Therapy potx
... physics and technology One of the major goals of molecular imaging has become the development of noninvasive strategies of molecular profilingº in living subjects, i.e., the acquisition and analysis ... characterization and measurement of biologic processes at the cellular and molecular level.º This broad definition emerged during the last few years as a consequence of the convergence of molecular and cell ... field of molecular imaging stands in respect to imaging just as molecular biology stands in respect to biological chemistry, i.e., it deals with nucleic acids and genetics This part of molecular...
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The use of gold nanostructures in the imaging and therapy of cancer
... seeding gold hydroxide nanoparticles at (a) pH of 4, (b) pH of 6, (c) pH of and (d) pH of 11 on the surface of amine functionalized silica cores to illustrate the influence of pH on the seeding ... z-stacks of a series of confocal optical sectioning of CNE2 cells shown on the top and right side of the en face image show the staining on the cross section side profile of the cells The top and ... the chain length of the PEG used and the size of the gold nanoshells……………………………….……158 Table 7.1 The mean histogram value and standard deviation of the 8-bit OCT Mscan images of different samples...
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Báo cáo hóa học: " Both FA- and mPEG-conjugated chitosan nanoparticles for targeted cellular uptake and enhanced tumor tissue distribution" docx
... efficiency of MMC were calculated using the equations listed below Loading content (% ) = Weight of drug in the nanoparticles × 100 Weight of nanoparticles Loading efficiency (% ) = Weight of drug ... were compared Results and discussion The preparation and characteristics of differential kinds of NPs Figure shows the process of the preparation and modification of NPs, and the scanning electron ... longlasting and effective MMC delivery system In vitro cellular uptake of different kinds of NPs To visualize the effect of FA-mediated endocytosis of different kinds of modified NPs, the distribution of...
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Báo cáo y học: "Rasburicase represents a new tool for hyperuricemia in tumor lysis syndrome and in gout Lisa Cammalleri and Mariano Malaguarnera"
... the use of rasburicase, owing to risk of TLS, are those who have hyperuricemia, high tumor burden, high growth rate of tumor, high sensitivity to chemotherapy and renal impairment Standard measures ... the type of malignancy and drugs used The use of low doses of rasburicase may permit to spare the total cost on the management of patients and to reduce the risk of the development of antibodies ... rasburicase, during the first cycle of chemotherapy, none required dialysis and normalization of uric acid levels and control of creatinine levels were achieved [66] The absence of needing for dialysis is...
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Báo cáo khoa học: Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis pptx
... and cell–ECM interactions, and by maintaining the structural integrity and self-assembly of the ECM [10,11] Notably, one of the characteristics of malignant transformation is downregulation of ... head and neck carcinoma and multiple myeloma as examples of solid and hematological malignancies Heparanase in head and neck carcinoma: signaling in motion Squamous cell carcinoma of the head and ... result of cancer of the oral cavity and pharynx, and the outcome has not improved significantly in the past 25 years [37] Tumor metastases are common among patients with head and neck cancer with...
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adobe digital imaging how-tos 100 essential techniques for photoshop cs5, lightroom 3, and camera raw 6
... images of day planners, curled-up post-it papers stuck to the base of your monitor, to-do lists etched onto a coffee shop napkin, even cleaning up the office! (No, that random pile of books and ... photography and your setup I hope that you get a lot of mileage from these tips and that the book can serve as a frequent reference in your work Best of luck, and remember: There’s a part of this ... digital photographers and imaging professionals The introduction of Photoshop CS5 and ACR 6, as well as Lightroom 3, brought many new capabilities and improvements When I was offered the chance...
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patel, chellapa - sparse representations and compressive sensing for imaging and vision
... an overview of some of the recent works in computer vision and image understanding that make the use of compressive sampling and sparse representation In particular, we show have CS and sparse ... image understanding and computer vision problems such as background subtraction and target tracking one is often faced with the problem of data deluge [7] Large amounts of data can be of detriment ... Φ B, let δ = M be a normalized measure of undersampling N K factor and ρ = M be a normalized measure of sparsity A plot of the pairing of the variables δ and ρ describes a 2-D phase space (δ ,...
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báo cáo hóa học:" Comparative study of 64Cu/NOTA-[D-Tyr6,beta-Ala11,Thi13,Nle14]BBN(6-14) monomer and dimers for prostate cancer PET imaging" potx
... pressure and the regulation of cell growth in some malignant cell lines [1, 2] The presence of GRPR has been documented in small cell lung cancers [3], prostate cancers [4, 5], breast cancers [6-8] and ... we studied cellular uptake and efflux of NOTA-monomer and NOTA-dimer on PC3 cells The expected advantages of multimeric compound are a higher uptake and retention of the peptide on GRPR-expressing ... imaging and confirmed by dissection and counting Results: NOTA-monomer, NOTA-dimers and were prepared with purity of 99%.The inhibition constants of the three BBN peptides were comparable and in...
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Báo cáo y học: "Autologous chondrocyte implantation for cartilage repair: monitoring its success by magnetic resonance imaging and histology" ppt
... not applicable; N/A not available with standard and polarised light and images captured and digitised using a closed-circuit television and Image Grabber software (Neotech Ltd, Hampshire, UK) R62 ... slides and stained with haematoxylin and eosin (H&E) and safranin O (0.5% in 0.1-M sodium acetate, pH 4.6, for 30 s) for general histology, measurement of cartilage thickness, and assessment of metachromasia ... characteristics of the cartilage and also highlights fluid in the joint and oedema in the subchondral bone (TR = 58.6; TE = 9; flip angle = 40°; field of view = 18 cm; matrix 256 × 192; number of excitations...
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Báo cáo khoa học: "Preoperative Y-90 microsphere selective internal radiation treatment for tumor downsizing and future liver remnant recruitment: a novel approach to improving the safety of major hepatic resections" docx
... graph Figureanalysis of left and right hepatic lobe volumes during the course of the treatment Graph Graph analysis of left and right hepatic lobe volumes during the course of the treatment Note ... Burton M, Moroz P, Anderson J, Gebski V: Randomized trial of SIR-spheres plus chemotherapy vs chemotherapy alone for treating patients with liver metastases from primary large bowel cancer Ann Oncol ... emerged as an effective liverdirected therapy with a favorable therapeutic ratio SIRT, both as a stand-alone therapy and in conjunction with systemic or regional chemotherapy (chemo-SIRT), has been...
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Báo cáo y học: "Expression of ADAM15 in rheumatoid synovium: up-regulation by vascular endothelial growth factor and possible implications for angiogenesis" ppt
... major immunoreactive bands of 100, 76, 66, 47, 41, 38, 34 and 29 kDa were observed (Fig 6, lane 2) Because the molecular weight of the 100-kDa band Effect of cytokines and growth factors on ADAM15 ... (lane 4) The molecular weight of the immunoreactive 15-kDa band corresponds to that of the R1161 Figure Characterization of monoclonal antibody against human ADAM15 ADAM15 Lysates of Escherichia ... expressed in 38% and 13% of RA and OA samples, respectively ADAMs 8, 20, 21, 28 and 30 were R1162 Arthritis Research & Therapy Vol No Komiya et al expressed in less than 13% of both RA and OA samples...
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Báo cáo khoa học: "Planning target volume margins for prostate radiotherapy using daily electronic portal imaging and implanted fiducial markers" docx
... and 63% of treatments along the L-R, S-I and A-P axes respectively, of which 14%, 31% and 29% were larger than mm In 88% of all treatments, the patient’s position had to be adjusted because of ... Braithwaite (Tom Baker Cancer Center) and Colette Schiltz (Saskatoon Cancer Center) Author details Department of Radiation Oncology, Tom Baker Cancer Center and University of Calgary; 1331 29 St ... S-I2 and A-P2 , and L-R1 , S-I1 and A-P1, represent during-treatment and pre-treatment (uncorrected) isocenter positions along the L-R, S-I and A-P axes respectively, and cL-R , cS-I and cA-P represent...
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Báo cáo khoa học: "Value of diffusion weighted MR imaging as an early surrogate parameter for evaluation of tumor response to high-dose-rate brachytherapy of colorectal liver metastase" docx
... Boxplot depicting changes of mean ADC of nontreated and treated tumors at early and follow-up MRI compared to baseline MRI Boxplot illustrates changes of mean ADC of non-treated and treated colorectal ... current understanding of therapy induced changes assessed by DWI: effective anticancer treatment results in tumor lysis, loss of cell membrane integrity, increased extracellular space, and, therefore, ... Figures and 6) How may this decrease in mean tumor ADC and increase in TV be explained? Current models of tumor response postulate cell swelling to occur soon after initiation of anticancer therapy...
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Báo cáo khoa học: "Stereotactic body radiotherapy for stage I lung cancer and small lung metastasis: evaluation of an immobilization system for suppression of respiratory tumor movement and preliminary results" ppsx
... with an average of 26 mm Of the 55 lesions, tumor location was the right upper, middle and lower lobes in 17, and 13 cases, respectively, and the left upper and lower lobes in 13 and 10 cases, ... study and drafted the manuscript YS indicated the design of the study and gave final approval of the version to be published NT participated in analysis and interpretation of data CIH, KO and SA ... acquisition and analysis of data HO participated in the design of the study and helped to perform the statistical analysis CS participated in analysis and interpretation of data and helped to...
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Báo cáo khoa học: " Ipsilateral irradiation for well lateralized carcinomas of the oral cavity and oropharynx: results on tumor control and xerostomia" pot
... Development of a European Organization for Research and Treatment of Cancer (EORTC) questionnaire module to be used in quality of life assessments in head and neck cancer patients EORTC Quality of Life ... clinical examination, by both the head and neck surgeon and the radiation oncologist, endoscopy and CT scan of the head and neck region A chest X-ray or chest CT and blood test were performed to rule ... contralateral submandibular; mean dose to the right parotid Gy, mean dose to the submandibular gland 20 Gy completion of RT Mean score for dry mouth was 28.1 on a scale of 0-100, and 26.5 for sticky...
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Báo cáo khoa học: " Kinetic modeling of tumor growth and dissemination in the craniospinal axis: implications for craniospinal irradiation" pps
... chemotherapy, which is another means of treating the entire subarachnoid space [7,8] Delivery of CSI with standard photon therapy presents a geometric dilemma that is typically solved by the use of ... phase and by the rate of shedding of cells from the solid phase into the fluid phase We assume that adhesion and shedding are described by the product of cell number and the rate constants kadh and ... effect of initial number of tumor cells in the brain parenchyma, Nb,t, and radiosensitivity, D0, on treatment outcome is shown Failure is more likely the higher the value of Nb,t and D0 Page of (page...
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Báo cáo y học: "Targeted genomic capture and massively parallel sequencing to identify genes for hereditary hearing loss in middle eastern families" pot
... probands of Israeli Jewish and Palestinian Arab origin and identified mutations associated with hearing loss in a subset of our probands and their extended families Results Targeted capture of ... Ministry of Health, the Human Subjects Committees of Bethlehem University, and the Committee for Protection of Human Subjects of the University of Washington (protocol 33486) Eleven probands and both ... Bioinformatics section of Materials and methods) and classified by predicted effect on the protein, as described in Materials and methods Discovery of novel mutations In each of the 11 probands, multiple...
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Tìm thêm: xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng 9 tr 25