metabolism study in rat after oral administration of rhubarb decoction and characterization identification of the rat metabolite of scutellaria baicalensis
... participated in design and coordination ofthestudyand drafted the manuscript NL participated in design and coordination ofthestudyand helped to draft the manuscript TE participated in design ofthe ... in this studyandthe intensivists and nurses at the ICUs andthe clinical chemical and pharmaceutical laboratories ofthe St Elisabeth Hospital andthe TweeSteden hospital in Tilburg and Catherijne ... concentrations after subcutaneous administrationof 2,500 IU dalteparin (Table 2) The measurements of anti-Xa activity are inthe lower part ofthe calibration curve; some ofthe data are below the...
... response and infiltration regulating the pro-inflammatory environment and intercellular interactions Conclusion Daily oraladministrationof diazoxide in EAE mice during the effector phase ofthe ... observed, corresponding to the acute inflammatory phase ofthe disease [62] Interestingly, we did not observe any changes inthe number of infiltrating lymphocytes inthe spinal cord of diazoxide-treated ... lymphocytic infiltration into the spinal cord during EAE To determine whether diazoxide treatment affected T and B lymphocyte infiltration into the spinal cord of EAE mice, immunoflorescence using anti-CD3...
... norfloxacin in rabbits afteroraladministrationThe disposition of norfloxacin after a single oral dose Table Comparative pharmacokinetics of orally administered norfloxacin (100 mg/kg body weight) in ... therapeutic concentration of 0.5 μg/mL plasma against resistant pathogens infecting rabbits The reduction inthe loading and maintenance doses indicates that prior administrationof curcumin is of economic ... disposition of enrofloxacin and its metabolite ciprofloxacin after intravascular administrationof enrofloxacin in goats J Vet Pharmacol Ther 2000, 23, 365-372 Rao TS, Basu N, Siddiqui HH Anti-inflammatory...
... that are involved inthe induction of peripheral tolerance in an orally tolerized mouse model of arthritis R218 Our findings indicate that the serum levels of proinflammatory and anti-inflammatory ... production of IL-10, TGF-β and IFN-γ by lymphocytes of orally tolerized mice R216 To examine the effect oforal CII administration on the activity of immune cells, we measured the production of Figure ... draining lymph nodes and spleens of tolerized mice We then investigated the proliferation of T cells isolated from the draining lymph node and spleen on in vitro antigenic simulation with CII At and...
... and anti-inflammatory actions may be inhibited inthe presence of heparin at the cellular/endothelial level Heparin is known to interfere with the action of AT by binding to the active site of ... [13] demonstrated a rapid decline in soluble fibrin levels after antithrombin administration Soluble fibrin levels normalized within 24 h in 80% ofthe patients randomized to this therapy, whereas ... ofthe AT molecule, thus rendering it inert for interactions with endothelial glucoseaminoglycans and opposing the antithrombotic and antiinflammatory actions of AT [17,18] The interaction of...
... clear whether oraladministrationof IFN can treat CVB3-induced myocarditis in vivo In this study, the effect of IFN-transformed B longum by oraladministration on the development of CVB3-induced ... further In conclusion, oraladministrationof IFN-transformed B longum can decrease the severity of virus-induced myocarditis, reduce the virus titers inthe heart and induce a Th1 pattern inthe ... component of biopolymers such as hemicellulose and pectin [26] Theadministrationof IFNtransformed B longum has been demonstrated to increase the serum and intestinal IFN-α2b level and we hypothesize...
... clear whether oraladministrationof IFN can treat CVB3-induced myocarditis in vivo In this study, the effect of IFN-transformed B longum by oraladministration on the development of CVB3-induced ... further In conclusion, oraladministrationof IFN-transformed B longum can decrease the severity of virus-induced myocarditis, reduce the virus titers inthe heart and induce a Th1 pattern inthe ... component of biopolymers such as hemicellulose and pectin [26] Theadministrationof IFNtransformed B longum has been demonstrated to increase the serum and intestinal IFN-α2b level and we hypothesize...
... serial casting at another center Notice the medial and posterior deep skin creases, andthe severe equinus deformity ofthe foot point the pin was inserted under vision to avoid injury ofthe calcaneal ... ofthe talus longitudinally toward the talar head The navicular was then reduced, andthe pin was driven across the joint The Carroll method of reduction and fixation ofthe talo-navicular joint ... posteromedial incision was used in 19 feet, while the Cincinnati [10], incision and approach was used in 40 feet, (the same approach was used in revision cases including 19 Turco incisions and 14 Cincinnati...
... percent ofthe total local households are engaged in linkages with Hanoi urban area for income-generating activities The linkages that they are involved in include flows of goods and services and ... Figure The Sustainable Livelihood Framework In particular, thestudy explains why some households take advantage ofthe urban linkages, while the others not Inferential statistics and syntheses of ... drawn randomly from the total number of households ofthe commune The data gained from the survey was utilized to describe the urban linkages ofthe local households with the Hanoi urban area In...
... numbness and hypersensitivity exceeded the pre-operative baseline but scores for burning and/ or tingling and lancinating electric shock pains remained about 50% or less of her baseline Also after ... all the cardinal criteria for the diagnosis and her score of 36 on the 40-point International RLS rating scale was inthe very severe range The baseline polysomnogram showed a severe degree of ... head interspaces in addition to stump neuromas ofthe third interspaces, (b) physical findings were present (Mulder’s clicks inthe third and fourth interspaces and tenderness in all three interspaces...
... Clinical Practices (CPMP/ICH/135/95)5, andthe principles ofthe Declaration of Helsinki, local drug law and standard operating procedures ofthe investigator, sponsor and CRO involved Thestudy ... analyses and coordination ofthe study, interpretation of data and writing the manuscript All authors read and approved the final manuscript Competing interests The trial was funded by Marinomed ... thestudy day; i indicates the point of inclusion into thestudy taken within 48 hours of development of common cold symptoms Designed as an exploratory trial, the size ofthestudy was relatively...
... around the time point of vaccination The kinetic analysis ofthe early activation of B cells and CD4+ T cells after vaccination suggests that co -administration of IFNa4 might influence the CD4+ ... of IFNb [32] The protective effect of a vaccinia virus-vectored vaccine against influenza, on the other hand, was not improved by IFNb or IFNa4 co -administration [31] Interestingly, none ofthe ... disease with the augmented CD4+ T cell response, whereas the levels of binding and neutralizing antibodies are not equally increased by co -administration of all analyzed IFNs, indicating a direct...
... to the normal aging process of humans and has served as the aging model and has been utilized to investigate the mechanism related to the aging In our study, after 60 days of combined administration ... injury ofthe hippocampus and impairment of learning and memory in mice induced by D-galactose and NaNO2 In conclusion, our study demonstrated that SBG administration attenuated D-galaltose and ... NaNO induced aging related changes inthe brains of mice SBG increased the activity of SOD and catalase and decreased the expression of iNOS and COX-2 and MDA content SBG consequently improved the...
... http://www.biomedcentral.com/1471-2229/9/116 the gaseous phase The gas phase was drawn for 0.2 after pressuring the tube for at 70°C to carry the sample gas into the GC-MS inlet The temperature ofthe transfer line and syringe was maintained ... from these plants and to clarify the mechanism of synthesis of these compounds The emission rates of CH3I from these plants inthe presence of mM iodide were 0.4 (T aestivum), 3.1 (O sativa), and ... flow rate, 40 ml/min of N2) by GC The retention times of CH3CN and CH3SCN were 1.48 and 4.48 min, respectively, andthe products were quantified using the peak area To calibrate the concentrations...
... rats The images were taken under x400 magnification with haemotoxylin staining The intact Langerhan Islets explain the increase in plasma and pancreatic insulin contents despite theadministration ... characterized inthe STZ-induced diabetic Wistar rat model The results obtained from this study confirmed baicalin as the primary bioactive compound inScutellariabaicalensisin comparing and contrasting ... elucidation ofthe pathogenesis of diabetes occurred mainly inthe 20th century The role ofthe pancreas inthe disease pathogenesis of diabetes was discovered in 1889 by Joseph Von Mering and Oskar Minkowski...
... INTRODUCTION, present the rationale, aims ofthe study, significance ofthe study, methods ofthe study, scope ofthestudyand design ofthestudy Part two, DEVELOPMENT which is divided into chapters: ... methods ofthe study, scope ofthestudyandthe design ofthestudy I Rationale English is the main language in 30 countries, and there are about 375 million people who speak it is as their first ... future researchers specializing in demotivating factors with meaningful insights from the findings IV Methods ofthestudy To achieve the objectives ofthe study, the following research techniques...
... random and killed before the start ofthe experiment and 0, 1, 3, 5, and 10 days afterthe last dose Samples of liver, kidney, muscle, adipose tissue and serum were collected and stored inthe ... safety In this study, the withdrawal time of roxithromycin was estimated by the linear regression analysis ofthe log-transformed tissue concentrations, and was determined at the time when the Determination ... Determination of Roxithromycin by Liquid Chromatography/Mass Spectrometry after Multiple-Dose OralAdministrationin Broilers 39 Ta ble Concentration of roxithromycin in various tissues obtained...