na h exchanger 1 as a new molecular target in stroke interventions
Báo cáo y học: "High mobility group box protein-1 (HMGB-1) as a new diagnostic marker in patients with acute appendicitis" potx
... doi :10 .11 86 /17 57-72 41- 19-27 Cite this article as: Albayrak et al.: High mobility group box protein -1 (HMGB -1) as a new diagnostic marker in patients with acute appendicitis Scandinavian Journal ... who had a history of periumbilical or right lower quadrant pain, who exhibited nausea, vomiting, anorexia, or fever, who showed abdominal examination findings and/or whose condition was indicative ... macrophages and neutrophils, HMGB -1 also induces the production of proinflammatory cytokines such as TNF, interleukin (IL)- 1a and -1b, IL6 and macrophage inflammatory protein (MIP1) [10 ,14 ,16 ] During...
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Regulation of na+ h+ exchanger 1 (NHE1) stability in PTEN mouse embryonic fibroblasts
... protein Carbonic anhydrase II Heat shock protein 70 Death-domain-associated protein Protein tyrosine phosphatase Raf kinase β- Arrestin -1 Phosphofructokinase Protein phosphatase RSK ERK 1/ 2 NIK ... LIST OF ABBREVIATIONS 10 A1 MCF1 0A1 non-tumourigenic breast epithelial cells 10 AT1 MCF10AT1 pre-malignant breast epithelial cells Akt Protein kinase B CA 1a MCF10CA 1a malignant breast epithelial cells ... regulatory factor (NHERF1), which promotes Na+ /H+ exchanger (NHE1)-dependent invasion in breast cancer cells through protein kinase A (PKA)-gated RhoA/p38 mediated signaling66 Hypoxia has been also...
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Regulation of na+ h+ exchanger 1 (NHE 1) gene expression by mild oxidative stress
... hyaluronan receptor CD44 has shown to interact with NHE -1 and hyaluronidase-2 in lipid rafts This leads to an extracellular acidification, as well as hyaluronidase-2 and cysteine proteinase activation, ... maintenance of transformed phenotypes (Reshkin et al., 2000b) Moreover, a recent finding shows that the oncogenic protein nucleophosminanaplastic lymphoma kinase (NPM-ALK) induce an alkaline intracellular ... cardiac ischemia Activation of this exchanger is coupled with sodium influx which results in an increase of the intracellular calcium level by the Na+ /Ca2+ exchanger The elevated and accumulation...
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Tài liệu Báo cáo khoa học: Mammalian mitotic centromere-associated kinesin (MCAK) A new molecular target of sulfoquinovosylacylglycerols novel antitumor and immunosuppressive agents pptx
... a P-selectin receptor inhibitor from the alga Dictyochloris fragrans J Nat Prod 60, 387–389 Sahara H, Hanashima S, Yamazaki T, Takahashi S, Sugawara F, Ohtani S, Ishikawa M, Mizushina Y, Ohta ... sulfonoquinovosyl diacylglycerols of sea urchin Transplantation 74, 2 61 267 Mizushina Y, Watanabe I, Ohta K, Takemura M, Sahara H, Takahashi N, Gasa S, Sugawara F, Matsukage A, Yoshida S & Sakaguchi ... of a new mammalian DNA polymerase inhibitor, sulfoquinovosyldiacylglycerol Biol Pharm Bull 22, 11 1 11 6 Ohta K, Hanashima S, Mizushina Y, Yamazaki T, Saneyoshi M, Sugawara F & Sakaguchi K (2000)...
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BAMBOO AS A NEW FIBER SOURCE IN THE US PAPER INDUSTRY: A FEASIBILITY ANALYSIS FOR BOOSHOOT GARDENS, LLC docx
... principle that everyone who seeks their attention has an agenda, they don't always know a bias when they see one." This was a challenging balance when working with Booshoot because this company has developed ... by author Nancy Ohanian in Spain: "about 11 50, papermakers in Xatina, Spain, began to use water power to beat the rags They extended the axle of the waterwheel, inserted projections in the hub, ... saying it was what just what the company was hoping for and that my report was extremely thorough Booshoot Gardens has already started to find investors to propagate full grown bamboo and search...
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Báo cáo khoa học: "Combination therapy with docetaxel and S-1 as a first-line treatment in patients with advanced or recurrent gastric cancer: a retrospective analysis" docx
... W, Narahara H, Hara T, Takagane A, Akiya T, Takagi M, Miyashita K, Nishizaki T, Kobayashi O, Takiyama W, Toh Y, Nagaie T, Takagi S, Yamamura Y, Yanaoka K, Orita H, Takeuchi M: S -1 plus cisplatin ... oxaliplatin, and S -1 for patients with advanced gastric cancer Cancer Chemother Pharmacol 2009, 64:877-883 Yoshida K, Hirabayashi N, Takiyama W, Ninomiya M, Takakura N, Sakamoto J, Nishiyama ... orotate phosphorybosyl transferase was increased when docetaxel was administered in combination with S -1 In addition, in recent retrospective and phase I/II study [13 ,14 ,24], the combination therapy...
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Reactive oxygen species mediated regulation of the na+ h+ exchanger, NHE 1 gene expression a new mechanism for tumor cells resistance to apoptotic cell death
... they all lead to the 34 activation of kinases For example, Gαq acts through a protein kinase C-dependent mechanism, Ras acts through a Raf -1 and mitogen-activated protein kinase kinase (MAPK)-dependent ... proteins Kinases known to phosphorylate NHE1 include Erk 1/ 2, p90rsk, p160 ROCK, p38 and Nck-interacting kinase (Khaled AR et al, 20 01; Tominaga T and Barber DL, 19 98) The Na+ /H+ exchanger is maximally ... M14 pIRES Human Malignant Melanoma DMEM Hygromycin M14 RacV12 Human Malignant Melanoma DMEM Hygromycin U87 Human Malignant Glioblastoma RPMI - LNCaP Human Malignant Prostate Cancer RPMI - Table...
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Báo cáo y học: "Latent Membrane Protein 1 as a molecular adjuvant for single-cycle lentiviral vaccines" pot
... providing a new class of adjuvant for use in recombinant vaccine strategies In addition, LMP1 and LMP1 chimeras could be used as viral vector vaccine adjuvants or adjuvants for DNA or RNA based vaccines ... cells and macrophages (data not shown) These results confirm that LMP1 and LMP1CD40 are able to activate DCs and macrophages in vitro both in humans and non-human primates These data show that incorporating ... Total cellular RNA was isolated, reverse transcribed to cDNA and MIP- 1a, MIP1b, and RANTES mRNA expression was analyzed by real time PCR assay When macrophages were infected with recombinant...
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Tài liệu Activity 1.1: Designing a New Type of Motorcycle doc
... 2 Activity 1. 1: Designing a New Type of Motorcycle Exercise 1: Determining Your Gathering and Analysis Process Your research indicates that more people would like to ride motorcycles, but that ... develop the motorcycle Participate in small groups assigned by the instructor Provide at least three sources from which you can try to obtain information Be specific If you want to interview a person, ... person, specify their job or characteristics Indicate at least two questions that you can ask each source Different sources may require different types of questions Assume that the three sources...
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Báo cáo khoa học: Subcellular compartmentalization of FADD as a new level of regulation in death receptor signaling pdf
... polyphosphate 5-phosphatases (INP 51, INP52 and INP53 gene products) in the yeast Saccharomyces cerevisiae Genetics 14 8, 17 15 17 29 14 Itoh T, Koshiba S, Kigawa T, Kikuchi A, Yokoyama S & Takenawa T ... Discussion FADD is an essential adaptor protein in the CD95mediated apoptotic signaling cascade that couples activated receptors with the activation of initiator caspase-8 [1, 18 ,19 ] Here, we demonstrate ... shuttles between the nucleus and the cytoplasm Whereas cytoplasmic TRADD mediates apoptosis through FADD and caspase-8 activation, nuclear TRADD acts through a mitochondrial apoptosis pathway [28] Our...
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Báo cáo khoa học: A new molecular tool for transgenic diatoms Control of mRNA and protein biosynthesis by an inducible promoter–terminator cassette docx
... mutant strains of Chlamydomonas reinhardtii Mol Gen Genet 18 6, 16 4 16 9 25 Fernandez E & Cardenas J (19 89) Genetics and regulatory aspects of nitrate assimilation in algae Molecular and Genetic Aspects ... the 4 41- bp fcp DNA fragment was used as a probe after labeling with digoxygenin (Roche, Mannheim, Germany) according to the manufacturer’s instructions Phage DNA of one positive clone was analyzed ... Total RNA was isolated from · 10 cells using mL TRI reagent (Sigma, St Louis, MO, USA) according to the manufacturer’s instructions Contaminating DNA was removed from the RNA preparation by DNase...
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Báo cáo Y học: Properties of the Na+/H+ exchanger protein Detergent-resistant aggregation and membrane microdistribution potx
... of Na+ /H+ exchanger present in the supernatant and the pellet [19 ], it was found that over 80% of the Na+ /H+ exchanger remained in the Triton X -10 0 insoluble fraction The Na+ /H+ exchanger has ... residues in the Na+ /H+ exchanger Arch Biochem Biophys 358, 11 6 12 4 10 Moor, A. N & Fliegel, L (19 99) Protein kinase mediated regulation of the Na+ /H+ exchanger in the rat myocardium by MAPkinase-dependent ... immunoprecipitate was run on SDS/PAGE and probed with anti-NHE1 monoclonal and a 10 0 10 5 kDa band was evident (Fig 1B) The results confirmed that the anti-NHE1 monoclonal was reacting with the Na+ /H+ exchanger...
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Báo cáo khoa học: S-Layers as a basic building block in a molecular construction kit ppt
... of amino-acid residues [13 ] The latter is a remarkable characteristic of many archaeal and some bacterial Molecular construction kit based on S-layers S-layer proteins The glycan chains and linkages ... 2,3-dideoxydiacetamidomannosamine uronic acid with a highly conserved N-terminal region lacking an SLH domain However, the cell326 wall-targeting domain is not necessarily located in the N-terminal region ... bacterial cells and the reassembly of native and recombinant S-layer proteins into crystalline arrays in suspension, on a solid support, at the air ⁄ water interface and on a planar lipid film, and...
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Diaspora Bonds as a New Funding Vehicle for Developing Countries pdf
... known The Philippines, India, China, Vietnam and Korea from Asia; El Salvador, Dominican Republic, Jamaica, Colombia, Guatemala and Haiti from Latin America and the Caribbean; and Poland from Eastern ... choose the law and the forum governing bond contracts Finally, factors that facilitate—or constrain—the issuance of diaspora bonds include having a sizeable and wealthy diaspora abroad, and a ... India has not made diaspora bonds a regular feature of its foreign financing forays Instead, diaspora bonds are used as a source of emergency finance While not explicitly stated, India has tapped...
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Báo cáo khoa học: "Bioavailability of the amino acid-attached prodrug as a new anti-HIV agent in rats" pdf
... tnemecnahnE VP nawiD ,KA niaJ ,BK inasalahC ,SA nahuahC ,S ivedirS 11 77 21- 47 21 ,84 ,5002 mehC deM J retropsnart 1TPEPh fo setartsbus laitnetop sa elozadimizneb )lysonarufobir-D-β( -1- orolhcid-6,5-omorb-2 ... sretemarap citenikocamrahP elba T 562 star ni tnega VIH-itna wen a sa gurdorp dehcatta-dica onima eht fo ytilibaliavaoiB nwohs sah ,siht ot roirp demrofrep LA1050-PV rof alumrof eninala dica onima ... elirtinoteca dna )ASU ,amgiS( etahpsohp muissatop cisabid M 10 .0 fo erutxim a saw esahp elibom ehT mn 462 ta tes saw htgnelevaw VU eht dna metsys tneidarg retaw-lonahtem ro -elirtinoteca na gnisu...
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Báo cáo khoa học: "Evaluation of the fullerene compound DF-1 as a radiation protector" doc
... thus reducing indirect DNA damage As a measure of radiation-induced DNA damage, we evaluated induction of nuclear foci of phosphorylated histone H2 AX ( H2 AX), which has been established as a sensitive ... and mice were irradiated with the indicated total body doses A 13 7Cs Gamma Cell 40 (Nordion International, Kanata, Ontario, Canada) was used as the ionizing radiation source The irradiator was ... DF -1, suggesting that DF -1 impacts the immediate DNA damage after irradiation At 24 hrs the number of H2 AX foci per cell was similar in the vehicle and both DF -1 groups suggesting that DNA DSB...
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Báo cáo y học: "Salivary gland derived peptides as a new class of anti-inflammatory agents: review of preclinical pharmacology of C-terminal peptides of SMR1 protein" pptx
... Page 10 of 11 10 11 12 13 14 15 Competing interests DAG is a research veterinarian and a minority shareholder in a company which has commercial rights to salivary-derived peptides for veterinary ... the small intestine, and in diarrhea in 85% of challenged animals [38,48] Oral dosage of feG at 350 μg/kg at the time of OA challenge totally abolished the intestinal anaphylactic reaction and ... neutrophil adhesion to gelatin, whereas in PAF-activated cells feG at 10 -11 and 10 -10 M significantly inhibited adhesion of human neutrophils However, within molar concentrations of 10 -11 to 10 -9...
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Báo cáo y học: " Clustering of sebaceous gland carcinoma, papillary thyroid carcinoma and breast cancer in a woman as a new cancer susceptibility disorder: a case report" pptx
... variant in the succinate dehydrogenase subunit B gene in a boy with malignant paraganglioma in a family with non-classical congenital adrenal hyperplasia Exp Clin Endocrinol Diabetes 2007, 11 5:S39 ... CL: Sebaceous Carcinoma of the Eyelids: Personal Experience with 60 Cases Ophthalmology 2004, 11 1: 215 1- 215 7 Kass LG, Hornblass A: Sebaceous carcinoma of the ocular adnexa Surv Ophthalmol 19 89, ... 33:477-490 Chao AN, Shields Cl, Krema H, Shields JA: Outcome with periocular sebaceous gland carcinoma with and without conjunctival intraepithelial invasion Ophthalmology 20 01, 10 8 :18 77 -18 83 Finan MC,...
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Characterisation of toll like receptor 8 as a new innate immune receptor for mycobacterium tuberculosis
... that! initiate! a! host! defence! response! against! the! invading! pathogen! (Janeway,! 19 89).!PRR!signalling!also!leads!to!dendritic!cell!maturation,!thereby!regulating! the!initiation!of!the!adaptive!immune!response!(Janeway!and!Medzhitov,!2002;! ... CpG$DNA$ Bacteria$and$mycobacteria$ ' Fungus' Zymosan$ Saccharomyces0cerevisiae$ Phospholipomannan$ Candida0albicans$ Mannan$ Candida0albicans$ Glucuronoxylomannan$ Cryptococcus0neoformans$ ' Parasites' ... protein! (TIRAP),! Toll/IL1R! domain.containing! adaptor!inducing! IFNβ!(TRIF)!or!TRIF.related!adaptor!molecule!(TRAM)(Kawai! and!Akira,!2 011 ).!! Two! main! TLR! signalling! pathways! have! been!...
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A non mouse adapted dengue virus strain as a new model of severe dengue infection in AG129 mice
... tissue damage and vii Summary vascular leakage was minimal; basal production of these cytokines was instead measured in the animals at moribund state, where tissue damage and vascular leakage were ... Wengler and Wengler 19 93) It has been identified that the C terminal portion of NS3 contains domains that allow RNA binding during RNA replication, as well as NTPase and helicase activities (Westaway ... has also been implicated in DEN disease; hence elevations in aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels (Burke et al., 19 88), - indicative of liver damage - are...
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