molecular organization of the pre and postsynaptic scaffold
Báo cáo y học: "Longitudinal evaluation the pulmonary function of the pre and postoperative periods in the coronary artery bypass graft surgery of patients treated with a physiotherapy protocol" ppt
Ngày tải lên :
10/08/2014, 09:21
... airway pressure days and 30 for the CAD group, and preoperation and postoperative days 3, 6, 15 and 30 for the CABG group Ventilation test Inclusion criteria We Included for the study were, all candidates ... (EC) [12] and the position of the drains [13] Pain due to thoracotomy is a limiting factor for mobility and breathing A high level of postoperative pain is common because of the cutting of the skin, ... supervised the study and contributed to the data analysis, manuscript writing and editing All of the authors read and approved the final manuscript Competing interests The authors declare that they...
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Molecular biology of the lung and kidney of the african lungfish, protopterus annectens, during three phases of aestivation cystic fibrosis transmembrane conductance regulator, gulonolactone oxidase and p53
Ngày tải lên :
09/09/2015, 17:55
... annectens, and the molecular characteristics of this sequence studied The next objective 18 was to determine the mRNA expression of p53 in the lung and kidney of P annectens during the three phases of ... from the primitive pharynx The study of the respiratory system of the lungfish is not only of special interest in our understanding the functional and structural design of the lungs in the early ... isoforms not expressed in the lung of the control fish were expressed in the lung of fish undergoing the maintenance and arousal phases of aestivation Some of these isoforms, are known to lead...
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Tài liệu Báo cáo Y học: Molecular modeling of the dimeric structure of human lipoprotein lipase and functional studies of the carboxyl-terminal domain docx
Ngày tải lên :
21/02/2014, 15:20
... illustrates the overall saddle shape of the dimeric structure and the key heparin-binding residues in the N-terminal domain held coordinately by the two subunits on the top of the hollow (Fig 1A) The ... for the WW mutant (Ala substituted for Trp393 and Trp394) and the WWW mutant (Ala substituted for Trp390, Trp393 and Trp394) (C,D) Protein expression of the wild type, the WW mutant, and the ... the C-terminal domain of apoCII interacts with the interface of the N- and C-terminal domains of LPL and part of the lid surface [32] Because the functional importance of LPL’s C-terminal domain...
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Molecular dynamics simulations of the tensile and melting behaviours of silicon nanowires
Ngày tải lên :
16/03/2014, 15:18
... atoms near the surface, as compared with those in the bulk, and the increasing dominance of the surface would decrease the strength of the structure 3.2 The melting properties of the SiNWs The variation ... [30], and in the present simulation the load is along the [11 0] orientation and the resolved shear stress on the (111) plane causes the sliding After the formation of the neck, the plastic deformations ... of (a) temperature and (b) strain rate on the tension behaviour of the SiNWs ties of nanowires as a function of their diameters (as shown in Fig 1) As for the triangular-shaped SiNWs in the present...
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Báo cáo khoa học: Cellular and molecular action of the mitogenic protein-deamidating toxin from Pasteurella multocida pptx
Ngày tải lên :
22/03/2014, 15:21
... whereas preadipocyte-specific markers, such as Pref1 [112], and Wnt ⁄ b-catenin signaling [113] are downregulated PMT prevents the expression of PPARc and C ⁄ EBPa in 3T3-L1 preadipocytes and the ... Although the precise localization of the domains responsible for receptor binding and translocation activity remains unclear, these domains are located in the N-terminus of each of these toxins and ... is the detection of the modification, which involves the detection of a molecular mass change of Da in a relatively large protein substrate (20–45 kDa) Another challenge is the development of...
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Báo cáo khoa học: Molecular dissection of the biosynthetic relationship between phthiocerol and phthiodiolone dimycocerosates and their critical role in the virulence and permeability of Mycobacterium tuberculosis doc
Ngày tải lên :
23/03/2014, 09:20
... bacteria of the PMM56 mutant strain were present in the spleen of these mice For the determination of the number of PMM56 bacteria present in the spleen of these four mice, we thus chose a value of ... i.e DIMs and PGL-tb; and (b) to address the question of the function of the two related molecules DIM A and DIM B According to the accepted model of DIM and PGL biosynthesis [17], DIM A and PGL-tb ... roles of the various members of the DIM family, e.g DIM A and DIM B, in these functions have never been investigated The recent developments in our understanding of the biosynthetic pathway of DIMs...
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EVOLUTION OF THE MOLECULAR BIOLOGY OF BRAIN TUMORS AND THE THERAPEUTIC IMPLICATIONS pdf
Ngày tải lên :
23/03/2014, 10:20
... Evolution of the Molecular Biology of Brain Tumors and the Therapeutic Implications high grade gliomas The structure and compounds of the ECM of the brain tissue have many specific differences from other ... mortality of the patient Moreover, the presence of the blood-brain barrier (BBB) limits the passage of a wide variety of anticancer agents The high incidence of recur‐ rence and poor prognosis of malignant ... Overexpression of dystroglycan decreased Evolution of the Molecular Biology of Brain Tumors and the Therapeutic Implications the growth rate of glioma cell lines so it was found to be involved in the...
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Báo cáo khoa học: Three-dimensional structure of a thermostable native cellobiohydrolase, CBH IB, and molecular characterization of the cel7 gene from the filamentous fungus, Talaromyces emersonii ppt
Ngày tải lên :
23/03/2014, 13:20
... With the exception of four a-helices and two pairs of short b-strands, the rest of the protein consists almost entirely of loops connecting the b-strands The loops extending from the Ó FEBS 2004 ... is the predominant product of hydrolysis and increases in concentration as the reaction proceeds [21] The exo-loop of 1CEL (amino acids 243–256) forms the roof of the active site tunnel at the ... was 1.8°, the standard deviation of the hydrogen bond energies was 0.7 and overall G-factor, a measure of the normality of the structure, was 0.0 Fig SDS/PAGE and activity analysis of recombinant...
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Báo cáo khoa học: Molecular cloning of the ecdysone receptor and the retinoid X receptor from the scorpion Liocheles australasiae pot
Ngày tải lên :
30/03/2014, 04:20
... we determined the cDNA sequences of the EcRs and the USPs (RXRs) of Chilo suppressalis [14] and Leptinotarsa decemlineata [15] Dissociation constants of the binding of PonA to these receptors ... sequences of the A ⁄ B and E regions of LaEcR-A and LaRXR with those of other arthropods are shown in Fig We compared the deduced amino acid sequences of LaEcR-A and LaRXR with those of EcRs and USPs ... the elucidation of EcR and USP (RXR) structures is important for understanding the molecular mechanism of the action of 20E In this study, we report the cloning of cDNAs for EcR and RXR from an...
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Báo cáo khoa học: Molecular analysis of the interaction between cardosin A and phospholipase Da Identification of RGD/KGE sequences as binding motifs for C2 domains pdf
Ngày tải lên :
30/03/2014, 11:20
... of charge and is positioned at the tip of a loop and is therefore reminiscent of RGD sequences present in integrin-binding molecules because of its exposed location On the basis of these structural ... located at the surface of the protein [4] The presence of this wellknown integrin-binding motif [11], and the previous purification of a cardosin A-binding protein from pollen, raised the idea that ... illustrated by the superimposition of the 3D structures of kistrin [32] and cardosin A (Fig 8) The importance of both motifs and in particular their basic residues was further emphasized by the complete...
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Báo cáo khoa học: Role of the N- and C-terminal regions of the PufX protein in the structural organization of the photosynthetic core complex of Rhodobacter sphaeroides pptx
Ngày tải lên :
31/03/2014, 09:20
... could influence the shortening processes of the assembled PufX protein The exchange of ubiquinone between the RC and the cyt bc1 in the presence of mutated PufX protein The role of the PufX protein ... toward/from the RC QB site A previous work on Rb sphaeroides demonstrated the role of the C-terminal amino-acid residues of the LH1 a polypeptide in the organization of the LH1–RC complex [12] In the present ... neither affects the photosynthetic capability of the bacteria nor the efficiency of exchange of the ubiquinol molecules between the RC and the bc1, as judged from the reduction kinetics of cytochrome...
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structural and functional organization of the synapse
Ngày tải lên :
06/07/2014, 15:30
... must occur within the tiny space of the synapse, the precise molecular organization of proteins, lipids, and membranes at the synapse is paramount Given the central role of the synapse in neuronal ... deciphering the structural and functional organization of the synapse We have assembled leaders in the field of synapse biology to describe and distill the wonders and mysteries of the synapse ... along the same presynaptic axon vary greatly in their dimensions (Fig 6) The size of the dendritic spine and its synapse correlates nearly perfectly with the number of vesicles in the presynaptic...
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Báo cáo y học: "Increased circulating levels and salivary gland expression of interleukin-18 in patients with Sjögren''''s syndrome: relationship with autoantibody production and lymphoid organization of the periductal inflammatory infiltrate" pptx
Ngày tải lên :
09/08/2014, 01:23
... counted The histological evaluation of the number of foci, the presence of IL-18 in inflammatory foci and ducts, the degree of organization of the mononuclear aggregates, and the presence of germinal ... salivary gland of SS, ductal IL-18 expression was observed both in the presence and in the absence of IL-18-producing cells in the periductal inflammatory foci and was also found in the absence of a ... fibrosis The lack of association between ductal IL-18 expression and the presence of periductal inflammation in all cases raises the intriguing possibility that the dysregulation of ductal IL-18 expression...
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Báo cáo y học: " Contrasting chromatin organization of CpG islands and exons in the human genome" pot
Ngày tải lên :
09/08/2014, 20:22
... bias, there will be no significant difference between the set of spliced exons and that of highly expressed exons Calculating the strength of exon splice sites The sum of the scores of the splice ... expressed genes It is the density of nucleosomes that differs between exons and introns Therefore, the absolute level of H3K36me3, the product of the nucleosome level and the relative modification ... exons of the transcript in question The difference between the read count of each exon and the average read count of all exons can indicate how inclusive or exclusive the mature transcript is of the...
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Báo cáo y học: " Molecular analysis of HBV genotypes and subgenotypes in the Central-East region of Tunisia" potx
Ngày tải lên :
12/08/2014, 02:20
... the region used for genotyping In addition to the risk of erroneous results, the limit of the rapid methods using classic PCR is the low sensitivity of DNA detection (the limit of detection of ... [9] The rate of HBsAg positivity varies widely from the north to the south of the country [9,10] Previous studies reported predominance of genotype D (over than 80%) with limited circulation of ... NH and OB conceived of the study, participated in its design, and in drafting the manuscript HT and JB participated in the study design and coordination and in discussing manuscript NH, NBF and...
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Báo cáo y học: " The role of the humoral immune response in the molecular evolution of the envelope C2, V3 and C3 regions in chronically HIV-2 infected patients" pdf
Ngày tải lên :
13/08/2014, 05:21
... for collecting the blood samples and the clinical data PG quantified the plasma viremia CN and PG helped with the interpretation of data and revision of the manuscript PB and NT preformed statistical ... identify the immune correlates of the molecular evolution of HIV-2 C2, V3 and C3 regions we have looked into all possible associations between the number of CD4+ T cells or the IgA and IgG antibody ... isolated the viruses and quantified the antibody responses HB and CR participated in virus isolation and in the sequencing analysis of some patients MD, FA and FM recruited the patients and were...
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Báo cáo y học: " Ancient, independent evolution and distinct molecular features of the novel human T-lymphotropic virus type 4" pot
Ngày tải lên :
13/08/2014, 05:21
... Figure Organization of the HTLV-4 genome (a) and schematic representation of the PCR-based genome walking strategy (b) Organization of the HTLV-4 genome (a) and schematic representation of the PCR-based ... sequence of the HTLV-4(1863LE) LTR and preNucleotide sequence of the HTLV-4(1863LE) LTR and pre- gag region The U3-R-U5 locations (vertical lines), the pre- B cell leukemia (Pbx-1, TGACAG) and c-Myb ... Disease Control and Prevention The findings and conclusions in this report are those of the authors and not necessarily represent the views of the Centers for Disease Control and Prevention K.N.P...
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Báo cáo y học: "Effects of ischemic pre- and postconditioning on HIF-1a, VEGF and TGF-b expression after warm ischemia and reperfusion in the rat liver" ppsx
Ngày tải lên :
13/08/2014, 13:20
... angiogenesis The aim of the present study was to examine how ischemia, with or without IPC and IPO, affects the expression of HIF-1a and the target genes VEGF and TGF-b1, in rodent liver Methods The surgical ... inactivates the degradation causing stabilization of the HIF-1a protein, which then translocate to the nucleus and forms dimers with the b-subunit [17] The active form of HIF-1 transactivates other ... and 30 minutes of reperfusion compared to the control group The main finding of this study was an absent of HIF-1a induction in IPC or IPC+IPO treated animals In both of these groups, the expression...
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Báo cáo y học: "Molecular model of the outward facing state of the human P-glycoprotein (ABCB1), and comparison to a model of the human MRP5 (ABCC5)" docx
Ngày tải lên :
13/08/2014, 16:21
... 9–12 of TMD2, and one part consisting of TMHs and of TMD2 and TMHs 3–6 of TMD1 (Figure 2) Interactions between the NBDs were relatively hydrophilic, and the secondary structure of the areas of ... comparative analysis of the ABCB1 and ABCC5 models in order to understand the molecular concepts of the substrate difference between ABCB1 and ABCC5 The comparative analysis included the electrostatic ... interactions with the surroundings of the model The best fitting loops are selected based on their relative energies N- and C-terminals were not included in the models Because of the length of the loop...
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designing clothes culture and organization of the fashion industry
Ngày tải lên :
21/08/2015, 17:30
... done in the interest of protecting the privacy of those mentioned in the book The reader should note that the information in this book represents the opinions and assessments of the author, and should ... be put forward by the firm, yet the identity of the brand must maintain a coherent representation in the minds of consumers In addition to taking account of the contingencies of the market, fashion ... is “born with the Renaissance, with the destruction of the feudal order by the bourgeois order and the emergence of overt competition at the level of signs of distinction.” In this previous social...
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