modulator fingolimod fty720 on experimental autoimmune encephalomyelitis
báo cáo hóa học: " Secreted phospholipase A2 activity in experimental autoimmune encephalomyelitis and multiple sclerosis" potx
... Sclerosis and Experimental Autoimmune Encephalomyelitis Page of (page number not for citation purposes) Journal of Neuroinflammation 2006, 3:26 http://www.jneuroinflammation.com/content/3/1/26 ... tested prior to immunization or in healthy human controls As in previous studies in which the active enzyme concentration was of interest, we confirmed that product formation in the presence of an ... collection, which was defined as a change of one or more points on the functional neurologic status score in the absence of fever or infection [19] Therapies noted in Table were interferon beta-1a...
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báo cáo hóa học: " CXCR7 antagonism prevents axonal injury during experimental autoimmune encephalomyelitis as revealed by in vivo axial diffusivity" potx
... remyelination upon cessation of toxin [59] Studies examining CXCR7 antagonism in this context may be more conducive for the evaluation of OPCs recruitment and maturation Alternatively, as CXCR7 antagonism ... injury and concussion from sport and recreation participation in a school population NeuroRehabilitation, 2007 22(3): p 191-8 Schwab, M.E and D Bartholdi, Degeneration and regeneration of axons in ... parenchyma of CXCR7 antagonist-treated mice versus controls Conclusions: These data suggest that CXCR7 antagonism not only prevents persistent inflammation but also preserves axonal integrity Thus,...
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báo cáo hóa học: " Interferon regulatory factor-7 modulates experimental autoimmune encephalomyelitis in mice" docx
... Modification of acute experimental autoimmune encephalomyelitis in the Lewis rat by oral administration of type interferons J Interferon Cytokine Res 1995, 15:115-122 Kozovska ME, Hong J, Zang ... expression, but had no effect on CCL2 [8, 31] The effect of type I IFN signaling on production of chemokine and cytokines seems to depend on context However, in line with our observation in this ... peripheral blood mononuclear cells is antagonized by interferon beta-1b through an effect on matrix metalloproteinase-9 J Neuroimmunol 1997, 80:38-46 Liuzzi GM, Latronico T, Fasano A, Carlone G, Riccio...
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EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS – MODELS, DISEASE BIOLOGY AND EXPERIMENTAL THERAPY docx
... Kakiuchi Part Experimental Therapeutic Approaches 81 Chapter Therapeutic Effects of the Sphingosine 1-Phosphate Receptor Modulator, Fingolimod (FTY720) , on Experimental Autoimmune Encephalomyelitis ... autoimmune encephalomyelitis (EAE) Toxic agents like the copper chelator 22 Experimental Autoimmune Encephalomyelitis – Models, Disease Biology and Experimental Therapy cuprizone cause demyelination ... 24 Experimental Autoimmune Encephalomyelitis – Models, Disease Biology and Experimental Therapy autoimmune diseases, the autoantigen, the time point and the site of the ensuing autoimmune response...
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Báo cáo khoa học: "Experimental autoimmune encephalomyelitis in cynomolgus monkeys" pdf
... immunization, all four monkeys appeared normal on neurological examinations However, one monkey (#4) which was immunized with brain white matter, showed signs of anorexia, weight loss on day 16, ... Petersen, J Peterson, S Cosgrove, A C Heide, K Marro, and L M Rose Experimental allergic encephalomyelitis in nonhuman primates: diffusion imaging of acute and chronic brain lesions Mult Scler., ... protein induce chronic relapsing paralysis and demyelination Nature, 1985, 317, 355-358 23 Zhang, B., Yamamura, T Kondo, T., Fujiwara, M., T Tabira Regulation of experimental autoimmune encephalomyelitis...
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Báo cáo khoa học: "Immunohistochemical Localization of Bcl-2 in the Spinal Cords of Rats with Experimental Autoimmune Encephalomyelitis" docx
... precursor T cell proliferation and effector T cell selection in experimental autoimmune encephalomyelitis J Neuroimmunol 1995, 56, 171-178 Waggoner, S.E., Baunoch, D.A., Anderson, S.A., Leigh, F., ... suggesting that the host cells escape death in autoimmune CNS inflammation This is one possible reason why brain cells, including neurons and glial cells, survive autoimmune injury Our finding that some ... Linington, C., Wekerle, H., Lassmann, H T-cell apoptosis in inflammatory brain lesions: destruction of T cells does not depend on antigen recognition Am J Pathol 1998, 153, 715-724 Bonetti,...
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Báo cáo khoa học: "Embryonic Intermediate Filaments, Nestin and Vimentin, Expression in the Spinal Cords of Rats with Experimental Autoimmune Encephalomyelitis" pdf
... anti-vimentin (clone V9, Lab Vision corporation, Fremont, CA), and rabbit anti-GFAP (Dako, Copenhagen, Denmark)] for h at room temperature To distinguish macrophages in the CNS, mouse monoclonal anti-rat ... EAE lesions [3] The latter focused on the remyelination capacity of the CNS after an EAE attack Consequently, we postulate that glial elements along the central canal and subpial regions are ... expression of phospholipase D1 in the spinal cords of rats with experimental autoimmune encephalomyelitis Neurosci Lett 2001, 316(2), 95-98 Calvo, J L., Carbonell, A L and Boya, J Co-expression 13...
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Báo cáo y học: "Therapeutic effect of the potent IL-12/IL-23 inhibitor STA-5326 on experimental autoimmune uveoretinitis" pot
... induction and expression of experimental autoimmune uveitis J Immunol 1998, 161:122-127 26 Yokoi H, Kato K, Kezuka T, Sakai J, Usui M, Yagita H, Okumura K: Prevention of experimental autoimmune ... Becton Dickinson, Franklin Lakes, NJ) Available online http://arthritis-research.com/content/10/5/R122 IL-12 production in the serum of STA-5326-treated or vehicle-treated mice after immunization ... expression in response to Klebsiella pneumoniae infection J Immunol 2003, 170:4432-4436 33 Happel KI, Dubin PJ, Zheng M, Ghilardi N, Lockhart C, Quinton LJ, Odden AR, Shellito JE, Bagby GJ, Nelson...
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Báo cáo y học: "CCR2 and CXCR4 regulate peripheral blood monocyte pharmacodynamics and link to efficacy in experimental autoimmune encephalomyelitis." ppsx
... detectable on 34% of bone marrow Ly6Chi monocytes, we did not detect expression on the corresponding blood monocyte population (Figure 6A) To assess the role of CXCR4 on the decrease in blood monocytes ... studies, we demonstrated the expression of CXCR4 on bone marrow Ly6Chi monocytes, but did not detect expression of this receptor on blood monocytes These data suggest that CXCR4 expression is highly ... excluded by gating on the Ly6G- population and monocytes were gated upon based on CD11b+Ly6Chi expression The expression of CXCR4 on the gated CD11b+Ly6Chi monocytes is indicated B, BALB/c mice...
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Báo cáo sinh học: " Effects of transplantation with bone marrowderived mesenchymal stem cells modified by Survivin on experimental stroke in rats" potx
... induction media cells showed adipocyte globules on oil red ‘O’ staining (D) Osteogenic differentiation of MSCs: Upon induction with osteogenic induction media cells showed calcium deposits on von ... in the contralateral hemisphere Liu et al Journal of Translational Medicine 2011, 9:105 http://www.translational-medicine.com/content/9/1/105 Evaluation of neurological function Evaluation of ... take full advantage of: • Convenient online submission • Thorough peer review • No space constraints or color figure charges • Immediate publication on acceptance • Inclusion in PubMed, CAS, Scopus...
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báo cáo hóa học: " Experimental allergic encephalomyelitis in pituitary-grafted Lewis rats" pptx
... D2dopamine agonist bromocriptine on acute and relapsing experimental allergic encephalomyelitis Psychoneuroendocrinology 1994, 19:135-142 Bartke A, Shrenker P: Effect of experimentally-induced chronic ... immunization Page of (page number not for citation purposes) Journal of Neuroinflammation 2006, 3:20 http://www.jneuroinflammation.com/content/3/1/20 Figure changing plasma prolactin levels on clinical ... conditions of controlled light (12:12 h light/ dark schedule, light on at 0800 h) and temperature (22 ± 2°C) All experiments were conducted in accordance with the guidelines of the International...
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báo cáo hóa học: " Immune response after experimental allergic encephalomyelitis in rats subjected to calorie restriction" pot
... splenic Con A mitogenic response, a significant interaction "diet x immunization" was found in factorial ANOVA (F2,36 = 3.48, p = 0.0415), i.e., SCH injection augmented Con A response in control ... http://www.jneuroinflammation.com/content/4/1/6 Mitogenic responses to Con A and LPS in spleen (left panels) and SmLN (right panels) of control and calorie-restricted rats Figure Mitogenic responses to Con A and ... interaction "diet x immunization" occurred for thymic T cell number, i.e., in contrast to the decrease after immunization seen in control and 33% calorie- Page of 10 (page number not for citation purposes)...
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o cáo hóa học:" Effects of transplantation with bone marrowderived mesenchymal stem cells modified by Survivin on experimental stroke in rats" docx
... induction media cells showed adipocyte globules on oil red ‘O’ staining (D) Osteogenic differentiation of MSCs: Upon induction with osteogenic induction media cells showed calcium deposits on von ... in the contralateral hemisphere Liu et al Journal of Translational Medicine 2011, 9:105 http://www.translational-medicine.com/content/9/1/105 Evaluation of neurological function Evaluation of ... take full advantage of: • Convenient online submission • Thorough peer review • No space constraints or color figure charges • Immediate publication on acceptance • Inclusion in PubMed, CAS, Scopus...
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Báo cáo khoa học: "Enhanced expression of constitutive and inducible forms of nitric oxide synthase in autoimmune encephalomyelitis" pdf
... on experimental allergic encephalomyelitis in the induction and progression phase J Neuroimmunol 1998, 81(1-2), 201-210 Raine, C S Experimental allergic encephalomyelitis and related conditions ... oxide and the immunomodulation of experimental autoimmune encephalomyelitis Eur J Immunol 1997, 27(11), 2863-2869 18 Gonzalez-Hernandez, T and Rustioni, A Expression of three forms of nitric ... manufacturers instructions (Oncor, London, UK) [16] In brief, the paraffin sections were deparaffinized, rehydrated, and washed with PBS The sections were treated with 0.005% pronase (Dako, Denmark)...
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Báo cáo khoa học: "Melatonin ameliorates autoimmune encephalomyelitis through suppression of intercellular adhesion molecule-1" pps
... This study constitutes the first clinical demonstration that exogenous melatonin affects the progression of the autoimmune disease model EAE The underlying mode of melatonin action in preventing ... exact function of melatonin in modulating the immune system response needs further study Taking all of these observations into consideration, we postulate that melatonin suppresses autoimmune ... that melatonin has an anti-inflammatory effect on EAE, caused by suppression of ICAM-1 and possibly by induction of NK cells production Although we found amelioration of EAE in melatonintreated...
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Báo cáo khoa học: "Effects of Corticosteroid and Electroacupuncture on Experimental Spinal Cord Injury in Dogs" doc
... examination After induction of paresis, all dogs were examined everyday on motor and sensory functions by postural reaction, superficial pain and deep pain These neurological examinations were continued ... stimulations with V, 25 Hz were done for 20 m in by using of electrical stimulator (Pulse stimulator AM3000, Tokyo Electronic Co., J apan) Cage confinement was applied concurrently Eva lu a tion Neurological ... responded normally Somatosensory Evoked Potentials (SEPs) SEPs were measured for prediction of sensory functions According to Poncelets method [18], SEPs were represented as spinal conduction...
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Báo cáo khoa học: "Increased expression of osteopontin in the spinal cords of Lewis rats with experimental autoimmune neuritis" doc
... Changjong Moon, Taekyun Shin Table CD44 and osteopontin immunoreactivity in the spinal cords of normal and CFA-immunized control rats, and rats with EAN Antibody and cell type Anti-CD44b Neurons ... temporarily function as a pro-inflammatory mediator at the early activation stage, and thereafter function in an antiinflammatory role, through the suppression of nitric oxide generation in an autocrine ... investigations of a variant model of autoimmune CNS disease [16] Taken all the findings into consideration, it is postulated that OPN and its receptor CD44 increase in the spinal cord, a remote lesion,...
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Báo cáo khoa học: " Effect of probiotic containing Saccharomyces boulardii on experimental ochratoxicosis in broilers: hematobiochemical studies" docx
... containing soluble pAPN at the concentration of 24 pg/ml Group C was injected with ml of PEDV (104.5 TCID50/ml) only without pAPN treatment, and group D was a control of T-VM Booster injection ... ml of PEDV containing soluble pAPN at the concentration of 24 ng/ml Group C was injected with ml of PEDV only without pAPN treatment, and group D was a control of T-VM Two inoculations were Indirect ... of soluble pAPN on antibody production against PEDV concentration of pAPN treatment when compared to body weights of animals used On the other hand, it could be due to a reason why sows hold...
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Báo cáo khoa học: "Effect of probiotic containing Saccharomyces boulardii on experimental ochratoxicosis in broilers: hematobiochemical studies" pptx
... benzoacetonitrile in it 21 Spot 20 µl of it, on TLC plate 22 Spot the Standard of ochratoxin A on TLC plate with dilutions, 100 µl, 20 µl, and 10 µl 21 Run the TLC plate in solution containing ... Abramson D, Phillips GD Organ weight, liver constituent and serum components in growing chicks fed ochratoxin A Arch Environ Contam Toxicol 1989, 18, 404-410 22 Trenk HL, Butz ME, Chu FS Production ... (OA) Mycelial growth started to appear on broken wheat by third day with condensation of moisture inside the flask, after inoculation of spore suspension in it The wheat media gradually turned...
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