... liquid-chromatography of aspirin, salicylate, and salicyluric
acid in plasma, with a modification for determining aspirin metabolites in urine. Clin Chem 28:1200–1203
9) Reidl U (1983) Determination of acetylsalicylic ... liquid chromatographic determination of
acetylsalicylic acid, salicylic acid, diflunisal, indomethacin, indoprofen and indobufen. Eur J Clin Pharmacol
20:375–378
Poisoning cases
350 Acetylsalicylic ... of a rabbit, to which ASA had been administered intravenously 15 min before sampling
HPLC analysis of ASA and its metabolites in plasma, tissues and urine
344 Acetylsalicylic acid
Procedure
i....
... received an intra-gingival injection of Xylocaine™ solution (contain-
ing 2 % lidocaine and a small amount of epinephrine) at a dental clinic; the amount of lido-
caine hydrochloride salt administered ... injection
volume: 1 àL. 1: IS (ketamine); 2: lidocaine; 3: a changed form of MEGX; 4: procaine;
5: mepivacaine; 6: cocaine; 7: tetracaine; 8: bupivacaine; 9: dibucaine.
⊡ Figure 8.3
Poisoning ... highly
soluble in formic acid, soluble in
water, slightly soluble in ethanol,
relatively insoluble in anhydrous
ethanol and almost insoluble in
ether; melting point: 148° C.
Spinal, epidural,...
... measurements in the SIM mode should be
made. In this method, large-volume injection is being realized by combining a wide-bore cap-
illary column and a PTV sample-introducing device, resulting in higher ... (1.5 min) → 7 °C/min → 200 °C → 5 °C/min → 330 °C
(7 min); interface temperature: 280 °C; injection device: a PTV
c
splitless high-pressure in-
jection
d
method, 50 °C (0.01 min) → 250 °C/(min) ... compounds of principal hair dye components.
1: catechol; 2: o-aminophenol; 3: o-phenylenediamine; 4: hydroquinone; 5: p-aminophenol;
6: p-phenylenediamine plus resorcinol; 7: m-aminophenol; 8:...
... important tasks in emergency medi-
cine; it requires both rapidness and accuracy. In the Japan-shaking poisoning incidents taking
place in 1998, such as curry (arsenous acid) poisoning in Wakayama, ... Public Health)
8
â Springer-Verlag Berlin Heidelberg 2005
I.8 Problems in toxin analysis
in emergency medicine
By Makoto Nihira
Introduction
e identi cation of a causative toxin is one of the ... analysis should mainly cover these
drugs. In this chapter, the author presents some of our analytical system and discusses on prob-
lems arising during maintaining the system.
62 Problems in...
... drawn into the gas-tight syringe together with pushing the plunger of the
plastic disposable syringe. e gas in the gas-tight syringe is injected into GC.
vii. When another injection into GC ...
place using city gas containing about 9% CO. However, during recent years, city gas is being
replaced by natural gas containing no CO, resulting in drastic decrease of the number of CO
poisoning ... carboxyhemoglobin analysis. Forensic Sci Int 48:89–96
11) Sato K, Katsumata Y, Aoki M et al. (1983) A new reagent for the rapid determination of total hemoglobin as
hemiglobincyanide in blood containing...
... temperature: 30°C (3 min)→ 25°C/min→ 105°C→ 10°C/min→ 145°C; injection and de-
tector temperature: 280°C; carrier gas: He; its ow rate: 0.7 mL/min. e SPME ber is injected
into GC in the splitless ... A er 15 min of heating, about 0.6 mL volume of the headspace va-
por is drawn into a gas-tight syringe
c
. Just a er the vapor volume in the syringe is adjusted
to 0.3 mL
d
by pushing the ... stirring and heating at 60°C for 10 min.
iiii. A er the exposure, the ber is withdrawn into the needle, and the needle of the syringe is
taken out of the vial and immediately injected into...
... plunger -in- needle syringe is designed to be used for injecting as small as 0.1 àL of
sample solution with high precision. e authors are using the syringe (code No. 0.5BNR-5)
obtained from SGE International ... min) →10 °C/min → 40 °C (10 min) → 20 °C/min → 240 °C; injection
temperature: 200 °C; detector temperature: 240 °C; carrier gas: helium; its ow rate: 3 mL/min.
e breath gas is injected into ... GC analysis of ethanol in
blood and urine using headspace extraction and wide-bore capillary columns; an ultra-sensi-
tive analysis of breath ethanol is also given.
Determination of ethanol in...
... (oven) temperature: 50 °C (1 min) → 20 °C/min → 200 °C →
7 °C/min → 290 °C (8 min); analysis time: 29.4 min; injection mode: splitless; injection tem-
perature: 250 °C; injection pressure: about ... available in Japanese markets [2]; it is essential to identify a causative chemical to make
the nal clinical diagnosis in a poisoning-suspected case.
Since sensitive and simultaneous analysis ... Toxic Poisoning in
Japan, No. 33. National Police Agency, Tokyo, pp 32–102 (in Japanese)
8) Pharmaceutical Society of Japan (ed) (1982) Standard Methods of Chemical Analysisin Poisoning. With...
... and their conjugates in plasma from two
case of cresol poisoning. In: Tatsuno Y (ed) Proceedings of the 6th Indo Pacific Congress on Legal Medicine and
Forensic Sciences. INPALMS-1998-KOBE, pp ... was playing on a slide
in a park, and slid into a puddle with his buttocks getting wet with water probably containing
a large amount of cresol. A er 30 min, he fell into a disturbance of consciousness, ... (1997) The analysis of cresols in biological materials from a case of cresol poisoning
by high-performance liquid chromatography. In: Takatori T (ed) Proceedings of the 14th Meeting of the Inter-
national...
... extents, coarse-graining transferring information with increasing
grain size, and fine-graining transferring information with decreasing grain size.
Sometimes, upscaling and downscaling refer specifically ...
downscaling, the two steps are disaggregating information and singling out
(Figure 2.1). Disaggregating coarse-grained information is to derive the detailed
pattern within a spatial domain (fine-graining) ... studies in scaling and uncertainty
analysis that are relevant to ecology. The series of case studies included here
illustrate how scaling and uncertainty analysis are being conducted in ecology...
... an insurance company and investment portfolios
3.3.1 Mathematical appendix 5
3.4 Risks in traditional and innovative methods in life insurance
3.5 Reinsurance risks
3.6 Extended analysis of insurance ... of optimal investment.
In the previous sections we studied investment strategies (portfolios) from the
point of view of hedging contingent claims. Another criterion for comparing invest-
ment ... dollars) and invests the obtained 46.8 dollars in a bank
account.
Note that in both examples the ‘minimal hedging’ price coincides with the ‘risk-
neutral’ price and they differ from the intuitive...
... to EPA’s network, with some assets containing
sensitive information such as personally identifiable information.We interviewed
several headquarters ISOs who expressed interest in using the ... a training
plan and user manual when training users of new IT investments. The training
plan should outline objectives, target audience, strategies, and curriculum.
TISS conducted informal ... Establishing clear
procedures for assessing the
current and potential business
impact of incidents is critical, as
is implementing effective
methods of collecting,
analyzing, and reporting data....
... "stimulus" is
definitely in the VN car market will continue to bustling, vibrant.
3. Analysis of strategic issues of TMC in Vietnam
3.1. International strategies of TMC in Vietnam
Facing a firm with ... units 2,667 units
Input 1
Phase 1
Inventory 1 Input 2
Phase 2
Inventory 2
Input n
Phase n Final output
Inventory
Sales
20
3.2.2. Business-level strategy
Firms can be successful in the marketplace ... parts, including: antennas, exhaust valve and the throttle pedal to the 13
regions in 10 countries around the world including Thailand, Indonesia,
Philippines, Malaysia, India , Argentina, South...
... Statistical Analysis
The preprocessing of data that included averaging of tech-
nical repeats, interpolation of missing or non-aligned
points, binning of neighboring points to reduce data com-
plexity, ... denaturing organic solvent (acetonitrile) that
destroyed the majority of protein interactions and
allowed analysis of individual peptides dissociated from
(not interacting with) other proteins (e.g., ... expected in the
dataset (+/-95% CI). The resulting spectral components
reflect peaks recorded in multiple samples during mass
spectrometric analysis, which contained either single pep-
tide/protein...