molecular modeling of amp 945 2 adrenergic ligands
Spectral stability study and molecular modeling of fluorence based conjugated polymers 2
... study of electronic structure of conjugated polymers, which contain extended πconjugated chain and exhibit unusual color changes 2- 1 -2 Photoluminescence spectroscopy (PL) During the process of absorbing ... after excitation by photons 2- 1-3 Differential scanning calorimetry (DSC) DSC measures the heat flow of a sample with increasing temperature, and is a determinant of exo/endothermic transitions ... the aim of overcoming some common defects in MNDO (Modified Neglect of Diatomic Overlap), such as overestimation of energies for sterically crowded molecules and inadequate description of hydrogen...
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Tài liệu Modeling of Data part 2 doc
... are often taught, rather casually, that, on average, measurements will fall within ±σ of the true value 68 percent of the time, within 2 95 percent of the time, and within ±3σ 99.7 percent of ... 15 Modeling of Data estimate of the model parameters is obtained by minimizing the quantity N 2 ≡ i=1 yi − y(xi ; a1 aM ) σi (15.1.5) Sample page from NUMERICAL RECIPES IN C: THE ART OF SCIENTIFIC ... problem of fitting a set of N data points (xi , yi ) to a straight-line model y(x) = y(x; a, b) = a + bx (15 .2. 1) Sample page from NUMERICAL RECIPES IN C: THE ART OF SCIENTIFIC COMPUTING (ISBN 0- 521 -43108-5)...
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Tài liệu Báo cáo Y học: Molecular modeling of the dimeric structure of human lipoprotein lipase and functional studies of the carboxyl-terminal domain docx
... et al (Eur J Biochem 26 9) Ó FEBS 20 02 Fig Molecular modeling of the dimeric structure of LPL Two dimeric model structures of LPL were constructed using INSIGHT II version 20 00 on a Silicon Graphics ... Cys239 and Cys216 (black) and two distinct structures of the lid (orange) Ó FEBS 20 02 Dimeric model structure and function of lipoprotein lipase (Eur J Biochem 26 9) 4705 Table Heparin affinity of ... emission from 4 32 nm to 505 nm [28 ] The product of the lipase reaction, free fatty acid, was measured after the addition of ADIFAB to Ó FEBS 20 02 Dimeric model structure and function of lipoprotein...
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Báo cáo khoa học: Functional fine-mapping and molecular modeling of a conserved loop epitope of the measles virus hemagglutinin protein pdf
... virus encephalitis Ó FEBS 20 03 1 526 M M Putz et al (Eur J Biochem 27 0) ¨ 10 11 12 13 14 15 16 17 18 19 20 21 22 23 by monoclonal antibodies binding to a cystine loop domain of the H protein mimicked ... binding of free mAb BH216 in solution to the immobilized reporter peptide during an association time of 180 s and a dissociation time of 120 s at a constant flow rate of 20 lLÆmin)1 at 25 °C The ... capacity) of (29 0 /24 96.8)Æ150 000 ¼ 17 422 RU, if every immobilized peptide molecule bound one antibody molecule With 15 nM of mAb BH216, Req (defined as the steady-state binding level) values of 144...
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Báo cáo khoa học: Enzymatic characterization and molecular modeling of an evolutionarily interesting fungal b-N-acetylhexosaminidase pot
... 2a 721 a 0.13 ± 0.01 0.54 ± 0.04 347 ± 13a 26 69a 1.10 ± 0.07 n.i 563 ± 17 511 1.01 ± 0. 02 n.i 22 7 ± 22 4 1.04 ± 0.06 n.i 723 ± 21 695 2. 02 ± 0 .22 n.i 419 ± 20 7 0.07 ± 0.01 0.06 ± 0.01 16 ± 1a 22 9a ... Fenice M (20 01) The chitinolytic activity of Penicillium janthin- b-N-Acetylhexosaminidase from Penicillium oxalicum 17 18 19 20 21 22 23 24 25 26 27 28 29 30 ellum P9: purification, partial characterization ... belonging to clade B [28 ,29 ]) such as a high ratio of GalNAc-ase ⁄ GlcNAc-ase activity and its FEBS Journal 27 8 (20 11) 24 69 24 84 ª 20 11 The Authors Journal compilation ª 20 11 FEBS 24 79 ˇ ´ H Ryslava...
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Báo cáo hóa học: " Quantification of the effects of an alpha-2 adrenergic agonist on reflex properties in spinal cord injury using a system identification technique" pptx
... cats Journal of Neurophysiology 1998, 79(6) :29 41 -29 63 21 Delwaide P: Electrophysiological analysis of mode of action of muscle relaxants in spasticity Ann Neurol 1985, 17:90-95 Page of 22 Pierrot-Deseilligny ... delivery of 2 NE agonists [20 ] Tizanidine is an 2- adrenergic agonist and presumably acts on presynaptic terminals and on interneurons [21 ,22 ] within the spinal cord to restore noradrenergic ... November 20 09 Accepted: 23 June 20 10 Published: 23 June 20 10 © 20 10 Mirbagheri et al; licensee BioMed under the 7 :29 This is an Open Access from:and Rehabilitation 20 10,terms of the Creative Commons...
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Báo cáo y học: " Molecular characterization of porcine circovirus 2 isolated from diseased pigs co-infected with porcine reproductive and respiratory syndrome virus" pot
... 13I 91 22 T 13S 92 134 23 V 9N 12I 36T 151 28 T 17P 169 10R 33S 2G 190 19T 14S 12A 191 5R 13A 27 G 20 6 30I 15K 21 0 13E 14D 21 5 8I 37V 29 34T 11A 40 12 R 10S 88 41Q 4E 100 25 F 20 L 101 9Y 9N 1 02 ORF3 ... 77 105 ORF1 23 F 18M 22 L 27 I Received: 13 September 20 10 Accepted: 27 October 20 10 Published: 27 October 20 10 121 41T 14 F 31Y 39V 6L 53 39F 6I 57 34V 12 I 59 15R 7K 23 A 63 75 25 R 39N 11K 6K ... circovirus J Virol 20 02, 76: 323 2- 323 9 13 Tian K, Yu Y, Zhao T, et al: Emergence of fatal PRRSV variants: Unparalleled outbreaks of atypical PRRS in china and molecular dissection of the unique hallmark...
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Coordination chemistry of pyrazolone based schiff bases relevant to uranyl sequestering agents synthesis, characterization and 3d molecular modeling of some octa coordinate mono and binuclear di
... 109.5 120 120 – 120 120 – 120 120 – 120 120 – 120 195 196 197 198 199 20 0 20 1 20 2 20 3 20 4 20 5 20 6 20 7 20 8 20 9 21 0 21 1 21 2 21 3 21 4 21 5 21 6 21 7 21 8 21 9 22 0 22 1 22 2 22 3 22 4 22 5 22 6 22 7 22 8 22 9 23 0 23 1 ... 25 7 25 8 25 9 26 0 26 1 26 2 26 3 26 4 26 5 26 6 26 7 26 8 26 9 27 0 27 1 27 2 27 3 27 4 27 5 27 6 27 7 27 8 27 9 28 0 28 1 28 2 28 3 28 4 28 5 28 6 28 7 28 8 28 9 29 0 29 1 29 2 29 3 29 4 29 5 29 6 29 7 29 8 29 9 300 301 3 02 303 304 ... H( 125 )–C (24 )–C (25 ) H( 125 )–C (24 )–C (23 ) C (25 )–C (24 )–C (23 ) H( 124 )–C (23 )–C (24 ) H( 124 )–C (23 )–C (22 ) C (24 )–C (23 )–C (22 ) H( 127 )–C (26 )–C (25 ) H( 127 )–C (26 )–C (21 ) C (25 )–C (26 )–C (21 ) H( 123 )–C (22 )–C (23 ) H( 123 )–C (22 )–C (21 )...
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The role of ORF3 protein in the molecular pathogenesis of porcine circovirus 2 infection
... Introduction………………………………………………………… 2. 2 26 Materials and methods……………………………………………… 27 29 iii 2. 2.1 Viruses and cell culture……………………………………… 29 2. 2 .2 Generation of Mutant viruses and their characterization.…… 29 2. 2.3 Yeast ... 32 2 .2. 8 Histology…………………………………………………… 33 2. 2.9 Flow cytometry……………………………………………… 2. 3 34 Results……………………………………………………………… 35 2. 3.1 Mutations and genetic stability of the virus.………………… 35 2. 3 .2 Molecular ... kinetics of PCV2 108 Figure 26 Role of ORF3 in the release of PCV2 from infected cells……… …111 Figure 27 Role of ORF3 induced apoptosis on the In Vivo spread of PCV… 113 Figure 28 Role of Macrophages...
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Molecular modeling of localized collective motions and dynamics in proteins
... C-N-H C2-N-C C2-N-H C-C2-N C2-C-O C2-C-N O-C-N in degrees 119.8 121 .9 118.4 110.3 120 .4 116.6 122 .9 in kcal/(mol.degrees ^2) 35.0 50.0 38.0 80.0 80.0 70.0 80.0 29 PHD thesis National University of ... analysis (PCA), Monte Carlo methods [21 ,22 ,23 ,24 ] essential dynamics analysis (EDA) [25 ] or molecular optimal dynamic coordinates analysis [26 ] These aspects of Molecular Dynamics modelling have ... length of H-bond in proteins Table 2D Key parameters used in our caculations of the H-bonds in proteins Bond a(Å) r0(Å) V0 (mdyn Å) Lmax (Å) NH1-H-O 2. 884 2. 693 0. 025 7 3. 124 NZ-H-OG 2. 349 2. 805...
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Spectral stability study and molecular modeling of fluorence based conjugated polymers 5
... shown in Figure 5 .2 and Table 5 .2 90 E (eV) LUMO -2 -4 -6 -8 HOMO -10 I II III IV V VI VII Figure 5 .2 AM1 calculated energies of HOMO and LUMO of the various unit cells Table 5 .2 AM1 calculated ... 0.04 + 0.10 - 0 .20 - 0 .26 - 0. 72 The band gap of II is calculated to decrease by 0.05 eV with respect to that of I This band gap lowering is due to asymmetric destabilizations of the HOMO and ... between that of MEH-PPV and poly (2, 5-dicyano-1,4phenylene vinylene) Therefore we can infer that the band gap of poly (2, 5-dicyano1,4-phenylene vinylene) is less than 1. 92 eV The band gap of poly(paraphenylene...
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Spectral stability study and molecular modeling of fluorence based conjugated polymers 4
... 418 426 415 396 4 12 3 82 450 465 410 418 UV-vis absorption spectral parameters of the polymers Polymers PDHF PDHFDET PDHFCP λmax, Abs (nm) 3 82 355 369 74 For PDHFDDOP, with the concentration of ... that of PDHF This is attributed to the decrement of electron density in the backbone of polymer induced by the electronwithdrawing effect of the substituted groups The advantage of the backbone of ... Absorbance 1.4 0% 10% 10% (10 later) 90% 1 .2 0.8 90% (10 later) 0.6 0.4 0 .2 250 300 350 400 450 500 550 600 650 700 750 800 Wavelength (nm) b 25 0 Light Intensity 20 0 0% 10% 150 10% (10 later) 90% 100...
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Spectral stability study and molecular modeling of fluorence based conjugated polymers 3
... 62 >11600 2. 90 379 2. 88 451 585 39 PDHFP 11800 1.70 371 2. 92 446, 431 630 62 PDHFDHP 9400 1.54 324 3 .25 409 533 58 PDHFDMOP 27 700 1.78 3 72 2. 92 425 (448) 580 52 PDHFDHOP 50500 2. 00 373 2. 91 425 ... 425 (448) 575 49 PDHFDDOP 41400 2. 08 3 72 2. 92 425 560 46 Polymers Mn Mw/Mn 6400 PDOFBSF PDHF The PL spectra of the polymers in film states are shown in Figure 3 .2 Except PDHFDHP, which emits in ... improvement of thermal spectral stability of PDOFBSF compared to PDHF is thus attributed to the higher Tg of PDOFBSF Because of the relatively high planarity of polyfluorene backbone, PDOFBSF also...
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Spectral stability study and molecular modeling of fluorence based conjugated polymers 1
... poly(p-phenylenevinylene) 2. 5 n RO-PPV poly (2, 5-dialkoxy-p-phenyl 2. 2 OR enevinylene) n RO PT P3AT poly(3-alkylthiophene) S polythiophene S n R 2. 0 2. 0 S S n R PTV poly (2, 5-thiophenevinylene) S ... 19 92, 357, 477 24 Gao, J.; Heeger, A J.; Lee, J Y.; Kim, C Y., Synth Met., 1996, 82, 22 1 25 Cao, Y.; Yu, G.; Zhang, C.; Menon, R.; Heeger, A J., Appl Phys Lett., 1997, 70, 3191 26 Campbell, I H.; ... between 2, 7-dibromofluorene derivatives and 2, 7-diboronylfluorene derivatives [Figure 1.4(B)].59 The utilization of a phase transfer catalyst gives higher molecular weight (a number-average molecular...
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Tài liệu Báo cáo khoa học: Molecular modeling and functional characterization of the monomeric primase–polymerase domain from the Sulfolobus solfataricus plasmid pIT3 doc
... TEMP 20 -mer *5¢-CGAACCCGTTCTCGGAGCAC-3¢ oligo(dT )28 66 45 36 29 24 Rep245 20 M C kDa 66 45 36 29 24 Rep516 Rep245 20 14 .2 Fig Schematic representation and production of truncated variants of the ... following regions: 31–60, 61– 123 , 128 –130, 136–141, 150–159, 164–184, 199 23 0 and 23 3 24 4 of the Rep245 protein, i.e all regions except those with gaps ⁄ inser- tions In the Rep245 model, all secondary ... FEBS Journal 27 5 (20 08) 4389–44 02 ª 20 08 The Authors Journal compilation ª 20 08 FEBS S Prato et al Analysis of the pIT3 prim–pol domain A Fig Structure-based sequence alignment of Rep245 prim–pol...
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Tài liệu Báo cáo khoa học: Molecular characterization and allergenic activity of Lyc e 2 (b-fructofuranosidase), a glycosylated allergen of tomato pdf
... between the two isoforms of the protein, only the molecular mass of 50 kDa would suggest that we had purified the truncated isoform Cloning of the cDNA of two isoforms of tomato b-fructofuranosidase ... Biochem 27 0) 1337 27 Laemmli, U.K (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4 Nature 22 7, 680–685 28 Katayama, H., Nagasu, T & Oda, Y (20 01) Improvement ... ¼ ¼ ¼ ¼ SPT pos 10) 2) 2) 3) 2) 0) 1) 1) 1) 5) 3) 0) 3/3 0/1 1/1 2/ 3 1 /2 0/0 0/0 1/1 0/1 3/3 3/3 0/0 Ó FEBS 20 03 1330 S Westphal et al (Eur J Biochem 27 0) For inhibition of IgE-binding : 10 diluted...
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Tài liệu Báo cáo khoa học: Molecular and functional characterization of adenylate kinase 2 gene from Leishmania donovani pdf
... M (1996) Ancient divergence of long and short isoforms of adenylate kinase: molecular evolution of the nucleoside monophosphate kinase family FEBS Lett 385, 21 4 22 0 Coombs, G.H (1986) Intermediary ... (19 92) Molecular characterization of cDNA encoding for adenylate kinase of rice (Oryza sativa L.) Plant J 2, 845–854 20 Brune, M., Schumann, R & Wittinghofer, F (1985) Cloning and sequencing of ... 575–580 25 Bradford, M.M (1976) A rapid and sensitive method for quantification of microgram quantities of protein utilising the principle of protein-dye binding Anal Biochem 72, 24 8 25 4 ´ 26 Sanchez,...
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Báo cáo khoa học: Binding of berberine to human telomeric quadruplex – spectroscopic, calorimetric and molecular modeling studies pot
... as telomerase inhibitors: 17 18 19 20 21 22 23 24 25 the interaction of tetra-(N-methyl-4-pyridyl)porphine with quadruplex DNA J Am Chem Soc 120 , 326 1– 326 2 Anantha NV, Azam M & Sheardy RD (1998) ... 10 15 20 25 30 )0 .2 )0.9 )1.3 )1.7 )2. 1 4.5 2. 0 0.8 0.4 0 .2 0.85 0.90 0.95 1.00 0.90 )8.5 )8.3 )7.9 )7.7 )7.3 8.3 7.4 6.6 6.0 5 .2 )94.0 (±5.0) 3974 (±0 .2) (±0 .2) (±0.3) (±0.3) (±0.3) (±0 .2) (±0.1) ... (A2) MH1 Quadruplex Berberine DAtot MH2 Quadruplex Berberine DAtot 3976 4306 424 8 550 = )493 4079 41 72 551 = )645 ˚ DAnp (A2) DAnp DAnp 1533 1370 459 = )29 6 1419 1 424 461 = )466 ˚ DAp (A2) 27 73...
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Báo cáo Y học: The cold-active lipase of Pseudomonas fragi Heterologous expression, biochemical characterization and molecular modeling pdf
... model was built These SCRs span the peptide segments 5 23 , 31–49, 54–68, 76– 120 , 129 –148, 155–181, 191 20 1, 21 4 21 8, 23 7 24 2, 24 5 26 7 and 27 7 29 3 of PFL It is interesting to note that most nonSCRs ... with the side-chains of S211 and D2 12 (S244 and T245 in BCL) In PFL, these residues are substituted by L219 and H 220 Due to the hydrophobic nature of leucine, the binding energy of the water molecule ... FEBS 20 02 3 322 C Alquati et al (Eur J Biochem 26 9) to + 924 ), where a restriction site for HindIII was inserted Reaction was carried out in a total volume of 100 lL and was catalyzed by 2. 5 U of...
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![Báo cáo khoa học: Benzo[a]pyrene impairs b-adrenergic stimulation of adipose tissue lipolysis and causes weight gain in mice A novel molecular mechanism of toxicity for a common food pollutant doc](https://media.store123doc.com/images/document/14/rc/rp/small_luUKRIz7Xm.jpg)
Báo cáo khoa học: Benzo[a]pyrene impairs b-adrenergic stimulation of adipose tissue lipolysis and causes weight gain in mice A novel molecular mechanism of toxicity for a common food pollutant doc
... inactivates cAMP by its conversion to 5 AMP [23 ,24 ] cAMP levels regulate FEBS Journal 27 3 (20 06) 13 62 13 72 ª 20 06 The Authors Journal compilation ª 20 06 FEBS 1363 Benzo[a]pyrene inhibition of lipolysis ... B[a]P (mg/L) 20 25 1.6 1 .2 0.8 0.4 25 10 15 20 30 Incubation time in the presence of B[a]P (min) 4.5 FFA release (mM/mg prot) 1.6 1 .2 0.8 0.4 0 10 15 B[a]P (mg/L) 20 25 E D ns 3.5 2. 5 * * * ** ... 58, 1 72 177 FEBS Journal 27 3 (20 06) 13 62 13 72 ª 20 06 The Authors Journal compilation ª 20 06 FEBS P Irigaray et al 15 Kazerouni N, Sinha R, Hsu CH, Greenberg A & Rothman N (20 01) Analysis of 20 0...
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