... calculation ofthe equivalent ofthe degree of difficulty [25] as a measure of an Index of Discrimination (D) in order to identify those items from the TEMPS-A scale that best discriminate groups The ... between the different genotype groups to a high degree, no scale compiling these items showed high sensitivity and specificity with respect tothe presence ofthe s allele Even the combination ofthe ... carried the ss genotype, 50 (36.23%) the ll and 69 (50%) sl genotype A total of 88 subjects (63.77%) carried the s allele while 50 subjects (36.23%) did not carry the s allele The frequency of the...
... the hospital along with feasibility to evaluate biomarkers of response to chemotherapy in these biopsies The correlation to response, if proven, would help clinicians to tailor chemotherapy to ... responders, similar to those reported in literature, are indirect evidence ofthe efficacy ofthe chemotherapy in these patients in eliminating the mitotic fraction It is intriguing to note that, as ... specimens using immunohistochemistry (IHC) c) Quantification of extent of change in these biomarkers of response to chemotherapy one day and 21 days after first cycle of chemotherapy http://www.wjso.com/content/7/1/35...
... peak to peak ofthe M-wave Motor distal latency (MDL) was obtained from the onset latency ofthe M-wave The latency between the anterior cells and the muscle was calculated according tothe formula ... in the F-wave ofthe median nerve in CTS [17,18] Stoehr and colleagues found that the extent ofthe retrograde changes correlated with the degree of CTS severity [28] The sensory fibers ofthe ... cells and the muscle from the onset latency of MEPcr The latency from the anterior horn cells tothe rootlet (CRL) was calculated by subtracting the onset latency ofthe MEPcv from the latency...
... instrument Phase 3: assessment ofthe reliability and validity ofthe new theory-based global instrument The objective of phase is toassessthe reliability and validity ofthe new theory-based global ... assessthe relationships between the constructs based on the proposed integrated model using path analysis Observation ofthe expected relationships will be further proof ofthe validity ofthe ... half ofthe participants, randomly selected, will be asked to complete the evaluation instrument both before and at the end ofthe CPD activity, and half ofthe participants will be asked to complete...
... 1% (-11% to +11%) and 9% (-4% to +21%) 6% (-31% to 33%) and 10% (-16% to 31) 31% (17% to -14%) and 19% (62% to 24%) 3% (17% to -14%) and 14% (-3% to +28%)1 13% (29% to -6%) and 36% (17% to 50%) ... be imprinted with the name ofthe patient and addressed directly tothe primary care physician The statement will be faxed tothe physician following the completion ofthe patient's coronary angiogram ... access tothe data None ofthe local opinion leaders received any financial compensation for their participation in the study or endorsement ofthe evidence summaries Discussion We report the protocol...
... the SSRIs Furthermore, medication was superior to placebo in reducing the severity ofthe three symptom clusters of PTSD, as well as alleviating the symptoms of depression, and in improving the ... treatment of PTSD, the findings of prior topiramate studies suggest that this anticonvulsant may be promising in the management of patients with PTSD Aims ofthe Study 1) To compare the efficacy of topiramate ... prognosis [2] The development of treatments for PTSD is challenging due tothe complexity ofthe symptoms and psychiatric comorbidities Psychotherapy and pharmacotherapy are the two main classes of PTSD...
... person within the area unit irrespective of where they live in that unit, the amount of time that they spend in the area, and their ability to travel within and beyond the boundary ofthe administrative ... measures of physical activity) so that the precise location where the physical activity is occurring is also captured [33,34] Given the high cost ofthe equipment, these data are often costly to collect, ... devices also enable investigators to track the mobility patterns of individuals through the environment to develop measures of their travel routes and activity spaces [32] These technologies have...
... mirror ofthe recording head and to close the flux loop from the head 1.2.2 Read and Write head The read sensor, the writer coil, together with the air bearing surface (ABS) are fabricated together ... relative tothe position of linear stages A camera is positioned perpendicular tothe plane ofthe disk media and guiding lines are drawn within the acquisition window to align the edge ofthe cartridge ... 2-1(a), the narrow peaks correspond tothe harmonics of repeatable mechanical distortions (RRO) due tothe rocking mode ofthe spindle system as well as disk surface distortions due to disk clamping...
... alpha-fetoprotein (AFP), found their way at an early stage into clinical laboratories Many others have followed in the meantime However, most of them are not tumor specific The use of changes of serum ... standard chemotherapies is usually high and that therefore the value of being able to escape useless treatments can be great The high cost of tests has to be considered too, yet the costs of drug treatment ... strategy of cancer drug therapy seems to be necessary, i.e the management may include, in cases ofthe detection of broad drug resistance, the omission of aggressive chemotherapy This would help to...
... In studies assessing the effect of ligand-binding on the quaternary structure ofthe receptors, the possibility that the antibodies could inhibit binding tothe receptor also needs to be controlled ... expressed as the ratio ofthe distance ‘r’ separating the donor and the acceptor over the distance resulting in 50% ofthe maximal efficacy (R0) As indicated by the Forster equation, the efficiency of ¨ ... efficiency of transfer is determined both by the orientation ofthe energy transfer partners and by the distance between them [28] The fact that the efficiency of transfer varies with the 6th-power of the...
... malignant according tothe histology To characterize the prosurvival activityofthe peritoneal fluids against TRAIL, we assessed the cell viability in the presence or absence of peritoneal fluids ... anti-apoptotic activityof ascites Effect of ascites on drug sensitivity The sensitivity of CaOV3 cells to chemotherapeutic drugs was compared to that of TRAIL in the presence or absence of ascites ... sub-type of ovarian cancer In addition, the effect of ascites on primary tumor cells and most importantly the clinical significance ofthe prosurvival activityof ascites have not been assessed The...
... polymorphism, finding up to 32 polymorphic bands in all the trees evaluated On the other hand, the understanding ofthe genetic diversity presents in a species and the distribution of this variation ... 0.283) The 27.0% ofthe genetic diversity of this last group was detected among populations; however, this value was higher in Cordoba with 34.8% of total genetic diversity The proportion of genetic ... analyzed Previous to protein extraction, the samples (≈ 50 mg of cotyledon) were un-lipped with diethyl ether and acetone Cotyledon proteins were sequentially extracted according tothe method described...
... in these multidimensional scales we used the unweighted scores In both cases, the higher the scores, the better the HRQoL, and vice versa (2) The Spanish version ofthe TOOL questionnaire The ... guided by the estimation ofthe utility function according to which a large number of patients is needed to maximise the precision and reduce the risk of measurement error To this end, in the present ... than 0.20 in the discrimination rate Toassessthe dimensionality ofthe questionnaire, an exploratory factorial analysis (extraction criterion of eigenvalue >1) was also conducted The Spearman...
... levels of MMP9 Implication of matrix metalloproteinases in proteolytic reactivity found in synovial fluids of RA patients To further assessthe contribution of MMP-9 and other members ofthe MMP ... product ofthe chondrocytes, have predominant roles because they are rate limiting in the process of collagen degradation [27,28] The efficiency of these two inhibitors to block the enzymatic activity ... the net proteolytic activity resulting from the balance between the active forms of proteases and the naturally occurring protease inhibitors, to measure for the first time the diversity of the...
... care due to a lack of recognition by practitioners of ischemia or an underestimation ofthe severity of infections [10] Comprehensive assessments by health care professionals of risk factors are ... and their use of research evidence to inform practice [27,51-63] Similarly, a systematic review of 30 studies identified the lack of support from managers, and 'other staff' to be one ofthe ... diabetes 2) To determine the impact ofthe intervention on client, nurse and system outcomes 3) To understand the feasibility of influencing leadership behaviours through the intervention 4) To test...
... to inform them which arm ofthe trial they have been allocated to RA2 contacts the relevant support worker who will guide the relative through the intervention and instructs them to arrange the ... the participant’s views on the consequences ofthe illness, comprehension ofthe illness, knowledge of prognosis, the extent to which they attribute blame, knowledge of potential causes and their ... contributed to design ofthe intervention, recruits and assesses participants, and manages the process of randomisation; VP contributed tothe design ofthe intervention and management ofthe project;...
... care due to a lack of recognition by practitioners of ischemia or an underestimation ofthe severity of infections [10] Comprehensive assessments by health care professionals of risk factors are ... and their use of research evidence to inform practice [27,51-63] Similarly, a systematic review of 30 studies identified the lack of support from managers, and 'other staff' to be one ofthe ... diabetes 2) To determine the impact ofthe intervention on client, nurse and system outcomes 3) To understand the feasibility of influencing leadership behaviours through the intervention 4) To test...
... (divergent selection from the top and bottom 5% ofthe population) to 0.83 (selection from the top 10% ofthe population) Sample sizes to detect significant = departures of Regr(u from its expectation ... absorption of ) fixed effects into u equations and factoring of residual variance from both sides ofthe equation, the coefficient matrix for u has: = = where A is the ratio of residual to sire ... ofthe u distribution a varied uniformly l l over the interval 0.7 to 0.95 AS2: 20 000 animals from the upper and lower 10% ofthe ui distribution a varied l uniformly over the interval 0.7 to...
... ―in terms ofthe appropriateness ofthe translator‘s intention to that ofthe author ofthe original, not ofthe appropriateness ofthe translator‘s intention to that ofthe evaluator‖ (1987:223) ... and professional activity but also tothe field or topic ofthe text in its widest sense or ―area of operation‖ ofthe language activity, as well as details ofthe text production as far as these ... address the target audience ofthe translation because they are tight tothe culture and the language community where they originate Therefore, to this type of translation, the function ofthe translation...