... functions of PtdIns3P [29] Additional PtdIns3P-binding proteins that not contain FYVE or PX domains include the Proppin ⁄ WIPI proteins, which bind PtdIns3P [and to some extent the related PtdIns(3,5)P2] ... which contains as many as five ubiquitin-binding domains, serves to sequester ubiquitinated cargoes, whereas ESCRT-I and -II, which also contain ubiquitin-binding domains, serve to form invaginations ... and PtdIns3P binding proteins in cytokinesis A surprising finding when using a green fluorescent protein-tagged version of the 2xFYVE probe was that PtdIns3P accumulates in the bridge separating two...
... and increased incidence of chronic bronchitis in women and acute respiratory infections in children In addition, evidence is now emerging of links with a number of other conditions, including ... combustion and increased incidence of chronic bronchitis in women and acute respiratory infections in children in developing countries In addition, evidence is now emerging of links with a number ... clearance capacity of the lung, resulting in increased residence time of inhaled particles, including microorganisms In situ detoxification, the main mechanism of defense in the deepest non-ciliated portions...
... sources included in the model were: road traffic, shipping, aviation, railroad, industries and larger energy and heat producers, small scale heating, working machines, working vehicles, and working ... due to a lower response rate in the more polluted city of Malmö (73% vs 80% in the remaining region) Outcome measures The following outcomes were investigated, as obtained by the postal questionnaires: ... smoking [OR(95%CI)] sure among people living in these surroundings might have been underestimated This may partly explain why effects from NOx were seen in the urban city of Malmö but not in the...
... cannot be organized in opposite clusters As pointed out by Levi (1978), the intrinsic meaning of these adjectives is something along the following lines: ‘of, relating/pertaining to, associated ... strategy for distinguishing between different adjective classes is maintained: listing lexical items in different files3 As pointed out in the previous section, even if the distinction between ... can offer interesting insights concerning adjective linguistic behavior and the identification of relevant common features, which may set the basis for an accurate modeling of this POS in computational...
... chromatin remodeling complex, termed NoRC, a member of ATP-dependent chromatin remodeling machines comprising the ATPase SNF2h and a large subunit, TIP5 (TTF-Iinteracting protein [60]) NoRC interacts ... machinery is highly dynamic, assembling in a stochastic fashion, sometimes individually and sometimes in subcomplexes [18] Quantitative single-cell imaging combined with computational modeling ... TTF-I binding Inhibits UBF/SL1 interaction p53 GSK3β pRb ARF PTEN Induces UBF Inhibits SL1–UBF interaction degradation Disrupts SL1 TIF-IA TTF-I Pol I SL1 UBF Increases UBF expression Increases...
... types of agents, representing two different kinds of cells (or two kinds of molecules) can move freely and interact within the containing space; e) Interacting state machine: systems are represented ... genome-scale kinetic modeling of metabolism, begin with the network topology, modeled in the constraintbased framework, and then refine the models by adding the kinetic structure in order to generate ... Genes are transcribed into RNA molecules, which are subsequently translated into proteins These proteins are involved in all cellular functions Some proteins are enzymes involved in the catalysis...
... relay maintains private information pertaining to its behavior The private information and the sequential nature of cooperative interactions gives relay terminals a dominant position in deciding ... reciprocate Terminals are rational in that they behave in a manner to maximize their individual benefit of cooperation We assume that terminals maintain private information pertaining to their behavior ... source terminal i Source terminal i may share its trust vector with other terminals in the network For instance, terminal i may inform terminal l about behavior of terminal k Terminal l then...
... as mmol/g In the text the following definitions were used: (e) = elements in propanol extract of autoclaved bark, (b) = elements remaining in bark after propanol extraction, digested in concentrated ... several tree species in a montane rain forest in New Guinea [15] Complex forming metals, such as Cu and Mn, bind strongly to cellulose and hemicellulose and cell wall proteins contain S [19], thus ... can increase the frequency of frost injuries in trees through lowered starch concentration and delayed hardening [8] Bark lesions caused by frost injuries are frequently observed on declining...
... was investigated by examining disease activity of patients terminating therapy because of treatment failure We did not find any differences in the level of disease activity when comparing infliximab ... Ethical approval was obtained before making the register linkage To minimise follow-up loss, data for all patients included were checked every months In case of incomplete clinical data for a period ... TNF-blocking drugs in combination with MTX or as monotherapy is shown in Table The number of patients initiated on TNF-blocking agents in combination with other DMARDs was too small to allow meaningful subgroup...
... an increase of the relative risk of each when present in combination with anti-CCP antibodies This was also found in individuals who subsequently developed RA [7,20] In the present study, in ... for developing rheumatoid arthritis in patients, stratified for anti-cyclic citrullinated peptide (anti-CCP) antibodies Nonsmoking Smoking Cases/controls Relative risk (95% confidence interval) ... 1858 T variant in patients and controls Smoking was, in this patient cohort, a risk factor for RA independent of the 1858T variant and seropositivity for anti-CCP antibodies Competing interests The...
... of infrastructure such as traffic-calming measures aiming to increase pedestrian and bicycle safety [14,15] In a systematic review, van Sluijs, McMinn, and Griffin stated that interventions, including ... by questions regarding how healthpromoting measures were prioritised in the municipality) Are there any measures taken in order to increase walking and biking to school and in general? [30,31] ... there any measures taken in order to increase walking and biking to school and in general? Significant measures taken = Yes, measures are taken to increase both walking and biking to school 14 11...
... extremely useful in working on a modeling approach to BMP evaluation (see Chapter 15 on BMPs in this book; Gitau et al 2001) An initial step inmodeling BMP-induced reduction in P loss is the ... Thus, existing databases are increasingly being linked to nonpoint source models, often via geographical information systems (GIS) Generally, key input data for nutrient transport models involve ... nonpoint pollutant loading model Proceedings of the First Federal Interagency Hydrologic Modeling Conference, April 19–23, Las Vegas, NV Deere and Company 1995 Managing nonpoint source pollution in...
... factor in determining the erosivity of individual rainfall events is a major factor in generating this overprediction–underprediction problem Kinnell and Risse (1998) showed that combining the EI index ... Assigned erosion rate NI NI Modeling Phosphorus in the Environment Model Modeling Runoff and Erosion in Phosphorus Models 59 determine in ltration using the Green-Ampt or other in ltration equation ... rainfall intensity Total rainfall mass, or kinetic energy at impact, also has been found to in uence rainfall erosivity A number of soil characteristics have been identified as in uencing rainfall...
... modeling routines depicting P leaching in the soil profile Recent interest in determining P leaching losses may lead to alternative methods for modeling P leaching Simplified forms of the adsorption ... 96 Modeling Phosphorus in the Environment to simulate P loading to streams from base flow or tile flow (Neitsch et al 2002a); however, this may lack continuity with modeling routines depicting ... concentration in interflow and tile drainage Furthermore, a single model may use both partial descriptions but may lack the continuity and conservation of mass linking them in an actual setting 4.3...
... therein), groundwater modeling, including Bayesian averaging of model structures (e.g., Ye et al 2004), and rainfall-runoff modeling (e.g Kavetski et al 2002; Vrugt et al 2002, 2003) In principle, ... 132 Modeling Phosphorus in the Environment 6.1 SOURCES OF UNCERTAINTY INMODELING P TRANSPORT TO STREAM CHANNELS The starting point for this contribution is the extensive ... concentration is P inputs from grazing animals These inputs were poorly known, both in their timing and their magnitude, and were not included as model inputs The likely effects of grazing inputs on discharge...
... within a land segment there is variability in ET due to differences in, for example, rooting density Rainfall is distributed in PWATER in the following manner Some of the rainfall first goes to interception ... parameter (unitless) IIMAX line II (interflow + infiltration capacity) IIBAR IMAX MSUPY Inches of water/interval Inches of water/interval IBAR IIMIN IMIN line I (infiltration capacity) 50 % of area ... watershed into sub-basins Within each sub-basin it models water, sediment, and P movement in land segments representing the dominant land uses and in a stream-reach segment The equations describing in ltration...