mitochondria as targets of free radicals

Báo cáo y học: " Role of free radicals in the pathogenesis of acute chest syndrome in sickle cell disease" pot

Ngày tải lên : 12/08/2014, 18:20

... at baseline In addition, we observed a ninefold increase in the plasma levels of F2 isoprostanes, a stable marker of lipid peroxidation, in the plasma of ACS patients as compared with that of ... activation of enzymes such as myeloperoxidase [30] In a transgenic sickle cell mouse model, induction of acute lung injury was associated with increased myeloperoxidase activity as compared with wild-type ... patients at baseline have increased myeloperoxidase activity [33] Although not directly measured in human ACS, demonstration of increased myeloperoxidase activity in sickle WBCs at baseline and...

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A COMPUTATIONAL STUDY OF FREE RADICALS IN CHEMISTRY AND BIOLOGY

Ngày tải lên : 11/09/2015, 21:28

... configurations Free radicals can react readily with many molecules, in a myriad of mechanisms The study of free radicals is an interest of many research groups worldwide This comes as no surprise, since radicals ... number of basis functions needed for each atom Split valence basis sets have a larger number of basis functions per atom Two or more sizes of basis functions are assigned to the valence shells of ... NO2• and CO3•− free radicals have been attributed as a source of free radicals in biological systems [16] A computational study of the above reaction using density functional theory was carried out,...

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Báo cáo Y học: The mitochondrial-lysosomal axis theory of aging Accumulation of damaged mitochondria as a result of imperfect autophagocytosis ppt

Ngày tải lên : 17/03/2014, 23:20

... majority of senescent changes in postmitotic cells INTRALYSOSOMAL ACCUMULATION OF LIPOFUSCIN Deposition of lipofuscin pigment within postmitotic cells, one of the most prominent signs of aging, has ... damaged mitochondria Increased replication of defective mitochondria A number of congenital mitochondrial neuropathies, myopathies and cardiomyopathies begin, in young age, as discrete heteroplasmic ... intermembranous space, despite an increased overall production of Æ) O2 As a result, the membranes of defective mitochondria may suﬀer less oxidative damage than those of normal mitochondria, may be less...

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Báo cáo khoa học: B1–Proteases as Molecular Targets of Drug Development B1-001 DPP-IV structure and inhibitor design ppt

Ngày tải lên : 23/03/2014, 15:20

... the names PAS-40, PAS-52, PAS-70, PAS-110, PAS-151 and PAS-170 (PrtA Substrate molar mass) The N-terminal amino acid sequence of two PAS proteins, PAS-52 and PAS110, identied the former as Manduca ... Third- to fth-passage cells from human RPE were cultured with TPEN Leakage of LDH into the medium was measured as a marker of RPE cell damage Activity of calpains was assessed by casein zymography, ... peroxidase Blood plasma and eluate from surface of blood cells of cancer patients demonstrated increased level of anti- hydrophilic protease activity compared with healthy donors Increase of protease...

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Modelling of reaction between antioxidants and free radicals

Ngày tải lên : 13/09/2015, 21:10

... (∆S#), free energies of activation (∆G#) of phenolics with 3-OHs in solvents 65 Table 4.1: B3LYP gas-phase OH BDEs (kJ mol-1) as a function of basis sets 88 Table 4.2: Comparison of bond ... TABLE OF CONTENTS ACKNOWLEDGEMENTS i GENERAL INTRODUCTION 12 1.1 Free radicals 12 1.2 Effect of free radicals on biological system 13 1.3 Effect of free ... Figure 1.3: Chemical Struture of different types of polyphenols 1.5 Effect of antioxidants on free radicals in food and biological system Free radicals initiate oxidation of lipids in food systems...

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Role of central nervous system ceramides and free radicals in a mouse model of orofacial pain

Ngày tải lên : 14/09/2015, 08:42

... sphingomyelinase (ASMase), ASMase splice variant, Mg2+-independent neutral sphingomyelinase (NSMase), Mg2+-dependent NSMase and alkaline sphingomyelinase Among these, Mg2+-independent NSMase and the ... action of ASMase VIII Summary Since D609 is also found to be a free radical scavenger, phenyl-N-tert-butylnitrone (PBN), a free radical spin trap was ICV injected to elucidate the role of free radicals ... Increased ASMase activity was found in the left primary somatosensory cortex at days after facial carrageenan injection And ICV injection of ASMase inhibitor D609 significantly reduced ASMase...

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Báo cáo y học: "Thioglycosides as inhibitors of hSGLT1 and hSGLT2: Potential therapeutic agents for the control of hyperglycemia in diabetes"

Ngày tải lên : 26/10/2012, 10:04

... luminescence for ATP detection was assessed using a MicroBeta Trilux (PerkinElmer) A standard curve was used to determine the amount of ATP in mg of protein measured from the number of cells per well After ... Fluorescence emission was recorded at 460 and 580 nm After a 20 sec baseline reading, 0.1 ml of PBS containing 10 µM of the compound investigated was added, and the fluorescence signal was recorder for ... depolarization, as measured by FRET, was calculated As shown in Figure 3, a statistically significant linear relation between the changes in membrane potential and the transport activity of the cells was...

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current situation of outsourcing development, a number of favorable factors promoting this industry as well as analysis of outsourcing activities FPT Software.doc

Ngày tải lên : 27/10/2012, 16:41

... them, the software outsourcing stands out as one of the most profitable and fast-growing industry This paper studies the current situation of software outsourcing development, some of the favorable ... organizations The packaged software domain includes all software sold as merchantable products In terms of the software outsourcing activities, we have other kinds of classification such as business process ... traditional reason for offshore development Low-level tasks such as coding and software testing can be performed in less-developed countries at costs as low as ten percent of domestic ones Software outsourcing...

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Children security as part of the " living together with floods" strategy in the Mekong river delta, VietNam

Ngày tải lên : 18/10/2013, 12:15

... faced a historically high flood, as severe as that of 1961 which was the most destructive flood in past 70 years The flood in 2000 was extreme not only in terms of its very high peak level and ... areas are as important as safety helmets for people driving motorbikes on the highways In recent years, hundreds of children have drowned due to lack of life vests Children in the flood areas ... consideration of the activity effectiveness of structural and non-structural measures and analysis of human behaviour on flood risks in the Mekong River Delta REFERENCES Asian Disaster Reduction...

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Plants as Sources of Energy

Ngày tải lên : 25/10/2013, 05:20

... Carbon-Rich Biomass Wood gas (or synthesis gas) is another form of biogas produced by thermal gasification of woody biomass or other carbon-rich materials in a gasifier or wood gas generator Usable ... switchgrass, barley, hemp, kenaf, potatoes, sweet potatoes, cassava, sunflower, fruit, molasses, corn, stover, grain, wheat, straw, cotton, biomass in general as well as many types of cellulose waste ... mixture of ethanol is added to gasoline (as is common in E10 gasohol), aldehyde emissions increase by as much as 40%, and these components are not regulated in emissions laws The use of alcohol...

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Computer illiteracy as one of the main problem of business student

Ngày tải lên : 26/10/2013, 17:15

... more easy, than try itself to understand it Waste time - is the main problem of student who spend a lot of time and force for solving a problem, which can be solved with the help of PC faster ... of the problem of computer illiteracy is the lack of useful information in the course of information science The second cause is unwillingness to learning - many people think that easier to ask ... which is called “Simplification of access to computer classes.” We mean the organization of computer classes or computer courses in our University These classes must be free At first step we write...

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Benefits of free trade

Ngày tải lên : 27/10/2013, 09:15

... economies of scale as the mass production is spread over a larger market, where a lot of firms produce a greater variety of products Free trade advocates assert that free trade primarily increases ... for Taiwan has been an astounding record of economic growth (See Chart 2.) The 2000 Index of Economic Freedom ranks Taiwan as the 11th freest economy in the world With its economic freedom came ... money of the people Another blessing of free trade is that it minimizes the possibilities of war which is one of the greatest enemies of people And though small Also, free trade brings people of...

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The neuroscience of free will

Ngày tải lên : 01/11/2013, 09:20

... time of the committing of the act, the party ACCUSED was laboring under such a defect of reason, from disease of mind, as not to know the nature and quality of the act he was doing; or if he did ... light of the weight of other reasons Instead, weighting a reason is assigning a weight to a consideration for no reason at all The power to weight reasons, to reiterate, is the power to assign ... they have independently of the act of deliberation (in which case we are really weighing reasons) or your assignment is arbitrary, and the arbitrariness of the assignment of weight transfers to...

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Tài liệu THIS DISPOSTION IS NOT CITABLE AS PRECEDENT OF THE T.T.A.B04/3/02 Paper No. 12 RFC docx

Ngày tải lên : 20/12/2013, 23:15

... action in support of the final refusal were copies of a number of third-party trademark registrations on the Principal Register based on use In each registration, the list of goods includes skin ... be affirmed As applicant points out, in any likelihood of confusion analysis, two key considerations are the similarities of the goods and the similarities of the marks Tricia Guild Associates ... vitamin supplements of herbal or organic compounds,” in Class 5, that confusion would be likely In support of the refusal to register, the Examining Attorney included copies of excerpts retrieved...

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Tài liệu Transformation through Integration An Activity Theoretical Analysis of School Development as Integration of Child Care Institutions and the Elementary School ppt

Ngày tải lên : 16/01/2014, 16:33

... schoolchildren of working or studying parents, or in cases where the child has an individual need A place should be offered as close to the child’s home as possible As in the case of pre-school ... qualifying task has been complemented with its socializing task But as Isling claims, in the struggle between these two tasks the qualifying assignment has been dominant The double requirement has resulted ... that play has for learning as strongly as Fröbel had done Play June 28, 1840 was the date of the inauguration of the public German kindergarten This day was chosen by Fröbel because it was the 400-year...

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Tài liệu Đề nghị cấp giấy chứng nhận lưu hành tự do (Certificate of free sale) cho sản phẩm xuất khẩu docx

Ngày tải lên : 21/01/2014, 09:20

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Tài liệu Báo cáo khoa học: NirF is a periplasmic protein that binds d1 heme as part of its essential role in d1 heme biogenesis pdf

Ngày tải lên : 15/02/2014, 01:20

... structure of Met8P has shown that this protein has an aspartate residue (Asp141), which is important for both chelatase and dehydrogenase function [17]; interestingly, this aspartate, Asp129, is also ... the in vivo nitrite reductase activity as seen by the accumulation of large Tota l Inﬂuence of variations of conserved residues on the in vivo activity of NirF te amounts of extracellular nitrite ... alkaline phosphatase conjugate of strep-tactin antibody, we found that both membrane and cytoplasmic fractions were free of NirF protein and it was present only in the periplasmic fraction (Fig...

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Tài liệu BIOCHEMICAL TARGETS OF PLANT BIOACTIVE COMPOUNDS A pharmacological reference guide to sites of action and biological effects doc

Ngày tải lên : 17/02/2014, 05:20

... synthesis and topoisomerases Dihydrofolate reductase and thymidylate synthetase HIV- integrase and HIV- reverse transcriptase Actin, histone acetylase, histone deacetylase, cell division and tubulin ... and as such can act as "protonophores" to increase the proton (H+) permeability of the mitochondria1 inner membrane and hence act as "uncoupling" inhibitors of the key ATP-providing process of ... inhibitors of particular enzymes T h e inhibition of protein kinases by various hydrolysable tannins becomes more potent as the number of phenolic groups increases xiv Isoflavonoids Isoflavonoids...

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Tài liệu Freshwater sponges as indicators of water pollution: an investigative undergraduate lab pdf

Ngày tải lên : 18/02/2014, 04:20

... abnormalities (such as the absence of a well defined water vascular system) As mentioned earlier, normal sponge growth typically includes the production of a distinct water vascular system with a less ... Because of their simple morphological construction, many cells come into direct contact with the surrounding water as the sponge pumps Thus, a sponge's mode of feeding results in high levels of exposure ... life cycles of freshwater sponges (Life of the Freshwater Sponge) The running time of the film is 28 minutes, and it shows sponges in their natural environment and in the lab The film was produced...

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Tài liệu Báo cáo khoa học: Diversity and junction residues as hotspots of binding energy in an antibody neutralizing the dengue virus doc

Ngày tải lên : 19/02/2014, 07:20

... kon and koff were measured at 25 °C with the Biacore instrument, with MalE–E3-H6 in the immobile phase and Fab4E11H6 in the mobile phase The mean and associated SE values of koff in measurements ... for the side chain (sc-ASA) of the wild-type residue in column 1, as measured in a three-dimensional model of Fv4E11 (see Fig 4) Column 5, variation DDG of the free energy of interaction between ... The concentration of free Fab4E11-H6 was then measured by an indirect ELISA in which MalE-E3-H6 was immobilized in the wells of a microtiter plate and the bound Fab4E11-H6 was revealed with a...

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