nanoemulsions as drug delivery systems
Development of controlled drug delivery systems using uniform nanoporous materials as matrices
Ngày tải lên :
13/09/2015, 19:46
... resulting in a release rate that is proportional to the surface area of the drug delivery system (See Figure 2.5b) a Drug Drug Drug- loaded biodegradable particles b Drug Drug Drug- loaded biodegradable ... Polymeric drug delivery systems under wide investigations are classified according to the mechanism controlling the release of the drug Some of the basic systems are described as below 2.1.1 ... give benefits to drug companies by creating new forms of established drugs and offering improved versions of drugs It has been shown that companies developing new drug delivery systems seem to...
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Drug Delivery Systems
Ngày tải lên :
25/10/2013, 08:20
... for Drug Delivery Systems Drug delivery systems modify the kinetics or the location of the escape of the drug from the medicine Tables 15.1 and 15.2 provide generic reasons for using drug delivery ... numerous types of protein drug [21–23] 15.6 Examples of Biodegradable Polymer Drug Delivery Systems Under Development 15.6.1 Polyketals Polyketal-based drug delivery systems are under development ... accelerates as the PLGA component degrades For example, ReGel has been used to release an anticancer agent, paclitaxel, for approximately 50 days [40] 15.6.7 Peptide-Based Drug Delivery Systems The...
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Chemical Aspects of Drug Delivery Systems pptx
Ngày tải lên :
28/03/2014, 10:20
... such as solubility and stability Chemical Aspects of Drug Delivery Systems Table Routes of administration and general classification of drug delivery systems ROUTES OF ADMINISTRATION DRUG DELIVERY ... Chemical Aspects of Drug Delivery Systems Table Mechanisms and properties influencing drug release from particle carrier systems* MECHANISM OF DRUG RELEASE PROPERTIES INFLUENC~NG DRUG DIFFUSION DRUG ... problems of controlled release drug delivery systems, Chemical Aspects of Drug Delivery Systems 12 particularly the low availability of some drugs, short residence time, first-pass metabolism and insufficient...
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THE CHEMISTRY OF DRUG DELIVERY SYSTEMS (hoá học các hệ dẫn truyền thuốc)
Ngày tải lên :
18/04/2014, 15:37
... Generalities of drug delivery Liposomes as drug delivery systems Polymers and polymeric systems for drug delivery Dendrimers for drug delivery GENERALITIES OF DRUG DELIVERY DRUG DELIVERY SYSTEM ... Targeted drug delivery systems: deliver drug to a desired body location, organ, tissue, specific cells… Controlled-release drug delivery systems: preprogramed drug release By the route of delivery: ... Prodrug = Drug + Drug delivery system How to design a prodrug? Increase solubility or absorption Increase chemical and metabolic stability Mask irritation or taste MAIN TYPES OF PRODRUGS...
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nanoparticulate drug delivery systems, 2007, p.382
Ngày tải lên :
04/06/2014, 14:47
... formulated as drug- delivery systems A brief description of each of the polymeric systems follows Hydrogel-Based Nanoparticulate Drug- Delivery Systems A progressively increasing interest has been ... finding a place in drug discovery as well as NPDDS (27–31) DRUG- DELIVERY SYSTEMS An ideal drug- delivery system possesses two elements: the ability to target and to control the drug release Targeting ... 0‑8493‑9073‑7 (alk paper) Drug delivery systems Nanoparticles I Thassu, Deepak II Deleers, Michel III Pathak, Yashwant IV Series [DNLM: Drug Delivery Systems ‑methods Nanostructures Drug Carriers W1 DR893B...
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Báo cáo hóa học: " Nanotechnology-based drug delivery systems" pdf
Ngày tải lên :
20/06/2014, 00:20
... application of nanodelivery systems in medicine Design of nanotechnology – based drug delivery Systems Nanoparticles can be used in targeted drug delivery at the site of disease to improve the ... survival at multiple points that include increasing p53 and BAX action, increasing caspase-3 and caspase-8 activities, decreasing Akt activity, and increasing expression of TNF-α [47] Our research ... therapy The effectiveness of drug delivery systems can be attributed to their small size, reduced drug toxicity, controlled time release of the drug and modification of drug pharmacokinetics and...
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Báo cáo hóa học: " The application of carbon nanotubes in target drug delivery systems for cancer therapies" docx
Ngày tải lên :
20/06/2014, 22:20
... application of CNTs as the molecular transporter in drug delivery Page 14 of 22 Drug delivery targeted to lymphatic system Many cancers metastasize through lymphatic canal The drug delivery systems targeted ... decisive conclusion has not been reached about whether CNTs are the best carriers in anticancer drug delivery systems because there are many other anticancer drug delivery systems based on other nanomaterials, ... CNT-based drug delivery systems in practical therapy comes into fruition The biosafety of SWCNT used as drug carriers Although there are exciting prospects for the application of CNTs as drug...
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Ophthalmic Drug Delivery Systems - part 1 pptx
Ngày tải lên :
10/08/2014, 00:20
... and Ashim K Mitra 251 III Drug Delivery Systems A: Conventional Systems Ocular Penetration Enhancers Thomas Wai-Yip Lee and Joseph R Robinson 281 10 Corneal Collagen Shields for Ocular Drug Delivery ... edited by Robert A Nash and Alfred H Wachter 130 Ophthalmic Drug Delivery Systems Second Edition, Revised and Expanded, edited by Ashim K Mitra 131 Pharmaceutical Gene Delivery Systems, edited by ... solutions to novel delivery systems such as biodegradable polymeric systems, corneal collagen shields, iontophoresis, and viral and nonviral gene delivery systems, to name a few An increase in our understanding...
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Ophthalmic Drug Delivery Systems - part 2 pdf
Ngày tải lên :
10/08/2014, 00:20
... in the former case or via the nasal mucosa and gastrointestinal tract in the latter case As discussed previously, the conjunctiva can absorb drug and, via the sclera, deliver drug to the eye; ... include catechol-Omethyltransferase, monamine oxidase, steroid 6-betahydroxylase, oxidoreductase, lysosomal enzymes, peptidases, and glucuronide and sulfate transferase (107) In addition, cytochrome ... the patient or in the case of removal of a diseased eye As a result, pharmacological response measurements usually replace concentration assays in describing the effect of a drug in the human eye...
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Ophthalmic Drug Delivery Systems - part 4 doc
Ngày tải lên :
10/08/2014, 00:20
... injection, increased as the drug diffusivity was reduced Furthermore, the rate of drug elimination, which is inversely related to the drug s elimination halflife, decreased significantly as the drug diffusivity ... of ascorbate was perturbed by surgery Surgical trauma can result in increased peroxide generation as a result of the inflammatory cascade (69) There are no reports of studies evaluating basal ascorbate ... nonlinear leastsquares regression analysis assessment of the transport kinetics of ascorbate was performed Contrary to previous reports (58,63), ascorbate blood concentrations, which were increased...
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Ophthalmic Drug Delivery Systems - part 5 doc
Ngày tải lên :
10/08/2014, 00:20
... contact lenses to deliver drugs to the cornea was proposed as far back as 1971 by Kaufman (1) In this procedure, the hydrophilic lens was placed on the cornea and the drug was administered topically ... enhance delivery of TFT to the cornea with an intact epithelium In corneas with poor epithelium, drug penetration was higher but variable They concluded that the role of collagen shields as a drug delivery ... ocular drug delivery J Pharm Sci 80:50–53, 1990 Harris, D., and Robinson, J R Bioadhesive polymers in peptide drug delivery Biomaterials 11:652–658, 1990 Grass, G M Mechanisms of Corneal Drug Penetration...
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Ophthalmic Drug Delivery Systems - part 6 docx
Ngày tải lên :
10/08/2014, 00:20
... J (1995) Review: Delivery systems for intraocular routes, Adv Drug Delivery Rev., 16:107–123 132 Velez, G., and Whitcup, S M (1999) New developments in sustained release drug delivery for the ... iontophoresis as a noninvasive method of drug delivery Peptide and protein drugs (e.g., insulin and vasopressin) have been delivered iontophoretically without the pain and side effects associated ... systemic delivery of peptide drugs via the ocular route with surfactants, Drug Dev Res., 27:177–183 80 Harris, D., Liaw, J H., and Robinson, J R (1992) Routes of delivery: case studies (7) Ocular delivery...
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Ophthalmic Drug Delivery Systems - part 8 docx
Ngày tải lên :
10/08/2014, 00:20
... ocular absorption of peptide drugs is metabolism by ocular enzymes, specifically peptidases Endopeptidases, like plasmin and collagenase, and exopeptidases, like aminopeptidases, are present in the ... sclera has been studied (91) DAMEA was administered with and without peptidase inhibitors bestatin (aminopeptidase inhibitor) and SCH 39370 (enkephalinase inhibitor) It was found that sclera was the ... (1991) Nasal route delivery of peptide and protein drug delivery In: Peptide and Protein Drug Delivery V H L Lee (ed.) Marcel Dekker, New York, Chap 13 52 Harris, A S (1986) Biopharmaceutical aspects...
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Ophthalmic Drug Delivery Systems - part 9 pot
Ngày tải lên :
10/08/2014, 00:20
... independence and increased efficacy as a slow release system for therapeutically active drugs This is a fascinating technology that has the potential of being a tailor-made delivery system that ... as an adenovirus and was found to be dependent on adenovirus for its replication (27) AAV has not been associated with any disease, but it has been isolated in humans in association with adenoviruses ... the eye are carried out using viral vector, but plasmid delivery of a few therapeutic genes, such as tissue plasminogen activator and IFN- , has been tested and shows potential benefits in treating...
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Ophthalmic Drug Delivery Systems - part 10 ppt
Ngày tải lên :
10/08/2014, 00:20
... one drug can be designated as an orphan drug for the same rare disease, and more than one applicant can obtain designation for the same drug and rare disease The drug must be designated as an ... designation of a drug as an orphan drug for a rare disease A rare disease is defined as one where there are fewer than 200,000 patients in the United States diagnosed with the disease at the time ... shipment of food and drugs was enacted in 1906 and was known as the Pure Food and Drug Act It prohibited the interstate shipment of adulterated or misbranded foods or drugs In 1912 it was amended by...
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Ophthalmic Drug Delivery Systems - part 1 ppsx
Ngày tải lên :
10/08/2014, 03:20
... and Ashim K Mitra 251 III Drug Delivery Systems A: Conventional Systems Ocular Penetration Enhancers Thomas Wai-Yip Lee and Joseph R Robinson 281 10 Corneal Collagen Shields for Ocular Drug Delivery ... edited by Robert A Nash and Alfred H Wachter 130 Ophthalmic Drug Delivery Systems Second Edition, Revised and Expanded, edited by Ashim K Mitra 131 Pharmaceutical Gene Delivery Systems, edited by ... solutions to novel delivery systems such as biodegradable polymeric systems, corneal collagen shields, iontophoresis, and viral and nonviral gene delivery systems, to name a few An increase in our understanding...
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Ophthalmic Drug Delivery Systems - part 4 pdf
Ngày tải lên :
10/08/2014, 03:20
... injection, increased as the drug diffusivity was reduced Furthermore, the rate of drug elimination, which is inversely related to the drug s elimination halflife, decreased significantly as the drug diffusivity ... of ascorbate was perturbed by surgery Surgical trauma can result in increased peroxide generation as a result of the inflammatory cascade (69) There are no reports of studies evaluating basal ascorbate ... nonlinear leastsquares regression analysis assessment of the transport kinetics of ascorbate was performed Contrary to previous reports (58,63), ascorbate blood concentrations, which were increased...
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