molecular genetics of cellulose biosynthesis in trees
A medical molecular genetics of orofacial clefting role of ABC transporter polymorphisms in disease risk
Ngày tải lên :
16/09/2015, 14:04
... saquinavir, indinavir, dexamethasone, aldosterone, hydrocortisone, morphine, loperamide, quinidine, digoxin, amiodarone, Cyclosporin A (low concentration), Vincristine, Vinblastine, Daunorubicin, ... non-syndromic orofacial clefting For the family based study, 150 nuclear families of single affected offspring with oral clefs were recruited from Singapore and Taiwan The phenotype of interest included ... consist of two distinct domains, the hydrophobic transmembrane domain (TMD) and the hydrophilic nucleotide-binding domain (NBD) The TMD, also known as membrane-spanning domain (MSD) or integral...
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Báo cáo khoa học: The subcellular organization of strictosidine biosynthesis in Catharanthus roseus epidermis highlights several trans-tonoplast translocations of intermediate metabolites docx
Ngày tải lên :
15/03/2014, 00:20
... 3¢ ends of the coding sequence of the N-terminal (YFPN, amino acids 1–173) and C-terminal (YFPC, amino acids 156–239) fragments of YFP This led to the production of a set of four distinct fusion ... steps preceding the biosynthesis of the first MIA strictosidine within the epidermis This led us to establish a complete scheme of strictosidine biosynthesis in epidermal cells, highlighting several ... Compartmentalization of strictosidine biosynthesis G Guirimand et al Fig RT-PCR analysis of expression of G10H, LAMT and SLS in C roseus cells C20D cells cultured in either maintenance medium (MM) in presence of...
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Báo cáo khoa học: Recent insights into cerebral cavernous malformations: the molecular genetics of CCM pot
Ngày tải lên :
15/03/2014, 10:20
... [9–13] The CCM1 gene contains 16 coding exons which encode for Krit1, a 736-amino acid protein containing three ankyrin domains and one band 4.1 ezrin radixin moesin (FERM) domain CCM2, a 10-exon gene, ... splicing has been located within the C-terminal part of the phosphotyrosin binding domain of CCM2 [12] This mutation has been shown to abolish the interaction of CCM2 and CCM1, strongly suggesting ... germline mutations in CCM lesions Based on the autosomal dominant pattern of inheritance of CCM and the presence of multiple lesions in familial CCM, contrasting with the detection of a single...
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Báo cáo khoa học: Theoretical study of lipid biosynthesis in wild-type Escherichia coli and in a protoplast-type L-form using elementary flux mode analysis potx
Ngày tải lên :
22/03/2014, 21:20
... decarboxylated again (Fig 2) The remaining EFMs are capable of producing all of the main metabolites that we are interested in Obviously, in order to produce one of the forms of lipid A or phospholipids, ... study of lipid biosynthesis in E coli D Kenanov et al Introduction Lipid biosynthesis is a complex subsystem of metabolism, because of the chain elongation reactions of fatty acids and the combinatorial ... contain mutations in a cell wall-free mutant Examination of the EFMs remaining in the deficient system allowed us to estimate the significance of those enzymes The investigation also gave an idea of...
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Báo cáo khoa học: Molecular basis of cerebral neurodegeneration in prion diseases pdf
Ngày tải lên :
30/03/2014, 09:20
... mediate an interaction of PrPC with accessory proteins, such as transmembrane proteins involved in PrP-induced signaling Alternatively, deletion of the HD could indirectly affect intermolecular interactions ... or a combination of both (Fig 1) In the following, such in vivo models are described which address certain aspects of membrane topology, folding, intracellular targeting and trafficking of PrP The ... basolaterally, indicating that this domain acts as a dominant sorting signal Vice versa, Dpl or PrPC lacking the HD were found mainly at the apical surface of MDCK cells [36] An interesting activity of PrPC...
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molecular genetics of mammalian cells
Ngày tải lên :
11/04/2014, 09:52
... antigen Insulin-like growth factor carrier protein Plasminogen Prothrombin Retinol-binding protein Testosterone~estradiol-binding globulin Thyroxine-binding globulin Transcobalamin Transferrin Low-density ... Ceruloplasmin EGF stimulation of ornithine decarboxylase Fibrinogen Gc-Globulin Haptoglobin Hepatitis B surface antigen Insulin-like carrier protein Plasminogen Retinol-binding protein Transferrin Designation ... activation of adenylate cyclase Insulin receptors Insulin activation of glycogen synthetase and stimulation of glycogenesis Interaction with human antiinsulin receptor IgG Ribonuclease II Tyrosine aminotransferase...
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báo cáo hóa học:" Molecular Etiology of Hearing Impairment in Inner Mongolia: mutations in SLC26A4 gene and relevant phenotype analysis" ppt
Ngày tải lên :
18/06/2014, 15:20
... of Translational Medicine 2008, 6:74 Introduction Every year in China, about 30,000 children, compared to 840 in UK and one of every one thousand infants in US, are born with congenital hearing ... Huang D, Han D: Molecular etiology of patients with nonsyndromic hearing loss from deaf-muta schools in 18 provinces of China Chinese Journalof Otology 2006, 4:1-5 Cohen MM, Gorlin RJ: Epidemiology, ... or in combination with an incomplete partition of the apical turn of the cochlea as part of Mondini deformity PS is differentiated from nonsyndromic hearing loss with EVA by the presence of goiter,...
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Báo cáo sinh học: "Association between neuroserpin and molecular markers of brain damage in patients with acute ischemic stroke" pot
Ngày tải lên :
18/06/2014, 19:20
... Neuroserpin was used as a continuous variable since there was a linearity of the odds ratios for outcome The influence of neuroserpin decrease at 24 h on serum levels of molecular markers of brain injury ... defined as neuroserpin decrease All determinations were carried out in a laboratory blind to the clinical outcome and neuroimaging findings Endpoints The primary endpoint was the decrease of ... http://www.translational-medicine.com/content/9/1/58 our group obtained after investigating neuroserpin effects using an in vitro model of brain ischemia [40] The information reported here regarding biomarkers...
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Báo cáo sinh học: " Molecular biodiversity of cassava begomoviruses in Tanzania: evolution of cassava geminiviruses in Africa and evidence for East Africa being a center of diversity of cassava geminiviruses" pptx
Ngày tải lên :
18/06/2014, 22:20
... cassavagrowing areas of Tanzania in an effort towards identifying, determining molecular variability and mapping the distribution of CMGs In addition, because East Africa seems to be unusually rich in ... reported in East Africa, we investigated the extent of inter-CMG recombinations and examined their role in the evolution of CMGs in Africa Results Assessment of CMD symptoms Over 80% of the cassava ... mentioned in other general studies of geminivirus recombination [14] as well as in specific studies of particular groups of geminiviruses [20] Two categories of CMGs in Africa Based on recombination...
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báo cáo hóa học:" Association between neuroserpin and molecular markers of brain damage in patients with acute ischemic stroke" pdf
Ngày tải lên :
20/06/2014, 03:20
... Neuroserpin was used as a continuous variable since there was a linearity of the odds ratios for outcome The influence of neuroserpin decrease at 24 h on serum levels of molecular markers of brain injury ... defined as neuroserpin decrease All determinations were carried out in a laboratory blind to the clinical outcome and neuroimaging findings Endpoints The primary endpoint was the decrease of ... http://www.translational-medicine.com/content/9/1/58 our group obtained after investigating neuroserpin effects using an in vitro model of brain ischemia [40] The information reported here regarding biomarkers...
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báo cáo hóa học:" Molecular biodiversity of cassava begomoviruses in Tanzania: evolution of cassava geminiviruses in Africa and evidence for East Africa being a center of diversity of cassava geminiviruses" pot
Ngày tải lên :
20/06/2014, 04:20
... cassavagrowing areas of Tanzania in an effort towards identifying, determining molecular variability and mapping the distribution of CMGs In addition, because East Africa seems to be unusually rich in ... reported in East Africa, we investigated the extent of inter-CMG recombinations and examined their role in the evolution of CMGs in Africa Results Assessment of CMD symptoms Over 80% of the cassava ... mentioned in other general studies of geminivirus recombination [14] as well as in specific studies of particular groups of geminiviruses [20] Two categories of CMGs in Africa Based on recombination...
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Báo cáo khoa học: "Molecular analysis of hprt mutation in B6C3F1 mice exposed to ozone alone and combined treatment of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone and/or dibutyl phthalate for 32 and 52 weeks" ppsx
Ngày tải lên :
07/08/2014, 18:20
... hypoxanthine-guanine phosphoribosyltransferase (hprt) locus can provide information on the mechanisms of in vivo mutation in population exposed to exogenous carcinogens and in individual with inherent ... was used in a final volume of 20 µl RT-PCR containing µl of 10×VM buffer 10 mM MgCl2 (Promega, USA), 0.4 µl of each dNTP 25 mM (Promega, USA), 0.4 ml of oligo dT (0.5 µg/µl), 1.0 µl of hprt-specific ... expected by addition of their individual responses The study of these interactions can lead to a better understanding of the toxic mechanism of the chemicals involved A number of terms have been...
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Báo cáo y học: "Molecular profile of synovial fibroblasts in rheumatoid arthritis depends on the stage of proliferation" potx
Ngày tải lên :
09/08/2014, 06:22
... growth inhibition in murine cell lines [33] Recently, Taniguchi et al [34] showed that cyclin-dependent kinase inhibitor p16INK4a is induced in RA-SF by several growth-inhibited conditions, including ... protein (Fbx3) Nucleosome assembly protein 1-like Lysosome-associated membrane protein EGF-containing fibulin-like extracellular matrix protein (EFEMP1) Fibrillin Versican Laminin γ1 Fibronectin ... Discussion We analyzed the expression profile of proliferating RA-SF in comparison with that of nonproliferating RA-SF, and we observed that distinct sets of genes, including several novel genes that have...
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Báo cáo sinh học: " Quantitative genetics of growth traits in the edible snail, Helix aspersa Müller" docx
Ngày tải lên :
09/08/2014, 18:22
... from those matings were not used for reproduction Frequencies of the different types of matings and egg-layings obtained in each generation are shown in table I Growth As room was lacking to raise ... of its offspring Since there is no contact between the layer and its offspring, it is likely that the effect is passed on through the eggs Bride and Gomot (1991) showed that, often in pairs of ... effects Further studies on inbreeding and dominance effects will require well-designed experiments such as a diallele experiment involving inbred lines obtained by successive matings between related...
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Cellular and molecular control of skeleton formation in fish insights from osteoblast ablation and functional characterization of lrp5 and SOst
Ngày tải lên :
10/09/2015, 08:43
... choosing the following conditions: Initial denaturation of DNA took place at 95°C for minutes At the beginning of a cycle, there were 30 seconds of denaturation at 95°C followed by annealing of ... volume of 10μl Reaction profile: Initial denaturation of DNA took place at 96°C for minute at the beginning of a cycle There were 10 seconds of denaturation at 96°C followed by annealing of the ... Arrow in O points at CFP positive cells in rostral area of centra Arrowheads in P and S indicate intervertebral regions Arrow in S points at disorganized neural arch Note loss of CFP and fusion of...
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Molecular interactions of tectonin proteins in host and pathogen recognition
Ngày tải lên :
14/09/2015, 08:38
... of the GBP-CRP interaction 93 3.40 Binding affinity of infected GBP 94 3.41 Effect of infection upon GBP-CRP interaction with LA 95 3.42 Effect of calcium on infected proteins binding to LA 96 ... diseases In the clinical setting, hCRP is used mainly as a marker of inflammation Thus, measuring and charting hCRP levels can prove useful in determining the progress of the disease or indicate ... from the Tectonin domains of GBP and hTectonin bind LA with high affinity 123 4.14 Peptides derived from the Tectonin domains of GBP and hTectonin also bind LPS and ReLPS with high afiinity 124 xiii...
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Molceular genetics of y chromosome in male infertility
Ngày tải lên :
16/09/2015, 15:53
... chromodomain implicated in chromatin binding, and a catalytic domain involved in acylation reactions (Lahn and Page, 1997; 1999b) The predicted coding regions of CDY1 and CDY2 were 98% identical in amino ... method in isolating genes that are found within the AZF locus and the euchromatic region of Yq This study, in predominantly ethnic Chinese patients in Singapore, defines the subgroup at risk of Y ... Treatment of Infertility, with the objective of creating a standard protocol for the investigation of infertile couples Normal semen was classified as containing a sperm concentration of at least...
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GENETICS OF NEPHROTIC SYNDROME IN SINGAPORE PAEDIATRICS PATIENTS
Ngày tải lên :
07/10/2015, 10:02
... Mutations in TRPC6 resulted in a gain of function. Mutations in WT1 affect the DNA‐binding affinity of WT1 to the target gene. Heterozygous de novo mutations in WT1 resulting in the inability of ... C‐terminal domain of podocin (Huber et al., 2001). The phosphorylation of nephrin also increases the binding of nephrin and podocin (Li et al., 2004). TRPC6 TRPC6 is a member of the ... transduction(Huber et al., 2003b). Podocin has been found to increase the efficiency of nephrin signaling without the recruitment of other signaling molecules. The cytoplasmic tail of nephrin binds to podocin and this interaction ...
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GENETICS OF NEPHROTIC SYNDROME IN SINGAPORE PAEDIATRICS PATIENTS 2
Ngày tải lên :
12/10/2015, 17:35
... glomerulonephritis.GN: Glomerulonephritis. MCNS: Minimal change nephrotic syndrome. *Patient progressed to end‐stage renal disease. **Patient is resistant to calcineurin inhibitor. 151 Table 2: Genotyping profile of the significant SNPs for the patients. ... pT (p.Ala22Val) ... FSGS with a cellular crescent MCNS FGS FGS Not performed Glomerular minor abnormalities MCNS IgM nephropathy, MCNS Minimal change. Findings Poor Prognosis No No Steroid Resistant No No On CNI ...
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Báo cáo khoa học: Molecular cloning and characterization of methylenedioxy bridge-forming enzymes involved in stylopine biosynthesis in Eschscholzia californica doc
Ngày tải lên :
07/03/2014, 10:20
... bridge-forming P450 (CYP719) cDNA, the protein of which catalyzed the conversion of (S)-tetrahydrocolumbamine to (S)-tetrahydroberberine [(S)-canadine] in berberine biosynthesis, from cultured cells of ... CYP719A3 in stylopine biosynthesis in E californica Results Isolation of cytochrome P450 cDNAs To examine the presence of C japonica CYP719 homologs and their functions in stylopine biosynthesis in ... (S)-cheilanthifoline, not (S)-nandinine [7,30,31] If we assume that (S)-nandinine is produced in E californica, there may be no need for a catalyst from (S)-nandinine to (S)-stylopine However, nandinine could...
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