nanotechnology regulatory perspective for drug development in cancer therapeutics
nanotechnology for cancer therapy, 2007, p.810
... translated into similar clinical advances in cancer therapeutics One area that holds great promise for making such advances is the area defined as cancer nanotechnology, which involves the intersection ... long-circulating cisplatin-containing liposomes (where cisplatin is loaded passively) lack anti-tumor activity, whereas cisplatin in free form is capable of inserting cytotoxicity.19 This is in contrast ... by today’s drugs in the battle against cancer The combined creative forces of engineering, chemistry, physics, and biology will beget new and hopefully transformative options to old, intractable...
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báo cáo hóa học: " In vitro and in vivo pre-clinical analysis of a F(ab’)2 fragment of panitumumab for molecular imaging and therapy of HER1-positive cancers" pot
... cells in 0.2 mL of media containing 20% Matrigel ™(Becton Dickinson, Bedford, MA, USA) or intraperitoneal (i.p.) injections of × 10 cells in mL of media Animals bearing s.c tumors were used for ... colorectal carcinoma with disease progression while on or following fluoropyrimidine-, oxaliplatin-, or irinotecan-containing chemotherapy regimens [22] Panitumumab has been well tolerated in clinical ... 18.6 h for the i.v injected group and 19.3 h for the i.p.-injected group In contrast to the i.v.- injected sets of mice, the clearance (T1/2b phase) of the RIC following i.p injection in the...
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Surface functionalization of superparamagnetic iron oxide nanoparticles for potential cell targeting, imaging, and cancer therapy applications
... Chapter gives an alternative method for synthesizing FA-conjugated SPIONs for minimizing uptake by macrophages and enhancing the selectivity in targeting of cancer cells ATRP of GMA and poly(ethylene ... promising nanoscale materials, SPIONs have gained significant attention due to their great potential for various biomedical applications, including MRI for cell targeting and monitoring, drug/ gene ... delivery (IDD) has been used for bladder cancer therapy to prolong the residence time of the instilled drug in the bladder IDD involves direct instillation of drug into the bladder via a catheter,...
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Molecular Imaging: An Essential Tool in Preclinical Research, Diagnostic Imaging, and Therapy potx
... established for investigating protein-protein interactions in cultured cells and several are now being validated for use in living animals, including the two-hybrid system and protein fragment ... comprising a mutant herpes simplex virus thymidine kinase Imaging Protein-Protein Interactions in Whole Cells 37 (HSV1-tk) and green fluorescent protein (GFP) for readout of a tetracycline-inducible ... RNA in infected cells, but as a rule, the mRNA coding for a given protein is less abundant than the protein itself Abundant mRNAs such as the one coding for tyrosine hydroxylase in catecholaminergic...
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The use of gold nanostructures in the imaging and therapy of cancer
... absorption or scattering and offer promising clinical application especially in the area of cancer imaging by increasingly proving themselves to offer alternative angles in examining the same biological ... tyrosine kinase found in cellular surface The EGFR is a 170 kDa plasma membrane glycoprotein containing an extracellular ligand-binding domain, a single transmembrane region, a cytoplasmic domain ... available for use in laboratory research or clinical imaging of pathological conditions such as cancer, optical imaging finds its niche in providing subcellular resolution which is a pre-requisite for...
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Báo cáo hóa học: " Both FA- and mPEG-conjugated chitosan nanoparticles for targeted cellular uptake and enhanced tumor tissue distribution" docx
... Weight of drug in the nanoparticles × 100 Weight of nanoparticles Loading efficiency (% ) = Weight of drug in the nanoparticles × 100 Weight of the feeding drug In vitro drug release study The drug ... Imparting a stealth shielding on the surface of these drug delivery systems prevents plasma proteins from recognizing these particles and increasing the systemic circulation time from minutes ... be present in the circulation for enough time to reach to its intended target tissue Plasma proteins can bind circulating NPs and remove them from the circulation within seconds to minutes through...
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Báo cáo y học: "Rasburicase represents a new tool for hyperuricemia in tumor lysis syndrome and in gout Lisa Cammalleri and Mariano Malaguarnera"
... synthesis, and inosine that will be degraded into hypoxanthine and xanthine and finally into uric acid Hypoxanthine and guanine may enter in a salvage pathway, using hypoxanthine-guanine phosphoribosyltranferase ... The PEGylation consists in binding with a covalent link a protein (adenosine-deaminase, asparaginase, interferons, granulocyte colonystimulating factor, liposomal doxyrubicin) to poly(ethylene) ... with azathioprine or cyclosporine is contraindicated for the risk of leukocytopenia [47,48] Azathioprine is converted into mercaptopurine that is metabolized by xanthine oxidase into inactive compounds,...
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Báo cáo khoa học: Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis pptx
... structure [9] Accumulating evidences indicate that HSPGs act to inhibit cellular invasion by promoting tight cell–cell and cell–ECM interactions, and by maintaining the structural integrity and self-assembly ... protein-coding genes contain introns that are removed in the nucleus by RNA splicing and are often alternatively spliced Alternative splicing increases the coding capacity of the genome, generating ... signaling capacity The existence of a C-terminus domain (C-domain) emerged from a prediction of the 3D structure of a single-chain heparanase enzyme [73] In this protein 3894 variant, the linker...
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adobe digital imaging how-tos 100 essential techniques for photoshop cs5, lightroom 3, and camera raw 6
... transmitted in any form by any means, electronic, mechanical, photocopying, recording, or otherwise, without the prior written permission of the publisher For information on getting permission for reprints ... primary focus for this chapter The Library module in Lightroom provides robust tools for importing photos; categorizing and applying attributes; comparing similar images in detail; and exporting files ... fix minor flaws caused by lens distortions Slideshow Module Lightroom provides options for creating slideshow presentations for clients and other interested parties, including robust formatting...
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patel, chellapa - sparse representations and compressive sensing for imaging and vision
... entries in α The main approach taken in CS is to minimize the -norm instead ˆ α = argmin α α subject to y = Aα (2.7) Surprisingly, the minimization yields the same result as the minimization in ... results can also be obtained using the hard-thresholding instead of the softthresholding in (2.14) [11] Other methods for solving (2.13) have also been proposed See for instance GPSR [61], SPGL1 ... recovered by taking the inverse Fourier transform In this way, one can view an MRI scanner as a machine that measures the information about the object in Fourier domain See [154] for an excellent...
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báo cáo hóa học:" Comparative study of 64Cu/NOTA-[D-Tyr6,beta-Ala11,Thi13,Nle14]BBN(6-14) monomer and dimers for prostate cancer PET imaging" potx
... 64 Cu/NOTA-dimer after final formulation (green line), 24 h incubation in mouse plasma (red line), h in vivo (blue line), 24 h in vivo (purple line) and free 64Cu (black line) Figure Bio-distributions ... simultaneous binding to receptors All peptides in the current research feature only short linkers, limiting the possibility of multiple binding to targets simultaneously Therefore, statistical rebinding ... used lysine side chain or a 6-aminohexanoic acid spacer for their homodimer and obtained promising in vitro results We used one and two PEG spacers between the binding sequences to fine-tune...
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Báo cáo y học: "Autologous chondrocyte implantation for cartilage repair: monitoring its success by magnetic resonance imaging and histology" ppt
... much staining for types I and III collagens, patchy staining for type II collagen, and a little for type VI collagen Most glycosaminoglycan staining was for chondroitin-4-sulfate, with less for keratan ... except in sample 24, which had slight staining in the upper surface zone The glycosaminoglycan epitopes that stained most strongly were keratan sulfate and chondroitin-4-sulfate Less staining was ... being totally negative for type II collagen Type I collagen immunostaining was seen in all samples but was more variable than for type II collagen In the fibrocartilagelike samples, the staining...
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Báo cáo khoa học: "Preoperative Y-90 microsphere selective internal radiation treatment for tumor downsizing and future liver remnant recruitment: a novel approach to improving the safety of major hepatic resections" docx
... treatment that offers meaningful improvement in survival in patients with colorectal cancer liver metastases (CRCLMs) Indications for surgical resection continue to expand An increasing number of patients ... demonstrated a mild centriacinar steatosis No inflammatory/ fibrotic changes were observed in the central vein region Reticulin stain demonstrated intense fibrotic reaction in the portal tracts Page ... obtained from the patient for publication of this case report Competing interests The authors declare that they have no competing interests Authors' contributions SG is the authorized user for...
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Báo cáo y học: "Expression of ADAM15 in rheumatoid synovium: up-regulation by vascular endothelial growth factor and possible implications for angiogenesis" ppt
... tyrosine kinase; Flt-1) and VEGFR-2 (kinase insert domain-containing receptor; KDR) Neuropilin-1, an isoform-specific co-receptor of VEGFR-2, enhances the bioactivity of VEGF165 by increasing ... 3,3'-diaminobenzidine tetrahydrochloride in 50 mM Tris-HCl buffer, pH 7.6, containing 0.006% H2O2 Counterstaining was performed with hematoxylin As for a control, sections were reacted by replacing ... synovial lining cells, endothelial cells of blood vessels and macrophage-like cells in the sublining layer of the RA synovium (Fig 5a,b), confirming the findings from in situ hybridization No staining...
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Báo cáo khoa học: "Planning target volume margins for prostate radiotherapy using daily electronic portal imaging and implanted fiducial markers" docx
... statistics are shown in Table 2, in the right-hand columns ("during treatment”) In the figures, any deviation of individual points from the intersection of the x and y axes represents a combination of ... Calypso® markers Real time tracking of transponder position for minutes, to provide information about intra-fraction motion “Average” CTV to PTV margins, calculated using the method of van Herk [17], ... added in quadrature to the total error, to account for inaccuracies in the on-line correction process Average individualized CTV to PTV margins are shown, although several patients had margins...
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Báo cáo khoa học: "Value of diffusion weighted MR imaging as an early surrogate parameter for evaluation of tumor response to high-dose-rate brachytherapy of colorectal liver metastase" docx
... anticancer treatment results in tumor lysis, loss of cell membrane integrity, increased extracellular space, and, therefore, an increase in water diffusion [24,25] Our results were also in accordance ... responsible for the transient increase in TV Obviously, the timing of the evaluation of tumor response after the start of treatment is a key issue For the present study, we chose to perform MRI including ... early MRI, before inferences can be drawn that influence the therapeutic strategy Conclusions In conclusion, DWI is a promising imaging biomarker for early prediction of tumor response in patients...
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Báo cáo khoa học: "Stereotactic body radiotherapy for stage I lung cancer and small lung metastasis: evaluation of an immobilization system for suppression of respiratory tumor movement and preliminary results" ppsx
... a therapeutic option in stage I NSCLC either for inoperable patients or for patients refusing surgery SBRT for lung cancer is under evaluation in clinical trials Japan Clinical Oncology Group ... be confirmed with CTguided biopsy in patient, this case was included in the study considering the positive FDG-PET finding and the increase in tumor size during observation period Of the 55 lesions, ... set-up is required for SBRT, so immobilization devices are used for diminishing the positioning error, i.e repositioning accurately Some of them also have effect of diminishing the organ motion...
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Báo cáo khoa học: " Ipsilateral irradiation for well lateralized carcinomas of the oral cavity and oropharynx: results on tumor control and xerostomia" pot
... promising, these findings require validation in a larger patient cohort, especially for oral cavity cancer 13 14 15 16 Competing interests The authors declare that they have no competing interests ... factors: extracapsular nodal invasion in one patient and positive resection margin in the other The objective of adding concurrent chemotherapy in these patients was to increase the loco-regional ... include protection of the salivary glands by daily amifostine during RT [26] or stimulation with pilocarpine [27] These methods could only be complementary to planning efforts aimed at reducing...
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Báo cáo khoa học: " Kinetic modeling of tumor growth and dissemination in the craniospinal axis: implications for craniospinal irradiation" pps
... suspend treatment of the spine temporarily while treatment of the brain continues Since the brain and spine are in communication via the cerebrospinal fluid, holding treatment in one compartment may ... radiation induced cancer after spinal irradiation for childhood medulloblastoma? A comparative treatment planning study Acta Oncol 2005, 44:554-562 Jain S: Kinetic model for designing a cancer therapy ... in a single center Int J Radiat Oncol Biol Phys 2004, 58:1165-1170 Linstadt D, Wara W, Edwards M, Hudgins R, Sheline G: Radiotherapy of primary intracranial germinomas: the case against routine...
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Báo cáo y học: "Targeted genomic capture and massively parallel sequencing to identify genes for hereditary hearing loss in middle eastern families" pot
... mutations in genes for hearing loss in the Israeli Jewish population [4] and in 13 genes in the Palestinian Arab population [5-7] As elsewhere, the most common gene involved in hearing loss in the ... identify inherited mutations involved in hearing loss We designed oligonucleotides to capture the exons and regulatory regions of 246 genes involved in hearing loss, in human or in mouse The inclusion ... [1] and many more for syndromes including hearing loss Despite the very rapid pace of gene discovery for hearing loss in the past decade, its cause remains unknown for most deaf individuals Most...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến dòng điện stato i1 fi p2 thông tin liên lạc và các dịch vụ từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25