... stability Chemical Aspects ofDrugDeliverySystems Table Routes of administration and general classification ofdrugdeliverysystems ROUTES OF ADMINISTRATION DRUGDELIVERY CLASS ORAL SOLIDS ... imposed by the nature of the various routes of administration available for drugdelivery ROUTES OF ADMINISTRATION AND CLASSIFICATION OFDRUGDELIVERYSYSTEMS The principal routes of administration ... Aspects ofDrugDeliverySystems Table Mechanisms and properties influencing drug release from particle carrier systems* MECHANISM OFDRUG RELEASE PROPERTIES INFLUENC~NG DRUG DIFFUSION DRUG RELEASE...
... A4: series of multiple doses of a conventional drugdelivery system B: ideal drug concentration profile PRODRUG What is a prodrug? Prodrug is an inactive precursor of a drug Prodrug reconversion ... Targeted drugdelivery systems: deliver drug to a desired body location, organ, tissue, specific cells… Controlled-release drugdelivery systems: preprogramed drug release By the route of delivery: ... Society of Chemistry, American Chemical Society, Wiley InterScience journals… CONTENTS Generalities ofdrugdelivery Liposomes as drugdeliverysystems Polymers and polymeric systems for drug delivery...
... construction ofdrugdeliverysystems in not too long a time The functionalization of CNTs used in the construction ofdrugdeliverysystems will be discussed in later sections In vivo behavior of functionalized ... application of CNTs as the molecular transporter in drugdelivery Page 14 of 22 Drugdelivery targeted to lymphatic system Many cancers metastasize through lymphatic canal The drugdeliverysystems ... schematic illustration of the strategy for the preparation of the CNT-based drugdeliverysystems Figure The modification of CNTs Schematic illustration of modification of CNTs with various molecules...
... surface of the polymer, resulting in a release rate that is proportional to the surface area of the drugdelivery system (See Figure 2.5b) a DrugDrug Drug- loaded biodegradable particles b DrugDrug ... application of SBA-15 in the deliveryof the small molecule model drugof ibuprofen (IBU), with emphasis on the influence of the different functional methods on the adsorption and release of IBU Chapter ... sustained release of the large protein model drugof bovine serum albumin (BSA) on SBA-15 Chapter covers the factors affecting stability of the released BSA in fabrication ofdrugdelivery systems, including...
... for DrugDeliverySystemsDrugdeliverysystems modify the kinetics or the location of the escape of the drug from the medicine Tables 15.1 and 15.2 provide generic reasons for using drugdelivery ... terms of duration of clinical use and Table 15.1 Use of a drugdelivery system for kinetic control Dissolution ofdrug is too slow Drug and/or formulation is physically removed from the site of ... containing numerous types of protein drug [21–23] 15.6 Examples of Biodegradable Polymer DrugDeliverySystems Under Development 15.6.1 Polyketals Polyketal-based drugdeliverysystems are under development...
... define drug- deliverysystemsof a certain size range Reflecting this trend of size definition, Nanoparticulate DrugDeliverySystems is a worthy attempt to bring together a wide range of drug- delivery ... nanoparticulate drug- deliverysystems The first chapter covers a complete overview of the nanoparticulate drugdelivery system, covering wide applications and evaluation of the nanoparticulate drug- delivery ... and Rainer H Müller Lipid-Based Nanoparticulate DrugDeliverySystems 89 Jun Wu, Xiaobin Zhao, and Robert J Lee NanoengineeringofDrugDeliverySystems Ashwath Jayagopal and V Prasad Shastri...
... application of nanodelivery systems in medicine Design of nanotechnology – based drugdeliverySystems Nanoparticles can be used in targeted drugdelivery at the site of disease to improve the uptake of ... therapy The effectiveness ofdrugdeliverysystems can be attributed to their small size, reduced drug toxicity, controlled time release of the drug and modification ofdrug pharmacokinetics and ... uptake of poorly soluble drugs [8,9], the targeting of drugs to a specific site, and drug bioavailability A schematic comparison of untargeted and targeted drugdeliverysystems is shown in Figure...
... Preface A major goal of pharmacotherapeutics is the attainment of an effective drug concentration at the intended site of action for a desired length of time Efficient deliveryof a drug while minimizing ... edited by James W Munson 12 Techniques of Solubilization of Drugs, edited by Samuel H Yalkowsky 13 Orphan Drugs, edited by Fred E Karch 14 Novel DrugDelivery Systems: Fundamentals, Developmental ... Overview of Ocular DrugDelivery Figure Miosis-time profiles: Plots of the average observed changes in pupillary diameter (ÁPD) as a function of time following the instillation of 25.0 mL of the...
... loss of efficacy, the development of prodrugs takes advantage of the increased corneal permeability of the prodrug and the subsequent hydrolysis of the prodrug to active compound (16, 99,100) Prodrugs ... advantages of direct topical drug administration include targeted drugdelivery to the anterior segment of the eye and avoidance of systemic drug toxicity Many of the disadvantages of eyedrops, ... is the study of the biological effects of drugs (112) More specifically, it is the study of how the concentration ofdrug in the biophase (site of action) relates to the magnitude of biological...
... increased utility of the microdialysis approach in the study of ocular drugdelivery and disposition Unique applications of the microdialysis approach in the examination ofdrug ocular disposition ... pathophysiology of the posterior eye segment affects the distribution and elimination ofdrug from the vitreous (29) In particular, the effect of three conditions were examined: changes in the diffusivity of drugs ... weight of the diffusing species, and CP represents the concentration of polymer (collagen and hyaluronic acid) in the hydrogel in units of grams of polymer per gram of hydrogel Using the sum of the...
... to promote site-specific deliveryof drugs to intraocular tissues in the back of the eye (23) The increasing interest in intraocular deliveryof peptide and protein drugs, drug therapy targeting ... framework for rational design ofdrugdeliverysystems for therapeutic agents that are poorly absorbed across the cornea or require delivery to posterior segment of the eye Drugdelivery across the conjunctiva ... STUDIES A variety of studies have described the pharmacokinetics of ocular deliveryof dyes and drugs by collagen shields as well as the use of the shields in the chemotherapy of various disorders...
... surfactants, Drug Dev Res., 27:177–183 80 Harris, D., Liaw, J H., and Robinson, J R (1992) Routes of delivery: case studies (7) Ocular deliveryof peptide and protein drugs, Adv DrugDelivery Rev., ... fundamental basis ofdrug penetration via the noncorneal pathway The challenge for the future is to creatively apply the available knowledge to the practical design of drugs and drugdeliverysystems for ... Noncorneal delivery is not a panacea and will probably have niche utility in ocular drugdelivery The greatest potential for the concept appears to be in the area of intraocular deliveryof polar...
... OCULAR DELIVERYOF PEPTIDE AND PROTEIN DRUGS Peptides and proteins may be instilled into the eye for local/topical use Instillation of a topical dose of a drug to the eye leads to absorption of a drug ... route deliveryof peptide and protein drugdelivery In: Peptide and Protein DrugDelivery V H L Lee (ed.) Marcel Dekker, New York, Chap 13 52 Harris, A S (1986) Biopharmaceutical aspects of the ... (94) demonstrated the feasibility of effective systemic deliveryof topically instilled peptides in the eye Their findings suggest that systemic deliveryof peptide drugs is superior to the parenteral...
... advantageous properties of several deliverysystems will enhance the use of gene therapy and provide flexibility in the treatment of many diseases Non Viral Vectors One of the greatest concerns ... therapeutically active drugs This is a fascinating technology that has the potential of being a tailor-made delivery system that will improve the therapeutic index of a number of drugs Another modification ... terms of the types of cells that or not support expression An experimental animal model of the disease should be available for preclinical testing of therapy Since the systemic deliveryof genes...
... reviewed as a new drug product by the FDA’s Drug Center (CDER) V CLINICAL TESTING OF NEW OPHTHALMIC DRUGDELIVERYSYSTEMS A Human Versus Animal Testing Human drug products are often tested during ... regulation of food, drugs, devices, and cosmetics One of the major provisions of the Act was the reauthorization of PDUFA for years as described above A number of the reforms affecting drug products ... therapeutics: drugdelivery and targeting Adv DrugDelivery Rev., 18:115–131 167 J W Jaroszewski, and J S Cohen (1991) Cellular uptake of antisense oligodeoxynucleotides Adv DrugDelivery Rev.,...
... Preface A major goal of pharmacotherapeutics is the attainment of an effective drug concentration at the intended site of action for a desired length of time Efficient deliveryof a drug while minimizing ... edited by James W Munson 12 Techniques of Solubilization of Drugs, edited by Samuel H Yalkowsky 13 Orphan Drugs, edited by Fred E Karch 14 Novel DrugDelivery Systems: Fundamentals, Developmental ... Overview of Ocular DrugDelivery Figure Miosis-time profiles: Plots of the average observed changes in pupillary diameter (ÁPD) as a function of time following the instillation of 25.0 mL of the...
... increased utility of the microdialysis approach in the study of ocular drugdelivery and disposition Unique applications of the microdialysis approach in the examination ofdrug ocular disposition ... pathophysiology of the posterior eye segment affects the distribution and elimination ofdrug from the vitreous (29) In particular, the effect of three conditions were examined: changes in the diffusivity of drugs ... weight of the diffusing species, and CP represents the concentration of polymer (collagen and hyaluronic acid) in the hydrogel in units of grams of polymer per gram of hydrogel Using the sum of the...
... to promote site-specific deliveryof drugs to intraocular tissues in the back of the eye (23) The increasing interest in intraocular deliveryof peptide and protein drugs, drug therapy targeting ... framework for rational design ofdrugdeliverysystems for therapeutic agents that are poorly absorbed across the cornea or require delivery to posterior segment of the eye Drugdelivery across the conjunctiva ... STUDIES A variety of studies have described the pharmacokinetics of ocular deliveryof dyes and drugs by collagen shields as well as the use of the shields in the chemotherapy of various disorders...