molecular mechanisms of cell death
Molecular mechanisms of mechanosensing at cell cell and cell matrix adhesion 2
Ngày tải lên :
09/09/2015, 08:13
... at cell- adhesions As cell adhesions play a pivotal role in the proper function of cells, misregulation of cell adhesions often leads to severe pathological consequences Altered cell- cell and cell- matrix ... the formation and functioning of tissues Cell- cell adhesion is one of the corner stones in the arising of multicellular organisms Depending on the context, cell- cell adhesion could serve different ... MOLECULAR MECHANISMS OF MECHANOSENSING AT CELL- CELL AND CELL- MATRIX ADHESIONS YAO MINGXI B Sci (Hons.), NUS, 2009 A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY MECHANOBIOLOGY...
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Báo cáo khoa học: Post-ischemic brain damage: the endocannabinoid system in the mechanisms of neuronal death ppt
Ngày tải lên :
07/03/2014, 03:20
... amounts of nitric oxide (NO) generated by pathological expression of NO synthase isoforms are certainly neurotoxic, whereas homeostatic levels of NO produced by the endothelial isoform of this ... mediators of CB-induced hypothermia [89] Activation of cytoprotective/anti-apoptotic signaling pathways Biochemical pathways that trigger apoptotic cell death or cytoprotective cellular mechanisms ... stroke and in the mechanisms of post-ischemic neuronal death (Table 1) To this end, models of focal and global ischemia in vivo, with or without reperfusion, as well as models of oxygen glucose...
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Báo cáo khoa học: Molecular mechanisms of the phospho-dependent prolyl cis ⁄ trans isomerase Pin1 docx
Ngày tải lên :
07/03/2014, 05:20
... et al Molecular mechanisms of Pin1 tPro213 Fig NOESY spectrum of the triply phosphorylated SRSRpT212PpS214LPpT217PPTR peptide of Tau The cis conformation for the Pro219 is below the limit of detection ... 2007 FEBS 5215 Molecular mechanisms of Pin1 G Lippens et al populations, as one of the forms would continuously disappear from the pool of free peptides Structural characterization of the MPM-2 ... redundancy of protein copy numbers in the cell, at least under normal growth conditions Indeed, they found that although wild-type yeast cells contain on the order of 200 000 molecules of Ess1 per cell, ...
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Chapter 114. Molecular Mechanisms of Microbial Pathogenesis (Part 1) potx
Ngày tải lên :
07/07/2014, 04:20
... any part of a host organism In general, the type of disease produced by a particular microbe is often a direct consequence of its route of entry into the body The most common sites of entry are ... presence of potentially pathogenic microbes in or on a host), infection (attachment and growth of pathogens and avoidance of host defenses), and disease (often, but not always, the result of activities ... constitute a major area of study in the field of microbial pathogenesis Adhesins comprise a wide range of surface structures, not only anchoring the microbe to a tissue and promoting cellular entry where...
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Chapter 114. Molecular Mechanisms of Microbial Pathogenesis (Part 2) potx
Ngày tải lên :
07/07/2014, 04:20
... and histocompatibility major class I antigens Bacterial Pathogens Neisseria spp Pili Membrane cofactor protein (CD46) Pseudomonas Pili and flagella Asialo-GM1 Lipopolysaccharide Cystic aeruginosa ... Fungal Pathogens Blastomyces dermatitidis Candida albicans matrix proteins and integrins Int1p Extracellular proteins matrix Protozoal Pathogens Plasmodium Merozoite form Duffy Fy antigen Plasmodium ... vivax falciparum Entamoeba protein 175 (EBA-175) Surface lectin histolytica a A novel dendritic cell specific C-type lectin N-Acetylglucosamine ...
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Chapter 114. Molecular Mechanisms of Microbial Pathogenesis (Part 3) doc
Ngày tải lên :
07/07/2014, 04:20
... individual cell may have pili with a variety of functions Most pili are made up of a major pilin protein subunit (molecular weight, 17,000–30,000) that polymerizes to form the pilus Many strains of Escherichia ... residues on globosides of the human P blood groups Both of these types of pili have proteins located at the tips of the main pilus unit that are critical to the binding specificity of the whole pilus ... micrographic images of fixed cells of Pseudomonas aeruginosa Flagella (A) and pili (B) projecting out from the bacterial poles can be seen C and D Atomic force microscopic image of live P aeruginosa...
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Chapter 114. Molecular Mechanisms of Microbial Pathogenesis (Part 4) potx
Ngày tải lên :
07/07/2014, 04:20
... that bind to extracellular matrix proteins Transformation of normally nonadherent Saccharomyces cerevisiae with this gene allows these yeast cells to adhere to human epithelial cells The agglutinin-like ... endothelial cells under inflammatory conditions Host Receptors Host receptors are found both on target cells (e.g., epithelial cells lining mucosal surfaces) and within the mucous layer covering these cells ... that is probably attributable to different concentrations of cell surface molecules, including microbial adhesins, at specific places on the cell surface (Fig114-1D ) Fungal Adhesins Several fungal...
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Chapter 114. Molecular Mechanisms of Microbial Pathogenesis (Part 5) ppt
Ngày tải lên :
07/07/2014, 04:20
... distinct from the free-living individual cells referred to as planktonic cells Growth in biofilms leads to altered microbial metabolism, production of extracellular virulence factors, and decreased ... grow The growth of viral pathogens entering skin or mucosal epithelial cells can be limited by a variety of host genetic factors, including production of interferons, modulation of receptors for ... virulence and induction of disease Avoidance of Innate Host Defenses As microbes have probably interacted with mucosal/epithelial surfaces since the emergence of multicellular organisms, it is...
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Chapter 114. Molecular Mechanisms of Microbial Pathogenesis (Part 6) docx
Ngày tải lên :
07/07/2014, 04:20
... failure of airway epithelial cells to ingest and promote the removal of P aeruginosa via a properly regulated inflammatory response has been proposed as a key component of the hypersusceptibility of ... (CFTR), the cell receptor for bacterial ingestion B Entry of P aeruginosa into murine tracheal epithelial cells after infection by the intranasal route Curiously, the less virulent strains of many ... be primarily a manifestation of host defense, resulting in bacterial clearance by both shedding of epithelial cells containing internalized bacteria and initiation of a protective and nonpathogenic...
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Chapter 114. Molecular Mechanisms of Microbial Pathogenesis (Part 7) ppsx
Ngày tải lên :
07/07/2014, 04:20
... the fungal pathogen Cryptococcus neoformans is to elaborate large -molecular- weight surface polysaccharide antigens, often in the form of a capsule that coats the cell surface Most pathogenic bacteria ... structure of the microbial constituents that elicit inflammation, and detailed knowledge of these structures for bacterial pathogens has contributed greatly to our understanding of molecular mechanisms ... frequently found at sites of infection with protozoan or multicellular parasites Successful pathogens, by definition, must avoid being cleared by professional phagocytes One of several antiphagocytic...
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Chapter 114. Molecular Mechanisms of Microbial Pathogenesis (Part 8) pdf
Ngày tải lên :
07/07/2014, 04:20
... spread Bacteria may invade deeper layers of mucosal tissue via intracellular uptake by epithelial cells, traversal of epithelial cell junctions, or penetration through denuded epithelial surfaces ... PhoP/PhoQ genes control other genes, to enter and survive within cells; intracellular survival entails structural changes in the cell envelope LPS Tissue Invasion and Tissue Tropism Tissue Invasion ... proteins are critical to epithelial cell invasion and bacterial multiplication Neisseria and Haemophilus spp penetrate mucosal cells by poorly understood mechanisms before dissemination into...
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Chapter 114. Molecular Mechanisms of Microbial Pathogenesis (Part 9) pot
Ngày tải lên :
07/07/2014, 04:20
... stimulating certain T cells to proliferate without processing of the protein toxin by antigen-presenting cells Part of this process involves stimulation of the antigen-presenting cells to produce ... toxin production is one of the best-characterized molecular mechanisms of pathogenesis, while host factors such as IL-1, TNF-α, kinins, inflammatory proteins, products of complement activation, ... host target cells by means of a complex set of proteins referred to as the type III secretion system Loss or inactivation of this virulence system usually greatly reduces the capacity of a bacterial...
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Chapter 114. Molecular Mechanisms of Microbial Pathogenesis (Part 10) pps
Ngày tải lên :
07/07/2014, 04:20
... symptoms of septic shock The severity of septic shock is associated with the degree of production of host effectors Disease due to intracellular parasitism results from the formation of granulomas, ... neoformans and (possibly) levels of cell wall glucans in some pathogenic fungi, the molecular basis for fungal invasiveness is not well defined Melanism has been shown to protect the fungal cell ... provoke the formation of an abscess, probably because of the presence of zwitterionic surface polysaccharides such as the capsular polysaccharide of Bacteroides fragilis The outcome of an infection...
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Chapter 114. Molecular Mechanisms of Microbial Pathogenesis (Part 11) pps
Ngày tải lên :
07/07/2014, 04:20
... in the formation of infectious foci In summary, the molecular mechanisms used by pathogens to colonize, invade, infect, and disrupt the host are numerous and diverse Each phase of the infectious ... recognition of viral infection Nat Immunol 7:131, 2006 [PMID: 16424890] Knirel YA et al: Structural features and structural variability of the lipopolysaccharide of Yersinia pestis, the cause of plague ... Res 12:3, 2006 [PMID: 16420739] Mendes-Giannini MJ et al: Interaction of pathogenic fungi with host cells: Molecular and cellular approaches FEMS Immunol Med Microbiol 45:383, 2005 [PMID: 16087326]...
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Báo cáo y học: "Higher susceptibility to Fas ligand induced apoptosis and altered α modulation of cell death by tumor necrosis factor-α in periarticular tenocytes from patients with knee joint osteoarthritis" ppt
Ngày tải lên :
09/08/2014, 01:23
... modulation of signalling pathways downstream of Fas may alter significantly the susceptibility of cells to Fas induced cell death [17] However, the expression of Fas receptor on the cell surface ... higher rate of spontaneous apoptosis but also were significantly more susceptible to FasL mediated cell death Of note, apoptosis of fibroblast-like cells is regulated at a number of different ... mesenchymal, fibroblast-like cells, and alterations in the susceptibility of such cells to Fas-induced cell death have been strongly implicated in the pathogenesis of inflammatory joint diseases...
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Báo cáo y học: " Molecular mechanisms of autoimmunity triggered by microbial infection" potx
Ngày tải lên :
09/08/2014, 07:20
... dendritic cells and control of regulatory T cells In vertebrates, autoreactive T cells are kept under tight control by a number of mechanisms, including the suppressive effect of regulatory T cells ... cells 218 Specificity of TLR signalling The specificity of TLR signalling depends on their cell typespecific expression, the potential for heterodimerization of certain TLRs, and on a group of ... state of regulatory T cells They identified IL-6 to be this factor and showed that IL-6 can induce proliferation of autoreactive T cells through functional blockade of CD4+/CD25+ regulatory T cells...
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Báo cáo y học: " Cellular and molecular mechanisms of cigarette smoke-induced lung damage and prevention by vitamin c" ppsx
Ngày tải lên :
11/08/2014, 08:22
... mechanism of cell death, a process by which the cells eliminate unwanted damaged cells The markers of apoptosis include DNA fragmentation, activation of caspase and over expression of the proapoptotic ... compared to PBStreated cells, the per cent of cells with DNA damage is significantly high (p < 0.001, n = 3) following treatment of A549 cells with 50 μl of AECS (45% ± 7), 180 nmoles of p-BSQ (54% ± ... labelling (TUNEL) assay in A549 cells A549 cells (2 × 106) were treated with 50 μl of AECS, 180 nmoles of p-BSQ or 90 nmoles of p-BQ in culture medium at 37°C for 24 hours The cells were then fixed with...
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Báo cáo khoa học: "Mechanisms of cell entry by human papillomaviruses: an overview" pps
Ngày tải lên :
12/08/2014, 04:21
... by using VLPs, PsVs or QVs HPV-host cell interactions Cell surface binding: receptors Host cell entry of HPV is initiated by binding of the virus particle to cell surface receptors (Figure 1) It ... virions [8] Condon optimization of capsid genes yielded high-level expression of capsid proteins and the development of packaging cell lines harboring high copy numbers of packaging plasmids finally ... http://www.virologyj.com/content/7/1/11 Page of Figure Putative model of interaction of HPV capsids with the ECM and cell surface 1) HSPG, a widely expressed and evolutionary conserved cell surface receptor, is...
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Báo cáo y học: "Lung epithelium as a sentinel and effector system in pneumonia – molecular mechanisms of pathogen " pdf
Ngày tải lên :
12/08/2014, 16:20
... global burden of pneumonia, the increasing number of antibiotic- resistant bacteria, and the emergence of new pulmonary pathogens into account, an exact analysis of molecular mechanisms of disease ... consisting of ciliated cells, secretory goblet cells and cells with microvilli provide mechanisms for mucocilliary clearance In the bronchioles, cuboidal epithelium and secretory clara cells line ... Distribution and subcellular expression of TLRs differ between immune cells and epithelial cells Most results, however, were obtained by analysis of different (immortalized) cell lines and a systematic...
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Báo cáo y học: "Molecular mechanisms of severe acute respiratory syndrome (SARS)" pot
Ngày tải lên :
12/08/2014, 18:21
... identification of a new coronavirus as the causative agent of SARS and of a southern Chinese province as the first area of occurrence, animal species of this area have been speculated to be the origin of ... spikes of the SARS-CoV (Figure 3) Intra- and extracellular proteases often cleave the S protein into S1 and S2 domains, with the cleavage process often increasing infectivity of the virus Molecular ... treatment is of major importance [60] Molecular mechanisms of SARS virus pathogenesis Cytocidal mechanisms Coronaviruses are known to exert their effects by cytocidal and immune-mediated mechanisms...
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