musculoskeletal and anti inflammatory drugs
Báo cáo hóa học: "Clinically important improvement in the WOMAC and predictor factors for response to non-specific non-steroidal anti-inflammatory drugs in osteoarthritic patients: a prospective study" docx
... conceived the study and supervised its design, execution, and analysis and participated in the drafting and critical review of the manuscript IH, FA and RA did data management and statistical analyses ... for each two samples categories (womac and transition scale), (womac and both transition scale and womac), (transition scale and both transition scale and womac) Factors found to be significant ... Moroccan population, and second, to identify the best pre-treatment predictors on the change of health after treatment by non-specific, non-steroidal anti- inflammatory drugs (NSAIDs), and to evaluate...
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Báo cáo y học: "Prescription channeling of COX-2 inhibitors and traditional nonselective nonsteroidal anti-inflammatory drugs: a population-based case–control study" pot
... recommended for anti- inflammatory indications (22.1%) in comparison with celecoxib (3.4%) and rofecoxib (18.2%) Conversely, the majority of COX-2 inhibitors were prescribed at standard anti- inflammatory ... 2.8 3.8 2.9 Values are expressed as percentages NSAID, nonsteroidal anti- inflammatory drug antidepressant and benzodiazepine use and prescription of COX-2 inhibitors Prescriber specialty at the ... unit, quantity dispensed and prescribed duration Daily dosages were subsequently categorized into low, standard and high, (for each product the dosage thresholds are listed in Table 1) Standard...
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Báo cáo y học: "Patients, their doctors, nonsteroidal anti-inflammatory drugs and the perception of risk" docx
... Gastrointestinal toxicity with celecoxib vs nonsteroidal antiinflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: a randomized controlled trial JAMA 2000, 284:1247-1255 ... of prescription and over the counter nonsteroidal anti- inflammatory drugs: a view from the Aramis Database Am J Ther 2000, 7:115-121 Farkouh ME, Kirshner H, Harrington RA, Ruland S, Vereught ... is defined as ‘all observational (nonrandomized) postapproval scientific and data gathering activities relating to the detection, assessment and understanding of adverse events’ [7] This includes...
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Báo cáo y học: "Proton-pump inhibitors are associated with a reduced risk for bleeding and perforated gastroduodenal ulcers attributable to non-steroidal anti-inflammatory drugs: a nested case-control study" pptx
... actual and recent medication, co-morbidity and medical history The questionnaire contained specific items on the use of NSAIDs, aspirin, anticoagulants, gastroprotective drugs, and steroids, and ... Bujanda L, Gomollon F, Forne M, Aleman S, Nicolas D, Feu F, Gonzalez-Perez A, et al.: Effect of antisecretory drugs and nitrates on the risk of ulcer bleeding associated with nonsteroidal anti- inflammatory ... Gastrointestinal toxicity with celecoxib vs nonsteroidal antiinflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: a randomized controlled trial Celecoxib Long-term Arthritis...
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Báo cáo y học: "Faecal blood loss with aspirin, nonsteroidal anti-inflammatory drugs and cyclo-oxygenase-2 selective inhibitors: systematic review of randomized trials using autologous chromium-labelled erythrocytes" ppsx
... Fracture risk associated with use of nonsteroidal anti- inflammatory drugs, acetylsalicylic acid, and acetaminophen and the effects of rheumatoid arthritis and osteoarthritis Calcif Tissue Int 2006, ... Hernández-Diaz S, García Rodriguez LA: Association between nonsteroidal anti- inflammatory drugs and upper gastrointestinal tract bleeding and perforation: An overview of epidemiological studies published ... Fortun PJ, Hawkey CJ: Nonsteroidal antiinflammatory drugs and the small intestine Curr Opin Gastroenterol 2007, 23:134-141 Adebayo D, Bjarnason I: Is non-steroidal anti- inflammaory drug (NSAID) enteropathy...
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Báo cáo y học: "A multicentre case-control study of nonsteroidal anti-inflammatory drugs as a risk factor for severe sepsis and septic shock" docx
... fasciitis and non steroidal anti- inflammatory drugs: a case series and review of the literature N Z Med J 2001, 114:3-6 Holder EP, Moore PT, Browne BA: Nonsteroidal anti- inflammatory drugs and necrotising ... gangrene and non-steroidal antiinflammatory drugs Br Med J (Clin Res Ed) 1985, 290:1786 Rimailho A, Riou B, Richard C, Auzepy P: Fulminant necrotizing fasciitis and nonsteroidal anti- inflammatory drugs ... use of nonsteroidal antiinflammatory drugs and necrotizing fasciitis caused by group A streptococcus Medicine 2003, 82:225-235 Stevens DL: Could nonsteroidal anti- inflammatory drugs (NSAIDs) enhance...
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Role of Non-Steroidal Anti-Inflammatory Drugs in Gynecology potx
... C.;Derks R.S Nonsteroidal anti- inflammatory drugs for primary dysmenorrhoea Cochrane Database Syst Rev 2010, 1, CD001751 Dawood, M.Y Nonsteroidal anti- inflammatory drugs and changing attitudes toward ... COX-2 inhibitors and cardiovascular (CV) and thromboembolic events A review of 13 randomized trials was done to assess the effects of NSAIDs as a tocolytic agent on maternal, fetal and neonatal outcomes ... the ratio of prostaglandin E2 to F2 and the ratio of prostacyclin (prostaglandin I2) to thromboxane are elevated [8] These substances are present both in the endometrium and myometrium, although...
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báo cáo hóa học: " Inhibition of secreted phospholipase A2 by neuron survival and anti-inflammatory peptide CHEC-9" docx
... Neuroinflammation 2006, 3:25 Background Pro -inflammatory enzymes and cytokines are increasingly attractive as therapeutic targets for a variety of inflammatory diseases and for the inflammatory component of neurodegenerative ... survivalpromoting, anti- inflammatory polypeptide DSEP/Dermcidin/PIF [6,8-12] Following cerebral cortex lesions, a subcutaneous injection of CHEC-9 results in anti- inflammatory and neuron survival ... sPLA2 enzyme activity to inflammatory and degenerative disorders of the nervous system is increasingly appreciated Given the nature of inflammatory stimuli and of the inflammatory cascade, inhibitors...
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Báo cáo khoa học: " The Antinociceptive and Anti-inflammatory Effect of Ethylacetate Extracts from Bang-Poong (Radix ledebouriellae) on the Freund’s Adjuvant-Induced Arthritis in Rats" pot
... BP (BPE) and hexane fraction of BP (BPH) were extracted from whole BP and antinociceptive and anti- inflammatory effect on experimentally evoked RA in rats was demonstrated Materials and Methods ... and spinal Fos expression in SDH and NP (E) In contrast to this, BPH did not inhibit these arthritis-related changes (C and F ) The Antinociceptive and Anti- inflammatory Effect of Ethylacetate ... characterized by degenerative joint destruction, deformity and inflammatory pain in most cases Currently non-steroidal anti- inflammatory drugs (NSAIDs) such as indomethacin are commonly used to...
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Báo cáo y học: "Biology of recently discovered cytokines: Discerning the pro- and anti-inflammatory properties of interleukin-27" pptx
... recombinant IL-27 can augment proliferation and secretion of IFN-γ by naïve CD4+ T cells [3,39,40] and when combined with The paradoxical pro- and anti- inflammatory properties of IL-27 Through ligation ... Molecular phylogeny within type I cytokines and their cognate receptors Immunity 2003, 19:159-163 Villarino AV, Huang E, Hunter CA: Understanding the pro- and anti- inflammatory properties of IL-27 J Immunol ... can also have proinflammatory effects in these cells (Fig 2) IL-27 can directly induce expression of IL-1 and TNF-α by primary mast cells and production of IL-1, TNF-α, IL-12p35 and IL-18 by monocytes...
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Báo cáo y học: "Risk of acute myocardial infarction with nonselective non-steroidal anti-inflammatory drugs: a meta-analysis" ppsx
... BIDS and EMBASE, between January 1980 and June 2005 Relevant keywords (as MeSH terms and text words) relating to NSAIDs (for instance, anti- inflammatory agents, non steroidal anti- inflammatory) and ... steroidal anti- inflammatory drugs and risk of coronary heart disease Lancet 2002, 360:1071-1073 Ray WA, Stein CM, Hall K, Daugherty JR, Griffin MR: Non steroidal anti- inflammatory drugs and risk ... conventional non-steroidal anti- inflammatory drugs: population based nested case-control analysis BMJ 2005, 330:1366 Asano TK, McLeod RS: Non steroidal anti- inflammatory drugs (NSAID) and aspirin for preventing...
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Báo cáo y học: " Smoking status and anti-inflammatory macrophages in bronchoalveolar lavage and induced sputum in COPD" doc
... display pro -inflammatory and cytotoxic properties and can eradicate intracellular pathogens In contrast, antiinflammatory or alternatively activated macrophages (M2) display anti- inflammatory ... severe COPD patients i) ex-smokers have more M2 and anti- inflammatory mediators in BAL and induced sputum compared to current smokers; ii) M2 and anti- inflammatory mediators are relatively higher ... secrete pro -inflammatory cytokines, like IL-(Interleukin)-12 and tumor necrosis factor (TNF)-a, have good antigen presenting capacity and promote Th1 immunity In contrast, M2 secrete anti- inflammatory...
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Báo cáo y học: "Dynamics of pro-inflammatory and anti-inflammatory cytokine release during acute inflammation in chronic obstructive pulmonary disease: an ex vivo study" pps
... balance between pro -inflammatory TNFα and anti- inflammatory IL-10 in both resolution of inflammation and normal homeostasis of the lung Our finding that lung tissue from GOLD I and GOLD II COPD ... obstruction (GOLD I and II) release elevated concentrations of pro -inflammatory cytokines TNFα, IL-6 and CXCL8 in response to LPS but failed to mount an appropriate anti- inflammatory IL10 response ... hour The tissue was then embedded and sequential sections of the lung parenchyma stained with monoclonal antibodies for TNFα (figure 4A and 4C) and CD68 (4B) and mast cell tryptase (4D) Staining...
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Báo cáo khoa học: "Endotoxin neutralization and anti-inflammatory effects of tobramycin and ceftazidime in porcine endotoxin shock" ppt
... TNF-α and IL-6 concentrations were chosen as primary end-points because endotoxin has been shown to induce a quick and reproducible response both in vitro and in animal models [20], and at and ... administration and was given for 10 Antibiotics The antibiotics were obtained as reference substances with known potencies Ceftazidime was purchased from Glaxo Wellcome AB (Gothenburg, Sweden) and tobramycin ... analysis of endotoxin, TNF-α and IL-6 were drawn immediately before addition of antibiotics and hourly until the end of the experiment At the same time points arterial blood gas and base deficit were...
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Báo cáo y học: "Cost-effectiveness analysis for joint pain treatment in patients with osteoarthritis treated at the Instituto Mexicano del Seguro Social (IMSS): Comparison of nonsteroidal anti-inflammatory drugs (NSAIDs) vs. cyclooxygenase-2 selective inh
... pharmacotherapy are to achieve an anti- inflammatory and analgesic effect [4,5] Analgesic and anti- inflammatory properties of nonsteroidal anti- inflammatory drugs (NSAIDs) are based on the inhibition ... prostaglandins, thromboxanes and leukotrienes in the body [7] Anti- inflammation and pain decrease with the effects of NSAIDs, resulting from the inhibition of COX-2-mediated prostaglandin synthesis ... drug has the lowest rate for decreasing inflammation [11,12] Drugs such as naproxen and ibuprofen have a higher analgesic and antiinflammatory effect, but the risk of GI bleeding is increased,...
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Báo cáo y học: "Anti-allergic and anti-inflammatory effects of butanol extract from Arctium Lappa " pdf
... that ALBE may have antiallergic and anti- inflammatory effects Conclusions ALBE may exert anti- allergic and anti- inflammatory activities by suppressing the transcription of NF-B and the activated ... IL-4 and IL-5, were from BD Biosciences, the protein assay kit was from Bio-Rad Laboratories, anti- pERK, antiERK, anti- pJNK, anti- JNK, and anti- p-p38 were from Cell Signaling Technology, anti- p65 ... significantly inhibited antigen-induced b-hexosaminidase release Atopic dermatitis is a chronic, allergic inflammatory skin disorder, and we investigated both the anti- allergic and anti- inflammatory effects...
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Determination of Non-Steroidal Anti-Inflammatory Drugs (Nsaids) in Surface Water at Ho Chi Minh City
... sodium and mefenamic acid standard (IDQC, purity >99.9%) Stock solutions of 1,000mg/L were prepared in methanol and stored at 40C Working solutions were prepared by diluting the stock standard ... mefenamic acid were measured at 254, 218, 276 and 218nm, respectively 2.2.5 Calibration curve, method detection limit and method quantitation limit Calibration standards were prepared in the concentration ... acid and 20 - 2,000µg/L for ibuprofen Method detection limit (MDL) and method quantitation limit (MQL) were determined by analyzing five times of spiked samples which are prepared by adding standard...
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Báo cáo y học: " Anti-inflammatory and immunosuppressive drugs and reproduction" pot
... Table Effect of non-steroidal anti- inflammatory drugs, glucocorticosteroids and bisphosphonates on human pregnancy and fertility Drug Non-steroidal anti- inflammatory drugs FDA riska Transplacental ... Non-steroidal anti- inflammatory drugs, corticosteroids and bisphosphonates during lactation Drug Secretion into breast milk Effect on nursing infant Breastfeeding allowed Non-steroidal anti- inflammatory drugs ... level IV) New anticoagulant drugs Currently, the most widely used drugs for treatment and secondary prevention of thromboembolic manifestations and pregnancy morbidity caused by antiphospholipid...
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Báo cáo y học: "Cellular transport of anti-inflammatory pro-drugs originated from a herbal formulation of Zingiber cassumunar and Nigella sativa" ppsx
... Authors' contributions PT and WG conceived the study design, synthesized the compounds 1, 2, and D, performed HPLC and UV analysis, and drafted the manuscript JK and PO designed and performed the Caco-2 ... ester pro -drugs and compound D This procedure was repeated for compounds and Results Chemical hydrolysis study of the compounds in transport medium Solution of compound 1, and at 53 μM and 106 ... the com- Compounds 1, and were prepared in transport medium at concentrations of 53 μM and 106 μM and stored at 4°C for 96 hours The samples were collected every 12 hours and analyzed on the HPLC...
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Báo cáo khoa học: Modulation of heme and myristate binding to human serum albumin by anti-HIV drugs An optical and NMR spectroscopic study potx
... of highly effective combination regimens of antiretroviral drugs has led to substantial improvements in morbidity and mortality [43] The anti- HIV drugs include three different classes among nucleoside ... Modulation of HSA ligand binding by anti- HIV drugs G Fanali et al Fig Binding isotherms for Fe(III)heme binding to HSA (FA free) and to HSA–myristate complexes in the absence of drugs (A) and presence ... HSA ligand binding by anti- HIV drugs Table Values of intermolecular energies (kJÆmol)1) obtained from the docking simulation of the three anti- HIV drugs in the heme binding cavity (FA1) and in...
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