neuropathology neurochemistry and pathogenesis
Tài liệu Transmission and Pathogenesis of Tuberculosis docx
... Chapter 2: Transmission and Pathogenesis of Tuberculosis 42 References American Thoracic Society and CDC Diagnostic standards and classification of tuberculosis in adults and children Am J Respir ... specimen handling procedures that generate infectious droplet nuclei E Negative pressure in an infectious TB patient’s room Chapter 2: Transmission and Pathogenesis of Tuberculosis 25 Pathogenesis ... in Figure 2.3 Figure 2.3 Pathogenesis of LTBI and TB Disease Area of detail for boxes 2, 4, and Droplet nuclei containing tubercle bacilli are inhaled, enter the lungs, and travel to the alveoli...
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Báo cáo y học: "Aetiology and pathogenesis of reactive arthritis: role of non-antigen-presenting effects of HLA-B27" pdf
... immunoglobulin M (IgM), immunoglobulin A (IgA) and immunoglobulin G (IgG) antibody concentrations – and in Yersinia-triggered ReA, IgA antibody concentrations – are higher and persist longer in the sera of ... of the inhibitory molecule (IκB) bound to NF-κB and thus allowed faster and prolonged activation of NF-κB in HLA-B27-expressing cells than HLA-A2 and mock transfectants The secretion of TNF-α was ... Non-antigen-presenting effects of HLA-B27 and animal models HLA-B27 transgenic rat and mice models have been generated to study the role of HLA-B27 in the pathogenesis of SpA in detail In the rat...
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Báo cáo y học: "Myocardial dysfunction in rheumatoid arthritis: epidemiology and pathogenesis" pps
... arthritis Fewer statistics on incidence and prevalence rates for CHF in patients with RA are available and are derived from a handful of population-based [24-26] and clinic-based RA cohorts [5,27,28] ... approximately 10 months) and the CHF phenotype evolves more gradually, characterized by ventricular hypertrophy and dilatation, interstitial infiltrates and fibrosis, and depressed adrenergic ... arthritis and temporomandibular joint destruction Scand J Rheumatol 1988, 17:273-279 Zamarron C, Maceiras F, Mera A, Gomez-Reino JJ: Effect of the first infliximab infusion on sleep and alertness...
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ALZHEIMER''''S DISEASE: ITS DIAGNOSIS AND PATHOGENESIS - PART 1 doc
... modification and improvement of criteria for the diagnosis of AD is therefore necessary until we understand, and either prevent or cure, this illness IIh Pathogenesis To understand the pathogenesis ... performed Both Lopez and colleagues (1990) and Kukall and colleagues (1990) used four raters to evaluate the NINCDS-ADRDA criteria Using cases with dementia (AD and non-AD) and n o n d e m e n ... neuropathological diagnosis of AD, dementia is reliably associated with stages V and VI and to a variable degree with stages III and IV (Braak and Braak, 1991; Harding et al., 2000) NFTs first form in the pre-a...
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ALZHEIMER''''S DISEASE: ITS DIAGNOSIS AND PATHOGENESIS - PART 2 doc
... transmembrane domain, and a large N-terminal extracellular domain (Haas, 1996; Neve and Robakis, 1998; Storey and Cappai, 1999; Wilson et al., 1999; Coughlan and Breen, 2000; Gandy and Petanceska, ... on its ability to form fibrils (Haas, 1996; Neve and Robakis, 1998; Storey and Cappai, 1999; Wilson et al., 1999; Coughlan and Breen, 2000; Gandy and Petanceska, 2000) The peptide is derived by ... pathway generating Aft peptide (Haas, 1996; Neve and Robakis, 1998; Storey and Cappai, 1999; Wilson et al., 1999; Coughlan and Breen, 2000; Gandy and Petanceska, 2000) During transport to the cell...
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ALZHEIMER''''S DISEASE: ITS DIAGNOSIS AND PATHOGENESIS - PART 3 pptx
... understanding of the association between A/3 deposition (required for a diagnosis of AD) and the degenerative process The link between soluble A/3 and brain atrophy needs to be clarified, and mechanisms ... from 2.1 to 9.9 and reflect data obtained from prevalence and incidence studies 190 JILLIAN J KRIL AND GLENDA M HALLIDA¥ A DOMINANT INHERITANCE It is estimated that between 5% and 10% of AD cases ... of e2, e3, and e4, and the presence of the e4 allele has been f o u n d to increase the risk o f A D (Katzman, 1994; Strittmatter and Roses, 1995) ApoE is involved in lipid transport and is present...
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ALZHEIMER''''S DISEASE: ITS DIAGNOSIS AND PATHOGENESIS - PART 4 pps
... 259-265 Gahtan, E., and Overmier, J B (1999) Inflammatory pathogenesis in Alzheimer's disease: Biological mechanisms and cognitive sequeli Neurosci Biobehav Rev 23, 615-633 Gandy, S., and Petanceska, ... Braak, H., and Mandelkow, E.-M (1994) A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads Acta Neuropathol 87, 554567 Braak, H., and Braak, ... disease and its risk factors and an increased risk of AD B SUMMARY A hypothesis has been presented that links many of the identified and putative risk factors forAD and suggests a mechanism for...
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ALZHEIMER''''S DISEASE: ITS DIAGNOSIS AND PATHOGENESIS - PART 5 doc
... 12260-12264 Price,J L., and Morris,J C (1999) Tangles and plaques in nondemented aging and "Preclinical" Alzheimer's disease Ann Neurol 45, 358-368 Prince, M., Rabe-Hesketh, S., and Brennan, E (1998) ... 392402 Shefer, V E (1973) Absolute number of neurons and thickness of the cerebral cortex during aging, senile and vascular dementia, and Pick's and Alzheimer's disease Zhurnal Nevropatologii i Psikhiatrii ... Smith, M A., and Friedland, R P (2000) Vascular abnormalitites: The insidious pathogenesis of Alzheimer's disease Neurobiol Aging 21,357-361 Simic, G., Kostovic, I., Winblad, B., and Bogdanovic,...
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Molecular biology and pathogenesis of coronavirus virus and host factors involved in viral RNA transcription
... of viral transcription and replication, uncapped double-stranded RNA intermediates are generated and these may have served as ligands for the RIG-I and/ or Mda5 Both RIG-I and Mda5 have been implicated ... moved out and Associate Professor Tan Yee Joo for allowing me to work in her lab at IMCB for several months Lastly, I would like to thank my husband for his unceasing love and understanding for ... chicks and are mainly associated with upper respiratory tract infections in adults, and to a lesser extent, nephrogenic infections In larger livestock like pigs and cattle on the otherhand, coronaviruses...
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Evaluation of the role of autophagy in fungal development and pathogenesis 2
... diameter) and contain RAB5 and RAB4, with Transferrin and its receptor and EEA1 as markers (Hopkins and Trowbridge, 1983) Late endosomes are also known as MVBs (multiple vesicular bodies) and are ... appressorium formation and function (Adachi and Hamer, 1998; Choi and Dean, 1997; Dean, 1997; Mitchell and Dean, 1995; Tucker and Talbot, 2001; Xu and Hamer, 1996; Xu et al., 1998; Xu, 2000) ... atg8∆ mutant and the role of autophagy and nutrient utilization was investigated during conidiation and in planta growth in Magnaporthe By genetic and biochemical studies, autophagy and glycogen...
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Evaluation of the role of autophagy in fungal development and pathogenesis 3
... a-amylase and amyloglucosidase, and then measuring the released glucose in a colorimetric assay containing glucose oxidase, peroxidase and o-dianisidine (Gascon and Lampen, 1968; Lillie and Pringle, ... mutant and investigate the role of autophagy and nutrient utilization during conidiation and in planta growth in Magnaporthe By genetic and biochemical studies, we show that autophagy and glycogen ... autophagy in yeast and fungal species and focus on the methods that are useful to monitor the induction and rate of autophagy in filamentous fungi The following protocols and methods have been...
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Evaluation of the role of autophagy in fungal development and pathogenesis
... autophagy and Magnaporthe pathogenesis 79 3.2.10.1 Gph1-catalyzed glycogen catabolism and Magnaporthe pathogenesis 79 3.2.10.2 Sga1-catalyzed glycogen catabolism and Magnaporthe pathogenesis ... 1.3.2 Genetic and biochemical regulation of M oryzae conidiogenesis and pathogenesis 16 1.4 Carbohydrate metabolism and fungal sporulation / pathogenicity 19 1.5 Aims and objectives ... Fan, He Yun long and Selvarai Poonguzhali, for making our lab a most pleasant and stimulating working environment The TLL community, especially the sequencing lab and the microscopy and imaging facility...
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Báo cáo y học molecular approaches to the analysis of deformed wing virus replication and pathogenesis in the honey bee, apis mellifera
... of negative and positive-strand DWV RNA in tissues of symptomatic and TaqMan Real-Time qRT-PCR for quantification of negative and positive-strand DWV RNA in tissues of symptomatic and asymptomatic ... magnetic4 beads Figure plot purification and standard curve of TaqMan quantitative RT-PCR (qRT-PCR) incorporated with biotinylated primer and Amplification plot and standard curve of TaqMan quantitative ... Quantification of positive and negative-strand in the Varroa mites showed no significant difference (p = 0.07) between the titers of the negative-strand and positive-strand RNAs as seen in the honey...
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Tài liệu Báo cáo khoa học: Proteomic analysis of dopamine and a-synuclein interplay in a cellular model of Parkinson’s disease pathogenesis docx
... each sample and data were processed using CellQuest software (Becton-Dickinson) Fluorescent emission of propidium iodide and Annexin V-FITC were collected through a 575 and a 530 ⁄ 30 bandpass filter, ... putative kinase mutations Mitochondrial and proteasome dysfunction and oxidative stress could account for the selective degeneration of dopaminergic SNpc neurons and their specific vulnerability [1–6] ... (GST)p, Ran binding protein and C1q binding protein], related to cell signaling, apoptosis and cytoskeleton regulation (Fig 2, insets; shaded versus white bars) On the other hand, six proteins were...
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Báo cáo khoa học: Purification and structural analysis of the novel glycoprotein allergen Cyn d 24, a pathogenesis-related protein PR-1, from Bermuda grass pollen pot
... allergic to BGP require individual diagnosis and therapy, and an understanding of the structure of these allergens is essential to the improvement of diagnosis and the design of adequate therapeutic ... as fungal and bacterial infections, flooding, freezing temperature, or chemicals such as ethylene and salicylic acid [21] Many plant allergens from food and pollen have been found to be pathogenesis- related ... combination of CM-TSK and RP-HPLC The final material was homogenous, as shown by the presence of a single band on SDS ⁄ PAGE, a single sharp peak on RP-HPLC, and a single band on immunoblotting...
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Low Back Pain Pathogenesis and Treatment Edited by Yoshihito Sakai pptx
... shape profiles for males (light and dark blue: CON n=113 and LBP n=84) and females (light and dark red: CON n=79 and LBP n=129) 14 Low Back Pain Pathogenesis and Treatment First of all, trunk ... L5/s1 Fig X-ray findings and averaged age 30 Low Back Pain Pathogenesis and Treatment 3.1 Disc score and osteophyte score Averaged disc score and osteophyte score were 1.4±1.5 and 8.3±3.1, respectively ... Schröder, Förster & Mattes, 2008, p 46) Low Back Pain Pathogenesis and Treatment For a better understanding of geometry and corresponding anatomical landmarks, spine shape parameters were illustrated...
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Báo cáo khoa học: FLIP and MAPK play crucial roles in the MLN51-mediated hyperproliferation of fibroblast-like synoviocytes in the pathogenesis of rheumatoid arthritis pdf
... transcriptional and post-translational control; (3) FLIP expression is induced; and (4) this results in the anti-apoptotic proliferation of FLS, contributing to the pathogenesis of RA (Fig 6) MLN51 and MLN51-induced ... FLS proliferation and anti-apoptosis in RA pathogenesis Thus, MLN51 and FLIP are attractive targets for the development of new RA therapeutics Experimental procedures Isolation and establishment ... Logan, UT, USA) supplemented with 10% fetal bovine serum (Gibco, Grand Island, NY, USA) and 100 lgÆmL)1 each of penicillin and streptomycin GM-CSF (LG Life Science, Seoul, Korea), cycloheximide...
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Báo cáo khóa học: Genetic defects in fatty acid b-oxidation and acyl-CoA dehydrogenases Molecular pathogenesis and genotype–phenotype relationships ppt
... summarized below, focused on one hand on the biogenesis and stability of the variant K304E MCAD protein, coded from the 985AdefiGua allele, and on the other hand on the activity and chain-length selectivity ... used for the constructions are: VLCAD [82,83] and NCBI nucleotide database gi: 3273227; MCAD [84] and NCBI nucleotide database gi: 187432 and SCAD [85] and NCBI nucleotide database gi: 2995253; 2821943 ... published in 2001 [7,8] and the assembly of large contigs and the annotation of genes makes it possible to find gene and genome structures for all genes that encode the enzymes and transport proteins...
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Báo cáo hóa học: " La Crosse virus infectivity, pathogenesis, and immunogenicity in mice and monkeys" docx
... histopathological and immunohistochemical (IHC) examination (n = 3, daily for six days), and the data is summarized in Table and Figures and Virus titers for nasal turbinates, brain, spinal cord, muscle, and ... the IN and IP groups (2.4 and 2.3 log10 PFU, respectively) with the LD50 following IP injection in agreement with previous experiments [6] The ID50 titers (1.5 and 1.6 log10 PFU for the IN and IP ... IHC and HE (n = 3) Viral antigen or lesions were not observed in nasal turbinates, muscle, spleen, or pancreas Tissues from three control mice were collected on days and and processed for HE and...
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Báo cáo hóa học: " Pathogenesis and vertical transmission of a transplacental rat cytomegalovirus" doc
... lymphocytes and plasma cells were often present in both white and red pulps Salivary gland Localization of RCMV infection in all salivary glands, i.e parotid, submandibular and sublingual glands was ... brain, salivary gland, heart, lung, spleen, liver, kidney, uterus, ovary and the one-day old neonatal tissues (salivary gland, liver and kidney) were subjected to H&E staining and IIP test Additional ... experiments and drafted the manuscript MAML participated in the experimental design and coordination and helped to draft the manuscript SOAR conceived of the study and participated in its design and...
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