... reduced inflammatory cytokine production inthe synovium It remains to be established whether the data inthe preclinical models can be translated to the clinical setting Discussion Our main finding ... washed and thereafter incubated for 30 minutes with biotinylated antibody After washing, streptavidin-PE was added and incubated for 10 minutes The Bioplex-protein assay reader from Luminex was ... circulating estrogen, the differential expression of ERα or ERβ in different cell types andthe microenvironment involved impacting the class of the immune response Here, we focused on defining the...
... studies and analysis of mRNA DT and AM selected the donors, obtained the samples of fat and aided inthe interpretation of the data All authors read and approved the final manuscript Competing interests ... 48 h was examined inthe studies shown in figure There were significant additional increases inthe mRNAs for IL-8, HIF1a, and 11b HSD1 inthe nonfat cells over the 48 h incubation There was also ... nonfat cells Interestingly over the 48 h incubation there was a marked increase in 11b HSD-1 gene expression in nonfat but not in fat cells [Figure 4] The increases in IL-8 release and mRNA in non-fat...
... comprising parts of the 5¢ region andthe open reading frame encoded by the W38-1 gene [35], was inserted into StyI/PstI cleaved pT5S/HDP containing the PR-1a gene The resulting plasmid was linearized ... infected with TMV, and PR-1 proteins were monitored inthe necrotic tissue induced by the spreading lesions Whereas lesions andthe accumulation of PR-1 proteins remained strictly localized in ... only six amino acids from the PR-1a preprotein inthe N-terminal moiety of the protein Most importantly, the W38-1 pseudogene part of the W38-1::PR-1a chimeric gene contains an amino acid exchange...
... involved inthein vivo data gathering ST performed or participated in both thein vitro andin vivo studies MJ performed the immunofluorescence and flow cytometry studies DGD conducted the immunofluorescence ... data FVC was the primary investigator on the T32 training grant and edited the manuscript LMC was the primary investigator on the NIH grants and Department of Defense grant listed inthe acknowledgements ... acknowledgements section and was involved inthe study design HED-L was involved inthe conception of the study and was the primary investigator on Award Number R21CA129725 listed inthe acknowledgements...
... effective in reducing this response [6] Thus inthe present study we focused on IL-6 and fibrinolysis In addition to the feedback between the release of inflammatory markers and fibrinolysis, other ... considered inthe release of these markers After CPB (Figure 2) we observed a clear increase inthe levels of IL-6 and other interleukins, which interact with each other [16,17] and are involved in producing ... bleeding and IR [6] These results were encouraging but left unanswered the question of whether the postoperative dose, coinciding with greatest fibrinolytic activation, was determinant in decreasing...
... and four established inflammatory markers The relative influence of the components of the MetS on these inflammatory markers may be of clinical significance aiding inthe establishment of clinical ... and drafted the paper SB and IS conceived the study, participated in its design and coordination and helped to draft and review the manuscript TF, TC and OKB helped inthe data organization and ... potential influence on theinflammatory markers and/ or the metabolic components such as angiotensin converting enzyme (ACE) inhibitors, angiotensin II receptor blockers, statins, fibrates and aspirin,...
... and four established inflammatory markers The relative influence of the components of the MetS on these inflammatory markers may be of clinical significance aiding inthe establishment of clinical ... and drafted the paper SB and IS conceived the study, participated in its design and coordination and helped to draft and review the manuscript TF, TC and OKB helped inthe data organization and ... potential influence on theinflammatory markers and/ or the metabolic components such as angiotensin converting enzyme (ACE) inhibitors, angiotensin II receptor blockers, statins, fibrates and aspirin,...
... indirectly by regulating cytokine production in other inflammatory cells Further investigation is required to determine how the neutrophil influences theinflammatory process in sepsis Page of (page ... alter the production of TNF-α inthe lung which then may influence theinflammatoryresponse later inthe course of endotoxemia The observed differences between studies may be a function of timing ... Macrophage inflammatory proteins: biology and role in pulmonary inflammation Exp Lung Res 1994, 20(6):473-490 Matsushima K, Oppenheim JJ: Interleukin and MCAF: novel inflammatory cytokines inducible...
... F-amidine and Cl-amidine, using a cell line and an assay measuring PAD4-mediated citrullination of a nuclear protein andthe resulting enhancement in binding to another protein, indicated that these ... arrector pili muscles, and sweat glands Citrullination of filaggrin and keratin, facilitating proteolysis and crosslinking of the proteins and contributing to skin cornification Maintains hydration of ... tissue, and synovial fluid Citrullination of myelin basic protein inthe brain and spinal cord, promoting electrical insulation of myelin sheaths Citrullination of vimentin in apoptotic monocytes and...
... from bovine mammary glands Therefore, it remains unclear whether apoptosis is involved in regulating the lifespan in macrophages and whether apoptosis of these cells participates intheinflammatory ... variance The significance of differences in RESMAC and INFMAC before and during theinflammatoryresponseand during in vitro cultivation were tested by determining the proportions of apoptotic and ... observed in 7% of monocyte-like RES MAC andin 23% of vacuolized RESMAC Apoptosis and necrosis of inflammatory macrophages during theinflammatoryresponseInthe INF MAC population obtained 24...
... glutamine substantially [28] These findings suggest that IL-6 may play a role inthe reduction in glutamine levels during inflammation The aim of the present study was to investigate whether glutamine ... glutamine infusion had an effect on the cytokine and WBC response to endotoxin Refuting our hypothesis, we were unable to detect any effect of glutamine on either cytokines or the HSP70 content in ... endotoxin caused a significant drop in plasma glutamine • Intravenous glutamine infusion allowed volunteers to maintain plasma glutamine levels above baseline after endotoxin injection • Glutamine infusion...
... remains to be determined in which cells the increased signaling occurs The circulating Gas6 is presumably derived locally inthe affected tissue andthe doubling in plasma we observe during inflammatory ... increased during organ failure, and Gas6 is increased in patients receiving intensive care or experiencing kidney failure, again indicating that Gas6 is increased in severe inflammatory states There ... failing, whereas sAxl correlates to bilirubin, Gas6, procalcitonin and number of failing organs, indicating that both Gas6 and sAxl are increased ininflammatory states Gas6 and sAxl are increased...
... NFB and mitogenactivated protein kinases (MAPKs), as well as the production of multiple inflammatory cytokines, and also that flagellin initiates proapoptotic responses predominantly inthe intestine ... in transgenic mice overexpressing the antiapoptotic protein Bcl-2 in their intestinal epithelium [32,33] Here we sought to determine the ability of flagellin to initiate apoptotic signaling in ... the activation of NF-B and MAPKs The innate immune response to bacterial flagellin promotes systemic inflammation and triggers apoptotic signalling inthe intestine • Flagellin/TLR5 signaling...
... authoritative inthe Middle Ages called their authority into question When combined with the propaganda potential of the printing press to disseminate such findings, printing became a major force behind the ... extinguished the public sphere inthe Netherlands in both and , in Italy, in revolutionary France and, to a slightly lesser extent, in Napoleonic Germany Inthe Napoleonic period, the ... Dublin He has published many works on both French and Irish history, including The Newspaper Press inthe French Revolution (), Ireland andthe French Revolution () andThe Terror in the...
... ‘lean’,’ incline’, ‘be’ - The same corrupt dispositions which incline men to sinful ways of getting, will incline them to the like sinful ways of spending." (Henry, M.) (10) In order to show the act ... their idioms, their synonyms and other microlinguistic factors that effect the uses of the two verbs The findings of the study on the ground of general meanings may help the translators to find ... meanings andthe distribution of forms and meanings of their native language and culture to the foreign language and culture- both productively and when attempting to speak the language and to act in...
... determine the Theme/ Rheme boundary The Interpersonal Theme includes all elements coming before the topical Theme that express interpersonal meaning The interpersonal part of the Theme in English ... participant saying, telling, stating, informing, asking, demanding, offering, threatening, suggesting and so on, The Sayer can be a human or human-like speaker, and also any other symbolic source Other ... functions: giving information, demanding information, giving goods -and- services and demanding goods -and- services The usual labels for these functions are: statement, question, offer, and command Table...
... designed in parts: Part A is the Introduction giving the reasons for choosing the topic, the aims of the study, the scope of the study, the methods andthe design of the study 13 Part B is the Development ... connective according to the internal role they have inside logic, regardless of meaning they are intended to have (if any) The semantic point of view, in contrast, is based on the intuitive meaning of ... pronoun The negative form above includes indefinite pronoun as the subject of sentence But in this kind, the indefinite pronoun is placed after the main verb as the object of sentence For instance:...
... improving reading skill andin doing some English-Vietnamese translation I found that students still have many problems in understanding the texts, and especially in interpreting the writers opinion ... would be interesting to investigate their uses in them all However, in order to make our tasks manageable in keeping the aims of the study, within the time allowance, it is intended that the most ... and by other linguistic and paralinguistic devices Also, in this chapter, basic knowledge about modal verbs in English andin Vietnamese is provided And finally, to consolidate the analysis and...
... time-varying differences inthe prices, andinthe liquidity and insurance benefits of these two assets, which rationalize the movements in spread curves and maturity composition observed inthe data ... their median relative to when spreads are below their median inthe model andinthe Brazilian data Debt duration inthe model mirrors the dynamics of duration inthe bond data of Brazil Inthe ... remain high, andthe probability of default further inthe future falls The persistence and mean reversion of default and repayment probabilities driven by the dynamics of debt and income therefore...