molecular structure of adhesion molecules
Báo cáo khoa học: "Changes in some Blood Micronutrients, Leukocytes and Neutrophil Expression of Adhesion Molecules in Periparturient Dairy Cows" ppt
... migration of blood neutrophils can be explained by a lower expression of the adhesion molecules CD62L (L-selectin) and CD11/ CD18, which are of vital importance for their migration to the site of inflammation ... deficiency of beef cattle in Idaho and Washington and a practical means of prevention Corn Vet., 1983, 73, 323-332 Lee E-K, Kehrli M: Expression of adhesion molecules on neutrophils of periparturient ... hematocrit content of 35% (Schalm 1986) Statistical analysis Analyses of variance for the concentrations of nutrients and leukocytes, and the proportions and MFI for the neutrophil adhesion molecules...
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Tài liệu Báo cáo Y học: Molecular modeling of the dimeric structure of human lipoprotein lipase and functional studies of the carboxyl-terminal domain docx
... Fig Molecular modeling of the dimeric structure of LPL Two dimeric model structures of LPL were constructed using INSIGHT II version 2000 on a Silicon Graphics workstation The model structure of ... steps of 1.0 fs time-step RESULTS Model structure of human LPL All model structures of dimeric human LPL were constructed using the INSIGHT II program and were based on the crystal structures of ... dimeric form of LPL, the model structure of monomeric LPL was duplicated and superimposed on the crystal structure of the horse PL dimer After the energy minimization by setting at iteration of 300...
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Báo cáo khoa học: Molecular mass of macromolecules and subunits and the quaternary structure of hemoglobin from the microcrustacean Daphnia magna ppt
... both Hb isoforms also display a different quaternary structure After purification of red D magna hemolymph by chromatofocusing [removal of ring-like molecules (‘ferritin’), but retention of high ... by chromatofocusing, resulting in a small quantity of ferritin in comparison to the large number of Hb molecules in the samples In addition, structures clearly representing ferritin molecules ... [14] gave a molecular mass of 505 ± 35 kDa in a first experiment and one of 483 ± 27 kDa in a second experiment, resulting in an overall molecular mass of 494 ± 33 kDa For the subunits of D magna...
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PREDICTION OF CHEMICAL REACTIVITY PARAMETERS AND PHYSICAL PROPERTIES OF ORGANIC COMPOUNDS FROM MOLECULAR STRUCTURE USING SPARC pptx
... properties to Program Offices (e.g., Office of Water, Office of Solid Waste and Emergency Response, Office of Prevention, Pesticides and Toxic Substances) and Regional Offices Also, SPARC has been used ... number of molecular structures The values of these latter parameters, in most instances, must be derived from measurements or from the expert judgment of specialists in that particular area of chemistry ... potential of a particular S to "exert" a given effect (Independent of the property, C and R), molecular network conduction, which describes the "conduction" properties of the molecular structure...
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Báo cáo khoa học: Three-dimensional structure of a thermostable native cellobiohydrolase, CBH IB, and molecular characterization of the cel7 gene from the filamentous fungus, Talaromyces emersonii ppt
... present the 3D structure of the native CBH IB from T emersonii, the first structure of any protein from this source and the first structure of a native fungal CBH core (glycoprotein) Molecular cloning, ... during the structure solution of the native enzyme Family contains both CBHs and endoglucanases The structure of CBHs is distinguished from that of endoglucanases by the presence of loops of polypeptide ... 1.25 U of Pfu DNA polymerase, · Pfu reaction buffer, 200 lM of each Ó FEBS 2004 Structure and analysis of T emersonii CBH IB (Eur J Biochem 271) 4497 deoxynucleotide triphosphate and lM of the...
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Báo cáo khoa học: B1–Proteases as Molecular Targets of Drug Development B1-001 DPP-IV structure and inhibitor design ppt
... relax of beta barrel structure of Pla and the progressive approximation and stabilization between the cleavage site of Plg into the extracellular loops of Pla, followed of the increase of hydrogen ... of Biochemistry, Science Institute, University of Iceland, Reykjavik, Iceland, 2Laboratory of Molecular Genetics, Institute of Biology, University of Iceland, Reykjavik, Iceland, Department of ... sites of 20S complexes We performed exible docking studies of analogues of a natural product TMC-95A using 1JD2 crystal structure to describe the active site of protein and the position of the...
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Báo cáo khoa học: H NMR study of the molecular structure and magnetic properties of the active site for the cyanomet complex of O2-avid hemoglobin from the trematode Paramphistomum epiclitum pdf
... is oriented out of the heme pocket in both forms with the Tyr32(B10) in one of the structures [16,17] serving as a H-bond acceptor to a ligated water molecule The two structures of WT metHb and ... secondary Fig Schematic representation of the heme pocket of Pe Hb as found in the crystal structure of Pe metHbH2O [16] and as conrmed herein by solution 1H NMR of Pe metMbCN Proximal and distal ... the tilt of the major magnetic axis, z, away from the heme normal (z axis), a is the angle between the projection of the tilt of the z axis on the xÂ, y plane (dened direction of tilt of z and...
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Báo cáo khoa học: Upregulation of endothelial adhesion molecules by lysophosphatidylcholine pptx
... concentration (25 lm) of LPC (Fig 1D) Contribution of NF-jB to LPC-induced activation of AMs To define the molecular mechanism of LPC-induced upregulation of AMs, the influence of LPC on NF-jB activation ... (2006) Upregulation of aortic adhesion molecules during aging J Gerontol Biol Sci Med Sci 61, 232–244 Zou Y, Jung KJ, Kim JW, Yu BP & Chung HY (2004) Alteration of soluble adhesion molecules during ... the molecular mechanisms underlying the effects of LPC on the upregulation of AMs Our data suggested the existence of two pathways, through NF-jB or through GPR4, emphasizing the involvement of...
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The Estimation of Mechanical Properties of Polymers from Molecular Structure ppt
... the utility of this approach in estimating the strength of ordered polymers The effects of molecular weight on the strength of glassy polymers is to increase from near zero at very low molecular ... discussion of these phenomena The molecular weight dependence of a polymer is strongly related to the entanglement molecular weight Above 2Me, the viscosity of the melt increases as the 3.4 power of ... polystyrene as a function of temperature Shear Yielding There have been many attempts to describe the yield strength from the molecular point of None of these relates well to basic molecular parameters...
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krafft carl - spiral molecular structure the basis of life
... "bodies of unicellular orgajiisms after removal of the water is due tc All protein substances, upon hydrolytic decomposition, yield a mixture of amino acids having the follov/ing molecular structure; ... necessity for confining ourselves to the use of hexagons If, for example, v/e foim the surface structure of pentagons instead of hexagons, the number of exposed corners on each compartment would ... to account for the tendency of unicellular organisms to divide Except in rare cases of coincidence, different molecular structures would occupy different amounts of space, so that as the organism...
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Báo cáo khoa học: "Molecular structure and biochemical properties of lignins in relation to possible self-organization of lignin networks" pdf
... organization of a system, can be and of time function of redundancy (see Annex) Evolution of the organization as a expressed as a be calculated function of time can thus different types of showing ... 1976), as in the case of secondary metabolism (Terashima and Fukushima, 1988) these authors: in Fagus, the lignin moiety of LCC would consist of a small number of extremely large molecular fractions, ... Cy-hydroxyls of a monomeric propane chains (Fig 1C5to Molecular associations and cell wall lignification Formation of molecular associations with other cell wall components is the third main feature of...
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Báo cáo y học: " Expression of endothelia and lymphocyte adhesion molecules in bronchus-associated lymphoid tissue (BALT) in adult human lung" pot
... HEVs in any of the BALT samples The adhesion molecule profile of HEVs in human BALT is similar to that of HEVs in mouse BALT, differing only in the extent of VCAM-1 expression (66% of HEVs in ... test) Adhesion molecules on BALT HEVs To determine which adhesion molecules are expressed on BALT HEVs, we stained frozen sections of BALT with mAbs against endothelia adhesion molecules that ... used to determine which adhesion molecules mediate the binding of viable lymphocytes to HEVs on frozen sections of tissues [12,35] Due to the scarcity of frozen samples of human BALT, we were...
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Báo cáo y học: " The predictive role of serum and bronchoalveolar lavage cytokines and adhesion molecules for acute respiratory distress syndrome development and outcome" pptx
... up-regulation of p70 S6 kinase on Thr389 after incubation with insulin for 15 to 16 hours Phosphorylation of p70 S6 kinase on Thr389 is essential for the activation of the kinase [22] In the presence of ... upregulate the synthesis of SP-A in rat type II cells [25] Thus, phosphorylation of p44/42 MAPK may be involved in the up-regulation of SP-A gene expression, results consist- Page of 10 (page number ... not affect the phosphorylation of p44/42 MAPK after 16 hours (C) The phosphorylation of Thr389 in p70 S6 kinase was increased in the presence of insulin after 15 of incubation and remained increased...
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Báo cáo y học: " The predictive role of serum and bronchoalveolar lavage cytokines and adhesion molecules for acute respiratory distress syndrome development and outcome" doc
... sequence and severity of the events during the development of ARDS and to correlate this with clinical outcome, we measured soluble adhesion molecules of serum and BALF in a series of 65 patients with ... leukocytes and adhesion molecules appear to coordinate a cascade of interactions between leukocytes and endothelial cells, which result in tissue injury [18] To our knowledge soluble adhesion molecules ... Determination of plasma cy- Predictive serum and BALF levels of all studied molecules for ARDS development in patients at risk (groups B and C) are shown in Table The two groups of molecules studied...
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Báo cáo y học: " Adhesion molecules in different treatments of acute myocardial infarction" doc
... levels of adhesion molecules, probably indicating endothelial activation as a result of reperfusion of the ischemic myocardium Limitation of this study is the lack of samples taken before start of ... modality chosen appear to be involved in the regulation of these adhesion molecules Elucidation of the clinical relevance of altered adhesion molecules awaits larger studies with later endpoints ... Reperfusion of occluded vessels leads to an activation of endothelial cells and an extravasation of leukocytes This consecutive extravasation is regulated by the sequential interaction of adhesion molecules...
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Báo cáo y học: "Human T-cell leukemia virus type I infects human lung epithelial cells and induces gene expression of cytokines, chemokines and cell adhesion molecules" ppt
... days At the end of this period, the level of HTLV-I p19 core protein was measured in culture supernatants Production of HTLV-I p19 was evident after day of infection; the levels of HTLV-I p19 in ... transcription of the viral genome but also the expression of various cellular genes [33] Therefore, we investigated the expression of inflammatory cytokines, chemokines and cell adhesion molecules ... supernatants of A549 and NCI-H292 cells infected with HTLV-I were 1337 and 1023 pg/ml, respectively The level of p19 in the supernatant of the MMC-treated MT-2 cells, the number of which http://www.retrovirology.com/content/5/1/86...
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Molecular mechanisms of mechanosensing at cell cell and cell matrix adhesion 2
... consequences Altered cell-cell and cell-matrix adhesion function is one of the hall marks of cancer [49, 50] The proper functions of cell adhesions, both in terms of adhesion strength and underlying signaling ... believed to form adhesion structures reminiscent to these structures formed in 2D culture systems in terms of molecular architecture and functions [42] Figure 1.2: Different cell-matrix adhesions have ... mechanosensing related proteins at cell-adhesions As cell adhesions play a pivotal role in the proper function of cells, misregulation of cell adhesions often leads to severe pathological consequences...
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Structure basis for molecular recognition of folic acid by folate receptor
... curves of FRα double mutants .75 Figure 29 Comparison of FRα and chicken riboflavin binding protein 79 Figure 30 Structure alignment of human FRα and FRβ 81 Figure 31 Structure of FRα in ... X-ray crystal structure of human TS in complex with dUMP and raltitrexed .98 Figure 38 Chemical structures of raltitrexed and BGC945 103 Figure 39 Chemical structures of pemetrexed ... form of folate in circulation is 5-methyl tetrahydrofolate (5-methyl THF) [7] a) b) Figure Chemical structure of folic acid and folate derivatives a) Constitution of folic acid b) Tetrahydrofolate...
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Molecular transport and structure of DNA in a congested state
... MOLECULAR TRANSPORT AND STRUCTURE OF DNA IN A CONGESTED STATE ZHU XIAOYING (Ph.D.) A THESIS SUBMITTED FOR THE DEGREE OF DOCTER OF PHILOSOPHY DEPARTMENT OF PHYSICS NATIONAL UNIVERSITY OF SINGAPORE ... 061905 (2010) ii Table of Contents Acknowledgement i List of Publications ii Table of Contents iii Summary vi List of Tables vii List of Figures viii Chapter Introduction 1.1 Biomolecules in crowded ... the properties of biomolecules are unclear There is increasing interest in crowding on the structure, stability and transportation of biomolecules, in order to clarify how biomolecules behave...
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