metabolism of proteins amp amino acids

Biodegradable Polymers Composed of Naturally Occurring α-Amino Acids

Ngày tải lên : 25/10/2013, 08:20

... M (1961) Chemistry of the Amino Acids, John Wiley & Sons, Inc., New York, London Zavradashvili, N (2008) New functional biodegradable poly(ester amide)s composed of α -amino acids and their potential ... This leads to imbalance of stoichiometry and contributes to the limitation of chain growth In spite of this, Huang’s study initiated a rational synthesis of a large variety of key monomers – TAADs ... the termination of the chain growth, whereas in case of phosgene no monofunctional compound is formed since it hydrolyses with the liberation of CO2 and HCl 5.2.3.4 Transformation of AABBPs All...

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Tài liệu Proteins và Amino Acids trong thức ăn thủy sản pptx

Ngày tải lên : 26/01/2014, 18:20

... Nhu cầu Amino Acid Các amino acids có nhu cầu, xác đònh phương u, ng pháp dose-reponse EAA tương tự động vật cạn, ngoại trừ ARG ng n, Một vài EAA chia phần NEAA example: CYS sparing of MET CYS ... tính chất nhiệt hay acid hóa ng Proteins liên kết Nucleoproteins: protein + nucleic acid (e.g., seed germs) glycoproteins: protein + COH group (e.g., mucus) phosphoproteins: protein+ hợp chất chứa ... động cân protein sinh tổng hợp tiêu hao protein cho lượng chức sinh học khác Oxy hóa amino acids Các amino acids bò khữ gốc NH3 phản ứng (oxy hóa) hay chuyển gốc amin Khữ gốc NH3 phương thức chuyển...

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Báo cáo khoa học: Transport of taurocholate by mutants of negatively charged amino acids, cysteines, and threonines of the rat liver sodium-dependent taurocholate cotransporting polypeptide Ntcp docx

Ngày tải lên : 17/03/2014, 09:20

... negatively charged amino acids, cysteines and C-terminal threonines by sequence identity An alignment of the amino acid sequence of nine SBAT proteins, namely ﬁve basolateral Ntcp -proteins together ... importance of negatively charged amino acids for sodium-coupled substrate cotransport or exchange [12,13,16–18] Mutations of all conserved and two nonconserved negatively charged amino acids to ... mutagenesis of Ntcp (Eur J Biochem 270) 1121 Fig Topology model of rat Ntcp based on hydropathy analysis of the amino acid sequence (according to [1]) Transmembrane domains are symbolized as blocks of amino...

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báo cáo hóa học:" Minireview: Transaminases for the synthesis of enantiopure beta-amino acids" doc

Ngày tải lên : 21/06/2014, 17:20

... β -amino acids including (1) the resolution of racemic β -amino acids, (2) the use of naturally occurring chiral α -amino acids, and (3) asymmetric synthesis (Liu and Sibi 2002) As resolutions of ... application of transaminases for the synthesis of β -amino acids Of particular interest are methods that can be used at small scale compatible with microtiter plates Enantiopure β -amino acids represent ... variety of aliphatic and aromatic β -amino acids as amino donors with good accuracy Furthermore, by using both enantiomers of an amino donor separately, information on the enantiopreference of the...

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Báo cáo y học: " Potential therapeutic effects of branched-chain amino acids supplementation on resistance exercise-based muscle damage in humans" pps

Ngày tải lên : 11/08/2014, 23:21

... time of muscle soreness induced by exercise Nosaka et al.[3] 900 actions (30 min) of arm curl with 1.80 to 3.44 kg of range of workload BCAA-enriched amino acid mixture (60% of the essential amino ... Shimomura Y, Harris RA: Metabolism and physiological function of branched-chain amino acids: discussion of session J Nutr 2006, 136(1 Suppl):232S-233S 31 Sharp CP, Pearson DR: Amino acid supplements ... Laboratory of Applied Nutrition and Metabolism, School of Physical Education and Sports, University of São Paulo, São Paulo, SP, Brazil; Institute of Biomedical Science, University of São Paulo,...

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Báo cáo y học: "Cerebral net exchange of large neutral amino acids after lipopolysaccharide infusion in healthy humans" potx

Ngày tải lên : 13/08/2014, 20:21

... decrease was associated with Table Cerebral delivery of large neutral amino acids Table Cerebral net exchange of large neutral amino acids Amino acid Cerebral delivery μmol/ 100 g/min Baseline ... FS: Cerebral metabolism of ammonia and amino acids in patients with fulminant hepatic failure Gastroenterology 2001, 121:1109-1119 18 Møller SE: Quantification of physiological amino acids by gradient ... Structure of the blood-brain barrier and its role in the transport of amino acids J Nutr 2006, 136:218S-226S 30 Yudkoff M, Daikhin Y, Nissim I, Horyn O, Luhovyy B, Lazarow A, Nissim I: Brain amino...

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Microbial Production of Amino Acids in Japan

Ngày tải lên : 26/10/2013, 02:20

... soybea1ns contain lower amounts of lysine, which is one of Microbial Production of Amino Acids in Japan 77 the essential amino acids for those livestocks The estimated amount of l-lysine produced in ... successful introduction of the technology, various methods were searched for and developed for microbial production of other amino acids Today a whole array of amino acids are produced by microbial ... various amounts of sodium pyruvate, g of ammonium acetate, 0.6 g of pyrocatechol, 0.2 g of sodium sulfite, 0.1 g of EDTA, and cells harvested from 100 ml of broth, in a total volume of 100 ml.The...

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Tài liệu Báo cáo khoa học: The mechanism of a-proton isotope exchange in amino acids catalysed by tyrosine phenol-lyase doc

Ngày tải lên : 19/02/2014, 16:20

... side chain of any bound amino acid The lability of the a-proton observed for a large number of amino acids [5] under the action of TPL gives evidence for the orthogonal orientation of the a-proton ... with respect to the cofactor plane [17], and shows that the pattern of binding is the same for a variety of amino acids It has been established [5] that for a number of amino acid inhibitors ... References Konnikova, A.S., Dobbert, N.N & Braunstein, A.E (1947) Labilization of a-hydrogen of amino acids under the action of aminoferase Biokhimia 12, 556–568 (in Russian) Ó FEBS 2004 Esaki, N., Nakayuma,...

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Báo cáo khoa học: The ATPase activities of sulfonylurea receptor 2A and sulfonylurea receptor 2B are inﬂuenced by the C-terminal 42 amino acids doc

Ngày tải lên : 06/03/2014, 11:20

... activities of NBD2A and NBD2B could result from an inhibitory effect of the C-terminal 42 amino acids of NBD2B or a stimulatory effect of the equivalent amino acids of NBD2A To determine which of these ... last 42 amino acids Figure 2A and Table show that the ATPase activity of NBD2-DC was greater than that of SUR2B but similar to that of NBD2A, favoring the idea that the last 42 amino acids of NBD2B ... equation using a Km of 460 lM, a Vmax of 2.52 nmol PiÆminÆmg)1 and an offset of 0.1 nmol PiÆminÆmg)1 for SUR2A, and a Km of 41 lM, a Vmax of 0.73nmol PiÆminÆmg)1 and an offset of 0.05 nmol PiÆminÆmg)1...

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Báo cáo khoa học: Control of mammalian gene expression by amino acids, especially glutamine potx

Ngày tải lên : 07/03/2014, 00:20

... involved in the action of amino acids on gene expression Amino acid(s) manipulations Factor(s) implied Inhibiting effect resulting from the presence of amino acids Pooled amino acids deprivation Increased ... presence of amino acid(s) resulted in inhibition of the DNA binding of the involved transcription factors By contrast, the presence of amino acid may also result in stimulation of the DNA binding of ... effects of different amino acids (except glutamine), together with the identiﬁed transcription factors and the responsive elements involved Most of the data concern the inhibitory effect of amino acids...

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Báo cáo khoa học: Covalent activation of heart AMP-activated protein kinase in response to physiological concentrations of long-chain fatty acids docx

Ngày tải lên : 07/03/2014, 15:20

... the abundance of AMPK a-subunit protein Activation of AMPK by fatty acids does not require changes in cellular adenine nucleotides Fig Eﬀect of palmitate on the phosphorylation state of acetyl-CoA ... for comparison of 60 with 20 values chargeÕ in control compared with that in control (Table 3) Time-dependence of the activation of AMPK by fatty acids No signiﬁcant activation of AMPKs by 0.5 ... omitted from these assays Activation of a-2 AMPK by these fasting concentrations of NEFA was also seen in assays with AMP By contrast, with AMP present, a-1 AMPK appeared to be insensitive to palmitate...

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Báo cáo khoa học: Amino acids at the N- and C-termini of human glutamate carboxypeptidase II are required for enzymatic activity and proper folding pptx

Ngày tải lên : 07/03/2014, 15:20

... to consist of six domains: the N-terminal cytoplasmic tail (amino acids 1–18), the helical transmembrane region (amino acids 19–43), and four extracellular domains spanning amino acids 44–150 ... recovered, apparently as a result of the blocking of the N-terminal amino acid Subsequent Western blot analysis, exploiting the 7E11 mAb recognizing the ﬁrst six amino acids of the full-length GCPII [31], ... removal of as few as 15 amino acids from the C-terminus completely abolished NAAG-hydrolyzing activity (the 44/736 variant), and the C-terminal extension (addition of the V5-His tag in the case of...

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Báo cáo khoa học: Drosophila proteins involved in metabolism of uracil-DNA possess different types of nuclear localization signals pdf

Ngày tải lên : 15/03/2014, 11:20

... T-ag UDE of D melanogaster TDG of D melanogaster v-Jun of Homo sapiens dUTPase of Homo sapiens H2B of Saccharomyces cerevisiae c-Myc of Homo sapiens dUTPase of D melanogaster c-Myc of Xenopus ... very end of the C-terminus and has a high proportion of positively charged amino acids Underlined residues are predicted to be part of the NLS Each sequence starts with the neutral amino acid ... maintenance of the normal homeostatic function of cells We identiﬁed and characterized two types of monopartite nuclear localization sequences of D melanogaster proteins involved in uracil-DNA metabolism...

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Báo cáo khóa học: Vertical-scanning mutagenesis of amino acids in a model N-myristoylation motif reveals the major amino-terminal sequence requirements for protein N-myristoylation ppt

Ngày tải lên : 16/03/2014, 16:20

... study, to examine the effect of the combination of amino acids at positions and on protein N-myristoylation, sequential vertical-scanning mutagenesis of the amino acids at positions and in a model ... counted, 74% (58 of 78) of these proteins had a Ser residue and 13% (10 of 78) had a Thr residue at position (Fig 4) The number of N-myristoylated proteins having other amino acids at position accounted ... because of the presence of these amino acids at position in naturally observed N-myristoylated proteins (Fig 4) The results revealed that amino acid requirements at position very similar to those of...

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Báo cáo khoa học: Identiﬁcation of amino acids in antiplasmin involved in its noncovalent ‘lysine-binding-site’-dependent interaction with plasmin pptx

Ngày tải lên : 17/03/2014, 03:20

... half-lives of plasmin in these experiments (also before 50% of the plasmin activity was inhibited) Computer model of the C-terminal 40 amino acids in antiplasmin A computer model of the C-terminal 40 amino ... absence of 6-aminohexanoic acid) The reactions between ‘native’ human antiplasmin and plasmin in the presence or absence of 6-aminohexanoic acid were also studied for comparison All variants of antiplasmin ... vicinity of the side chain of Phe448 Lys436, on the other hand, is found at the surface of the molecule with a protruding side chain Discussion Antiplasmin belongs to the serpin superfamily of proteins...

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Báo cáo Y học: Amino acids 3–13 and amino acids in and ﬂanking the 23FxxLF27 motif modulate the interaction between the N-terminal and ligand-binding domain of the androgen receptor pdf

Ngày tải lên : 17/03/2014, 10:20

... obtained by exchange of a 1.8-kb HindIII fragment of pSVAR3 with the corresponding fragment of pGAD3D3–37 For construction of pSVAR.NTDD3-37, a 1.7-kb HindIII/Asp718 fragment of pSVAR.NTDwt was ... of three independent experiments Fold induction is shown to the right of each bar and represents the ratio of activities determined in the presence and absence of R1881 (C) Western analysis of ... substitutions of amino acids ﬂanking 23FQNLF27 reduced the binding to AR LBD Most prominent inhibitory effects were found for amino acid residues directly ﬂanking 23FQNLF27 Note that expression levels of...

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Báo cáo khoa học: Arg143 and Lys192 of the human mast cell chymase mediate the preference for acidic amino acids in position P2¢ of substrates pdf

Ngày tải lên : 22/03/2014, 21:21

... aromatic amino acids (Phe, Tyr, and Trp); negatively charged amino acids (Asp and Glu); positively charged amino acids (Lys and Arg); small aliphatic amino acids (Gly and Ala); larger aliphatic amino ... negatively charged amino acids, and instead preferred aliphatic or noncharged amino acids at this position The identiﬁcation of Arg143 and Lys192 as P2¢ preference-determining amino acids facilitates ... side chains of substrates, but not when the negative charge is situated at a C-terminal carboxyl group of a P2¢ amino acid of Fig Analysis of cleavage speciﬁcity by the use of new types of recombinant...

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Báo cáo khoa học: Endoplasmic reticulum stress caused by aggregate-prone proteins containing homopolymeric amino acids doc

Ngày tải lên : 23/03/2014, 07:20

... pathogenesis of these conformational disorders In the present study, we used hydrophobic HPAAs as model proteins of conformational disorders, taking advantage of different levels of solubility ... aggregate-prone proteins 5620 Results Aggregation of hydrophobic HPAAs and accumulation of ubiquitinated proteins in mammalian cells We previously expressed 20 different HPAAs of approximately ... that inhibition of the UPS by the aggregate of diseasecausative proteins may lead to secondary neuronal damage Endoplasmic reticulum (ER) stress has been attributed to the pathology of neurodegenerative...

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Báo cáo khoa học: Chromophore attachment in phycocyanin Functional amino acids of phycocyanobilin – a-phycocyanin lyase and evidence for chromophore binding doc

Ngày tải lên : 23/03/2014, 10:21

... affect the stability of the proteins [28] The C terminus of CpcF shows only little homology for as much as 50 amino acids A truncation by 53 amino acids reduced the solubility of the protein, possibly ... modiﬁcations of amino acids Chemical modiﬁcations of arginine, lysine, carboxyl groups, tryptophan and histidine were performed as described before [28] The number of essential residues of a certain amino ... terminus of CpcF showed more homology: a 10 amino acid truncation reduced the activity to 26%, and it was lost completely when 20 amino acids were truncated Among the 10 N-terminal amino acids, ...

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