neuroimaging for the affective brain sciences and its role in advancing consumer neuroscience
Distribution of betaine gaba transporter BGT 1 in excitotoxic brain injury and its role in osmoregulation in the brain
... function in the brain BGT-1 is capable of transporting both betaine and GABA, as examined in Xenopus oocytes and various cell lines But the physiological substrate of BGT-1 in the brain remains to ... betaine/GABA transporter BGT-1 in normal brain and in excitotoxic brain injury, as well as the expression and functional changes of BGT-1 in astrocytes in response to hyperosmolarity in vitro and ... tool for evaluating the functional role of GAT-3 in the brain (Borden et al., 1994) GAT-3 mRNA is widely expressed in the brain, as examined by radiolabelled oligonucleotide probes and in situ...
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Báo cáo y học: " Beyond the first 25 years: The International AIDS Society and its role in the global response to AIDS" pps
... also increasingly involved in the development and delivery of a range of education and training programmes designed to help individuals working in HIV advance professionally, from administering the ... Programme for IAS 2007 Providing education and training opportunities for its membership is important for any professional society, and the IAS is looking at ways to strategically expand its role in ... cross-disciplinary linkages and dialogue, and to strengthen the focus on youth – began to be implemented in the planning for the XVI International AIDS Conference (AIDS 2006) in Toronto and will...
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Development of a novel toll like receptor based two hybrid assay for detecting protein protein interactions and its application in the study of CD14 dimerization and FcyRIIA activation
... known protein by expressing the protein in fusion with BD domain and then screening proteins in fusion with AD It also allows the identification of specific binding sites on proteins in combination ... CD42b is formed by tandem repeats of individual LRRs The β-strands together form the concave surface of the horseshoe/solenoid structure and the α-helices form the convex surface, lining the outer ... Professor Lu Jinhua, for accepting me as a PhD student, for always reminding me that science is a passion and especially for inspiring me to become an independent thinker Without his advice and inspiration...
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Tài liệu Báo cáo khoa học: Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth – structure and function of the second kinase noncatalytic C-lobe domain docx
... in the KIND2 domain of v-KIND contain the core MAP2 binding module To identify the core MAP2-binding site within the KIND2 domain (amino acids 456–620), we analyzed five EGFP-fused KIND2 domain ... understood, the data obtained in the present study indicate that the 43 residues (amino acids 702–744 in mice) that reside in the middle region of the CD act as the v-KIND binding core The v-KIND-binding ... determined the structural and functional properties of the protein–protein interaction between v-KIND and MAP2 We defined the binding core regions for the v-KIND–MAP2 interaction and showed that the...
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Tài liệu Multiple Vulnerabilities qualitave data for the stydy of orpharns and vulnerable children in South Africa ppt
... Springfontein ja, I think it’s Springfontein number one And the reason for that is that in Springfontein you have, it’s on the N1, the Springfontein, you have trucks coming in and out the area ... took place And the reason for that (high rates of HIV infections in Springfontein) is that in Springfontein you have, it’s on the N1, the Springfontein, you have trucks coming in and out the area ... developing and implementing interventions to provide assistance to OVC, their carers and their communities and act as part of the baseline information for evaluating these interventions Thirty in- depth...
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Tài liệu Báo cáo khoa học: High affinity copper binding by stefin B (cystatin B) and its role in the inhibition of amyloid fibrillation docx
... histidine residues are central to copper binding in many proteins they probably form part of the copper binding sites in this protein Although there are four histidines in the C-terminal, another ... important in the brain, therefore the role of copper binding or loss of its binding could be related to specific cerebellar function(s) of stefin B [18], which remains to be seen by more in vivo ... propose that in globular proteins which bind Cu2+ specifically, the metal binding can be protective against amyloid fibril formation Therefore, maintaining correct metal ion protein interactions...
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Tài liệu Báo cáo khoa học: Inorganic pyrophosphatase in the roundworm Ascaris and its role in the development and molting process of the larval stage parasites doc
... concerning the kinetics and properties of the enzyme More strikingly, we show a novel role of the PPase enzyme in the development and molting process of A suum larvae in vitro constructed in UniZap ... (Software Inc) and the BLAST network server of the National Center for Biotechnology Information (NCBI) were used to analyze the nucleotides and deduce the amino acid sequences in determining similarities ... gauze and suspended in NaCl/Pi containing 100 lgÆmL)1 penicillin/ streptomycin at 37 °C for h After incubation the tissues were removed, and the larvae were collected from the bottom of the tube The...
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Báo cáo khoa học: Molecular and functional characterization of a novel splice variant of ANKHD1 that lacks the KH domain and its role in cell survival and apoptosis docx
... VBARP and Vpr is specific The input panel represents the amount of protein used in this assay indicating that an equal amount of protein was used in all our samples and that the lack of interaction ... lymph node and kidney Interestingly, muscle and brain were almost negative, indicating that there is a differential expression of these transcripts within different human tissues Interestingly, MASKBP3 ... ankyrin repeat proteins, using the consensus established by Kohl et al [10] and Mosavi et al [11], which contains ankyrin repeats from over 4000 proteins, indicated that the ankyrin repeat domains...
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Báo cáo khoa học: The calpain 1–a-actinin interaction Resting complex between the calcium-dependant protease and its target in cytoskeleton doc
... to interact with Calp1 This indicates the presence of a calpain binding site in the C-terminal domain of smooth muscle a-actinin Involvement of the C-terminal domain of ask in Calp1 binding In ... a-actinin, either in direct contact or in a complex including the two proteins In conclusion, our study proves the interaction between a-actinin and calpain and locates binding motifs within regions ... Binding interface between Calp and ask was further located in this study Calpain binding structures were found within the 10 kDa C-terminal domain of the a-actinin molecule The inability of the...
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Báo cáo khoa học: Characterization of Trypanosoma brucei PEX14 and its role in the import of glycosomal matrix proteins pptx
... of the various bands, the proteins were extracted from the native gel and analysed by SDS/PAGE (Fig 1B) Indeed both proteins form a complex and run together as they are present in the same band ... with a binding constant Kd of 2.75 lM, and that the amino-terminal domains of the two peroxins were responsible for this interaction The role of TbPEX14 in glycosome biogenesis received further ... cerevisiae that both the N-terminal and the C-terminal domain are at the cytosolic face of the peroxisomal membrane [15,16,20] The prediction of a membrane-anchoring subdomain is therefore speculative...
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báo cáo hóa học:" Research Article Automatic Speech Recognition Systems for the Evaluation of Voice and Speech Disorders in Head and Neck Cancer" pdf
... computed for each of the raters using the respective other raters as reference, that is, the mean of the four other raters for the LE group and the three other raters for the OC group For the comparison ... T4 The patients’ mean age was 60.1 ± 10.4 years The treatment included the excision of the tumour and additional radiotherapy for most of the patient except for T1 grading Recording was performed ... cancer group on the five-point scale and 2.5 ± 1.0 for the group of laryngectomees The effect of the language model is investigated in Table using the OC data With growing n-gram context, the recognition...
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Báo cáo hóa học: " An Improved Algorithm for the Piecewise-Smooth Mumford and Shah Model in Image Segmentation" docx
... EURASIP Journal on Bioinformatics and Systems Biology curves, better properties in edge preserving, and the evolution of curves being independent of the choice of the initial curve The rest of this ... ±τ/2} Here the pixel points that fall within the narrowband are obtained from the original image Moreover a compound image is composed of u+ , u− , and the region of narrowband as shown in Figure ... of California: Los Angeles, Los Angeles, Calif, USA, 2000 T F Chan and L A Vese, “A level set algorithm for minimizing the Mumford-Shah functional in image processing,” in Proceedings of the IEEE...
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Báo cáo toán học: "Improved bounds for the number of forests and acyclic orientations in the square lattice" doc
... for ≤ n ≤ The values are shown in Table The values for f (7) and α(7) can be used to improve the upper bound given in [7] by using Theorem 6.1 and Theorem 5.4 from the same paper, obtaining the ... that the edge set C ⊆ E(Pk ) has to contain the edge joining vertices (1, 1) and (2, 1) We denote by Λk the corresponding matrix for this case Then the analogue to Theorem 3.2 is the following Theorem ... evaluation of the Tutte polynomial at these points is #P-hard for planar bipartite graphs [11] and even for grid graphs of maximum degree [12] The approach for obtaining the bounds in Sections and is...
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báo cáo khoa học: " Exploring ethical considerations for the use of biological and physiological markers in population-based surveys in less developed countries" docx
... Reporting Results The reporting of findings of individual biological and physical measurements to survey participants is determined, in part, by the nature of the parameter and the clinical meaning ... lines for future genetic testing The samples were "anonomized" so that no investigator, including those inside the government can link the sample to the identity of a sample person The on-going ... dealt with the following types of ethical issues: safety of the survey to subjects and workers in survey, obtaining appropriate informed consent, confidentiality of information collected in the survey,...
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Báo cáo y học: "Inhibition of complement C5a prevents breakdown of the blood-brain barrier and pituitary dysfunction in experimental sepsis" ppt
... surrounding brain cells, relaying into the brain inflammatory response and jeopardising the functional integrity of the BBB [55-57] In the present study, we found that, during experimental sepsis, the ... described to reduce the LPS-induced activation in the paraventricular nucleus and the central amygdala [81] Thus, as we are beginning to gain novel insights into the crucial role of C5a in the development ... of the BBB and restore the immunological and endocrinological homeostasis in the septic brain Materials and methods Experimental CLP model All procedures were performed in accordance with the...
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THE MECHANISMS REGULATING THE TRANSCRIPTION FACTOR ATF5 AND ITS FUNCTION IN THE INTEGRATED STRESS RESPONSE
... ATPase domain in its N-terminus, and a peptide binding domain in its C-terminus GRP78 binds to the hydrophobic patches of nascent polypeptides in ER with its peptide-binding domain and uses the energy ... Wenzhao, Jingliang Yan, Lin Lin and Sixin Jiang I would like to thank my parents, Xin Zhou and Shulan Yang, and my motherand father -in- law, Xihong Mo and Bin Zhong, for making the life of my wife and ... ER-resident transmembrane protein kinase, with its cytosolic portion containing the protein kinase domain, and the ER luminal part containing the regulatory elements for PERK The regulatory elements...
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Distribution of secretory phopholipase group XIIA in the CNS and its role in lipid metabolism and cognition
... cPLA2 immunolabelling is found in the hindbrain with light immunostaining observed in the forebrain and midbrain (Farooqui et al., 2000c) iPLA2 has been shown to be implicated in neurodegenerative ... hippocampus including CA1-3 fields, dentate gyrus and brainstem (Shirai and Ito, 2004) The significance of PLA2 in maintaining membrane lipid homeostasis of the brain is evident in all these studies ... expressed in the liver and small intestine and may be differentially expressed during tumorigenesis (Rouault et al., 2003) 17 Section II Aims of the present study 1.4 PLA2 Function in the Brain The brain...
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Tài liệu Báo cáo khoa học: A novel splice variant of occludin deleted in exon 9 and its role in cell apoptosis and invasion docx
... protein were examined first [20] We observed that the intracellular calcium level increased in OccWT-overexpressing cells, and that 2-APB inhibited the effects of OccWT Therefore, the increase in intracellular ... cells, the methylation status of the occludin promoter P1 could be examined Therefore, we tested the occludin promoter 3150 P1-containing CpG island region in liver cell lines, and observed that the ... are involved in cell adhesion and migration; their downregulation can cause epithelial transformation, whereas their upregulation induces apoptosis and inhibits invasion [8] Occludin, one of the...
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Tài liệu Báo cáo khoa học: Biochemical characterization of human 3-methylglutaconyl-CoA hydratase and its role in leucine metabolism docx
... in the AUH gene This indicated that AUH, in addition to its RNA binding function, must play an important role in leucine catabolism AUH was overproduced in E coli and characterized by measuring ... of leucine catabolism at the protein and DNA levels and developed a novel assay for enzyme analysis in a diagnostic setting The human AUH protein was first recognized by its ability to bind A + ... [15] For the kinetic characterization of AUH described in the work at hand, AUH was overproduced in Escherichia coli as a maltose binding protein fusion (MBP-AUH) The complete AUH gene (producing...
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Solar and Space Physics and Its Role in Space Exploration doc
... principal operating agency of both the National Academy of Sciences and the National Academy of Engineering in providing services to the government, the public, and the scientific and engineering communities ... broadly and that include exploration to understand the origin and evolution of the universe, the formation of planets and planetary systems, the origin and extent of life, and the environment and ... the charter of the National Academy of Sciences, as a parallel organization of outstanding engineers It is autonomous in its administration and in the selection of its members, sharing with the...
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