molecular mechanisms of metastasis epithelial mesenchymal transition anoikis and loss of adhes
Báo cáo y học: "Relevance of the stroma and epithelial-mesenchymal transition (EMT) for the rheumatic diseases" docx
... genes and initiate epithelial- mesenchymal transition Complexes of Smad7 and Smurf1 or Smurf2 promote ubiquination and degradation of activated receptors limiting the intensity and duration of signaling ... completion of EMT: loss of epithelial adhesion properties; de novo alpha smooth muscle actin (αSMA) expression and actin reorganization; disruption of TBM; and enhanced cell migration and invasion ... the loss of constraints imposed by cell-cell adhesion, that is, EMT The level of E-cadherin expression is often inversely correlated with tumor grade and stage and inactivating mutations of E-cadherin...
- 11
- 622
- 0
Báo cáo y học: " Effects of PPARg ligands on TGF-b1-induced epithelial-mesenchymal transition in alveolar epithelial cells" ppsx
... Page of 13 Figure Regulation of TGF-b1-induced E-cadherin expression by PPARg ligands (A) Effect of TGF-b1 on expression of epithelial marker E-cad (n = 4) (B) Effect of RGZ on regulation of E-cad ... http://respiratory-research.com/content/11/1/21 Page of 13 Figure Regulation of TGF-b1-induced N-cadherin expression by PPARg ligands (A) Effect of TGF-b1 on expression of mesenchymal marker N-cad (n = 4) (B) Effect of PPARg ligands on ... E-cadherin and N-cadherin levels, and collagen I, CTGF and MMP-2 gene expression These markers facilitate identification of cells along the spectrum of transition from epithelial to mesenchymal...
- 13
- 242
- 0
Báo cáo khoa học: Molecular mechanisms of the phospho-dependent prolyl cis ⁄ trans isomerase Pin1 docx
... FEBS 5213 Molecular mechanisms of Pin1 G Lippens et al Fig Schematic view of the parallel between Pin1 and CKS in protein degradation Top: Model of the SCFCDC4 E3 ligase and the role of Pin1 Pin1 ... monomer and swapped dimer are mainly limited to the conformation of the Glu-Pro dipeptide in the hinge region between the last b-strand and the core of CKS The crystal structure of the complex of ... exact role of Pin1 in human disease, and Molecular mechanisms of Pin1 thereby its potential as a molecular target for novel drugs Acknowledgements We thank two anonymous reviewers and Dr E Appella...
- 12
- 477
- 0
Chapter 114. Molecular Mechanisms of Microbial Pathogenesis (Part 1) potx
... presence of potentially pathogenic microbes in or on a host), infection (attachment and growth of pathogens and avoidance of host defenses), and disease (often, but not always, the result of activities ... bloodstream and multiply there Specific ligands or adhesins for host receptors constitute a major area of study in the field of microbial pathogenesis Adhesins comprise a wide range of surface ... pH, and other antimicrobial factors on skin Once it is damaged (and particularly if it becomes necrotic), the skin can be a major portal of entry and growth for pathogens and elaboration of their...
- 5
- 362
- 0
Chapter 114. Molecular Mechanisms of Microbial Pathogenesis (Part 2) potx
... Coxsackievirus Viral coat proteins CAR and histocompatibility major class I antigens Bacterial Pathogens Neisseria spp Pili Membrane cofactor protein (CD46) Pseudomonas Pili and flagella Asialo-GM1 Lipopolysaccharide ... Herpes simplex Glycoprotein C Heparan sulfate HIV Surface glycoprotein CD4 and chemokine herpesvirus type virus receptors (CCR5 and CXCR4) Epstein-Barr Envelope protein CD21 (=CR2) Adenovirus Fiber ... pneumophila Mycobacterium tuberculosis Fungal Pathogens Blastomyces dermatitidis Candida albicans matrix proteins and integrins Int1p Extracellular proteins matrix Protozoal Pathogens Plasmodium...
- 5
- 325
- 0
Chapter 114. Molecular Mechanisms of Microbial Pathogenesis (Part 3) doc
... factor receptor); members of the immunoglobulin superfamily; two proteins called nectin-1 and nectin-2; and modified heparan sulfate Bacterial Adhesins Among the microbial adhesins studied in greatest ... or P pilus adhesin that mediates binding to digalactose (gal-gal) residues on globosides of the human P blood groups Both of these types of pili have proteins located at the tips of the main ... structures A and B Traditional electron micrographic images of fixed cells of Pseudomonas aeruginosa Flagella (A) and pili (B) projecting out from the bacterial poles can be seen C and D Atomic...
- 5
- 272
- 0
Chapter 114. Molecular Mechanisms of Microbial Pathogenesis (Part 4) potx
... adherence of pathogenic Candida to host tissues These adhesins are expressed under certain environmental conditions (often associated with stress) and are crucial for pathogenesis of fungal infections ... described that mediate colonization of epithelial surfaces, particularly adherence to structures like fibronectin, laminin, and collagen The product of the Candida albicans INT1 gene, Int1p, bears ... surface polysaccharide composed of poly-N- acetylglucosamine One function of this polysaccharide is to promote binding to materials used in catheters and other types of implanted devices; poly-Nacetylglucosamine...
- 5
- 295
- 0
Chapter 114. Molecular Mechanisms of Microbial Pathogenesis (Part 5) ppt
... pathogens can form biofilms during in vitro growth, and it is increasingly accepted that this mode of growth contributes to microbial virulence and induction of disease Avoidance of Innate Host Defenses ... variety of host genetic factors, including production of interferons, modulation of receptors for viral entry, and age- and hormone-related susceptibility factors; by nutritional status; and even ... composed of a thick mucous layer that entraps microbes and facilitates their transport out of the body by such processes as mucociliary clearance, coughing, and urination Mucous secretions, saliva, and...
- 5
- 269
- 0
Chapter 114. Molecular Mechanisms of Microbial Pathogenesis (Part 6) docx
... epithelial cell entry may be primarily a manifestation of host defense, resulting in bacterial clearance by both shedding of epithelial cells containing internalized bacteria and initiation of ... airway-surface infection with P aeruginosa in 80–90% of patients with cystic fibrosis The failure of airway epithelial cells to ingest and promote the removal of P aeruginosa via a properly regulated inflammatory ... Figure 114-2 Entry of bacteria into epithelial cells A Internalization of P aeruginosa by cultured human airway epithelial cells expressing wild-type cystic fibrosis...
- 5
- 335
- 0
Chapter 114. Molecular Mechanisms of Microbial Pathogenesis (Part 7) ppsx
... structure of the microbial constituents that elicit inflammation, and detailed knowledge of these structures for bacterial pathogens has contributed greatly to our understanding of molecular mechanisms ... protein CD14 found on the surface of professional phagocytes, including migrating and tissue-fixed macrophages and PMNs A soluble form of CD14 is also found in plasma and on mucosal surfaces A plasma ... strategies employed by bacteria and by the fungal pathogen Cryptococcus neoformans is to elaborate large -molecular- weight surface polysaccharide antigens, often in the form of a capsule that coats the...
- 6
- 295
- 0
Chapter 114. Molecular Mechanisms of Microbial Pathogenesis (Part 8) pdf
... cytoplasmic domains of all known TLRs and also to receptors that are part of the IL-1 receptor (IL-1Rc) family Numerous studies have shown that MyD88-mediated transduction of signals from TLRs and IL-1Rc ... traversal of epithelial cell junctions, or penetration through denuded epithelial surfaces Among virulent Shigella strains and invasive E coli, outer-membrane proteins are critical to epithelial ... chemotaxis and kill these phagocytes Streptolysin O made by S pyogenes binds to cholesterol in phagocyte membranes and initiates a process of internal degranulation, with the release of normally...
- 5
- 286
- 0
Chapter 114. Molecular Mechanisms of Microbial Pathogenesis (Part 9) pot
... production is one of the best-characterized molecular mechanisms of pathogenesis, while host factors such as IL-1, TNF-α, kinins, inflammatory proteins, products of complement activation, and mediators ... invasion and destruction, toxin elaboration, and host response Viruses cause much of their damage by exerting a cytopathic effect on host cells and inhibiting host defenses The growth of bacterial, ... exotoxins A, S, T, and U; and pertussis toxin A number of these toxins (e.g., cholera toxin, diphtheria toxin, pertussis toxin, E coli heatlabile toxin, and P aeruginosa exotoxins A, S, and T) have...
- 5
- 268
- 0
Chapter 114. Molecular Mechanisms of Microbial Pathogenesis (Part 10) pps
... signs and symptoms of disease Infection promotes a complex series of host responses involving the complement, kinin, and coagulation pathways The production of cytokines such as IL-1, TNF-α, and ... signs and symptoms of septic shock The severity of septic shock is associated with the degree of production of host effectors Disease due to intracellular parasitism results from the formation of ... nitric oxide, superoxide, and hypochlorite Morphogenic variation and production of proteases (e.g., the Candida aspartyl proteinase) have been implicated in fungal invasion of host tissues If pathogens...
- 5
- 277
- 0
Chapter 114. Molecular Mechanisms of Microbial Pathogenesis (Part 11) pps
... in the formation of infectious foci In summary, the molecular mechanisms used by pathogens to colonize, invade, infect, and disrupt the host are numerous and diverse Each phase of the infectious ... recognition of viral infection Nat Immunol 7:131, 2006 [PMID: 16424890] Knirel YA et al: Structural features and structural variability of the lipopolysaccharide of Yersinia pestis, the cause of plague ... Interaction of pathogenic fungi with host cells: Molecular and cellular approaches FEMS Immunol Med Microbiol 45:383, 2005 [PMID: 16087326] Pizarro-Cerda J, Cossart P: Bacterial adhesion and entry...
- 5
- 130
- 0
Báo cáo y học: " Molecular mechanisms of autoimmunity triggered by microbial infection" potx
... by several coincident mechanisms that relate to the presence of autoreactive immune cell subsets and loss of tolerance Tolerance is maintained by controlling autoreactive T and B cells as well ... Sweet MJ, Hume DA: The molecular basis for the lack of immunostimulatory activity of vertebrate DNA J Immunol 2003, 170:3614-3620 76 Bird AP: CpG-rich islands and the function of DNA methylation ... mice and humans include: the expression of TLR3 by murine but not human macrophages (Table 2); the expression of TLR8 by human but not murine myeloid dendritic cells; and the expression of TLR9...
- 10
- 355
- 0
Báo cáo y học: " Cellular and molecular mechanisms of cigarette smoke-induced lung damage and prevention by vitamin c" ppsx
... known whether p-BSQ of CS causes apoptosis and emphysematous lung damage We have addressed this question for better understanding of the cellular and molecular mechanisms of emphysema, so that ... and Bcl-2 of the lung extracts of guinea pigs exposed to air or CS supplemented with A, Immunoblots of caspase 3, PARP, A, Immunoblots of caspase 3, PARP, Bax and Bcl-2 of the lung extracts of ... mean perimeter (contour length) of air space and A is the area of air space [6] The number of air spaces and the S/V values calculated after 7, 14 and 21 days of smoke exposure are significantly...
- 22
- 301
- 0
Báo cáo y học: "Lung epithelium as a sentinel and effector system in pneumonia – molecular mechanisms of pathogen " pdf
... burden of pneumonia, the increasing number of antibiotic- resistant bacteria, and the emergence of new pulmonary pathogens into account, an exact analysis of molecular mechanisms of disease is mandatory ... liberation of immunodulatory cyto- and chemokines and up-regulation of adhesion molecules mediates the acute immune response by e.g recruitment of leucocytes to the site of infection and modulates ... of TLR1-3 but decrease the expression of TLR5 and TLR6 [79] Increased expression as well as membrane localization of TLR3 [95] and TLR4 [70] have been observed after RSV infection of airway epithelial...
- 17
- 287
- 0
Báo cáo y học: "Molecular mechanisms of severe acute respiratory syndrome (SARS)" pot
... identification of a new coronavirus as the causative agent of SARS and of a southern Chinese province as the first area of occurrence, animal species of this area have been speculated to be the origin of ... spikes of the SARS-CoV (Figure 3) Intra- and extracellular proteases often cleave the S protein into S1 and S2 domains, with the cleavage process often increasing infectivity of the virus Molecular ... treatment is of major importance [60] Molecular mechanisms of SARS virus pathogenesis Cytocidal mechanisms Coronaviruses are known to exert their effects by cytocidal and immune-mediated mechanisms...
- 16
- 423
- 0
Báo cáo y học: " Molecular mechanisms of neuroinvasion by monocytes-macrophages in HIV-1 infection" pdf
... expression of occludin, ZO-1, and ZO-2 in the caveolar compartment of HBMECs The effect of Tat is dependent on caveolin-1 and its modulation of Ras signaling Drugs of Abuse and Alcohol Abuse of psycho-stimulatory ... and addictive drugs seems to increase the risk of HIV-1 infection and of the development of HAND [127-130] HIV Tat and morphine apparently cooperate in diminishing the electrical resistance and ... BBB components, chemotaxis, regulation of adhesion molecules and tight junction proteins, and last not least the potential influence of drugs of abuse Gras and Kaul Retrovirology 2010, 7:30 http://www.retrovirology.com/content/7/1/30...
- 11
- 332
- 0
Báo cáo y học: " Molecular mechanisms of HIV-1 persistence in the monocyte-macrophage lineage" ppt
... Bcl-2 and Bcl-XL proteins and a decrease of pro-apoptotic Bax and Bad proteins [139] The role in apoptosis of viral proteins is often dual The protein Nef is a regulating protein expressed early and ... Various mechanisms are involved in this form of latency, such as hypermutation of the DNA induced by the restriction factor APOBEC3, a low level of dNTP pool and an impaired nuclear importation of ... HIV-1, and this favors the establishment and maintenance of latency [124] Recently, it was shown that miRNAs regulate the expression of the histone acetyltransferase Tat cofactor PCAF, and HIV...
- 16
- 299
- 0
Tìm thêm: xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ đặc tuyến hiệu suất h fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose