modulation by antidepressant drugs
Báo cáo khoa học: Typical 2-Cys peroxiredoxins – modulation by covalent transformations and noncovalent interactions doc
... participation of ATP in covalent transformations of (a) Thr90 catalyzed by CDK1, (b) CysR by autophosphorylation and (c) CysP assisted by Srx, and noncovalent interactions that drive the quaternary structure ... species with a propensity to the decameric form, not only by increasing the protein concentration and decreasing the ionic strength, but also by preventing the formation of the intercatenary disulfide ... 2-Cys Prxs concerns the mechanism by which a cycle of three distinct FEBS Journal 276 (2009) 2478–2493 ª 2009 The Authors Journal compilation ª 2009 FEBS M Aran et al Modulation of 2-Cys peroxiredoxins...
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Báo cáo khoa học: Oligosaccharide synthesis in Fibrobacter succinogenes S85 and its modulation by the substrate potx
... monitored by measuring the attenuance (D) at 600 nm and by succinate and acetate assays from 1H NMR spectra, respectively Maltodextrins of DP > were clearly metabolized by the cells, as shown by the ... h, and extracellular and intracellular media were separated by centrifugation and analysed in parallel by 1H NMR spectroscopy and by TLC Under these conditions, 12.5 mm succinate was produced ... intracellular media (see the Experimental procedures) were separated by centrifugation and analysed, in parallel, by 1H NMR spectroscopy and by TLC Consumption of the substrates and production of the final...
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Báo cáo khoa học: Structural characterization of N-linked oligosaccharides of laminin from rat kidney: changes during diabetes and modulation by dietary fiber and butyric acid pdf
... methods Total sugars were estimated by the phenol–sulfuric acid method [25], sialic acid was estimated by Aminoff’s method [26], protein content was estimated by Lowry’s method [27] FEBS Journal ... Oligosaccharides obtained by PNGase-F digestion were end-labeled with 2AA and purified on a lectin–agarose column using D-glucopyranoside as the eluent Elution profiles are shown by horizontal bars with ... 2100 2300 Fig Oligosaccharide moieties of laminin released by PNGase-F Oligosaccharide moieties were labeled with 2AA and seperated by lectin–agarose chromatography using stepwise elution Eluted...
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Báo cáo khoa học: Suppression of nuclear factor-jB activity in macrophages by chylomicron remnants: modulation by the fatty acid composition of the particles pot
... however, is not controlled by NF-jB-dependent mechanisms Thus, our findings that the secretion of TNFa, IL-6 and MCP-1 by THP-1 macrophages were all strongly downregulated by CRLPs, whereas TGFb release ... suppressed by CMR in macrophages and that cytokine expression is modified by the particles in a manner that correlates with NF-jB dependency Our findings contrast with those of one previous study by Okumura ... as determined by DNA binding, and this effect was clearly modulated by their fatty acid composition, with fish CRLPs causing the strongest inhibition ()94% after 24 h) followed by corn CRLPs ()70%),...
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Báo cáo khoa học: Interaction of ostreolysin, a cytolytic protein from the edible mushroom Pleurotus ostreatus, with lipid membranes and modulation by lysophospholipids pptx
... ostreolysin by lysophospholipids was further conrmed by enzymatic hydrolysis of pure phospholipids We found that even a partial hydrolysis of pure PtdCho, PtdOH, PtdEtn, PtdIns, PtdSer, and PtdGro by ... instructions Membranes of sheep erythrocytes were prepared by hypo-osmotic lysis in vesicle buffer diluted with distilled water (1 : 4), followed by centrifugation at C and 18 500 g The supernatant ... ostreatus, or fresh sheep brain, were obtained by Folch extraction [9]: 10 g tissue and 10 mL distilled water were homogenized on ice, followed by centrifugation (26 300 g, 30 min, C), and extraction...
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Báo cáo Y học: Expression of uncoupling protein-3 in subsarcolemmal and intermyofibrillar mitochondria of various mouse muscle types and its modulation by fasting docx
... from the muscle by homogenization than IMF mitochondria In a first attempt to prepare IMF mitochondria, we used the original technique of Krieger et al [11], which involves digestion by the Nagarse ... even when tightly controlled, was found by Western blot analysis to degrade UCP3 Therefore we adopted another technique in which we broke down myofibrils by strong mechanical disruption with a ... peroxidase-labeled secondary antibody The signals were detected by chemiluminescence using a standard ECL kit and developed Hyperfilm ECL film They were quantified by scanning photodensitometry using ImageQuant...
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Báo cáo lâm nghiệp: "Leaf morphology as species indicator in seedlings of Quercus robur L. and Q. petraea (Matt.) Liebl.: modulation by irradiance and growth flush" potx
... and veins NLOB: number of lobes (except the terminal lobe, irrigated by the midrib) NLUB: number of lobules (lobes irrigated by a third order vein) LOBL: mean of the length of the six largest lobes ... interaction between effects of irradiance regime and flush, eijkl: error term 3.1 Modulation of leaf morphology by irradiance The effects of irradiance regime on leaf morphology were mainly visible ... 74 S Ponton et al identify seedlings from the two species in natural regenerations (i.e., shaded by surrounding adult trees) For sun leaves of adult trees, the best features discriminating between...
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Báo cáo y học: "Antineutrophil cytoplasmic antibody (ANCA)-associated autoimmune diseases induced by antithyroid drugs: comparison with idiopathic ANCA vasculitides" pot
... MPA belong to the ISV group, they can be triggered by some chemicals, viral and bacterial infections and certain drugs, among which antithyroid drugs (ATDs) are very common [5] Propylthiouracil ... were measured by nephelometry (Orion Diagnostica, Espoo, Finland) Cryoglobulins were investigated by the standard procedure [11] Cryoprecipitate was analyzed for detection of ANCA by IIF, rheumatoid ... factor by nephelometry (Orion Diagnostica) and the presence of paraprotein by immunofixation (Binding Site, Birmingham, UK) Positive sera were analyzed for the presence of hepatitis C virus by ELISA...
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Báo cáo y học: " Peripheral blood and neuropsychological markers for the onset of action of antidepressant drugs in patients with Major Depressive Disorder" pps
... effective treatments for MDD The use of antidepressant drugs (ADs) for the treatment of MDD is well established However, effect sizes of currently available antidepressants are rather small than ... confirmed by the personally dated signature of the subject and by the personally dated signature of the person conducting the informed consent discussions All study components were approved by the ... important clinical model for the onset of antidepressants’ action [26] Biology underlying early improvement Furthermore, it resulted in the idea that an effective antidepressant treatment triggers and...
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Báo cáo y học: "Ulceration of the oral mucosa induced by antidepressant medication: a case report" pps
... environmental factors [3] Sertraline hydrochloride is an antidepressant agent used in clinical practice, which acts on the serotonin neurotransmitter Antidepressants such as selective and potent serotonin ... developed oral ulceration after the use of an antidepressant (sertraline hydrochloride) Case presentation A 78-year-old Caucasian woman was referred by her dentist to our outpatient clinic, with ... occurrence of the lesion was first noted After evaluation of the medication by the physician responsible, sertraline was replaced by 75 mg of venlafaxine and exfoliative cytology of the ulcer was performed...
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Báo cáo y học: "The gene expression profile of preclinical autoimmune arthritis and its modulation by a tolerogenic disease-protective antigenic challeng" ppt
... The gene expression profile of preclinical autoimmune arthritis and its modulation by a tolerogenic disease-protective antigenic challenge Hua Yu1, Changwan Lu2,3, Ming T Tan3 ... immunomodulation of RA Introduction Rheumatoid arthritis (RA) is a major global health problem that imposes a heavy socioeconomic burden on the society [1, 2] The disease is characterized by chronic ... appropriate model system to examine early pathogenetic events of autoimmune arthritis and their modulation by therapeutic regimen, including immune-based approaches Antigen-induced tolerance is one...
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Báo cáo y học: "Immune response modulation by curcumin in a latex allergy model" docx
... program D IFN-γ production (ng/ml) by antigen-stimulated spleens cells as measured by ELISA E IL-4 production (Pg/ml) by antigenstimulated spleen as measured by ELISA Page of 12 (page number not ... incorporated 3H thymidine was measured by liquid scintillation counting, and the stimulation indices (SI) were calculated as described before [26] Cytokine Production by Spleen Cells Spleen cells (1 ... cells were determined by counting five different microscopic fields Spleen Cells Spleens were processed into single cell suspensions and antigen dependent proliferation studied by tritiated thymidine...
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apoptotic b cells their interactions with macrophages and modulation by rituximab
... RTX:OVA by B cells, or secondary presentation by BMDM 175 Figure 5.7 Proliferative responses of OTII T cells after direct presentation of RTX:OVA by B cells, or secondary presentation by BMDM ... Figure 5.2 Activation of T cells by secondary presentation of antigen by BMDM 167 Figure 5.3 Level of activation of T cells after secondary presentation of RTX:OVA by BMDM .168 Figure ... Activation of T cells by secondary presentation of antigen by BMDM 165 5.2.2 Activation of OTII T cells after secondary presentation of differing concentrations of RTX:OVA by BMDM 169...
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Immune modulation by experimental filarial infection and its impact on e coli induced sepsis
... 2003a) 1.2.4 Effects of helminth-induced immune modulation on bystander responses Helminth infections induce type immune responses which are characterized by the induction of T helper cells, eosinophilia ... 2007; Doetze et al., 2000; Hoerauf et al., 2005; Taylor et al., 2006) The immunomodulation by helminths reduces bystander immune responses and can have protective effects on autoimmune diseases ... numbers expand at the site of infection by proliferation (Jenkins et al., 2011) and their plasticity was highlighted by the fact that AAM can be reprogrammed by TLR stimulation to restore microbial...
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Báo cáo khoa học: Modulation of heme and myristate binding to human serum albumin by anti-HIV drugs An optical and NMR spectroscopic study potx
... Modulation of HSA ligand binding by anti-HIV drugs G Fanali et al Fig HSA structure Atomic coordinates were taken from PDB entry 1O9X [28] FA-binding sites are indicated by arrows and ... FEBS 4493 Modulation of HSA ligand binding by anti-HIV drugs G Fanali et al Fig Binding isotherms for Fe(III)heme binding to HSA (FA free) and to HSA–myristate complexes in the absence of drugs (A) ... G Fanali et al Modulation of HSA ligand binding by anti-HIV drugs Table Values of intermolecular energies (kJÆmol)1) obtained from the docking simulation of the three anti-HIV drugs in the heme...
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Tài liệu Báo cáo khoa học: Modulation of a-synuclein aggregation by dopamine in the presence of MPTP and its metabolite pptx
... death induced by rotenone, MPP+, or paraquat Proc Natl Acad Sci USA 105, 15136–15141 14 Leong SL, Cappai R, Barnham KJ & Pham CL (2009) Modulation of alpha-synuclein aggregation by dopamine: a ... fibrillar aggregates are decided by the different compo- Fig Aggregation of a-synuclein after 240 h Samples containing MPTP (A and C) and MPP+ (B and D) were analysed by SDS ⁄ PAGE (A and B) on 5–15% ... The cleared supernatant was purified by DEAE-Sepharose anion exchange chromatography [18] The eluates were pooled and the amount of protein was determined by the bicinchoninic acid assay [38]...
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Tài liệu Báo cáo khoa học: Modulation of F0F1-ATP synthase activity by cyclophilin D regulates matrix adenine nucleotide levels pptx
... concentrations, and at mV produced by a maximal dose of the uncoupler We compared these ADPATP exchange rates mediated by the ANT with those obtained by direct ATP hydrolysis rates by the F0F1-ATP synthase ... alterations in ADPATP exchange rate mediated by the ANT caused by alterations in matrix ATP and ADP levels as a result of changes in F0F1-ATP synthase activity by kinetic modeling The rate equation ... recorded ATP inux and efux rates The acidication produced by the uncoupler was either minimized by methylamine (60 lm) or exacerbated by nigericin (1 lm), as also described previously [61] Matrix...
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Tài liệu Báo cáo khoa học: Modulation of sterol homeostasis by the Cdc42p effectors Cla4p and Ste20p in the yeast Saccharomyces cerevisiae pptx
... ⁄ v), separated by TLC (as described above) and visualized on TLC plates by staining with iodine vapor Bands of steryl esters were scraped off, and radioactivity was measured by liquid scintillation ... be maintained by endocytic cycling Curr Biol 13, 1636–1640 FEBS Journal 276 (2009) 7253–7264 ª 2009 The Authors Journal compilation ª 2009 FEBS 7263 Sterol homeostasis modulation by Ste20p and ... 7253–7264 ª 2009 The Authors Journal compilation ª 2009 FEBS M Lin et al Sterol homeostasis modulation by Ste20p and Cla4p Table Sterol analysis of cells lacking STE20 and CLA4 Data are mean values...
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Tài liệu Báo cáo khoa học: Modulation of the enzymatic efficiency of ferredoxin-NADP(H) reductase by the amino acid volume around the catalytic site pptx
... Enzyme efficiency modulated by amino acid volume M A Musumeci et al Leu268 is replaced by a serine in the bacterial reductases of subclass I (Azotobacter vinelandii) and by an asparagine in the bacterial ... groups introduced by the mutations was determined following the standard radii and volumes calculated by Tsai et al [32] b DDGMUT ⁄ WT indicates the energy barrier introduced by the mutations ... change of the R amino acid groups introduced by mutations was determined following the standard radii and volumes calculated by Tsai et al [32] b Determined by fluorescence spectroscopy using oxidized...
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Tài liệu Báo cáo khoa học: Modulation of cyclin D1 and early growth response factor-1 gene expression in interleukin-1b-treated rat smooth muscle cells by n-6 and n-3 polyunsaturated fatty acids pdf
... were scanned and quantified by densitometry by using QUANTITY ONE software (Bio-Rad, Hercules, CA, USA) Real-time quantitative RT-PCR Quantitative RT-PCR was performed by using the qPCR core kit ... are tested in duplicate Results Modulation of SMC proliferation by n-3 and n-6 PUFAs First, we evaluated the effect of PUFA on IL-1b-induced SMC proliferation by measuring BrdU incorporation ... IL-1b-stimulated cells was not significantly reduced by U0126 or by LY294002 (data not shown), and it was strongly stimulated (up to threefold) by incubation in medium containing fetal bovine serum...
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