models disease biology and experimental therapy
EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS – MODELS, DISEASE BIOLOGY AND EXPERIMENTAL THERAPY docx
... orders@intechweb.org Experimental Autoimmune Encephalomyelitis – Models, Disease Biology and Experimental Therapy, Edited by Robert Weissert p cm ISBN 978-953-51-0038-6 Contents Preface VII Part Disease Biology ... Hueng-Chuen Fan and Huey-Kang Sytwu Preface `Experimental Autoimmune Encephalomyelitis – Models, Disease Biology and Experimental Therapy` is totally focused on the model of multiple sclerosis, experimental ... be observed during the disease course Genetically Experimental Autoimmune Encephalomyelitis – Models, Disease Biology and Experimental Therapy Species Strain Induction Disease type Reference...
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Báo cáo khoa học: Active-site-specific chaperone therapy for Fabry disease Yin and Yang of enzyme inhibitors pptx
... identified for Gaucher disease [20,21], Tay-Sachs and Sandhoff disease [22] (details for Gaucher and Tay-Sachs ⁄ Sandhoff diseases are reviewed separately), GM1-gangliosidosis [23], and retinitis pigmentosa ... contains antiparallel b strands The galactose ligand is shown in yellow and red (B) Fabry disease- causing point mutations are shown on the human a-Gal A dimer The red, blue, and green bonds show mutations ... N215S, Q279E, M296I, and M296V), four mutations found in classic patients (E59K, A156V, L166V, and R356W), and two mutations present in both variant and classic patients (A97V and R301Q) were efficiently...
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vascular disease, molecular biology and gene transfer protocols
... bands, two corresponding to the two different single-stranded DNA molecules and the remainder corresponding to the doublestranded Usually the fastest migrating band represents the double-stranded ... vol 30: Vascular Disease: Molecular Biology and Gene Therapy Protocols Edited by: A H Baker © Humana Press Inc., Totowa, NJ 25 26 Miano, Garcia, and Krahe ing the human (16,17), and the mouse (18), ... in Molecular Medicine, vol 30: Vascular Disease: Molecular Biology and Gene Therapy Protocols Edited by: A H Baker © Humana Press Inc., Totowa, NJ Ye and Henney chemical cleavage analysis, both...
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báo cáo hóa học:" Impact of HIV-1 viral subtype on disease progression and response to antiretroviral therapy" pot
... six, nine and 12 months was, respectively: 66%, 78% and 88% for subtype B; 77%, 81% and 88% for subtype A; 82%, 85%, 92% for subtype C; 78%, 88% and 88% for subtype D; and 65%, 65% and 74% for ... for each subtype was estimated and compared using twolevel random effects multiple regression models, and for four other variables (ethnicity, gender, HIV risk group and age) This model recognizes ... 59; F, n = 17; and G, n = 15), followed by subtype C and D (each n = 10) [20] Other studies from Thailand have compared subtypes B and E In 130 seroconverters (103 with subtype E and 27 with subtype...
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Chapter 107. Transfusion Biology and Therapy (Part 1) ppsx
... phenotype) as well as to both A and B antigens and are therefore compatible only with other hh donors In most people, A and B antigens are secreted by the cells and are present in the circulation ... glycosphingolipids or glycoproteins, and are secreted into plasma and body fluids as glycoproteins H substance is the immediate precursor on which the A and B antigens are added This H substance ... placenta and bind fetal erythrocytes bearing the corresponding antigen, resulting in hemolytic disease of the newborn, or hydrops fetalis Alloimmunization to leukocytes, platelets, and plasma...
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Chapter 107. Transfusion Biology and Therapy (Part 2) pps
... Lewis antigens may be adsorbed onto tumor cells and may be targets of therapy I system antigens are also oligosaccharides related to H, A, B, and Le I and i are not allelic pairs but are carbohydrate ... and Alloantibodies More than 100 blood group systems are recognized, composed of more than 500 antigens The presence or absence of certain antigens has been associated with various diseases and ... transferase and maps to chromosome 19 The antigen is not an integral membrane structure but is adsorbed to the RBC membrane from the plasma Antibodies to Lewis antigens are usually IgM and cannot...
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Chapter 107. Transfusion Biology and Therapy (Part 3) pptx
... recipient consists of the "type and screen." The "forward type" determines the ABO and Rh phenotype of the recipient's RBC by using antisera directed against the A, B, and D antigens The "reverse ... content and small and hematocrit 3% amount of plasma Platelets 5.5 x 1010/RD 50–70 unit Increase platelet count 5000– 10,000/µL 200–400 ≥3.0 x CCI ≥10 x 1011/SDAP product 109/L within h and ≥7.5 ... cross-matching must be ABO compatible and lack antigens for which the patient has alloantibodies Nonreactive cross-matching confirms the absence of any major incompatibility and reserves that unit for the...
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Chapter 107. Transfusion Biology and Therapy (Part 4) pdf
... and each unit is anticipated to increase the platelet count 5000– 10,000/µL Patients who have received multiple transfusions may be alloimmunized to many HLA- and platelet-specific antigens and ... patient without cardiac disease; however, comorbid factors often necessitate transfusion at a higher threshold The decision to transfuse should be guided by the clinical situation and not by an arbitrary ... contain
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Chapter 107. Transfusion Biology and Therapy (Part 5) pps
... Willebrand disease Plasma Derivatives Plasma from thousands of donors may be pooled to derive specific protein concentrates, including albumin, intravenous immunoglobulin, antithrombin, and coagulation ... Babesia microti (babesiosis), Borrelia burgdorferi (Lyme disease) , Trypanosoma cruzi (Chagas disease) , and Treponema pallidum , human herpesvirus-8 and hepatitis G virus Note: FNHTR, febrile nonhemolytic ... to the chemical and physical properties of the stored blood component and its additives Transfusion-transmitted viral infections are increasingly rare due to improved screening and testing As...
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Chapter 107. Transfusion Biology and Therapy (Part 6) pot
... by chills and rigors and a ≥1°C rise in temperature FNHTR is diagnosed when other causes of fever in the transfused patient are ruled out Antibodies directed against donor leukocyte and HLA antigens ... sample and any untransfused blood should be sent to the blood bank for analysis The laboratory evaluation for hemolysis includes the measurement of serum haptoglobin, lactate dehydrogenase (LDH), and ... immune complexes that result in RBC lysis can cause renal dysfunction and failure Diuresis should be induced with intravenous fluids and furosemide or mannitol Tissue factor released from the lysed...
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Chapter 107. Transfusion Biology and Therapy (Part 7) pdf
... marrow aplasia and pancytopenia TA-GVHD is highly resistant to treatment with immunosuppressive therapies, including glucocorticoids, cyclosporine, antithymocyte globulin, and ablative therapy followed ... Graft-versus-Host Disease Graft-versus-host disease (GVHD) is a frequent complication of allogeneic stem cell transplantation, in which lymphocytes from the donor attack and cannot be eliminated by an immunodeficient ... host HLA antigens as foreign and mount an immune response, which is manifested clinically by the development of fever, a characteristic cutaneous eruption, diarrhea, and liver function abnormalities...
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Chapter 107. Transfusion Biology and Therapy (Part 8) ppsx
... components, chelates calcium and thereby inhibits the coagulation cascade Hypocalcemia, manifested by circumoral numbness and/ or tingling sensation of the fingers and toes, may result from multiple ... complication by using alternative therapies (e.g., erythropoietin) and judicious transfusion is preferable and cost effective Deferoxamine and other chelating agents are available, but the response is ... Iron Overload Each unit of RBCs contains 200–250 mg of iron Symptoms and signs of iron overload affecting endocrine, hepatic, and cardiac function are common after 100 units of RBCs have been transfused...
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Chapter 107. Transfusion Biology and Therapy (Part 9) pot
... culture and Gram stain Other Infectious Agents Various parasites, including those causing malaria, babesiosis, and Chagas disease, can be transmitted by blood transfusion Geographic migration and ... fever and chills, which can progress to septic shock and DIC These reactions may occur abruptly, within minutes of initiating the transfusion, or after several hours The onset of symptoms and signs ... clearly associated with any disease Parvovirus B-19 Blood components and pooled plasma products can transmit this virus, the etiologic agent of erythema infectiosum, or fifth disease, in children Parvovirus...
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Chapter 107. Transfusion Biology and Therapy (Part 10) pps
... Principles and Practices, 2d ed Philadelphia, Churchill Livingstone, 2006 Kitchen AD, Chiodini PL: Malaria and blood transfusion Vox Sang 90:77, 2006 [PMID: 16430664] Leiby DA: Babesiosis and blood ... with leukopenia related to high-dose chemotherapy Erythropoietin stimulates erythrocyte production in patients with anemia of chronic renal failure and other conditions, thus avoiding or reducing ... Agre P, Cartron JP: Molecular biology of the Rh antigens Blood 78:551, 1991 [PMID: 1907207] Burthem J, Roberts DJ: The pathophysiology of variant Creutzfeldt-Jakob disease: The hypotheses behind...
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Báo cáo y học: "Biology and therapy of fibromyalgia: pain in fibromyalgia syndrome" ppsx
... factor, IL-6 and IL-1, substance P, nitric oxide, prostaglandins, excitatory amino acids, ATP, and fractalkine [57], that, in turn, further increase the discharge of excitatory amino acids and substance ... relationship between tissue events and pain is necessary for understanding the clinical context of these pathologies, defining the relationship between injury and specific and relevant nociceptive responses ... fibromyalgia patients Scand J Rheumatol 2000, 29:8-12 Lautenschlager J, Bruckle W, Schnorrenberger CC, Muller W: Measuring pressure pain of tendons and muscles in healthy probands and patients with...
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Báo cáo y học: "Four-year follow-up of infliximab therapy in rheumatoid arthritis patients with long-standing refractory disease: attrition and long-term evolution of disease activity" pot
... VAS, CRP, and HAQ scores prior to infliximab withdrawal; and actual therapy at year All patients had long-standing, active, refractory RA After an induction regimen of mg/kg at weeks 0, 2, and 6, ... effectiveness and safety issues [27,28] Evaluation of the efficacy of long-term therapy shows that, after years of infliximab therapy, the majority of patients had a low level of disease activity and that ... infliximab therapy in patients with longstanding refractory RA over a 4-year period, (b) document the reasons for discontinuation, (c) describe the long-term course of disease activity, and (d)evaluate...
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Báo cáo y học: "Serum levels of autoantibodies against C-reactive protein correlate with renal disease activity and response to therapy in lupus nephritis" pps
... graded according to a standardized semiquantitative histological scoring protocol for activity and chronicity indices [31] Renal disease activity and response to therapy Renal disease activity was ... estimation of indices of renal disease activity and chronicity, today offers the best possibility to estimate renal disease and its response to therapy Biopsy is costly and is associated with considerable ... clinician's evaluation of disease activity and response to therapy in lupus nephritis Distinction of disease activity from organ damage in SLE remains a challenge Indirect assessment of disease activity...
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Báo cáo y học: "Comparison between single antiplatelet therapy and combination of antiplatelet and anticoagulation therapy for secondary prevention in ischemic stroke patients with antiphospholipid syndrome"
... with venous and arterial occlusive disease in multiple organs, miscarriages, and livedo reticularis Materials and Methods We focused on the secondary prevention of stroke with APS, and compared ... Med Sci 2010, with APS We therefore compared single antiplatelet therapy and a combination of antiplatelet and anticoagulation therapy for secondary prevention in ischemic stroke patients with ... prevention of stroke with APS, and compared single antiplatelet therapy and a combination of antiplatelet and anticoagulation therapy in ischemic stroke patients with APS The subjects were 20...
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Post-Harvest Biology and Technology of Citrus Fruits
... Source: Ivans and Feree (1987) Respiratory Rates of Some Nonclimacteric Fruits Respiration and Ethylene Production Rates These respiration rates are about double those reported in USDA Handbook 66 ... respiration rates are about double those reported in USDA Handbook 66 (2-4 at 5ºC and 10-17 ml CO2/kg.hr at 20ºC) for mandarins and oranges Skin Staining is a Preharvest Disorder Rind Staining Following ... Operations 90-95% 90- Ethylene During degreening, chlorophyll content (green color) decreases and allows the yellow and orange color (carotenoids) to become visible Ethylene accelerates chlorophyll degradation...
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Hydrodynamic and performance of low power turbines: conception, modelling and experimental tests
... (Graphics and 5) These trend curves are drawn based on the optimal best efficiency point estimated by the CFD model and the experimental results Graphic Comparisons between experimental test and simulation: ... highly developed, which allows studying its efficiency and versatility, searching and developing experimental components as computational models So this study presents analyses of new or adapted ... analysis of different scenarios and boundary conditions which are difficult to model experimentally These codes allow a better understanding of different hydraulic turbines and flow conditions [10]...
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