methods to approach other structure activity problems
Resampling methods to handle the class imbalance problems in predicting protein protein interaction site and beta turn
... 16 Chapter Methods for Dealing with Class-imbalance Problems The methods to handle the class-imbalance problem are categorized into two groups, data-level methods and algorithm-level methods This ... the predictor, and compare our results with the state-of-the-art approaches We also combine our algorithm with some other methods to enhance the better results In addition, we try to use a new ... prototypes [1] Because each residue relates to one of the fragments in a SA, a protein primary structure can be translated into a chain of prototypes in one dimension as the sequence of prototypes...
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Báo cáo khoa học: Methods to monitor the quaternary structure of G protein-coupled receptors doc
... current piece is to critically evaluate the approaches used to explore dimerization of class A GPCRs Coimmunoprecipitation The ability to differentially epitope-tag GPCRs has been central to the widespread ... C5a receptor [23] and the a1b-adrenoceptor [35] have suggested ways in which these GPCRs may organize into higher order structures Although not yet reported in relation to GPCR quaternary structure, ... membranes by the : GPCR : G protein stoichiometry of the fusion proteins allowing the G protein fused to one receptor to interact with the G protein of another receptor-G protein fusion that may or...
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Báo cáo khoa học: "From Chunks to Function-Argument Structure: A Similarity-Based Approach" doc
... with a stored instance exists In all other cases, the most similar tree from the instance base needs to be modified to match the chunked input This means that the output tree will group together ... structure are easy to envisage and are likely to significantly improve recall performance While we intend to pursue all three dimensions of refining the basic algorithm reported here, we have to ... memory-based learning to NLP tasks consisted of classification problems in which the set of classes to be learnt was simple in the sense that the class items did not have any internal structure and the...
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Báo cáo khoa học: "Discriminative Approach to Predicate-Argument Structure Analysis with Zero-Anaphora Resolution" pptx
... Table 2: Corpus Statistics their priority order to the List as another feature (‘SRLOrder’ feature) Another way to adopt contextual information is to restrict the candidate arguments When we analyzed ... could obtain dependency and predicate-argument structures because these corpora were annotated to almost the same newspaper articles We divided them into training, development, and test sets as shown ... 1991-2002, about 87 Case Nom Acc Dat Type Dep Zero-Intra Zero-Inter Total Dep Zero-Intra Zero-Inter Total Dep Zero-Intra Zero-Inter Total # of Args 14,287 4,581 3,063 21,931 9,316 742 271 10,329 5,409...
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Báo cáo toán học: "On the Parametric Affine Variational Inequality Approach to Linear Fractional Vector Optimization Problems" pot
... variational inequality approach to linear fractional vector optimization problems, which can help to obtain tight upper estimates for the number of components in the solution sets of these problems Some ... monotone affine variational inequality A similar representation is also valid for the weakly efficient solution set This parametric affine variational inequality approach to LFVO problems has proved to ... studying topological properties of the solution sets and solution stability of LFVO problems The aim of this paper is to develop furthermore the parametric affine variational inequality approach to LFVO...
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Báo cáo lâm nghiệp: "Timber harvesting in the ukrainian carpathians: Ecological problems and methods to solve them" ppsx
... skidding tracks is 8% of the total cutting area, the volume of soil damaged by erosion often amounts to 500 m3∙ha–1 Erosion on skidding tracks may reach up to 70% of its total volume on the cutting ... same dependences – Greater damage to the soil surface with high bearing capacity is typical of crawler tractors while wheeled tractors cause greater damage to the surface with low bearing capacity ... territories and are characterized by complex relief, soil-hydrological features, low concentration of harvested timber per unit area, one-sidedness of freight traffic volume and other factors...
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Báo cáo y học: "Moxibustion and other acupuncture point stimulation methods to treat breech presentation: a systematic review of clinical trials" pptx
... Moxibustion and other acupoint stimulation methods such as acupuncture and laser stimulation were found to be effective to treat breech presentation The present systematic review aims to evaluate ... and other acupoint stimulation methods to treat breech presentation in pregnant women Methods Databases and search strategy Two authors (JH and XL) searched the China National Knowledge Infrastructure ... selection Moxibustion plus other interventions versus other interventions An RCT [16], which investigated moxibustion on Zhiyin plus raising buttocks method versus raising buttocks method alone, showed...
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Computational methods for structure activity relationship analysis and activity prediction
... metric Activity similarity is represented as the logarithmic potency difference Thus, a large difference corresponds to low activity similarity and a small difference to high activity similarity activity ... paired with other molecules in the data set Another study utilized the MMP representation to classify molecule pairs as activity cliff forming and activity cliff non-forming using support vector machine ... the melatonin receptor 1A and nociceptin receptor, respectively Both graphs consist of six layers (i.e., CSKs contain a maximum of six rings), but their topology differs The melatonin receptor 1A...
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Báo cáo y học: "Current Status of Methods to Assess Cancer Drug Resistance"
... apoptosis and special growth factors like steroid receptors, human epidermal growth factor receptor, vascular endothelial growth factor and P-glycoprotein [69, 70] Thus nuclear medicine methods, ... beginning laboratory techniques were still in their infancy Short term cell cultures of cancer tissues were difficult to perform and procedures varied from laboratory to laboratory However, the ... growth factors, i.e their cell receptors as cancer biomarkers to develop new targeted anticancer drugs with better tumor response However, tumor concentrations of growth factor receptors not reliably...
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7Types of Hard CISSP Exam Questions and How To Approach Them
... the user (social) and leads toward a bad security decision (engineering) Approach First you need to recognize this as a subset question Draw arrows from one answer to another if you believe that ... and tips that you can immediately put to use Our expert instructors draw upon their experiences to help you understand key concepts and how to apply them to your specific work situation Choose ... train you to read the questions more carefully 2) Plus / Minus Approach Translate the underlined portion of the question into a more simply worded question For example, reduce the question to a “good”...
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Tài liệu Using the Get* Methods to Read Column Values doc
... and the DataReader Get* methods that return each C# type You use this table to figure out which method to call to get a specific column type For example, if you need to get the value of a bigint ... Chapter 2, "Introduction to Databases." Note The Get* methods are defined in all of the DataReader classes and work for all databases Next you'll see how to use some of the methods shown in Table ... smallmoney decimal GetDecimal() Table 9.4: SQL SERVER TYPES, COMPATIBLE STANDARD C# TYPES, AND GET* METHODS SQL SERVER TYPE COMPATIBLE STANDARD C# TYPE GET* METHOD sql_varient object GetValue() text...
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Tài liệu Báo cáo khoa học: Structure-activity relationships of a-conotoxins targeting neuronal nicotinic acetylcholine receptors ppt
... to contribute to a4b2 and a7 subtype activity but not a3b2 activity A decrease in a4b2 and a7 subtype activity but not a3b2 activity was observed in the [R12A]GID mutant [16] An alternative approach ... acid, Laa) to either the N-terminus (LaaMII) or to Asn5 (5LaaMII) The N-terminal LaaMII was shown to have a tertiary structure similar to that of the native conotoxin and maintained the activity ... Computational approaches to understand a-conotoxin interactions at neuronal nicotinic receptors Eur J Biochem 271, 2327–2334 McIntosh, J.M., Santos, A.D & Olivera, B.M (1999) Conus peptides targeted to...
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Tài liệu Báo cáo khoa học: Second messenger function and the structure–activity relationship of cyclic adenosine diphosphoribose (cADPR) doc
... interactions took place Astonishingly, another modification of the northern ribose, cyclic ADP carbocyclic ribose (cADPcR; Fig 3), showed weaker Ca2+ release activity indicating that the oxygen atom of ... extracellularly to intact T-cells, induced biphasic Ca2+ signalling comparable to T-cell receptor ⁄ CD3 stimulation [47] The biological activity of cIDP-DE is not restricted to T-lymphocytes; ... proteins by photoaffinity labeling J Biol Chem 268, 26686–26691 Noguchi N, Takasawa S, Nata K, Tohgo A, Kato I, Ikehata F et al (1997) Cyclic ADP-ribose binds to FK506-binding protein 12.6 to release...
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A comparative analysis of methods to represent uncertainly in estimating the cost of constructing wastew
... Chi-Mei Jui-Fang Ton-Kang Wu-Chia (Kaohsiung) Tei-Ton Nei-Pu Tei-Ton County Chao-Wan Nan-Tou Pe-Kang Chu-Pe Tei-Ton Miao-Li Tsao-Tun Lin-Hae Design Total construction Normalized total Levelg capacity ... These methods are frequently applied to preventing the eutrophication issues and maintaining the essential water quality in the reservoirs/lakes close to the water intakes Since the cost structures ... subject to a normalization process before the regression practices are performed The Construction Cost Index (CCI) was thus selected as an economic factor to normalize these cost data into a common...
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Practical packet analysis Using Wireshark to Solve Real-World Network Problems ppt
... Resolution Protocol (ARP) When one computer needs to send data to another, it sends an ARP request to the switch it is connected to The switch then sends an ARP broadcast packet to all of the ... sent to every port connected to that hub Therefore, to analyze a computer on a hub, all you have to is plug in a packet sniffer to an empty port on the hub, and you can see all communication to ... able to translate Layer MAC addresses into Layer IP addresses and vice versa in order to be able to forward traffic to the appropriate device This translation process is done through a Layer protocol...
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15 good study methods to improve English speaking skills ppt
... of English grammar, new words or conversation samples 14 Listen to the tapes and practice to take notes regularly 15 Apply all the methods above in about - months, and you should always practice...
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review on methods to deposit catalysts on structured surfaces
... precursor, the microstructured reactor was used to catalyse the oxidation of carbon monoxide as a modelreaction Its activity was compared to a Pt-sputtered microstructured reactor The Pt/Al2O3 catalyst ... crushed powder to prepare the suspension [155] Synthesis of zeolites on various structures The methods used to get a zeolite layer on structures differ from other oxides deposition Methods based ... deposited on various structures This section presents the different methods used to obtain a metal-on-oxide catalyst on the surface of structured reactors However, some methods concern only the...
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