molecular concept of penile carcinogenesis
Báo cáo y học: "Molecular Virology of Hepatitis C Virus (HCV): 2006 Update"
... Assistant Professor of Medicine and Staff Physician at the Department of Gastroenterology and Hepatology, University Hospital Freiburg, Germany Since 2004 he is the head of the Division of Gastroenterology ... independently of the pre-initiation factors necessary for cap-dependent translation The three-dimensional structure of the HCV IRES bound to the 40S ribosomal subunit illustrates the molecular basis of ... usefulness of this system was the identification of specific amino acid substitutions, i.e., cell culture-adaptive changes, that increased the efficiency of replication initiation by several orders of...
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Báo cáo y học: "Advances in Molecular Diagnosis of HBV Infection and Drug Resistance"
... is the appearance of serum markers of HBV infection that establishes the diagnosis of the disease Of these, HBsAg is considered to be the sentinel marker for the confirmation of acute infection ... necessary should the rate of emergence of resistance and the impact of such mutations turn out to be clinically relevant for therapy management Molecular Mechanisms of Drug Resistance HBV is ... technology, molecular beacons) that decrease the number of handling steps, reduce contamination, and increase throughput and the accuracy of quantification will further enhance the utility of these...
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Molecular Biology of Secondary Metabolism - Case Study for Glycyrrhiza Plants
... shows the contribution of this strategy to the development of plants with biofarming potential in the frame of a high demand of natural and ecologically accepted sources of renewable compounds ... the evolution of vascular plants The case of Fld and Cyt c6 shows that reintroduction of these genes in the proper subcellular compartment of model and crop plants restored some of the selective ... export of the excess of reducing power via the malate valve, and productive consumption of the surplus of NADPH by the Calvin cycle Finally, as is the case with iron deficiency, the extent of protection...
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Molecular Farming of Antibodies in Plants
... bars Molecular Farming of Antibodies in Plants 37 rearrangements of the germ-line immunoglobulin genes This part of the molecule is responsible for antigen recognition and binding The remainder of ... 3 Molecular Farming of Antibodies in Plants 53 After promoter choice, the next most important aspect of construct design is the inclusion of sequences that control subcellular targeting of the ... common of which are Agrobacterium-mediated transformation and the delivery of DNAcoated metal particles by microprojectile bombardment; (2) a stable transgenic line Molecular Farming of Antibodies...
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Tài liệu Chapter XIV Kinetic-molecular theory of gases – Distribution function doc
... the maximum of the curve shifts to higher speed 4/22/2008 21 2.3 Average speeds of molecules: Using the distribution function of molecular speeds one can calculate average values of molecular speeds ... total energy of each mode is Applying the principle of equipartition of energy we have, in average, for each of degree of freedom: kT For three orthogonal directions there are six degree of freedom ... equation in terms of mass of gas: mtot = n.M 4/22/2008 mtot pV RT M 1.2 Kinetic -molecular model of an ideal gas: GOAL: to relate state variables (temperature, pressure) to molecular motions...
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Tài liệu Báo cáo khoa học: Molecular basis of glyphosate resistance – different approaches through protein engineering doc
... of this enzyme, performed by various laboratories over the past three decades This review summarizes some of the key findings that have led to our current understanding of the molecular mode of ... molecular mode of action of glyphosate and the molecular basis for glyphosate resistance Structure and function of EPSPS EPSPS catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate ... however, was devoid of substrate or inhibitor, and consequently did not reveal the nature of the active site or the mode of action of glyphosate A decade later, the crystal structure of EPSPS was determined...
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Tài liệu Molecular Neurobiology of Alzheimer Disease and Related Disorders doc
... Alzheimer’s disease include the unraveling of the molecular mechanisms of neurofibrillary tangle formation in neuronal and glial cells; the molecular processing of amyloid precursor protein in intracellular ... pathogenesis of Alzheimer’s disease I am proud of this contribution of the Department of Neuropsychiatry, Osaka University which I chaired at that time and I am happy to observe the strong trend of psychogeriatric ... achievement of Professors Masatoshi Takeda, Toshihisa Tanaka, and Ramón Cacabelos, who dedicated their time to this monograph, cultivating the long tradition of research of the Department of Neuropsychiatry,...
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Tài liệu MULTICOLOR QUANTUM DOTS FOR MOLECULAR DIAGNOSTICS OF CANCER doc
... sections of tumor biopsies is not simple due to the high autofluorescence and the loss of antigen presentation associated with the Figure Molecular imaging of cells and tissues (A) 3D imaging of intracellular ... i– OH Multicolor quantum dots for molecular diagnostics = Expert Review of Molecular Diagnostics Figure Diagram of two general strategies for phase transfer of tri-n-octylphosphine oxide (TOPO)-coated ... confinement of the exciton is the principle that causes the optoelectronic properties of the QD to be dictated by the size of the QD [6–8] Decreasing the size of a QD results in a higher degree of confinement,...
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Tài liệu Báo cáo khoa học: EGF receptor in relation to tumor development: molecular basis of responsiveness of cancer cells to EGFR-targeting tyrosine kinase inhibitors docx
... phosphorylation state of their proteins, thereby changing the amount and localization of Bcl-2 family members However, each type of cancer has its own way of disrupting the balance of the networks of signaling ... associated with stimulation of ERK1 ⁄ and Pak1 pathways, gefitinib might lead to inhibition of invasiveness of human cancer cells through the inhibition of ERK1 ⁄ and Pak1 The use of gefitinib in cells ... of Bax activation in response to a variety of apoptosis-inducing stimuli Molecular mechanisms of sensitivity to EGFR-TKIs JNK and mitogen-activated protein kinase phosphatase-1 The activity of...
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Tài liệu Báo cáo khoa học: Molecular defect of isovaleryl-CoA dehydrogenase in the skunk mutant of silkworm, Bombyx mori ppt
... the effect of the mutation was further investigated by molecular modelling Together with the previously reported traits of the sku mutant, the molecular and physiological effects of IVD dysfunction ... consists of 10 amino acids, seven of which are conserved within the species (Fig 2C) and two of which are conserved within all ACAD family of enzymes, forming a highly conserved motif of Gly–Gly–X–Gly ... predicted molecular size of BmIVD mRNA, was detected in all the tissues tested (Fig 4A) The spatial expression pattern of BmIVD mRNA was similar between wild-type and sku and densitometric analysis of...
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Tài liệu Báo cáo khoa học: Molecular characterization of Arabidopsis thaliana PUF proteins – binding specificity and target candidates doc
... APUM-2 (A) Scheme of the three-hybrid strategy used in the screen (B) Number of colonies identified in each step of the screen (C) Distribution of the 63 distinct sequences in relation of their position ... Binding of APUM to NRE To test the predictions regarding the RNA-binding specificities of the putative APUM proteins, we investigated the capacity of APUM to bind to the NRE sequence of hunchback ... transcripts are potential targets for regulation by the PUF family of proteins The results obtained reveal a molecular conservation of PUF proteins in Arabidopsis thaliana and suggest that translational...
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Tài liệu Báo cáo khoa học: Isolation and molecular characterization of a novel D-hydantoinase from Jannaschia sp. CCS1 docx
... positions of the Ca of Ala156 in HYDJs and the Ca of Met156 in HYDBp located in the SGL3, which leads to the increased size of the substrate binding pocket of HYDJs The side chain of Ala156 is ... understanding of the roles of each of these residues will enable manipulation of these SGLs by rational design or molecular evolution methods to obtain the desired catalytic activity Overexpression of heterologous ... homodimers or homotetramers [4] Gel filtration analysis of native HYDJs indicated a molecular mass of about 253 kDa, and, as the subunit molecular mass of the His-tagged recombinant HYDJs was estimated...
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Tài liệu Báo cáo khoa học: Analysis of the molecular dynamics of medaka nuage proteins by fluorescence correlation spectroscopy and fluorescence recovery after photobleaching doc
... 0.8 0.6 0.4 0.2 min Fig Time-lapse LSM analysis of OlvasGFP reveals the dynamic nature of the nuage Schematic diagram of the preparation of PGCs of medaka specimen (A) OlvasGFP was expressed in ... suggesting the existence of some interactive cellular partner FRAP analysis of the nuage revealed the slow recovery of OlvasGFP (Fig 3B) When the whole part of the single compartment of nuage was bleached, ... processes of replacement of molecules in granules from other parts of the same granules or from the cytosol We performed a bleaching experiment in a whole part of a single compartment of the granule,...
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Tài liệu Báo cáo khoa học: Molecular determinants of ligand specificity in family 11 carbohydrate binding modules – an NMR, X-ray crystallography and computational chemistry approach doc
... chemistry approaches to identify the molecular determinants of ligand specificity of CtCBM11 By means of NMR studies, we have analyzed various cello-oligosaccharides of different sizes This approach ... the use of as little as nmol of protein with a molecular mass > 10 kDa [16,18,21] STD-NMR spectroscopy was used to analyze the binding of cellohexaose to CtCBM11 The STD-NMR spectrum of the hexasaccharide ... anomeric protons of the reducing end of the oligosaccharide In the region between 3.63 and 3.52 p.p.m., despite of the presence of STD signals, the individual contributions of protons aH4a, bH3a,...
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Tài liệu Báo cáo khoa học: Molecular aspects of rheumatoid arthritis: chemokines in the joints of patients pdf
... feature of chemokines is the redundancy of the system Several chemokines bind to more than one receptor, and the majority of chemokine receptors have multiple ligands, leading to the generation of ... the dominant source of MCP-1 ⁄ CCL2 production [19] The levels of MCP-1 ⁄ CCL2 correlate significantly with the levels of IL-1b, IL-6 and IL-8 ⁄ CXCL8 in culture supernatants of synovium from RA ... the joints of patients T Iwamoto et al positive chondrocytes results in a specific increase in the release of MMP-3 [10] Pathological concentrations of SDF-1 ⁄ CXCL12 induce the death of human chondrocytes...
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Tài liệu Báo cáo khoa học: Molecular aspects of rheumatoid arthritis: role of environmental factors pdf
... [7] A recent report showed evidence of the high prevalence of B19 DNA in patients with RA [8] However, a significant amount of evidence contradicts a role of B19 infection in RA pathogenesis For ... amplification of both NS1 and VP genes of B19 DNA in synovial membranes has revealed that the levels of B19 DNA are similar in RA and control synovial membranes [11] Thus, the contribution of B19 infection ... spectrum, 25–68% of infections are asymptomatic The most common clinical manifestation of acute infection is erythema infectiosum, characterized by a ‘slapped cheek’ rash Interestingly, 50% of adults...
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Tài liệu Báo cáo khoa học: Molecular aspects of rheumatoid arthritis: role of transcription factors ppt
... translocation of NF-jB in an Fig NF-jB activation pathway and the site of inhibition of various compounds immunohistochemical assay As shown in Fig 3A, FLS were incubated in the presence of 10 ngÆmL)1 of ... great variety of organs and cells One of the roles of Ca2+ is to regulate calcineurin, which in turn dephosphorylates and induces the nuclear localization of the cytoplasmic components of nuclear ... translocation of NF-jB, whereas pre-incubation of SAA with RAGE inhibited nuclear translocation [12] These data suggested that SAA of RA joints is actively involved in the pathogenesis of RA through...
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Tài liệu Báo cáo khoa học: Probing the molecular determinants of aniline dioxygenase substrate specificity by saturation mutagenesis docx
... consisted of 85 ng of atdA1A2, 50 ng of atdA3, 60 ng of atdA4A5, lL of 10· Pfu buffer, lL of 10· dNTP (mixture of dATP, dTTP, dGTP, and dCTP, each at a concentration of 100 mm), U of Pfu Turbo ... gene consisted of 150 ng of the pTA2-3 template, 50 pmol each of the forward and reverse primers, 10 lL of 10· Taq polymerase buffer, lL of 25 mm MgCl2, 10 lL of 10· dNTP, 1.25 U each of Taq DNA ... lack of characterization of the structural determinant of the substrate specificity of the AtdA enzyme has thus limited its development as a biocatalyst for the bioremediation of a wide range of...
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Tài liệu Báo cáo khoa học: Human enhancer of rudimentary is a molecular partner of PDIP46/SKAR, a protein interacting with DNA polymerase d and S6K1 and regulating cell growth docx
... variants of the human POLDIP3 gene encoding proteins of 421 amino acids with a molecular mass of 46 kDa and 392 amino acids with a molecular mass of 43 kDa, which differ only by an insertion of 29 ... there was a band of a protein with electrophoretic mobility of approximately 46 kDa, which corresponds to the molecular mass of isoform ⁄ a of PDIP46 ⁄ SKAR (Fig 3C) The band of this protein was ... plasmids using Lipofectamine Reagent according to the manufacturer’s suggested protocol (Invitrogen) Briefly, a mixture of lg of the plasmid DNA and lL of Lipofectamine in mL of antibiotic- and...
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Tài liệu Báo cáo khoa học: Molecular evolution of shark and other vertebrate DNases I pptx
... activity could be detected for only the first 30 of incubation, whereas that of the human Table Summary of the purification of DNase I from g of pancreas of H japonicus Purification step Protein (mg) ... expression of activity In order to examine the possible effect of the signal sequence region on the expression of activity, we constructed a series of chimeric Ó FEBS 2004 Molecular evolution of vertebrate ... lysates of cells that had been transfected with expression vectors containing the entire coding regions of the wild-type shark DNases I, substitution of the signal sequence regions of each of the...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25