... of CNT-based drugdeliverysystems in practical therapy comes into fruition The biosafety of SWCNT used asdrug carriers Although there are exciting prospects forthe application of CNTs asdrug ... there are great possibilities for them to be used in the construction ofdrugdeliverysystems in not too long a time The functionalization of CNTs used in the construction ofdrugdeliverysystems ... closed (B) The schematic illustration ofthe strategy forthe preparation ofthe CNT-based drugdeliverysystems Figure The modification of CNTs Schematic illustration of modification of CNTs with...
... The thesis is submitted forthe degree of Doctor of Philosophy in the Department of Oral & Maxillofacial Surgery at the National University of Singapore under the supervision of Associate Professor ... evaluate the efficacy ofthe scaffolds asdeliverysystemsfor multiple growth factors, platelet-rich plasma (PRP) was used The buffers sufficed as important determinants ofthe release profiles ... serve as effective protein deliverysystemsforthe repair 28 of bone tissue The merit ofthe work was that the PCL-based scaffolds could serve not only as a template for bone growth but also as...
... consequence of, selection of a sub-population of cells that are eventually capable of completing all the metastatic cascade steps (7) Typically, the process of metastasis has been viewed as a series of ... series of pre-malignant states into invasive cancers (3) 1.1.2 Metastasis of cancer Metastasis, the spread of cancer from its primary site to a distant organ, is responsible forthe major cause of ... overall VIII therapeutic efficacy ofthe conjugated anticancer drug was, to some extent, compromised after conjugation In addition, thedrug release profile of doxorubin from the matrix was in a sustained...
... adverse health effects for a high percentage ofthe population Asthe intake of a nutrient increases above the UL, the potential risk of adverse affects increases.35 The UL for some essential nutrients ... compounds in the diets was not reported, but the absence of these data does not diminish the value ofthe study In summary, the results of this study showed that the phenolic content in the blood of individuals ... nucleotides, and other cellular molecules.12 However, the acceptance of folic acid is more easily grasped by the consumer as an aid in the prevention of neural tube birth defects.13 The marketing of foods...
... Liposomes asdrugdeliverysystems Polymers and polymeric systemsfordrugdelivery Dendrimers fordrugdelivery GENERALITIES OFDRUGDELIVERYDRUGDELIVERY SYSTEM Definition: A drugdelivery ... Targeted drugdelivery systems: deliver drug to a desired body location, organ, tissue, specific cells… Controlled-release drugdelivery systems: preprogramed drug release By the route of delivery: ... absorption Increase chemical and metabolic stability Mask irritation or taste MAIN TYPES OF PRODRUGS FOR TARGETED DRUGDELIVERY (a): Classic prodrugs: prodrugs are transformed into one or...
... protection for pDNA together with the ease of dissociation and release of pDNA probably explain the increased efficiency ofthe DP 15-21 polyplexes in vivo The ease of dissociation in the presence of ... Non-viral gene deliverysystemsThe increased risk of using viral deliverysystemsfor gene therapy of genetic or acquired human diseases has motivated the search for, and utilisation of, safer carrier ... instead of using the transferred bacteria for pDNA delivery, they are exploited as a factory forthe production of therapeutic peptides or proteins in situ [77] AGT allows the levels ofthe expressed...
... than the coercivity ofthe medium The medium is then left for fast cooling in the presence ofthe applied field, which thus results in retention of magnetic information A schematic diagram ofthe ... and one ofthe first widespread uses of magnets was as a navigational aid in the form of a compass In a bar magnet, the end of magnet pointing toward North is termed the north pole, and the end ... image showing the area illuminated by the HAMR laser The domains in the black lines have a magnetic orientation opposite to that ofthe other areas on the sample (b) MFM image ofthe same lines...
... vectors for their transmission; therefore, the geographical distributions of these viruses follow the distributions of their vectors [5] With the worldwide presence ofthe Aedes mosquito in the tropics ... [54] Vascular leakage is a hallmark of severe dengue disease in humans; development of vascular leak in AG129 therefore significantly increased the relevance of this model forthe study of dengue ... (104 PFU) of virus [55] The uniqueness of this model lay in the onset of severe disease after the viraemic phase, which resembled the disease kinetic in humans Other mouse models, in contrast, exhibited...
... describes the application of SBA-15 in thedeliveryofthe small molecule model drugof ibuprofen (IBU), with emphasis on the influence ofthe different functional methods on the adsorption and release ... tolerance of a variety of manufacturing methods Polymeric drugdeliverysystems under wide investigations are classified according to the mechanism controlling the release ofthedrug Some ofthe basic ... observed that thedrug would be more soluble in the polymer phase asthe difference in the solubility parameters ofthedrug and polymer becomes smaller Therefore, forthe design of a specific...
... step-by-step approach in the analysis ofthe use of foams for controlled release of Paclitaxel as implants within the brain forthe post-surgical treatment of glioblastoma multiforme through combining ... in the resection cavity, and the wound was closed by suturing On day 8, the animal was re-anesthetized, the wound reopened and the foam was placed on top ofthe tumor implant The wound was then ... vitro release profile Reproduced from J Xie et al (2006) [26] 4.2 EHDA Microparticle In Vivo Release The objectives ofthe In vivo release was to compare the release profile ofthe microparticles...
... 15.2 The Clinical Need forDrugDeliverySystemsDrugdeliverysystems modify the kinetics or the location ofthe escape ofthedrug from the medicine Tables 15.1 and 15.2 provide generic reasons ... rate forthedrug Therefore, it is essential that manufacturing routes achieve control ofthe size ofthedrug phases within the polymer phase and efficient dispersion ofthedrug phase A further ... loading of up to 20% w/w of protein in the polymer with full retention ofthe protein enzymatic activity The addition of PEG to the formulation eliminated the burst release ofdrug and drug release...
... designated as feasible candidates fordrugdelivery systems, anti-cancer agents and vaccine immunotherapy For example, DNA vaccine delivery to APCs has been facilitated by microencapsulation of plasmid ... provide the basis forthe design of DNA vaccine in human clinical trial in the future Altogether, route of DNA immunization and its formulation could represent an important element in the design of ... that the technique of ultrasound can aid in the transduction of naked plasmid DNA into colon carcinoma cells Furthermore, the intra-tumoral injection of naked plasmid DNA followed by ultrasound...
... oxidase (COX) In these enzymes, the redox potential ofthe metals is harnessed to provide the enzymes with their electron transfer capabilities Paradoxically, it is the same redox potential ofthe ... into the cell White et al [60] demonstrated that CQ facilitated thedeliveryof Cu and Zn across the plasma membrane, as determined by inductively coupled plasma mass spectrometry Once inside the ... because of an imbalance in the activity of tau kinases and phosphatases [3] One particular tau kinase pertinent to metal dyshomeostasis in AD is glycogen synthase kinase-3 (GSK3) GSK3 has recently...
... To measure the phraseness of a candidate phrase we use a technique based on the χ2 independence test We measure the independence ofthe events of seeing the components ofthe phrase in the text ... which measures the maximum centrality score the phrase achieves across the entire book This can be thought ofas a measure ofthe importance ofthe phrase in a smaller coherent segment ofthe document ... means the elimination of instances from the majority class (in our case negative examples), while oversampling focuses on increasing the number of instances ofthe minority class Aside from the...
... sequencing of whole plastids and genomes of a number of photosynthetic organisms Recently, De Las Rivas et al [15] summarized the nature and composition ofthe extrinsic proteins of different ... with the result of Shibata et al [21] The presence of PsbV in C paradoxa is consistent with the presence ofthe psbV gene in the complete sequences ofthe cyanelle genome [24], in which the psbU ... this gene in the cyanelle genome suggested that this gene has been transferred to the nuclear genome in this organism, as in the case of red algae On the other hand, the failure of cross-reaction...
... clearance, and the constraints imposed by the nature ofthe various routes of administration available fordrugdelivery ROUTES OF ADMINISTRATION AND CLASSIFICATION OFDRUGDELIVERYSYSTEMSThe principal ... or sites has led to the development of alternative drugdelivery systems, which attempt to address the requirements of rate and extent ofdrug release, and thereby absorption Deliverysystems include ... advanced drugdeliverysystems Chemical Aspects ofDrugDeliverySystems Table Mechanisms and properties influencing drug release from particle carrier systems* MECHANISM OFDRUG RELEASE PROPERTIES...
... of its business: The bank’s operating income for months of 2012 before allowances for credit losses amounted to EUR 69.3 million During months of 2012, the amount of deposits with the bank has ... and customers for their loyalty and to all officers of ABLV Group for their important contribution in achievement ofthe company’s targets! ABLV Bank, AS public quarterly report forthe period ended ... present, the legal address ofthe bank is Elizabetes Street 23, Riga The bank operates in accordance with the legislation ofthe Republic of Latvia and the license issued by the Bank of Latvia...
... analysis from small to large scale circuits For example, the impulse response ofthe circuit of Figure 2(a) is the convolution ofthe impulse responses of each ofthe elementary cells: h(t) = (h1 ⊗ h2 ... linear circuit is the convolution ofthe individual impulse responses (a), the shaping curve ofthe concatenation of two shapers is the convolution ofthe individual shaping curves (b) There are thus ... (t) of a linear circuit to the sum of two inputs x + n is the sum ofthe individual responses (a), but the response ytot (t) of a greedy shaper to the aggregate of two input flows x + n is not the...
... anticancer drugs They demonstrated that thedrug release from these systems can be controlled by controlling the particle size, as they found the larger the NPs size, the lower was thedrug release The ... ofthe factors forthe formulation ofthe lipid NP are: thedrug payload depends on the oil content, the evolution ofthe hydrophilic–lipophilic balance of solutol HS15 is the driving force of ... armamentarium ofsystemsforthe targeting of drugs Parallel to these developments has been, since the early 1970s, the exploitation of liposomes as a delivery system for drugs and vaccines These superstructures,...