meningitidis interacting with the human innate immune system

Báo cáo khóa học: Collectins Players of the innate immune system docx

Ngày tải lên : 07/03/2014, 15:20

... players of the innate immune system (Eur J Biochem 271) 1241 interactions These conﬂicting results concerning the involvement of CRD in the mediation of chemotaxis might be explained by the assumption ... ligands, or that they are involved in the recognition of immune cell surface receptors In addition, the electrostatic potential pattern on the surface of the protein might be altered by the additional ... GluPro-Arg in the case of SP-A) triplet with Gln-Pro-Asp changes the CRD speciﬁcity from mannose-type to galactose-type [76], consistent with the fact that the latter triplet is conserved in the CRDs...

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báo cáo hóa học:" Angiostatin anti-angiogenesis requires IL-12: The innate immune system as a key target" docx

Ngày tải lên : 18/06/2014, 15:20

... particular the innate immune system, play a key role in induction of angiogenesis in cancer as well as other pathological and physiological conditions (see [16-18] for review), and that innate immune ... both the subunits of IL-12, similar to that observed after maturation with IFNγ and LPS (with the exception of CXCL10) Treatment with both AST and IFNγ/LPS was additive only in the case of the ... have independent functions The immune system is capable of sensing at least some forms of proteolytically generated peptides [34], a role for the immune system in the function of this class of...

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Báo cáo y học: " Lack of effect of glutamine administration to boost the innate immune system response in trauma patients in the intensive care unit" pdf

Ngày tải lên : 14/08/2014, 07:21

... may exert a positive effect on other cell types or even at the level of cross-talk between cells of the innate immune system Studies are on going to test these hypotheses In this study, we have ... positive effect on the innate immune system Given the importance of TLRs and TLRs-dependent signalling in host defence against infections we hypothesized that glutamine may increase the expression ... positive effect on the innate immune system • Given the importance of TLRs and TLRs-dependent signalling in host defence against infections we hypothesized that glutamine may increase the expression...

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Interacting with the Outside World Using Simple IO Devices

Ngày tải lên : 03/10/2013, 01:20

... kick start the programming and enhances the confidence level It also clarifies the basic infinite loop theory of the embedded systems by using while{1} construct The concept of passing the delay ... plate either of brass or stainless steel With their low power requirement, these devices can be driven by the microcontroller port to produce high acoustic output With the Application of the DC ... 20 Interacting with the Outside World Using Simple I/O Devices show pieces, etc Many of the embedded system products makes use of the SMD LED’s (owing to manufacturing ease) although they are...

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Báo cáo khoa học: The 3¢-UTR of the mRNA coding for the major protein kinase C substrate MARCKS contains a novel CU-rich element interacting with the mRNA stabilizing factors HuD and HuR ppt

Ngày tải lên : 08/03/2014, 08:20

... mRNA (A) The MARCKS 3¢-UTR, the stop codon UAA of the coding sequence (CDS) and the poly(A) sequence are depicted The box within the 3¢-UTR marked the identiﬁed CU-rich sequence interacting with ... 90-mm dish) and transfected the following day with the plasmid pTetoﬀ together with the empty pTRE vector (lanes 1, 2) or together with pTRE-HuD (lanes 3, 4) or together with pTRE-HuR (lanes 5, 6) ... and C2 with both the nuclear (Fig 5C, lane 1) and the cytoplasmic fraction (lane 4) To directly explore the involvement of HuR in forming a complex with the CU-rich sequence, we used the Hu-antiserum...

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Báo cáo khoa học: "Successful treatment of perineal necrotising fasciitis and associated pubic bone osteomyelitis with the vacuum assisted closure system" ppsx

Ngày tải lên : 09/08/2014, 07:21

... of the pelvis revealed extensive oedema of the urethra, vagina and rectum with fluid collections within the proximal thigh adductors bilaterally which contained an air/fluid level within the ... extensive oedema of all the muscle groups around the pelvis, most marked in the region of the obturators and the adductor muscles in the proximal thigh and bone marrow oedema in the symphysis pubis ... dressing (VAC Therapy™, KCI, Oxfordshire, United Kingdom) from day-9 after initial debridement (Figure 2) Owing to the considerable pain and the position of the wounds, the VAC system had to...

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Báo cáo y học: "Cell signalling in macrophages, the principal innate immune effector cells of rheumatoid arthritis" pps

Ngày tải lên : 09/08/2014, 10:23

... However, others suggest that IL-10 upregulates the soluble form of the TNFR rather than the membrane bound form, which in turn would inhibit inflammation [123] To confound the matter further, it ... [134] These, together with IL-17RB, RD and RE, form a distinct receptor superfamily with little similarity to other cytokine receptors Likewise, there are no fewer than six members in the IL-17 ... mechanisms of the immune system play a role in its pathology Current evidence in human suggests a strong influence of innate immune cells, such as macrophages and synovial fibroblasts, in the progression...

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Báo cáo y học: "Complicated sternal dehiscence treated with the strasbourg thoracic osteosyntheses system (STRATOS) and the transposition of greater omentum: a case report" pot

Ngày tải lên : 10/08/2014, 09:22

... by the bi-cortical insertion of the screws The remaining dead space after sternal reconstruction has been filled with the greater omentum The use of the greater omentum in the treatment of the ... of Figure The sternal wound is opened and the right half of the sternum is completely destroyed (A) The intercostal muscles and the bundle is removed (B) The rib clips are clung to the rib through ... cases in which the bone quality is poor and the sternum is completely destroyed This system is effectiveness in the stabilization of the chest wall, reducing the pain, improving the ventilation...

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Báo cáo y học: " Always one step ahead: How pathogenic bacteria use the type III secretion system to manipulate the intestinal mucosal immune system" doc

Ngày tải lên : 11/08/2014, 06:22

... important factor in the host defense The intestinal immune system faces the constant challenge of discriminating between the commensal microbiota and pathogens The response to the latter is usually ... the bacteria induce an inflammatory response with the detection systems of the host cells, they are able to inhibit the inflammatory pathways in a T3SS-dependent manner [52,53] By hampering the ... others aspect of pathogenesis Amongst them are the alteration of the intestinal epithelial tight-junctions, the effacement of the brush border microvilli, mitochondrial-dependant apoptosis, the...

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Báo cáo y học: " Antioxidant components of naturally-occurring oils exhibit marked anti-inflammatory activity in epithelial cells of the human upper respiratory system" pdf

Ngày tải lên : 12/08/2014, 13:22

... [42,43] by having the subjects make a mark on a horizontal 100 mm line indicating the level of the symptom described, with the least sensation at the far left and the most at the far right Scores ... the oil preparation To investigate the effects of the oil preparation on the global system of antioxidant genes induced within the respiratory epithelium by the Nrf2 transcription factor, representative ... associated with the protection observed in the nasal ozone intervention study Although seemingly unrelated in terms of their sources and the nature of their interactions with the respiratory system, ...

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Báo cáo y học: " Differential epithelial expression of the putative innate immune molecule SPLUNC1 in Cystic Fibrosis" pptx

Ngày tải lên : 12/08/2014, 15:21

... the epithelial cells of the smaller airways and also within the inflammatory cell containing mass within the plugged lumens SPLUNC1 did not co-localise with MUC5AC (I) There was no staining within ... Epithelial staining appeared to be present towards the apical surface of the cells and along the epithelial surface In addition to the greatly increased staining seen within the epithelium, the ... is the founder member of the PLUNC family of putative innate immune molecules, and is highly expressed in the epithelium of the upper respiratory tract, nasopharynx and submucosal glands [1] The...

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Báo cáo y học: "Host proteins interacting with the Moloney murine leukemia virus integrase: Multiple transcriptional regulators and chromatin binding factors" pot

Ngày tải lên : 13/08/2014, 05:20

... putative interacting proteins We chose to further characterize the interactions of 27 of these factors with MoMLV integrase and to test their interactions with HIV integrase A subset of the proteins ... observed with the two lexA-DB empty vectors, with the lexA-DB-mIN fusions transformed singly, nor with either of the empty GAL4 AD vectors pGADNOT or pACT2 (Table and data not shown) Activation of the ... intensity of the interactions between the GST subclones and the two retroviral integrases correlated well with the strength of the interactions observed in the yeast two-hybrid assays The MBP-mIN...

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Báo cáo khoa học: "Simulating the Behaviour of Older versus Younger Users when Interacting with Spoken Dialogue Systems" pdf

Ngày tải lên : 31/03/2014, 00:20

... of the standard methods for evaluating the quality of a SU is to run a user simulation on a real corpus and measure how often the action generated by the SU agrees with the action observed in the ... depending on the previous system prompt There are 389 distinct actions for older people and 125 for younger people The actions of the younger people are a subset of the actions of the older people ... of the corpus design, statistics, and annotation scheme is provided in (Georgila et al., 2008) Our analysis of the corpus shows that there are clear differences in the way users interact with the...

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Báo cáo sinh học: " Rotavirus nonstructural protein 1 antagonizes innate immune response by interacting with retinoic acid inducible gene I" pdf

Ngày tải lên : 18/06/2014, 18:20

... consist of the most important effectors of the innate antiviral immune system [24] Accumulating evidence demonstrates that RIG-I is a key component in antiviral immune responses [25] The production ... together, these findings indicate that RIG-I could be a potential target for NSP1 NSP1 interacts with RIG-I Subsequently, we examined whether NSP1 can interact with RIG-I We cotransfected the ... (β-TrCP) However, in addition to these targets, NSP1 may subvert innate immune responses via other mechanisms Results The NSP1 of rotavirus OSU strain as well as the IRF3 binding domain truncated...

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Báo cáo sinh học: " Modulation of macrophage functions by sheeppox virus provides clues to understand interaction of the virus with host immune system" docx

Ngày tải lên : 18/06/2014, 22:20

... not dependent on virus infectivity Later and systemically, the virus protects the host from any fatal consequences of the suppression of the immune system by compensatory enhanced activities of ... Competing interests The author(s) declare that they have no competing interests Authors' contributions Abu-El-Saad participated in the design of the study, carried out the work with the mice, assisted ... has the capacity to impair the initiation of an acquired immune response [16,21] If the viruses fail to secrete such immunomodulating proteins, as when the respective genes are deleted or the...

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báo cáo hóa học:" Modulation of macrophage functions by sheeppox virus provides clues to understand interaction of the virus with host immune system" doc

Ngày tải lên : 20/06/2014, 04:20

... not dependent on virus infectivity Later and systemically, the virus protects the host from any fatal consequences of the suppression of the immune system by compensatory enhanced activities of ... Competing interests The author(s) declare that they have no competing interests Authors' contributions Abu-El-Saad participated in the design of the study, carried out the work with the mice, assisted ... has the capacity to impair the initiation of an acquired immune response [16,21] If the viruses fail to secrete such immunomodulating proteins, as when the respective genes are deleted or the...

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Báo cáo y học: "Human metapneumovirus induces more severe disease and stronger innate immune response in BALB/c mice as compared with respiratory syncytial virus" pps

Ngày tải lên : 12/08/2014, 15:20

... study pathogenesis of and immune response to this pneumovirus [17] Although RSV can directly affect the integrity of the respiratory epithelium, the immune response is the most crucial factor in ... primary infection with human metapneumovirus and with other common respiratory viruses of infancy J Infect Dis 2004, 189:2047-2056 Alvarez R, Tripp RA: The immune response to human metapneumovirus ... we directly compare the kinetics of viral replication, pathogenesis, and immune response in the BALB/c mouse model after infection with the same dose of HMPV or RSV using either a low passage-clinical...

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Analysis of transcription factors in living human cells with the help of split ubiquitin system

Ngày tải lên : 29/09/2015, 13:01

... analyzed inside human HT1080HPRT- cells with the help of the two-component split-ubiquitin system The linker histone regulates the condensation and decondensation of chromatin by binding to the nucleosomes ... externally However, the position and the orientation of the linker histone with respect to the nucleosomal histone proteins are still not clear Studying the interaction of the linker histone with core ... networks from these model organisms The accuracy and coverage of the interactions predicted depend on the quality of the original model organism protein and the ability to identify the human orthologs...

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Interaction of burkholderia pseudomallei with cells of the immune system

Ngày tải lên : 08/11/2015, 16:31

... through the membrane to contact the cells in the bottom well, the latter were observed with the light microscope under high magnification to check for the absence of bacteria swimming among the cells ... capture the bacteria for digestion within the phagosomes The released immunogenic antigens are processed to peptides being complexed with MHC molecules and then presented to naïve T cells The latter ... cells control the adaptive immune response by acting as effector cells through cytotoxic activity and the production of lymphokines that further 23 help to activate innate cells like the macrophages...

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