molecular mechanisms regulating spermatogonial stem cell fate decisions
Báo cáo khoa học: Molecular mechanisms regulating molting in a crustacean Halagowder Devaraj and Ayithan Natarajan ppt
... external signals across cell membranes into the intracellular signaling systems, which in turn lead to cell proliferation, differentiation, and other responses in human Schwann cells [7] Receptor ... organization [6], nerve cell growth or differentiation [7], tyrosine kinase receptor activity [7], and the negative [8] and positive [7] control of cell cycling in human Schwann cells Receptor tyrosine ... regulation of several cellular processes, such as proliferation and differentiation, and directly modulate cellular functions that influence gene transcription and translation in cancer cells [10] The...
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Molecular mechanisms of mechanosensing at cell cell and cell matrix adhesion 2
... at cell- adhesions As cell adhesions play a pivotal role in the proper function of cells, misregulation of cell adhesions often leads to severe pathological consequences Altered cell- cell and cell- matrix ... regulated molecular interactions that can be fine-tuned by conformation changes At subcellular level, vinculin plays important roles in regulating cell- matrix and cell- cell adhesions Cells lacking ... thesis work devotes to understand the molecular mechanisms of a key mechanosensing functional modules centered around the vinculin protein at cell- matrix and cell- cell junctions Part of the work is...
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Dual roles of transcription factor zic3 in regulating embryonic stem cell pluripotency and differentiation
... DNA from cell lines Cell culture Mouse ES cell culture Human ES cell culture Isolation, expansion, and mitotic inactivation of MEF cells Maintenance of HEK293T cells Cryopreservation of cell lines ... 1.1 Derivation of embryonic stem cells 1.2 Regulation of embryonic stem cells 1.2.1 The key properties of ES cells 1.2.2 Extrinsic signalling pathways maintaining ES cell pluripotency 1.3 Transcriptional ... germ-line8,9, ES cells are viewed as an important potential tool for clinical therapy and drug discovery10 1.2 Regulation of embryonic stem cells 1.2.1 The key properties of ES cells Embryonic stem cells...
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Mechanisms of neurodegeneration and stem cell migration a study of molecular signals in the model of axotomy
... of neural stem or progenitor cells in the SVZ………… 50 6.2.3 Migration of endogenous neural stem or progenitor cells……………… 51 6.2.3.1 Migration of endogenous neural stem or progenitor cells in the ... of transplanted neural stem or progenitor cells……… 52 6.2.4 Mechanisms of the migration of neural stem or progenitor cells in the SVZ …………………………………………………………… 53 6.2.4.1 Cell contact-mediating ... the vagus nerve system.……………………………….34 5.2 Degeneration of the vagal motoneurons in the model of vagotomy…………… 37 Cell replacement in the CNS: potential neuroregeneration by stem cells…………….38 6.1...
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Báo cáo khoa học: Differing molecular mechanisms appear to underlie early toxicity of prefibrillar HypF-N aggregates to different cell types potx
... pathways in HypF-aggregate-treated cells C Cecchi et al Fig Changes in intracellular free Ca2+ levels in IMR90 and Hend cells determined by confocal analysis Cells were exposed for 15, 30, 60, ... HypF-aggregate-treated cells Fig 1A (inset) showing a substantial lack of LDH release from both Hend and IMR90 cells exposed to aggregates Mechanisms of apoptotic death in exposed cells Fig Time course ... means ± SD of three independent experiments Time (h) IMR90 Apoptotic cells (%) Necrotic cells (%) Hend Apoptotic cells (%) Necrotic cells (%) 0.5 24 0.60 0.35 0.60 3.10 1.60 1.70 0.81 0.90 1.22 0.83...
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Effects of high glucose concentrations on the expression of genes involved in proliferation and cell fate specification of mouse embryonic neural stem cells
... involved in proliferation and cell fate specification of embryonic neural stem cells Society for Neuroscience 35th Annual Meeting, Abstract Number 24.10 (24 Neural Stem Cells in Brain Injury and ... High glucose alters the expression of genes involved in proliferation and cell- fate specification of embryonic neural stem cells Diabetologia (2006) 49: 1027-1038 J Fu, S S W Tay, E A Ling, S T ... mouse neural stem cells J Neurochem (In revision) Conference Abstracts: J Fu, S S W Tay, E A Ling, S T Dheen (2004) Analysis of proliferation and differentiation of neural stem cells in a high...
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Connecting brain tumor stem cells with their primary tumor and exploring glycogen synthase kinase 3ß regulation of cell fate
... patient‟s original tumor 1.3 GLIOMA STEM CELLS OR -PROPAGATING CELLS In recent years, the distinction between glioma stem cells, gliomainitiating or –propagating cells has been highlighted Elegant ... shed light on the role of neural stem cells as the transformational cells in GBM formation, hence their accurate terminology as glioma stem cells or -initiating cells14, 16, 17 Traditionally, the ... these cells in clinical specimens has followed the studies involving first, leukemic stem cells20 and now several other tumor systems21-24; namely, tumor-initiating capacity was defined as cells...
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Tế bào gốc (Stem cell)
... loại tế bào gốc trưởng thành giai đoạn biệt hóa thấp c/ Tế bào gốc trưởng thành (Adult stem cells/Somatic stem cells): Còn gọi tế bào gốc thân Là tế bào chưa biệt hóa tìm thấy với số lượng mô người ... tế bào gốc thai, tế bào gốc trưởng thành a/ Tế bào gốc phôi (Embryonic stem cells-ESCs) tế bào mầm phôi (Embryonic germ cells) Tế bào gốc phôi tế bào gốc vạn lấy từ phôi giai đoạn sớm (4-7 ngày ... tế bào, mô định Các tế bào gốc phôi lấy từ khối tế bào bên (inner cell mass) tế bào gốc vạn c/ Tế bào gốc đa (multipotent stem cells): Là tế bào có khả biệt hóa thành nhiều loại tế bào thể từ...
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Tài liệu OXIDATIVE STRESS – MOLECULAR MECHANISMS AND BIOLOGICAL EFFECTS doc
... OXIDATIVE STRESS MOLECULAR MECHANISMS AND BIOLOGICAL EFFECTS Edited by Volodymyr Lushchak and Halyna M Semchyshyn Oxidative Stress Molecular Mechanisms and Biological Effects ... information gained from yeasts This is a very popular classic eukaryotic model system to disclose molecular mechanisms of cellular responses to oxidative stress (Lushchak, 2010) In the first chapter ... cellular constituents and its evaluation Above we mentioned that ROS can interact with virtually all cellular components, namely lipids, carbohydrates, proteins, Oxidative Stress Molecular Mechanisms...
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Tài liệu Review of Chronic Graft- Versus-Host Disease in Children After Allogeneic Stem Cell Transplantation: Nursing Perspective pptx
... common after peripheral blood stem cell transplantation than BMT because it is generally accepted that peripheral blood stem cells con tain greater numbers of infused T-cells (Bishop, 2009; Schmitz ... graft-versus-host disease; PBSCT, peripheral blood stem cell transplantation; BMT, bone marrow transplantation; UBMT, unrelated bone marrow transplantation; T-UBMT, T -cell- depleted bone marrow transplantation; ... double-positive cells expressing CD4+CD8+ antigens These double-positive cells undergo a process referred to as negative selection or apoptosis (Kansu, 2004) Only a few CD4 or CD8 single-positive cells...
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Tài liệu INNOVATIONS IN STEM CELL TRANSPLANTATION doc
... any cell type A stem cell does not differentiate directly to a specialized cell, however There are often multiple intermediate stages A stem cell will first differentiate to a progenitor cell ... investigating the role of stem cells in cell transplantation or regenerative medicine increased remarkably across all sections of the stem cell related journals The largest number of stem cell articles was ... aspects of stem cells and cell transplantation Although we are close to finding pathways for stem cell therapies in many medical conditions, scientists need to be careful how they use stem cells ethically...
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Tài liệu Báo cáo khoa học: Multisite protein phosphorylation – from molecular mechanisms to kinetic models pdf
... Schlessinger J (2000) Cell signaling by receptor tyrosine kinases Cell 103, 211–225 10 Acuto O, Bartolo VD & Michel F (2008) Tailoring T -cell receptor signals by proximal negative feedback mechanisms Nat ... curve between random and sequential mechanisms becomes more pronounced when the number of phosphorylation sites is large In addition to these intramolecular mechanisms, competition between several ... Precise timing of molecular events Multisite phosphorylation may function as a precise timing device, allowing synchronization of molecular events In eukaryotes, a complex molecular machinery...
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Tài liệu New Advances in Stem Cell Transplantation Edited by Taner Demirer ppt
... remain a stem cell, or become another type of cell with a more specialized function, such as a muscle cell, a red blood cell, or a brain cell Because of the unique abilities of stem cells, as ... Keratinocytes ND ND Neural stem cells
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Guidelines for Human Embryonic Stem Cell Research potx
... this report are common to other areas of human stem cell research, such as research with adult stem cells, fetal stem cells, or embryonic germ cells derived from fetal tissue Institutions and ... Embryonic Stem Cell Research http://www.nap.edu/catalog/11278.html Introduction Stem cells are capable of self-renewal and also of differentiation into specialized cells Some stem cells are more ... types of cells It is believed that stem cells also form reservoirs of repair cells to replace cells and tissues that degenerate over the life span of the organism The dual capacity of stem cells...
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Báo cáo khoa học: Polypyrimidine tract-binding protein is essential for early mouse development and embryonic stem cell proliferation potx
... disruption of Ptb in ES cells Ptb) ⁄ flox ES cells were generated by expression of Cre in Ptb) ⁄ flox-hyg ES cells Ptb) ⁄ ) ES cells were generated by infection of Ptb) ⁄ flox ES cells with a retroviral ... Ptb) ⁄ ) ES cells was reduced as compared with wild-type cells (C) Impairment of cell proliferation seen in the Ptb) ⁄ ) ES cells was rescued by ectopic expression of PTB Ptb) ⁄ ) ES cell clones ... ) ES cells exhibit reduced cell proliferation A Relative gene expression although the expression of a part of ES cell- specific markers was reduced in Ptb) ⁄ ) ES cells, both Ptb) ⁄ ) ES cell clones...
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Báo cáo khoa học: Unusual stability of human neuroglobin at low pH – molecular mechanisms and biological significance docx
... cytoglobin: molecular mechanisms and physiological significance J Biol Chem 279, 44417–44426 11 Burmester T & Hankeln T (2004) Neuroglobin: a respiratory protein of the nervous system News Physiol ... neuroprotective role under conditions of reduced oxygen availability, such as stroke [19] Brain intracellular and extracellular acidosis is an important feature of cerebral ischemic–hypoxic conditions The neuronal ... and prompts consideration of other mechanisms for the neuroprotective action of Ngb [10,11,70,71] It is noteworthy that Ngb was shown to be involved in the cellular detoxification of free radicals...
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Báo cáo khoa học: Molecular mechanisms of the phospho-dependent prolyl cis ⁄ trans isomerase Pin1 docx
... excellent general reviews on Pin1 [11–14] or to those reviews that emphasize its role in cellular processes related to diseases [15–17], we focus here on what is known about the molecular mechanisms ... isomerization: a novel cell cycle regulatory mechanism Prog Cell Cycle Res 4, 83–96 FEBS Journal 274 (2007) 5211–5222 ª 2007 The Authors Journal compilation ª 2007 FEBS 5219 Molecular mechanisms of Pin1 ... Molecular mechanisms of Pin1 G Lippens et al mere interaction of CypA with Gag might protect the virion from an as yet poorly identified cellular integration factor...
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Báo cáo Y học: Molecular mechanisms underlying SHP-1 gene expression potx
... Lymphoma cell line (i.e hematopoietic); HeLa and HT1080 are human epithelial cancer cell lines BW5147 is a mouse T -cell line and L cell are a mouse epithelial cell line RNA from the cell lines ... (B) cell lines and untransformed cells (II)SHP-1 Human cells Epithelial cell lines HeLa CAOV3 Calu I SKOV3 MDA453 HT1080 Hematopoietic cell lines K562 Raji HL60 BL-JC CEM U937 Hematopoietic cells ... TON-photohaemagglutinin Mouse cells Epithelial cells lines Y1 L cells LA-4 MMT060562 Hematopoietic cell lines BW5147 M1 NFS-5C1 J774 IC21 70Z/3 J558L A20 Hematopoietic cells Splenic T cells Thymus 0 0 (I)SHP-1...
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