nanoparticulate systems for central nervous system drug delivery
Genetic engineering and surface modification of baculovirus derived vectors for improved gene delivery to the central nervous system
... baculovirus-based vectors in order to achieve improved gene delivery to the Central Nervous System There are many important requirements for an ideal gene delivery system, including feasible vector production ... vectors for gene delivery to the nervous system has been limited by their ability to transfer genes only to dividing cells, although they are well suited for on-site delivery to neural precursors for ... SURFACE MODIFICATION OF BACULOVIRUS DERIVED VECTORS FOR IMPROVED GENE DELIVERY TO THE CENTRAL NERVOUS SYSTEM YANG YI (B Eng.) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY GRADUATE PROGRAMME...
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Development of hybrid promoters and viral vectors for improved gene delivery to the central nervous system
... to create an universal gene delivery system for the treatment of all diseases, or even for several similar diseases, since each disease has its specific requirements for the expression pattern ... elements of a gene delivery system, especially the promoter and the vector, need to be optimized and combined specially for each particular application 1.2 Gene delivery to the CNS Gene delivery to ... 1.4 Vectors used for gene delivery to the CNS Three types of gene delivery methods, namely physical methods, non-viral methods and viral methods, have been applied for gene delivery to mammalian...
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Báo cáo khoa học: " Experimental concepts for toxicity prevention and tissue restoration after central nervous system irradiation" ppt
... radiation-induced central nervous system toxicity: a role for amifostine? Anticancer Res 2004, 24:3803-3810 Publish with Bio Med Central and every scientist can read your work free of charge "BioMed Central ... the central nervous system: an interpretation of target cell responses Br J Cancer 1986, 53(Suppl 7):207-217 Schultheiss TE, Kun LE, Ang KK, Stephens LC: Radiation response of the central nervous ... Pintilie M, Wong CS: Hypoxia and hypoxiainducible factor-1 target genes in central nervous system radiation injury: a role for vascular endothelial growth factor Clin Cancer Res 2004, 10:3342-3353...
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Báo cáo y học: "The impact of therapy for childhood acute lymphoblastic leukaemia on intelligence quotients; results of the risk-stratified randomized central nervous system treatment trial MRC UKALL XI" ppsx
... informed consent from parents and patients (where appropriate for age) before entering patients into the study List of Abbreviations ALL: Acute lymphoblastic leukaemia; CNS: Central nervous system; ... cell disease: a biopsychosocial approach Oxford: Oxford University Press; 2006 Butler RW, Copeland DR: Neuropsychological effects of central nervous system prophylactic treatment in childhood ... Holland JC, Tull R, Berman A, Brecher ML, Harris M, Glicksman AS, Forman E, et al: Effects of different forms of central nervous system prophylaxis on neuropsychologic function in childhood leukemia...
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Chemical drug assisted gene transfer a sensible approach to improve transgene expression in the central nervous system
... new wave of modifications for gene delivery systems, and are representing exciting prospects for a more rational approach to gene therapy 24 Chapter Introduction Therefore, the purpose of this ... environmental change Thus choosing safe gene delivery vectors and gene delivery routes are very important for CNS gene therapy applications Non-viral gene delivery systems based upon polymer/DNA complexes ... animal models for CNS diseases, gene therapy for CNS diseases has drawn tremendous attention in recent years, especially in developing novel gene delivery vectors for CNS Gene therapy for different...
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Cancer of the Brain and Other Central Nervous System doc
... 87.7 81.2 76.7 69.5 63.7 60.6 Other Central Nervous System National Cancer Institute 205 SEER Survival Monograph Chapter 25 Cancer of the Brain and Nervous System Table 25.3: Cancer of the Brain: ... Specified 210 SEER Survival Monograph Chapter 25 Cancer of the Brain and Nervous System Table 25.7: Cancer of the Other Central Nervous System: Distributions and 5-Year Relative Survival Rates (%) by ... Institute 211 SEER Survival Monograph Chapter 25 Cancer of the Brain and Nervous System Table 25.9: Cancer of the Other Central Nervous System Cancer: 1-, 2-, 3-, 5-, 8-, & 10-Year Relative Survival Rates...
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Báo cáo khoa học: Planarian peptidylglycine-hydroxylating monooxygenase, a neuropeptide processing enzyme, colocalizes with cytochrome b561 along the central nervous system pptx
... (coral, jellyfish, sea anemones), which possess the most primitive form of nervous system, suggesting that the archetype nervous systems may have relied on amidated peptides [5] The C-terminal a-amidation ... cycling was performed with 40 cycles of the following step program: 94 °C for min, 43.5 °C for (primer annealing), and 72 °C for (primer extension) Final primer extension was made at 72 °C for The PCR ... kb, as found for higher vertebrate PAMs Therefore, PHM and PAL are coded for by different genes in the planarians and only later in the evolution these genes appear to have fused, forming a single...
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báo cáo hóa học: " Temporal expression and cellular origin of CC chemokine receptors CCR1, CCR2 and CCR5 in the central nervous system: insight into mechanisms of MOG-induced EAE" pptx
... archived on PubMed Central yours — you keep the copyright BioMedcentral Submit your manuscript here: http://www.biomedcentral.com/info/publishing_adv.asp Page 13 of 13 (page number not for citation ... though the chemokine network is notorious for its redundancy and receptor promiscuity in vitro, studies in rodent models for MS have utilized techniques for genomic deletion of chemokines [24], ... time-points at which subsequent kinetic analyses were performed Rats (n = 3/time-point) which conformed in the clinical score curve were chosen for histopathology and evaluation of CCR1, CCR2 and...
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Section III - Drugs Acting on the Central Nervous System docx
... Treatment of Central Nervous System Degenerative Disorders) These columnar ensembles serve to interconnect nested distributed systems in which sensory associations are rapidly modifiable as information ... the autonomic nervous system, and they may integrate somatic and vegetative functions, including those of the cardiovascular and gastrointestinal systems Limbic System The "limbic system" is an ... motor and autonomic nervous systems, the central junctions are characterized morphologically by various additional forms of paramembranous deposits of specific proteins (essential for transmitter...
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Báo cáo sinh học: "The long term effects of chemotherapy on the central nervous system" docx
... RF, Holland JC, Tull R, Berman A, Brecher ML, Harris M, Glickman AS, Forman E, et al.: Effects of different forms of central nervous prophylaxis on neuropsychologic function in childhood leukemia ... and, therefore, have no specific risk factors for cognitive dysfunction Rowland et al [10] reported in 1984 that children with acute lymphoblastic leukemia (ALL) who had been irradiated for CNS ... asymptomatic children with acute lymphocytic leukemia after prophylactic treatment of the central nervous system with radiation and intrathecal chemotherapy N Engl J Med 1978, 298:815-818 Duffner...
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Báo cáo sinh học: "Systemic 5-fluorouracil treatment causes a syndrome of delayed myelin destruction in the central nervous system" doc
... outcome of many forms of cancer treatment In contrast, there has been no comparable level of analysis for most other organ systems compromised by cancer treatments One of the tissues for which adverse ... the central nervous system (CNS) Although it has long been appreciated that targeted irradiation of the CNS may be associated with neurological damage, it has become increasingly clear that systemic ... delayed CNS damage associated with systemic exposure to chemotherapy, almost nothing is known about the basis for these effects For example, because of the multi -drug regimens most frequently used...
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Báo cáo sinh học: "How chemotherapy damages the central nervous system Christina A Meyers" ppsx
... Dietrich J, Luebke A, Mayer-Pröschel M, Noble M: Systemic 5-fluorouracil treatment causes a syndrome of delayed myelin destruction in the central nervous system J Biol 2008, 7:12 Lee GD, Longo DL, ... weeks later, when the treated rats performed no differently from controls This group did, however, find impaired long-term potentiation (a phenomenon critical for learning) in hippocampal slices ... other studies will guide the development of translational clinical research to protect the nervous system from injury, to better treat injury that has developed as a result of treatment, and...
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Báo cáo khoa học: "Immunohistochemical study of constitutive neuronal and inducible nitric oxide synthase in the central nervous system of goat with natural listeriosis" potx
... autoimmune disease of the central nervous system Proc Natl Acad Sci U.S.A 1995, 92, 5312-5316 Johnson, G.C., Fales, W.H., Maddox, C.W and RamosVara, J.A Evaluation of laboratory test for confirming the ... Magnification A and B, ×66 C and D, ×132 Immunohistochmical study of nitric oxide synthase in the central nervous system of goat Enhanced expression of nNOS and iNOS in L monocytogenes-infected brain At ... and the primary antisera were reacted for 60 min, followed by biotinylated antisera (Zymed) for 15 minutes and [strept]avidin- biotin peroxidase (Zymed) for 15 minutes Staining was done using...
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báo cáo khoa học: "Isolated angiitis of the central nervous system with tumor-like lesion, mimicking brain malignant glioma: a case report and review of the literature" pdf
... Primary central nervous system vasculitis: analysis of 101 patients Ann Neurol 2007, 62:442-451 MacLaren K, Gillespie J, Shrestha S, Neary D, Ballardie FW: Primary angiitis of the central nervous system: ... Angiitis of the Central Nervous System: a Case Report and Review CNS Spectrums 2008, 13:209-213 Page of 10 Ozawa T, Sasaki O, Sorimachi T, Tanaka R: Primary angiitis of the central nervous system: report ... the central nervous system: initial and follow-up MR features Neuroradiology 2009, 51:651-659 12 Ay H, Sahin G, Saatci I, Söylemezoğlu F, Saribaş O: Primary Angiitis of the Central Nervous System...
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Báo cáo y học: "Cerebrospinal fluid neopterin: an informative biomarker of central nervous system immune activation in HIV-1 infection" ppt
... central nervous system Archives of neurology 2008, 65(1):65-70 Hagberg L, Dotevall L, Norkrans G, Larsson M, Wachter H, Fuchs D: Cerebrospinal fluid neopterin concentrations in central nervous system ... 10.1186/1742-6405-7-15 Cite this article as: Hagberg et al., Cerebrospinal fluid neopterin: an informative biomarker of central nervous system immune activation in HIV-1 infection AIDS Research and Therapy 2010, ... phagocytes J Acquir Immune Defic Syndr 2002, 31(Suppl 2):S43-54 Williams KC, Hickey WF: Central nervous system damage, monocytes and macrophages, and neurological disorders in AIDS Annu Rev Neurosci...
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Báo cáo y học: " Primary central nervous system lymphoma presenting as a pure third ventricular lesion: a case report" pps
... Primary central nervous system lymphoma: radiologic-pathologic correlation RadioGraphics 17, 1497–1526 (1997) DE Hobson, BA Anderson, I Carr, M West, Primary lymphoma of the central nervous system: ... primary malignant lymphoma of the central nervous system Surg Neurol 26, 79–84 (1986) doi:10.1016/0090-3019(86)90068-6 NA Mohile, LE Abrey, Primary central nervous system lymphoma Neurol Clin 25, ... Primary central nervous system lymphoma presenting as a pure third ventricular lesion: a case report Journal of Medical Case Reports 2011 5:213 Submit your next manuscript to BioMed Central and...
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báo cáo khoa học: "Development of PEGylated PLGA nanoparticle for controlled and sustained drug delivery in cystic fibrosis" pptx
... development of novel nano -systems for pulmonary gene or drug delivery may provide a convenient, noninvasive method for the administration of gene or drugs to the lungs Such a system can also facilitate ... evaluation and selective delivery of this class of compounds for treatment of CF lung disease We evaluated the efficacy of PLGA based nano -systems for selective drug delivery A major drawback ... the toxicity and efficacy of nano -drug delivery system in both in vitro and in vivo (WT mice) systems, and evaluate the efficacy of PLGA-PEG mediated PS-341 lung delivery in controlling inflammatory...
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báo cáo khoa học: "In vivo observation of gold nanoparticles in the central nervous system of Blaberus discoidalis" potx
... nanoparticle vector for tumor directed drug delivery Drug Delivery 2004, 11:169-183 15 Bergen JM, Von Recum HA, Goodman TT, Massey AP, Pun SH: Gold nanoparticles as a versatile platform for optimizing ... wish to thank Jerry H Houl for his assistance in cryocutting, to CitoViva for performing the hyperspectral imaging, to Ke Wang for the XPS analysis, and to Carlos Sanchez for his assistance in cockroach ... Page of been used to investigate targeted drug delivery [14-16] However, these in vivo methods have not been applied for simpler and inexpensive biological systems like insects In the present work,...
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Báo cáo y học: "Possible gabapentin and ketamine interaction causing prolonged central nervous system depression during post-operative recovery following cervical laminoplasty: a case report" potx
... members J Trauma 2008, 64(2):S195-198 Neurontin and Ketamine Interactions Drug Information Online [http:// www.drugs.com /drug- interactions/neurontin_d03182_ketamine_d00272 html], Accessed March ... disorder, insomnia, chronic pain, and obstructive sleep apnea For these disorders his medication regimen included metformin, budesonide and formoterol fumarate dihydrate, albuterol, lisinopril, hydrochlorothiazide, ... is crucial for the clinician to remember cases such as this one if faced with an unusual postoperative recovery phase Consent Written informed consent was obtained from the patient for publication...
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báo cáo khoa học: "Extensive central nervous system involvement in Merkel cell carcinoma: a case report and review of the literature" docx
... Extensive central nervous system involvement in Merkel cell carcinoma: a case report and review of the literature Journal of Medical Case Reports 2011 5:35 Submit your next manuscript to BioMed Central ... Consent Written informed consent was obtained from the patient’s next of kin for publication of this case report and the accompanying images A copy of the written consent is available for review by ... the number of metastases, systemic spread of the disease and the accessibility to surgery We believe that the CNS metastases of MCC are an expression of a hematogenous systemic spread of the disease...
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