neurocognitive decline following cardiac surgery incidence risk factors prevention and outcomes
Báo cáo sinh học: "Association between neuroserpin and molecular markers of brain damage in patients with acute ischemic stroke" pot
... and treated following the European Stroke Organization guidelines [7] Medical history recording potential vascular risk factors, blood and coagulation tests, 12-lead ECG, chest radiography, and ... and designed the research; analyzed and interpreted the data; performed statistical analysis, handled funding and supervision and drafted the manuscript RRG, DB, OM, have acquired, analyzed and ... out on admission and between days and Infarct volume was calculated in the second CT by using the formula 0.5 × a × b × c, where a and b are the largest perpendicular diameters, and c is the number...
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báo cáo hóa học:" Association between neuroserpin and molecular markers of brain damage in patients with acute ischemic stroke" pdf
... and treated following the European Stroke Organization guidelines [7] Medical history recording potential vascular risk factors, blood and coagulation tests, 12-lead ECG, chest radiography, and ... and designed the research; analyzed and interpreted the data; performed statistical analysis, handled funding and supervision and drafted the manuscript RRG, DB, OM, have acquired, analyzed and ... out on admission and between days and Infarct volume was calculated in the second CT by using the formula 0.5 × a × b × c, where a and b are the largest perpendicular diameters, and c is the number...
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Báo cáo khoa học: "Biological markers of lung injury before and after the institution of positive pressure ventilation in patients with acute lung injury" potx
... contributions GC and MAM designed the study GC performed data acquisition GC and SB performed the immunoassays MC and MAM performed the data analysis and interpretation and drafted the manuscript MC and AS ... including IL-6, IL-8, vWF, and ICAM-1 IL-8 and IL-6 are pro-inflammatory cytokines that are elevated in patients with ALI and are predictive of clinical outcomes, and their levels are altered ... EJ, Hudson LD: Incidence and outcomes of acute lung injury N Engl J Med 2005, 353:1685-1693 Brun-Buisson C, Minelli C, Bertolini G, Brazzi L, Pimentel J, Lewandowski K, Bion J, Romand JA, Villar...
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Báo cáo y học: "Technical Considerations in Decompressive Craniectomy in the Treatment of Traumatic Brain Injury"
... with prevention from over-cephalocele Yang et al found that the patients who underwent decompressive craniectomy combined with initially augmentative duraplasty had better outcomes and lower incidences ... the dura and to allow it to stretch and expand They performed decompressive craniectomy combined with this technical improvehttp://www.medsci.org Int J Med Sci 2010, ment in six patients, and found ... effect, avoid surgical complications, and facilitate subsequent operations and management Although all of these methods are tentative and experiential, and in most reports the involved patient...
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awareness of deficit after brain injury clinical and theoretical issues jan 1991
... as aphasia and amnesia As pointed out by McGlynn and Schacter (1989), research concerning anosognosia declined over the years following the publication of the monograph by Weinstein and Kahn (1955) ... Freud, New York: Random House, pp 181-549 (original work published 1900) Friedland, R P., and Weinstein, E A (1977) Hemi-inattention and hemisphere specialization: Introduction and historical review ... French Societe de Neurologic in June 1914 and December 1918 are a further outstanding landmark The term "anosognosia" was coined there, and the clarity and elegance of Babinski's exposition was...
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Báo cáo hóa học: " Effectiveness of a Wii balance board-based system (eBaViR) for balance rehabilitation: a pilot randomized clinical trial in patients with acquired brain injury" ppt
... can become repetitive and aimless, and thus reduce the motivation and adherence to treatment Balance control, as the complex constellation of impairments following ABI, demands a multidisciplinary ... the scores of scales and tests The results are given in terms of mean ( X ) and standard deviation (s) The subindexes and 20 represent the ¯ assessments carried out before and after the treatment, ... using a basic random number generator Two patients of the control group and one patient of the trial dropped out of the treatment due to causes unrelated to the study and system, and, consequently,...
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báo cáo hóa học: "Usability of a virtual reality environment simulating an automated teller machine for assessing and training persons with acquired brain injury" pdf
... concepts and ideas in Part I of the study WAKY and YEWH collected and analyzed data for Part I KNKF formulated concepts in Part II of the study CBCH, LKCK, LJCK, and LTHY collected and analyzed ... reports of major outcomes before and after training, which included the average reaction time, percentage of incorrect responses, number of cues needed, and time spent The pre- and post-assessments ... practiced and learned to use the VR-ATM through tasks such as inserting a debit card, withdrawing cash, and entering a password The amount of cash to be withdrawn or transferred varied randomly...
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báo cáo hóa học: " Inhibition of the alternative complement activation pathway in traumatic brain injury by a monoclonal anti-factor B antibody: a randomized placebo-controlled study in mice" pot
... MET, and MR performed the TUNEL and immunohistochemistry experiments IL, MR and DH performed the real-time RT-PCR analyses DR and PAW performed the murine C5a ELISA experiments All authors read and ... hours and 24 hours, but not at days after TBI Data are shown as mean levels ± SD of n = animals per group and time-point *P < 0.05, for TBI_mAb 1379 (4 h) and TBI_mAb 1379 (24 h) vs TBI_placebo and ... conception and planning of the experiments, performing of all animal experiments, analysis of the data and writing of the manuscript VMH and JMT provided the anti-factor B antibody and performed...
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báo cáo hóa học: " Air pollution & the brain: Subchronic diesel exhaust exposure causes neuroinflammation and elevates early markers of neurodegenerative disease" pdf
... observations, body and organ weights, serum chemistry, hematology, histopathology, bronchoalveolar lavage, and serum clotting factors were shown to be modest [30,31] Brain tissue was snap frozen and stored ... system Band density was quantitated with ImageJ [34] and analyzed as a ratio of GAPDH and a synuclein Results are reported as a percent increase from control TNFa, IL-6, MIP-1a, IL-1b, Ab42, and ... disease and exposure to infectious agents and pesticides and the occurrence of brain injuries: role of neuroinflammation Environ Health Perspect 2003, 111:1065-1073 Akimoto H: Global air quality and...
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báo cáo hóa học: " Differential aquaporin 4 expression during edema build-up and resolution phases of brain inflammation" doc
... Bordeaux, France) for surgery supervision and Dr Marc Landry (CNRS, UMR 5297) for helpful discussion We thank Celine Girard and Geraldine Miquel for technical assistance with the animals and histology ... DM2500 TCS SPE on a upright stand, Leica Microsystems, Germany) using the following objectives: HCX PL Fluotar 20X oil NA 0.7 and HCX Plan Apo CS 40X oil NA 1.25 and diodes laser (488 nm, 532 ... marker of active inflammation and GFAP (astrocytes) as a marker of glial scarring following the MIQE guidelines [14] Brains were freshly extracted following transcardiac PBS perfusion A 3-mm-thick...
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báo cáo hóa học: " Origin and consequences of brain Toll-like receptor 4 pathway stimulation in an experimental model of depression" docx
... data and revising the manuscript critically; LB and EB contributed to acquisition, analysis and interpretation of CMS model and behavioural data; JAM and JRC revised the manuscript critically; and ... group values) for pro-inflammatory and oxidative/nitrosative parameters previously analyzed, including LPS and LBP plasma concentrations and TLR4 and MD-2 expression and mRNA levels In this vein, ... were analyzed to ensure linearity of the band intensities, and the housekeeping proteins b-actin and sp-1 were used as loading controls for cytosolic and nuclear protein fractions, respectively...
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báo cáo hóa học: " Interleukin-1alpha expression precedes IL-1beta after ischemic brain injury and is localised to areas of focal neuronal loss and penumbral tissues" pdf
... nucleus and cytosol was regulated (Figure 2F) We have previously reported that IL-1α is retained in the nuclei of dead and dying cells [11], and also that microglia die in the infarct following ... immune studies and analysis KJK contributed to the design and execution of the surgical studies GLC contributed experimentally DB contributed to design and analysis of the study and wrote the ... design and analysis of the study and wrote the manuscript All authors read and approved the final manuscript Acknowledgements This work was funded by the Wellcome Trust (DB, NML, GLC), and by...
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Báo cáo y học: "Plasmatic B-Type Natriuretic Peptide and C-Reactive Protein in Hyperacute Stroke as Markers of Ct-Evidence of Brain Edema." pptx
... main baseline characteristics and risk factors Table Main baseline characteristics and risk factors N=41 Mean age: 78.32 (SD: 6.77); range: 54-91 Sex: 26 male (634%) and 15 female Mean temperature ... Korpelainen JT, et al Natriuretic peptides and mortality after stroke Stroke 2005; 36: 1016-1020 14 Etgen T, Baum H, Sander K, Sander D Cardiac troponins and N-terminal pro-brain natriuretic peptide ... between systolic blood pressure on admission and values of CRP and NT-PBNP We neither found relationship between the baseline values of CRP and NT-PBNP and dependence at discharge or death The mean...
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Theory of Brain Function quantum mechanics and superstrings - part 4 ppt
... α-helix, 31% β-sheet and 29% random coil The α-tubulin consists of four α-helixes, four β-sheets, and two random coils, while the β-tubulin has six α-helixes, one β-sheet, and seven random coils Each ... ligand binding, and neighboring protein conformational changes In the case of MTs, the programmable and adaptable nature of the tubulin conformational states can be easily used to represent and ... “apparatus”, is made of Of course, protons and neutrons are mainly made of up (u) and down (d) constituent quarks, but for my arguments they are of comparable mass and thus would give the same results...
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Traumatic brain injury and the effects of diazepam, diltiazem, and MK-801 on GABA-A receptor subunit expression in rat hippocampus ppt
... supported Both α1 and γ2 subunit expression increased acutely after injury, but were significantly decreased by 24 h, while α3 and β3 showed time-specific transient changes and α2 and α5 subunits ... TBI, while diltiazem and DZ treatments had nearly identical effects, normalizing γ2 and altering α1 and α3 expression DZ also significantly increased α2 expression in both sham and injured animals ... VGCC blocker, and DZ, a GABAAR agonist, had statistically identical effects on the expression of GABAAR subunits α1, α3, and γ2, normalizing γ2 and significantly increasing α1 and decreasing...
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Báo cáo y học: "Regional characterization of energy metabolism in the brain of normal and MPTP-intoxicated mice using new markers of glucose and phosphate transport" doc
... EL and HA: carried out the immunofluorescence assays and drafted the manuscript; JLB and MS: conceived the envelope-derived tagged ligands while; JLB, HA, ML and JT: generated, optimized and ... labelled for PiT1 and PiT2 and irregularly labelled for GLUT1 The Purkinje cells were irregularly labelled for GLUT1 (Figure 1F), PiT1 and PiT2 (Figure 2D) Regional GLUT1, PiT1 and PiT2 distribution ... ligand, we observed a staining of GLUT1 in the corpus callosum and the basal ganglia apparently weaker than in the cerebellum and in the cortex These results were reproducible in all animals and...
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Textbook of Traumatic Brain Injury - part 1 ppt
... London, England Note: The authors have worked to ensure that all information in this book is accurate at the time of publication and consistent with general psychiatric and medical standards, and that ... drug dosages, schedules, and routes of administration is accurate at the time of publication and consistent with standards set by the U.S Food and Drug Administration and the general medical community ... source, and brain injury severity criteria and scoring: selected United States incidence studies Study Annegers et al 1980 Location and years Olmsted County, Minnesota, 1965– 1974 Case definition and...
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Textbook of Traumatic Brain Injury - part 2 potx
... retrograde amnesia and PTA, medical complications, and course of recovery); time of onset and types of neurobehavioral changes that occurred during the acute and postacute phases of recovery; and results ... electrophysiological, and neuropsychological testing delineating the location and extent of injury and pattern of cognitive and memory impairment associated with it Medical and psychiatric records ... fatigue, and dizziness, in addition to headache, mood lability, apathy, depressed mood, and anxiety (Hinkeldey and Corrigan 1990; Thomsen 1984; Van Zomeren and Van Den Burg 1985) Signs and Symptoms...
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Textbook of Traumatic Brain Injury - part 3 pot
... short-latency EPs and persistent postconcussive symptoms is not robust (Gaetz and Weinberg 2000; Schoenhuber and Gentilini 1986; Schoenhuber et al 1988; Werner and Vanderzant 1991) and are not useful ... judgment, reasoning, concept formation, and abstraction; initiation and fluency; planning and organizing; set maintenance and mental flexibility; and disinhibition and impulse control These skills enable ... and PTA (Jellinger and Seitelberger 1970) Deeper brain lesions were associated with more severe brain injury (Ommaya and Gennarelli 1974), and resulted in longer duration and degree of coma and/ or...
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