molecular basis of autoimmunity—the failure of self tolerance
Veterinary Medical Specialization: Bridging Science and Medicine Volume 39 doc
Ngày tải lên :
29/03/2014, 15:20
... 11 Molecular Basis of Autoimmunity-The Failure of Self- Tolerance 111 Screening for Canine Genes That Might Predispose toward Thyroiditis IV Models of Autoimmune Disease ... immunity against self and is caused by an immune-mediated reaction to self- antigens (i.e., failure of self- tolerance) (Sinha et al., 1990) Susceptibility to autoimmune disease has a genetic basis in humans ... Today, the molecular basis of antigenic recognition by T-cells and their pathways of activation, inactivation, and exhaustion have been defined (Lanzavecchia, 1993) The importance of T-lymphocytes...
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Autoimmune Diseases – Contributing Factors, Specific Cases of Autoimmune Diseases, and Stem Cell and Other Therapies pdf
Ngày tải lên :
16/03/2014, 21:20
... generation of antigen receptors on lymphocytes through the process of random gene recombination A negative consequence of this process is the generation of self- reactive receptors capable of responding ... reinstatement of sustained, specific non-responsiveness of the native immune system to self- antigen Manipulation of T cell activation and differentiation pathways has been at the center of current tolerance ... modify the course of disease The pathologic role of T cells in driving MS has resulted in numerous therapies aimed at inactivating T cells and/or the induction of T cell tolerance Tolerance induction...
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Báo cáo y học: "Autoantibody profiling for the study and treatment of autoimmune disease" docx
Ngày tải lên :
09/08/2014, 06:22
... complexity of fluorescence-based bead and tag systems Microfluidics approaches Microfluidics utilizes microchannels for analysis of antigen–autoantibody interactions Small quantities of biomolecules ... quantitation of binding kinetics and detection of low-affinity interactions are among the important advantages of this system Arrays of living cells 292 Several groups have described arrays of living ... responses at the macromolecular level [23,34] We believe the specificity of the autoantibody response is predictive of the specificity of the overall autoimmune response at the level of whole autoantigens...
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Báo cáo y học: "Amplification of autoimmune disease by infection" potx
Ngày tải lên :
09/08/2014, 06:22
... may also migrate to internal sites of inflammation, such as the synovium of an arthritic patient Reactivation of virus at these sites does not serve the purpose of the virus but may aggravate the ... selection of latently infected B cells J Immunol 2000, 165:2975-2981 20 Decker LL, Klaman LD, Thorley-Lawson DA: Detection of the latent form of Epstein–Barr virus DNA in the peripheral blood of healthy ... incidence of IgG class of Epstein–Barr virus capsid antibody in Indian patients of lepromatous leprosy Trans R Soc Trop Med Hyg 1982, 76:311-313 164 Nalesnik MA: The diverse pathology of post-transplant...
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Báo cáo y học: "Epitope spreading to citrullinated antigens in mouse models of autoimmune arthritis and demyelination" pot
Ngày tải lên :
09/08/2014, 13:22
... development and evolution of ACPA responses in rodent models of RA and MS, with the objective of gaining further insights into the aetiology, evolution and potential pathogenic role of such responses ... consistent with the timing of development of anti-CCP antibody responses in CIA reported by others [14] Following development of arthritis, we observed significant expansion of the ACPA responses ... results demonstrate extensive intramolecular and intermolecular spreading of autoantibody responses in both CIA and EAE It is unclear whether the epitope spreading of ACPA responses observed in acute...
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Tài liệu Báo cáo khoa học: Animal models of amyloid-b-related pathologies in Alzheimer’s disease docx
Ngày tải lên :
16/02/2014, 09:20
... disease pathogenesis Familial forms of AD, with an autosomal dominant mode of inheritance, account for < 2% of all AD cases Onset is most often before 65 years of age, and the penetrance is nearly ... [54] A substantial amount of CAA is often found in transgenic mice with the Swedish mutation, which is likely to be because of the high rate of synthesis and accumulation of Ab1-40 In Tg2576, more ... have often been used to study CAA pathogenesis It is most frequent at the adventitial surface of SMC in arteries ⁄ arterioles and is accompanied by degeneration of vascular SMCs, disruption of...
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báo cáo hóa học: " Gait dynamics in mouse models of Parkinson''''s disease and Huntington''''s disease" doc
Ngày tải lên :
19/06/2014, 10:20
... variability of the hind limbs was affected after the 2nd administration of 3NP (cumulative dose of 50 mg/kg) After the 3rd administration of 3NP (cumulative dose of 75 mg/kg), half of the 3NP-treated ... included increased gait variability of the forelimbs and eventual failure of hind limb stepping Our findings of different effects of 3NP on gait dynamics of forelimbs and hind limbs are in accordance ... sequences B Gait signals of the left and right forelimbs of a 3NP-treated mouse demonstrating coordinated stepping, despite hind limb failure of stepping The signals of left and right hind limbs...
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báo cáo hóa học: " Inflammatory cytokine levels correlate with amyloid load in transgenic mouse models of Alzheimer''''s disease" potx
Ngày tải lên :
19/06/2014, 22:20
... around areas of plaque deposition [4-7] Chronic administration of ibuprofen can reduce plaque pathology and brain Aβ levels in these animal models of AD [8,9] There are numerous reports of increased ... levels of cytokines in the brains of Alzheimer's disease patients, and in transgenic mouse models of Alzheimer's disease [10-12] However, all these reports have focused on a small number of cytokines ... brain slices from transgenic mouse models of AD at 15 months of age Cytokine production by brain slices from transgenic mouse models of AD at 15 months of age Freshly harvested brain slices were...
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Báo cáo y học: "The retinoic acid binding protein CRABP2 is increased in murine models of degenerative joint disease" pot
Ngày tải lên :
09/08/2014, 01:22
... result of these various factors is the loss of the integrity of the cartilaginous extracellular matrix (ECM), leading to a decrease in mechanical strength This increases the susceptibility of the ... and because of its limited ability to repair itself the disease worsens In OA, the structural integrity of the matrix is irreversibly lost, leading to joint dysfunction [7] One class of molecules ... develop and validate murine cartilage-sparing models of OA to facilitate the use of genetically modified lines and enable molecular analysis of gene expression in the articular cartilage For these...
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Báo cáo y học: " Multiple functions for CD28 and cytotoxic T lymphocyte antigen-4 during different phases of T cell responses: implications for arthritis and autoimmune disease" pot
Ngày tải lên :
09/08/2014, 01:23
... production of IL-2 The increased survival is a consequence of upregulated BclXL and the activation of nuclear factor (NF)-κB 46 activation of APCs, it is indispensable during the initiation phase of ... mediator of inhibition [68] Ligation of CD80/CD86 induces the production of indoleamine 2,3-dioxygenase, which breaks down tryptophan The absence of tryptophan mediates the downregulation of T cell ... affects the splicing of CTLA-4 mRNA; interestingly, this results in a lower expression of the soluble form of CTLA-4 mRNA The authors of the study speculate that a reduced interaction of B7 and soluble...
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Báo cáo y học: "Role of RUNX in autoimmune diseases linking rheumatoid arthritis, psoriasis and lupus" pptx
Ngày tải lên :
09/08/2014, 01:23
... the effect of the RUNX3 deficiency in another genetic backgound, to test whether a ‘permissible’ background would allow the development of an autoimmune phenotype Regulation of targets of the RUNX ... arthritis and part of the development of the disease might be related to the activity of RUNX2 in these tissues and its effect on some of the target genes, many of which, such as osteopontin [34,35], ... Regulation of the RUNX proteins References Little is known about the regulation of the RUNX proteins and the pathways in which they are controlled Most of our knowledge comes from studies of RUNX2...
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Báo cáo y học: "The current status of targeting BAFF/BLyS for autoimmune diseases" pps
Ngày tải lên :
09/08/2014, 01:24
... [BAFF-R]) A broken line indicates stages of differentiation that can occur independently of BAFF The necessity of BAFF for the survival of established memory cells or of long-lived plasma cells is not ... No Ramanujam and Davidson Mechanism of action of BAFF blockade BAFF blockade mediates profound effects on B cells in mice Within 1–2 weeks of administration of TACI-Ig or BAFF-R-Ig to normal mice, ... and because of possible alterations in the strength of the BCR signal, but the repertoire of established memory cells is unlikely to be altered Fourth, depletion of B cells by blockade of BAFF should...
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báo cáo khoa học: " Multi-locus models of genetic risk of disease" pptx
Ngày tải lên :
11/08/2014, 12:20
... on the basis of recurrence risks to relatives or on the basis of estimates of effect sizes of risk loci Slatkin [13] also compared the CRisch and Probit models and benchmarked on a range of parameters ... probability) of disease of an individual given their multilocus genotype of x risk alleles out of a possible 2n, where n is the number of loci that contribute to the genetic variance of the disease; ... odds of disease for risk allele compared to wild-type allele; λMZ, recurrence risk of disease in monozygotic twins of diseased individuals; λOG, recurrence risk of disease in grandoffspring of...
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Báo cáo y học: " Coxiella burnetii as a possible cause of autoimmune liver disease: a case report" pps
Ngày tải lên :
11/08/2014, 14:20
... features of both diseases Hepatic cytolysis and/or cholestasis are present Histological findings may be non-specific or typical of either AIH or PBC Serology shows markers of AIH (ANA, SMA) and of ... presence of chronic Q-fever hepatitis and autoimmune liver disease Serology for C burnetii is highly specific, and we are not aware of any reports of false-positive Q-fever serology in the context of ... function tests had not improved after month of levofloxacin (ALAT 80 U/L, ү-GT 596 U/L), a dramatic decrease in both ALAT and ү-GT levels was observed after month of ursodeoxycholic acid (ALAT 27 U/L,...
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Báo cáo y học: "B-lymphocyte stimulator/a proliferation-inducing ligand heterotrimers are elevated in the sera of patients with autoimmune disease and are neutralized by atacicept and B-cell maturation antigen-immunoglobulin" pdf
Ngày tải lên :
12/08/2014, 12:20
... [15,16,38] It would be of interest to repeat these studies of matched RA serum and synovial fluid samples by using our APRIL assay Page 12 of 14 Our analysis of the subset of serum samples from ... μl/well assay buffer To this, 25 μl of standard plus 25 μl of normal human serum (pre-screened for low heterotrimer levels) or 25 μl of sample serum plus 25 μl of assay buffer was added The plate ... Inc (Seattle, WA, USA) [20] The LOQ was ng/ml of APRIL in the serum Because of insufficient volume, one of 30 available SLE serum samples and one of 40 healthy donor samples could not be included...
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Báo cáo y học: "Spleen tyrosine kinase inhibition in the treatment of autoimmune, allergic and autoinflammatory diseases'''' pps
Ngày tải lên :
12/08/2014, 15:22
... ligation of the extracellular domain of the receptor, DAP12 or FcRγ is tyrosine-phosphorylated by Syk Activation of Syk initiates a number of signaling events DAP12, DNAX-activating protein of molecular ... on the surface membrane of mast cells, and crosslinking of receptor-bound IgE by multivalent antigen starts the activation of mast cells by promoting the aggregation of FcεRI [19,20] Degranulation ... transmission of BCR-mediated cell signaling events, subsequent activation of different types of PTKs, including Syk, is required [13] BCR aggregation can directly stimulate activation of pre-associated...
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Báo cáo y học: " Models of chronic obstructive pulmonary disease" pps
Ngày tải lên :
12/08/2014, 18:21
... image of overwhelming complexity of the underlying pathophysiology of COPD has emerged (Figure 1) The current challenge in COPD research is to identify the role of the various mediators and molecular ... understand the effect of smoking cessation on the pathogenetic process Studying the molecular pathways in human subjects is restricted to the use of morphological and molecular assessment of lung tissues ... progression of COPD [10] The changes are also most likely associated with an induction of mucin gene expression [44] The presence of increased numbers of B cells begs the question regarding the role of...
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Báo cáo y học: "Animal models of copper-associated liver disease" doc
Ngày tải lên :
13/08/2014, 13:20
... analysis of liver tissue [51,52] Liver disease may mimic various forms of common liver conditions, ranging from fulminant hepatic failure, chronic hepatitis, and cirrhosis [1] Animal models of Wilson's ... result of hemolysis [56] This mutant strain also possesses reduced hepatic selenium [58] Both accumulation of iron and depletion of selenium in the liver may contribute to the development of fulminant ... levels of ceruloplasmin remain reduced all the time [60], the copper concentration in serum increases mainly after the onset of jaundice [63] About half of the animals die within a week of the...
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Báo cáo y học: " A mechanistic model of infection: why duration and intensity of contacts should be included in models of disease spread" ppt
Ngày tải lên :
13/08/2014, 16:20
... Expected number of secondary cases versus number of contacts Expected number of secondary cases versus number of contacts The boxplots show the distribution of the expected number of secondary cases ... tal knowledge that the risk of disease transmission is not only a function of the infectivity of the infectious agent and the quality of the immune response but also of the host's exposure to a ... duration of a contact in the empirical data set of potentially contagious contacts This allows a qualitative discussion related to how the inclusion of variable contact intensities instead of a constant...
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Báo cáo y học: "Relationships between free radical levels during carotid endarterectomy and markers of arteriosclerotic disease"
Ngày tải lên :
26/10/2012, 10:03
... concentration of OXANO in the blank sample was subtracted from that of the corresponding test sample Around ten per cent of the signal was diminished as a result of the inhibitors 2.2.5 Measurement of MCP-1, ... containing a conformational epitope in the apoB-100 moiety of LDL that is generated as a consequence of substitution of lysine residues of apoB-100 with malondialdehyde The specificity for the ... The outcome of the PCA of the radical data, data concerning the degree of arteriosclerotic disease and some relevant clinical data are shown in Figure In order to increase the lucidity of the figure...
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