metalloproteinases ultrasound application and nitric oxide no
Báo cáo y học: "NITRIC OXIDE (NO), CITRULLINE – NO CYCLE ENZYMES, GLUTAMINE SYNTHETASE AND OXIDATIVE STRESS IN ANOXIA (HYPOBARIC HYPOXIA) AND REPERFUSION IN RAT BRAIN"
... accidents and also during incidents involving anesthesia To understand the role of citrulline -NO cycle enzymes, GS and the oxidative status in anoxia and reperfusion, NOS, AS, AL, GS and arginase ... of NOS in reperfusion group may be attributed to iNOS and nNOS and the relative contribution to the increased activity in reperfusion may be mainly the iNOS form and some contribution by nNOS, ... citulline -NO cycle enzyme activities are increased to facilitate high and continuous production of NO and increased NO may decrease the activity of GS and increase the oxidative stress in anoxia/reperfusion...
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báo cáo khoa học: " Auxin and nitric oxide control indeterminate nodule formation" ppt
... IAA-overproducing and wild type S meliloti produce NO and possess NO synthase-like activity Thus, NO level in nodules could be the result of both plant and bacterial production However, no difference in NO ... for IAA and NO in indeterminate nodule formation is hereby proposed To our knowledge, the data showing that nodule NO biosynthesis is increased in plants with higher nodulation and that a NO scavenger ... of IAA in the nodules was associated with enhanced nodulation and root growth (Fig and Fig 4), the number of nodules and the root growth did not significantly differ in bean plants nodulated by...
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Báo cáo y học: "Involvement of nitric oxide (NO) in cough reflex sensitivity between non-sensitized and OVA-sensitized guinea pigs" pptx
... sensitivity and NO In this study, we hypothesized that NO produced by iNOS might be a promoter in cough reflex sensitivity, and therefore performed the iNOS inhibition experiment using NOS inhibitors, ... of Non-sensitized and OVA-sensitized guinea pigs were divided into four groups: control (normal saline) group and groups receiving the non-selective NOS inhibitor LNAME at doses of 3, 10, and ... selective iNOS inhibitor ONO1714 Experimental protocol Experiment 1: NO depletion by the NOS inhibitor L-NAME The experimental protocol schemes are shown in Figure and Non-sensitized and OVA-sensitized...
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Báo cáo khoa học: Space, time and nitric oxide – neuronal nitric oxide synthase generates signal pulses pptx
... model and NO inhibition The product NO inhibits NOS [22] In iNOS and eNOS, inhibition is largely relieved by NO scavengers (e.g hemoglobin) [23]; relief by scavengers is less effective in nNOS ... purview and parameters Nat Rev Mol Cell Biol 6, 150–166 Lancaster J (1997) A tutorial on the diffusibility and reactivity of free nitric oxide Nitric Oxide 1, 18–30 Salerno JC (2008) Neuronal nitric ... Space, time and nitric oxide J C Salerno and D K Ghosh A Fig Stopped flow kinetics results at 37 °C showing traces at 426 nm (upper trace) and 440 nm (lower trace) after the initiation of turnover by...
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Báo cáo khoa học: Transport of L-arginine and nitric oxide formation in human platelets pdf
... amounts of substrate to cNOS for endogenous NO production and regulation Acknowledgements This study was supported by MURST Prin 2000 ÔCoordinated regulation of NO production and arginine transportÕ ... Atherosclerosis 117, 273–284 11 Wang, B.Y., Candipan, R.C., Arjomandi, M., Hsiun, P.T., Tsao, P.S & Cooke, J.P (1996) Arginine restores nitric oxide activity and inhibits monocyte accumulation after vascular ... L-arginine is essential for endothelial NO synthesis and demonstrate that a deficiency of endothelial NO production generates an abnormal vasomotor tone and a prothrombotic state In a group of...
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Báo cáo y học: "Ex vivo effects of flavonoids extracted from Artemisia herba alba on cytokines and nitric oxide production in Algerian patients with Adamantiades-Behcet''''s disease" pptx
... Koppenol WH: Nitric oxide, superoxide, and peroxynitrite: The good, the bad, and ugly Amer J Physiol 1996, 271: C1424C1437 12 Yu L, Gengro PE., Niedrberger M, Burk TJ , Schrier, RW: Nitric oxide: ... did not modulate NO production As shown in Figure 6, flavonoùds had no statistically significant effect (19.21 2.61àM with 10 àg/mL of flavonoùds and 16.36 4.25 àM with 50 àg/mL of flavonoùds) ... respectively Moreover, flavonoùds may prevent nitric oxide induced damages Keywords: Adamantiades-Behỗets disease; Immunomodulation; IL-4; IL-12; nitric oxide Artemisia herba alba; Flavonoùds; Background...
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Báo cáo y học: " The anti-inflammatory effects of the tellurium redox modulating compound, AS101, are associated with regulation of NFB signaling pathway and nitric oxide induction in macrophages" doc
... hepatocyte apoptosis by nitric oxide: in vivo, in vitro, and in silico studies Curr Mol Med 2004, 4:753-62 Moncada S, Higgs EA: Nitric oxide and the vascular endothelium Handb Exp Pharmacol 2006, ... LPS-induced iNOS protein expression (A-D) and NO( E) and IL-6 (F) secretion (A) LPS-stimulated RAW264.7 cells (1 × 106/ml) were treated with AS101(0.5 or [μg/ml]) for h (A) and h (C) The iNOS level ... iNOS expression and NO secretion NFB is known to play a critical role in the regulation of cell survival genes and coordination of pro-inflammatory mediators such as iNOS and NO[ 2] Therefore, the...
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Báo cáo y học: "Atrial natriuretic peptide infusion and nitric oxide inhalation in patients with acute respiratory distress syndrome" ppt
... Veenendaal, The Netherlands) Inspiratory concentrations of NO and NO2 were measured between the ‘Y’ piece of the ventilator and the endotracheal tube, using electrochemical sensors (NOxbox; Bedfont ... calibrated every months using a gas mixture containing 55 ppm NO and 5.5 ppm NO2 The limit of detection is 0.1 ppm for NO and 0.1 ppm for NO2 The range of detection is 0–200 ppm for both gases Additional ... arterial and mixed venous concentrations of cGMP increased significantly during NO inhalation EVLWI did not change either during ANP infusion or during NO inhalation In patients who responded to NO...
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Sphingosine kinase 1 regulates the expression of proinflammatory cytokines and nitric oxide in activated microglia
... iNOS- inducible nitric oxide synthetase kD-kiloDalton LPS- Lipopolysaccharide NO- Nitric oxide PBS- Phosphate buffered saline RT-PCR- Reverse transcription polymerase chain reaction xi SE- Standard ... cells and SphK1 alters the expression and production of proinflammatory cytokines and nitric oxide in microglia treated with lipopolysaccharide (LPS) LPS treatment increased the SphK1 mRNA and ... such as TNF-α and IL-1β and serve as antigen presenting cells (Carson, et al., 1998, Carson and Sutcliffe, 1999, Frei and Fontana, 1997, Hickey and Kimura, 1988) Increases in TNF-α and IL-1β have...
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Application and perspectives of non invasive urinary biomarker measurements in epidemiological research on child nutrition hydration and iodine status, two health relevant examples
... dentro, soñando, cantando hasta que se hundió Una hoja más del cuaderno y continuó su viaje en otro barquito de papel.” Humberto Ak´abal (poeta Guatemalteco1953-) SUMMARY SUMMARY Application and perspectives ... understanding the relationship between diet and metabolism is crucial The development of evidence-based clinical guidance, and effective programs and policies to achieve global health promotion and ... for detecting and predicting changes in nutritional status and nutrient intakes (e.g iodine, protein, water, sodium, folate) (5–10) , and are particularly attractive candidates for application...
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Báo cáo khoa học: Relationship between the structure of guanidines and N-hydroxyguanidines, their binding to inducible nitric oxide synthase (iNOS) and their iNOS-catalysed oxidation to NO pptx
... CH3(CH2)5 4-F-C6H44-CH3-C6H44-Cl-C6H4C6H4-CH2- NOHA Homo-NOHA – NOHGPA NOHGAgma ProNOHG BuNOHG TFBNOHG PentylNOHG HexNOHG FPhNOHG TolNOHG ClPhNOHG BzNOHG 18 ± lM 150 ± 40 lM n.d > mM 2.0 ± 0.7 mM ... 7- and 25-fold lower than that for l-Arg, and those for the non-a-amino acid N-hydroxyguanidines BuNOHG and TFBNOHG were 3- and 12-fold lower than that for NOHA The koff app values for BuGua and ... 10 and times higher than that for l-Arg, and those for BuNOHG and TFBNOHG were 20 and times higher than that for NOHA Interestingly, konapp values for the fluorinated compounds TFBGua and TFBNOHG...
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Báo cáo khoa học: In vivo degradation of nitric oxide synthase (NOS) and heat shock protein 90 (HSP90) by calpain is modulated by the formation of a NOS–HSP90 heterocomplex pot
... SDS-PAGE and blotted as described previously nNOS, eNOS and HSP90 were detected with specific mAbs (C) nNOS (open circles) and HSP90 (filled circles) immunoreactive materials detected in (A) and the ... SDSPAGE followed by immunoblotting, revealed with IgG1-eNOS or IgG1-nNOS mAbs (A) or IgG1-HSP90 mAb (B) The immunoreactive material of eNOS, nNOS and HSP90 was detected and quantified as described ... SDS-PAGE and blotted as described previously nNOS, eNOS and HSP90 were detected with specific mAbs (C) nNOS (open circles) and HSP90 (filled circles) protein detected in (A) and the corresponding nNOS...
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báo cáo hóa học: " Inhibition of microglial inflammatory responses by norepinephrine: effects on nitric oxide and interleukin-1β production" pdf
... leading to NOS2 expression, NO production and nitrite accumulation Under our experimental conditions, co-incubation with NE (0.1–10 µM) inhibited LPS-dependent NOS2 expression and NO and nitrite ... 50 µM) increased NO release, and a higher dose (100 µM) reduced NO release [23] An understanding of the contrasting effects of PKA and AC inhibitors on nitrite production and NOS2 expression may ... not play an important role in mediating microglial NOS2 expression The molecular mechanism(s) by which NE reduces microglial NOS2 expression and IL-1β production and expression are not yet known...
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Báo cáo y học: "Inhaled nitric oxide in acute respiratory distress syndrome with and without septic shock requiring norepinephrine administration: a dose–response study" ppt
... PaCO2 and VDA/VT were measured: (1) before NO administration (C1); (2) following seven randomized concentrations of NO between 0.15 and 150 ppm, and (3) after the cessation of NO (C2) ∆ PaCO2 and ... artery pressure and PVRI were measured: (1) before NO administration (C1); (2) following seven randomized concentrations of NO between 0.15 and 150 ppm, and (3) after the cessation of NO (C2) In both ... Vol No Mourgeon et al with a plateau effect at NO concentrations of 30-60 ppm [12,13] Nitric oxide concentrations > 30 ppm may result in elevated concentrations of nitrogen dioxide (NO2 ) and...
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Báo cáo y học: "Arginase attenuates inhibitory nonadrenergic noncholinergic nerve-induced nitric oxide generation and airway smooth muscle relaxation" potx
... L-arginine, oxygen and NADPH as substrates to produce NO and L-citrulline [10] Three isoforms of NOS have been identified: neuronal NOS (nNOS), endothelial NOS (eNOS) and inducible NOS (iNOS) In the ... airways, the constitutive NOS (cNOS) isoforms are mainly expressed in the iNANC neurons (nNOS), the endothelium (eNOS) and the epithelium (nNOS and eNOS), whereas iNOS, which is induced by proinflammatory ... Abbreviations cNOS, constitutive nitric oxide synthase; EFS, electrical field stimulation; eNOS, endothelial nitric oxide synthase; iNANC, inhibitory nonadrenergic noncholinergic; Page of (page number not...
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Tài liệu Báo cáo khoa học: Structural and mechanistic aspects of flavoproteins: electron transfer through the nitric oxide synthase flavoprotein domain pdf
... of the NOS flavoprotein domain D J Stuehr et al Scheme Reaction catalyzed by NOS NOS enzymes have novel features Fig Domain arrangement and electron flow in the NOS dimer nitric oxide (NO) via ... N-hydroxyarginine (Scheme 1) [6–9] There are three mammalian NOS enzymes: neuronal (nNOS), endothelial (eNOS) and inducible (iNOS) nNOS and eNOS are reversibly activated by the Ca2+-binding protein ... FMN-deshielded state is not enough on its own to support heme reduction and NO synthesis in nNOS Instead, additional and distinct effects on the FMN–NOSoxy interaction must be required, and the effects...
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Tài liệu Báo cáo Y học: Enhancement by a-tocopheryl hemisuccinate of nitric oxide production induced by lypopolysaccharide and interferon-c through the upregulation of protein kinase C in rat vascular smooth muscle cells docx
... LPS/IFN-induced NO production We compared the effects of a-T and its derivatives TA and TN with that of TS on LPS/IFN-induced NO production The additions of a-T, TA and TN did not induce NO production ... of PKA and PKC on TS-enhanced NO production As shown in Fig 5A, the PKA inhibitors KT-5720 and H8 and the PKC inhibitors Ro31-2880 and GF109203X did not affect apparently LPS/IFN-induced NO production ... shown) It is noteworthy that TA and TN also decreased the enhancing effect of TS on LPS/IFNinduced NO production Fig Effects of a-T and its derivatives (TA and TN) on LPS/IFNinduced NO production...
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Báo cáo khoa học: Nitric oxide formation from the reaction of nitrite with carp and rabbit hemoglobin at intermediate oxygen saturations pdf
... metHb and nitrate, whereby the entire production of NO needed not end up as HbNO Furthermore, some NO could dissociate from HbNO and or escape the system The difference between the observed and ... reaction intermediates other than metHb and HbNO [26] In carp and rabbit there was practically equal formation of metHb and HbNO, and the sum of metHb and HbNO concentrations by the time that deoxyHb ... whereby Hb exerts a NO scavenging role rather than a NO liberating role NO is tightly bound to carp Hb and neither Po2 changes nor conformation changes seem able to liberate NO from HbNO within the...
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