mitochondrial biology and oxidative stress in parkinson disease pathogenesis
Báo cáo y học: "NITRIC OXIDE (NO), CITRULLINE – NO CYCLE ENZYMES, GLUTAMINE SYNTHETASE AND OXIDATIVE STRESS IN ANOXIA (HYPOBARIC HYPOXIA) AND REPERFUSION IN RAT BRAIN"
Ngày tải lên :
26/10/2012, 09:07
... synthase. The increased
activities of argininosuccinate synthetase and argininosuccinate lyase suggest the increased
and effective recycling of citrulline to arginine in anoxia, making nitric ... arginine at the site of synthesis.
Arginine is a semi essential amino acid and in CNS, its
availability depends upon: (a) uptake from the circu-
lating arginine and (b) recycling of citrulline ... in brain in anoxia as observed by in-
crease in NOx concentration in this study support the
earlier findings of NO involvement in pathophysiol-
ogy of hypobaric hypoxia in brain (42-43). In this...
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Báo cáo khoa học: Calcium, mitochondria and oxidative stress in neuronal pathology Novel aspects of an enduring theme pdf
Ngày tải lên :
07/03/2014, 12:20
... by proteins resi-
ding in both the inner and outer mitochondrial
membrane, that is activated by mitochondrial Ca
2+
overloading and other factors including oxidative stress
[88,89]. In neurons ... neuron. The turning point upon which
the cell looses the ability to buffer the incoming calcium
resulting in an abrupt, sustained and irreversible
increase in [Ca
2+
]
c
, probably coincides with ... calcium
transients during reversible brain ischemia. Exp Brain
Res 104, 462–466.
188 Silver IA & Erecinska M (1992) Ion homeostasis in rat
brain in vivo: intra- and extracellular [Ca
2+
] and [H
+
]in
the...
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báo cáo hóa học: " Brain inflammation and oxidative stress in a transgenic mouse model of Alzheimer-like brain amyloidosis" pptx
Ngày tải lên :
19/06/2014, 22:20
... implicating both oxidative
stress and inflammatory mechanisms in AD pathogenesis.
Effect of indomethacin plus vitamin E supplementation on sol-uble Aβ levelsFigure 3
Effect of indomethacin plus ... domenico@spirit.gcrc.upenn.edu
* Corresponding author
Abstract
Background: An increasing body of evidence implicates both brain inflammation and oxidative
stress in the pathogenesis of Alzheimer's disease (AD). The ... therapeutic interventions suppressed brain inflammatory
and oxidative stress responses in the mice. This effect was accompanied by significant reductions
of soluble and insoluble Aβ1-40 and Aβ1-42 in...
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Báo cáo y học: "Nifedipine decreases sVCAM-1 concentrations and oxidative stress in systemic sclerosis but does not affect the concentrations of vascular endothelial growth factor or its soluble receptor" potx
Ngày tải lên :
09/08/2014, 01:23
... CD40 ligand, interleukin 1, or interleukin 6 [10]. Oxi-
dative stress also promotes angiogenesis [13]. The link
between oxidative stress and angiogenesis is emphasised
in SSc by the baseline correlation ... nifedipine can ameliorate endothelium injury in SSc
and that VEGF signalling may by impaired in this disease
without implication of the sVEGFR-1.
Endothelium injury is critical in SSc and is ... VEGF signalling is impaired
in SSc. However, more experimental evidence is needed to
determine whether the VEGF pathway is intrinsically defective in
SSc.
Keywords: nifedipine, oxidative stress, ...
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Báo cáo khoa học: Cotton GhMPK2 is involved in multiple signaling pathways and mediates defense responses to pathogen infection and oxidative stress doc
Ngày tải lên :
14/03/2014, 23:20
... MPK3 and MPK6 in Arabidopsis (group A
MAPKs), SIMK and SAMK in alfalfa, and
LeMPK1 ⁄ 2(Lycopersicon esculentum SA-induced pro-
tein kinase) and LeMPK3 (L. esculentum wound-
induced protein kinase) ... protein kinase and wound-
induced protein kinase, two MAPKs in group A, were
activated by inoculation with the tobacco mosaic virus
(TMV) [10]. Their orthologs in other plant species,
including ... accumulation in wild-type and transgenic
plants in response to abiotic and abiotic stresses. (A) Virus infec-
tion-induced H
2
O
2
accumulation detected by DAB staining. (B) Abi-
otic stress- induced...
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Báo cáo khoa học: Pyruvate:ferredoxin oxidoreductase and bifunctional aldehyde–alcohol dehydrogenase are essential for energy metabolism under oxidative stress in Entamoeba histolytica pdf
Ngày tải lên :
15/03/2014, 23:20
... indicating the presence of two catalytically
independent domains, the N-terminal domain, display-
ing ALDH activity, and the C-terminal domain, con-
taining an iron-binding domain, which is involved ... against oxidative stress
damage, have not been reported.
In vivo effects on glucose-fermenting enzymes
and fluxes under oxidative stress
Recently, we reported that amebas incubated for
30 min in ... solubilized extract were incubated in such buffers for 4 h
on ice, and the remaining enzyme activity was determined. Inset: EhPFOR time stability in N
2
-saturated buffer in the absence or presence
of...
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Psychiatric and Cognitive Disorders in Parkinson’s Disease pptx
Ngày tải lên :
28/03/2014, 22:21
... on both hands, mild rigidity and bradykinesia in the upper limbs,
gait slowness, and mild postural instability. He cried during the interview, and worried
about being unable to continue his work ... pallidotomy
Indications
Advanced disease with rigidity and bradykinesia, and a poor response to antiparkinsonian
medications
Disabling dyskinesias
Severe motor Xuctuations
Painful cramps and severe dystonias
Serious ... the cognitive and emotional side-eVects of
speciWc antiparkinsonian drugs, such as l-dopa, dopaminergic agonists,
amantadine, selegiline, and anticholinergic drugs.
In the eighth, and last, chapter...
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báo cáo hóa học: " The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer''''s disease" ppt
Ngày tải lên :
19/06/2014, 22:20
... global inhibition
of src-family tyrosine kinases or inhibition of phosphati-
dylinositol-3 kinase (PI3K) attenuates ROS production.
These findings suggest that these kinases are involved in
upstream ... leading to protein
tyrosine phosphorylation and activation of the src-family
kinases Lyn and Fyn as well as the tyrosine kinase Syk
[30,32,52]. Activation of these signaling cascades are
linked ... demon-
strated a ~70% reduction in AD incidence among patient
populations receiving statin treatment [117,118]. Despite
these promising findings, the use of statins in prospective
clinical trials has yielded...
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báo cáo hóa học:" Health-Related Quality of Life in Parkinson disease: Correlation between Health Utilities Index III and Unified Parkinson’s Disease Rating Scale (UPDRS) in U.S. male veterans" docx
Ngày tải lên :
20/06/2014, 16:20
... Access
Health-Related Quality of Life in Parkinson
disease: Correlation between Health Utilities
Index III and Unified Parkinson s Disease Rating
Scale (UPDRS) in U.S. male veterans
Galit Kleiner-Fisman
1*
, Matthew ... article as: Kleiner-Fisman et al.: Health-Related Quality of Life in
Parkinson disease: Correlation between Health Utilities Index III and
Unified Parkinson s Disease Rating Scale (UPDRS) in U.S. male ... for inclusion.
Review of the diagnosis of parkinsonism was further
scrutinized and only individuals fulfilling United King-
dom Brain Bank Criteria [18] for idiopathic PD (IPD)
were included in...
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Báo cáo khoa học: "Comparative study of PM2.5 - and PM10 - induced oxidative stress in rat lung epithelial cells" pptx
Ngày tải lên :
07/08/2014, 17:22
... study of PM2.5 - and PM10 - induced oxidative stress
in rat lung epithelial cells
Jin-Hyuk Choi, Jun-Sung Kim, Young-Chul Kim
1
, Yoon-Shin Kim
2
, Nam-Hyun Chung
3
and
Myung-Haing Cho*
Laboratory ... protection
standards for PM by adding an indicator for even “fine”
particles (PM2.5). In this trend, our government is trying to
update on ongoing litigation over PM2.5 standard. However,
relative less information ... study,
PM2.5 induced more MDA formation than PM10
suggesting that PM2.5 induced more oxidative stress than
PM10. In the single strand breakage assay using pBR322
DNA, the ratio of changed form II/total...
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Báo cáo lâm nghiệp: "Response to an ozone gradient of growth and enzymes implicated in tolerance to oxidative stress in Acer saccharum (Marsh.) seedlings" pot
Ngày tải lên :
08/08/2014, 00:22
... processes.
However, after 85 days, the NR activity in the seedlings was
lower and decreased with increasing O
3
. At that time in the
season and with increasing oxidative stress, NH
3
may have
been provided ... 10.1051/forest:2006019
Original article
Response to an ozone gradient of growth and enzymes implicated in
tolerance to oxidative stress in Acer saccharum (Marsh.) seedlings
Catherine G
a,b
*
,NadineC
c
,PaulW
c
, ... material from a single leaf was sam-
pled from each ush of each seedling, cut into 2 ì 2 mm pieces and
incubated in 5 mL of 100 mM phosphate buffer (pH 7.5) containing
40 mM KNO
3
and 1.5% 1-propanol....
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Báo cáo y học: "Phenomenology and management of cognitive and behavioral disorders in Parkinson''''s disease. Rise and logic of dementia in Parkinson''''s disease" pptx
Ngày tải lên :
08/08/2014, 21:20
... Access
Review
Phenomenology and management of cognitive and behavioral
disorders in Parkinson& apos;s disease. Rise and logic of dementia in
Parkinson& apos;s disease
Constantin Potagas* and Sokratis Papageorgiou
Address: ... prelim-
inary findings from an open trial. Mov Disord 2001,
16:1171-1174.
58. Aarsland D, Hutchinson M, Larsen JP: Cognitive, psychiatric and
motor response to galantamine in Parkinson& apos;s disease ... causes of the akinetic-rigid
syndrome, or errors in differentiating dementia from con-
fusional states, depression and even ageing, or in defining
and assessing dementia itself [3].
Indeed, the first...
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Báo cáo y học: "Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function" pptx
Ngày tải lên :
09/08/2014, 06:22
... maintain the
chondrocyte telomere length and proteoglycan remaining in the
cartilage explants, suggesting that oxidative stress induces
chondrocyte telomere instability and catabolic changes in
cartilage ... Our findings
clearly show the presence of oxidative stress in degenerat-
ing cartilage, and the resultant telomere erosion and dys-
function of chondrocytes in vitro and in vivo, suggesting a
role ... and
oxidative stress in OA cartilage, as discussed above, we
postulated that oxidative stress induces telomere instability
and dysfunction in chondrocytes, subsequently resulting in
cartilage ageing and...
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