mesenchymal transition the initiation step of tumor metastasis

Báo cáo y học: "Anticancer Activity of the PR Domain of Tumor Suppressor RIZ1"

... have not yet been addressed The first question is whether the expression level for RIZ1 varies over the progression of cancer; and the second question is whether the PR domain alone possesses ... mediate the translocation of PR domain into the cells To ensure the presence of PR domain within the cells, we transfected HuH7 cells with a plasmid (pcDNA/HisMax/PR) expressing the PR domain The ... described below; and the cell death rate was examined by the trypan blue method after 24 and 48 hr of transfections, respectively Western blot of PR domain The expression of the PR domain was examined...

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Tài liệu Báo cáo khoa học: Kinetic characterization of the ﬁrst step of the ribozyme-catalyzed trans excision-splicing reaction docx

Danh mục: Báo cáo khoa học

... not the same as) the role of the xG in the second step of self-splicing [4856] This suggests that the guanosine to be excised is likely binding to the GBS of the ribozyme for the exon-ligation step ... For the fraction of substrates that undergo the reaction, the resultant products dissociate from the ribozyme relatively slowly on the time scale of the reaction Furthermore, dissociation of the ... that there is room for improvement in terms of the rate of reaction This would be benecial not so much in terms of the rate of the overall reaction, as the cleavage reaction is not the limiting step...

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báo cáo hóa học:" More insights into the immunosuppressive potential of tumor exosomes" pptx

Danh mục: Hóa học - Dầu khí

... then a further pathway to the potential modulating properties of these peculiar organelles If tumor exosomes are such a powerful instrument of environmental shaping, then getting rid of them should ... hypothesized that this pathway may contribute to the in vivo moulding of immune as well as other cancer-related host responses More recent studies have then reported that the detrimental effect of ... be performed to assess what is the real impact that these vesicles play in cancer progression and what is the expected benefit of shutting off their production at tumor site Authors contributions...

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Báo cáo y học: "Onset of efficacy and tolerability following the initiation dosing of long-acting paliperidone palmitate: post-hoc analyses of a randomized, double-blind clinical trial" doc

Danh mục: Báo cáo khoa học

... increase the risk of the occurrence of Torsade de Pointes or sudden death Further details of the study design are reported by Pandina et al [14] Study Medications The study consisted of a screening ... questions regarding the initiation dosing of paliperidone palmitate, specifically the time to onset of efficacy and the associated tolerability, were addressed in these post-hoc analyses of a large, ... are also an area of concern with respect to the tolerability of an antipsychotic regimen Substantial literature supports that the incidence of these events as well as the time of onset differ...

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Báo cáo y học: " Epigallocatechin-3-gallate (EGCG) inhibits the migratory behavior of tumor bronchial epithelial cells" docx

Danh mục: Báo cáo khoa học

... of this mixture was added over the first layer and 1.5 ml of DMEM was placed into the basal compartment of the chamber that was thereafter maintained for 24 hours at 37°C To test the effect of ... cells present on the basal side of a porous membrane To date, the effect of EGCG on the migration speed of tumor cells has not been investigated We therefore used in vitro models of cell migration ... concentration (μg/ml) Figure zymography of the gelatinolytic activities of MMPs zymography of the gelatinolytic activities of MMPs Analysis of the gelatinolytic activities of MMP9 (92 kDa), pro-MMP2 form...

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Báo cáo khoa học: "Gastrointestinal stromal tumor of the stomach with lymph node metastasis" ppsx

Danh mục: Báo cáo khoa học

... http://www.wjso.com/content/6/1/97 Figure The histopathological examination of the tumor The histopathological examination of the tumor. A: A photomicrograph of the tumor showing epithelioid cells with prominent pleomorphism; ... drafted the manuscript, YO helped in preparation and editing of the manuscript, ON wrote the pathological part of the manuscript and OS performed the IHC and contributed the IHC part of the manuscript ... patients with localized, resectable GISTs The principle of surgery for GISTs is R0 resection of the tumor Tumor rupture or R1 resection of the primary tumor has a negative impact on disease free...

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Báo cáo y học: "Relevance of the stroma and epithelial-mesenchymal transition (EMT) for the rheumatic diseases" docx

Danh mục: Báo cáo khoa học

... interest in the influence of the stromal environment on neoplasia The role of the ECM and stroma in cancer Drivers and mediators of epithelial -mesenchymal transition (EMT) Early stage tumor cells ... manner on the CXCR4 receptors of tumor cells A comprehensive gene expression profile of breast carcinomas noted significant overexpression of the chemokines CXCL14 and CXCL12 in tumor myoepithelial ... Schematic illustration of the key events of epithelial -mesenchymal transition (EMT) involving the renal tubular basement membrane (TBM) and possible therapeutic interventions The diagram illustrates...

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Báo cáo khoa học: A novel metallocarboxypeptidase-like enzyme from the marine annelid Sabellastarte magniﬁca – a step into the invertebrate world of proteases pdf

Danh mục: Báo cáo khoa học

... appeared in the analysis of both parts of the animal, with a major presence of bands in the body (upper part) versus the crown (lower part) In Fig 3, we show, in the uncombined (Fig 3A,B) or in the combined ... to hydrolyze the ﬁrst of such C-terminal residues, glutamic acid, even after 60 of incubation Again, the addition of rPCI prevented any kind of hydrolysis by the enzyme The release of a glutamic ... the MS spectrum and capturing the MCP in the body extract The control spectra, as well as the ‘perturbed’ one (by rPCI addition, followed by removal of the captured targets by sedimentation of...

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Báo cáo khoa học: Enzymatic features of the glucose metabolism in tumor cells ppt

Danh mục: Báo cáo khoa học

... capable of reducing the level of fructose 2,6-P2 independent of the phosphorylation state of iPFK-2 Reducing the level of fructose 2,6-P2 and thus the activity of PFK-1 improves the supply of glucose ... concentration leads to detachment of PFK from the cytoskeleton and thus diminishes the provision of local ATP in the vicinity of the cytoskeleton [71] The expression of PFK in tumor cells can be enhanced ... changing the activity of the enzyme by x% results in a signiﬁcant change of the pathway ﬂux by at least 0.5x% (whether 0.5x% or higher is a matter of convention) The way that the change of enzyme...

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Every Step of the Way potx

Danh mục: Sức khỏe giới tính

... side of the grave, But then, once in a lifetime The longed-for tidal wave Of justice can rise up And hope and history rhyme Every Step of the Way is part of the larger effort by the Ministry of ... influence their environment according to their needs The traces are evident in the life and times of the hunter-gatherers of past millennia, the farmers, colonisers and industrialists of the last ... is easily the largest gold refinery in the world Nevertheless, the visitor is struck by the smallness of the building and the matter of fact way in which the glorious, golden stream of molten...

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Báo cáo khoa học: "Getting the Most out of Transition-based Dependency Parsing" doc

Danh mục: Báo cáo khoa học

... linear time In Proceedings of the Joint Conference of the 47th Annual Meeting of the ACL and the 4th International Joint Conference on Natural Language Processing of the AFNLP (ACL-IJCNLP’09), ... list-based algorithm (Nivre, 2008) The main difference between these two approaches is in their implementation of the SHIFT transition ChoiNicolov’s approach divides the SHIFT transition into two, deterministic ... represent indices of their corresponding word tokens The initial state is ([0], [ ], [1, ,n], ∅) The identiﬁer corresponds to an initial token, w0 , introduced as the root of the sentence The ﬁnal state...

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Báo cáo khoa học: An internal ribosome entry site mediates the initiation of soluble guanylyl cyclase b2 mRNA translation potx

Danh mục: Báo cáo khoa học

... Degree of agreement with the Kozac consensus sequence for the initiation of protein translation b Number of amino acids encoding for the upstream ORF (uORF) of the sGC b2 5¢-UTR c Whether this ... increased the translation of the downstream cistron 6.3-fold over the control (pSL3) and two-fold over the vector containing the EMCV IRES (Fig 5B) The IRES activity of the bicistronic vector with the ... normalized on the basis of the renilla luciferase activity of the transfection control vector pRLTK (Promega) and of the mRNA levels determined by TaqMan Real Time PCR The luciferase expression of the...

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Every Step of the Way doc

Danh mục: Khoa học xã hội

... side of the grave, But then, once in a lifetime The longed-for tidal wave Of justice can rise up And hope and history rhyme Every Step of the Way is part of the larger effort by the Ministry of ... influence their environment according to their needs The traces are evident in the life and times of the hunter-gatherers of past millennia, the farmers, colonisers and industrialists of the last ... is easily the largest gold refinery in the world Nevertheless, the visitor is struck by the smallness of the building and the matter of fact way in which the glorious, golden stream of molten...

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the organometallic chemistry of transition metals

Danh mục: Hóa học - Dầu khí

... mandate the use of renewable fuels The presence of d electrons in their valence shell distinguishes the organometallic chemistry of the elements of groups 3–12 of the periodic table, the transition ... by the crystal ﬁeld model The idea is to ﬁnd out how the d orbitals of the transition metal are affected by the presence of the ligands To this, we make the simplest possible assumption about the ... of their higher and CFSE Low- Versus High-Field Ligands The colors of transition metal ions often arise from the absorption of light that corresponds to the dπ –dσ energy gap, The spectrum of...

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báo cáo hóa học:" Summary of the primer on tumor immunology and the biological therapy of cancer" ppt

Danh mục: Hóa học - Dầu khí

... signaling processes The ligation of VEGFR-2 by the majority of VEGF isoforms triggers the proliferation, migration and survival of endothelial cells, which in tumors form the framework of immature new ... in the formation and maintenance of tumor vasculature and the progression of cancer VEGF and PDGF bind their corresponding receptors to trigger receptor autophosphorylation and the initiation of ... to receptors on the T cells The discovery of multiple costimulatory molecules that influence the course of T cell activation has increased our appreciation of the complexity of the T cell response...

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Báo cáo hóa học: " Adenoviruses with an avb integrin targeting moiety in the fiber shaft or the HI-loop increase tumor specificity without compromising antitumor efficacy in magnetic resonance imaging of colorectal cancer metastases" pdf

Danh mục: Hóa học - Dầu khí

... virus, increased tumor cell transduction is achieved with adenoviruses with RGD moieties in the HI loop of the fiber or in the KKTK domain of the fiber [30] Furthermore, mutation of the KKTK domain ... also the use of non-subcutaneous tumor models for tumor growth follow-up Tumors grown in the correct organ likely resemble the human disease more closely than subcutaneous tumor models [38,39] Therefore, ... the life of an adenovirus much tougher, requires further study RGD modification in the KKTK domain of the fiber shaft may have potential to increase the overall antitumor efficacy of the oncolytic...

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Báo cáo sinh học: " The internal initiation of translation in bovine viral diarrhea virus RNA depends on the presence of an RNA pseudoknot upstream of the initiation codon" doc

Danh mục: Hóa học - Dầu khí

... addition of 27 or 75 nt of the Npro coding region to the 5'UTR Additional support for the importance of the sequences immediately downstream of the initiating AUG is provided by the comparison of the ... stressing the importance of these regions for translation [2] The results concerning the 5' UTR boundaries of the BVDV IRES parallel the results reported for the mutational analysis of the closely ... part of the coding region of the BVDV strain SD-1 genome pT7 5'p20 encodes the 5' UTR and a portion of the coding region of BVDV strain NADL[15] pmβActin (Stratagene) harbors the cDNA of the mouse...

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Báo cáo hóa học: " The internal initiation of translation in bovine viral diarrhea virus RNA depends on the presence of an RNA pseudoknot upstream of the initiation codon" ppt

Danh mục: Hóa học - Dầu khí

... addition of 27 or 75 nt of the Npro coding region to the 5'UTR Additional support for the importance of the sequences immediately downstream of the initiating AUG is provided by the comparison of the ... stressing the importance of these regions for translation [2] The results concerning the 5' UTR boundaries of the BVDV IRES parallel the results reported for the mutational analysis of the closely ... part of the coding region of the BVDV strain SD-1 genome pT7 5'p20 encodes the 5' UTR and a portion of the coding region of BVDV strain NADL[15] pmβActin (Stratagene) harbors the cDNA of the mouse...

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báo cáo hóa học:" How to calculate the annual costs of NGO-implemented programs to support orphans and vulnerable children: A six-step approach" potx

Danh mục: Hóa học - Dầu khí

... allowance Fringe NGO office 7200 rent or office repairs Other NGO other office costs/supplies 7100 bank charges Other NGO other office costs/supplies 7300 communications Other NGO other office costs/supplies ... Results for Step (include the results of Steps 3-5 in an expanded cost profile) Based on the additional information developed in Steps 3-5, Table presents the final expanded cost profile for the BIDII ... from the purchase year to the end of the project) given a specific discount/interest rate A “scrap value” can be included if the item continues to have value at the end of the project (e.g., the...

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báo cáo hóa học:" Development of the Japanese version of the Pediatric Quality of Life Inventory™ Brain Tumor Module" pot

Danh mục: Hóa học - Dầu khí

... chemotherapy Convergent and discriminant validity was examined by correlating the scales of the Japanese version of the PedsQL™ Brain Tumor Module with the theoretically-predicted scales of the ... Additionally, proof of the validity of our results was evidenced on several points The fixed scale-development methods of the present study ensured the content validity and the results ensured ... responsibility of the PedsQL™ Brain Tumor Module and factors related to the child-parent discordance for the Worry scale Conclusions We developed the Japanese version of the PedsQL™ Brain Tumor Module...

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