mechanisms of skin damage
Báo cáo khoa học: Post-ischemic brain damage: the endocannabinoid system in the mechanisms of neuronal death ppt
... amounts of nitric oxide (NO) generated by pathological expression of NO synthase isoforms are certainly neurotoxic, whereas homeostatic levels of NO produced by the endothelial isoform of this ... discovery of new molecular targets for the development of innovative and effective therapeutic agents During the last decade a great deal of interest has been devoted to dissecting the role of the ... stroke and in the mechanisms of post-ischemic neuronal death (Table 1) To this end, models of focal and global ischemia in vivo, with or without reperfusion, as well as models of oxygen glucose...
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Báo cáo y học: " Cellular and molecular mechanisms of cigarette smoke-induced lung damage and prevention by vitamin c" ppsx
... large dosage of of lung C Histopathology vitamin sections of guinea pigs exposed to CS showing progressive lung damage and prevention by moderately Histopathology of lung sections of guinea pigs ... Bcl-2 of the lung extracts of guinea pigs exposed to air or CS supplemented with A, Immunoblots of caspase 3, PARP, A, Immunoblots of caspase 3, PARP, Bax and Bcl-2 of the lung extracts of guinea ... panel: Immunoblots of the DNP-derivatives of lung proteins of guinea pigs exposed to smoke from 1, and cigaA, Upper panel: Immunoblots of the DNP-derivatives of lung proteins of guinea pigs exposed...
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Báo cáo y học: "Proteomic analysis of mechanisms of hypoxia-induced apoptosis in trophoblastic cells"
... transfection of Bag-1 Morpho/AS to JAR cells did not alter the expression of PTEN after the exposure to hypoxia, which would mean that the expression of PTEN, and also that of Bcl-X, was independent of ... expression profiles of proteins involved in the mitochondrial (bcl-2, bax, and bcl-x, etc.) and stress reaction-related pathways of apoptosis (Fig 2) Table Altered protein expression of JAR cells ... calculated according to the formula: Changes in the level of phosphorylated JNK 1&2 (-fold of control) = absorbance of treated cells / absorbance of control cells All points were done duplicate X three...
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Study on the Photolytic Mechanisms of Red 141 Dye Wastewaters with an 185nm Vacuum-UV lamp
... vacuum-UV photolysis of water (H2O-VUV) is still a field of active research compared to other AOPs (Oppenlander and Gliese, 2000) The special requirements of the VUV photolysis of water according ... related to the formation of high local concentration of hydroxyl radicals (OH.) and a series of other species (Gonzalez and Braun, 1995) within a photochemical reaction zone of less than 0.1 mm (Heit ... differentiation of the contributions on the decomposition of Re 141 in aqueous solutions by UV direct photolysis, OH generated from the excitement of water, oxygen, and H2O2, respectively Development of the...
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ISOTOPE HYDROGRAPH SEPARATION FOR MODELING OF RUNOFF MECHANISMS OF ATMOSPHERICALLY DERIVED CHEMICAL AND RADIOACTIVE POLLUTANTS
... 22-23 of 2003 The amount of precipitation was 30 mm in total Figure shows the precipitation record of the studied event (Fig 2a) and the record of the river flow rate (solid line, Fig 2b) of the ... measurement, considering of their respective analytical errors A concept of two-component mixing was employed, in which it was assumed that runoff is composed of a mix of two components: one originating ... and by setting C1 and C2 as mentioned above, the fraction of new water evaluated for the main part of the runoff (0000 of Oct 22 to 1600 of Oct 23, 40 h in total) was found to be as shown in Fig...
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Mechanisms of Unstable Nitrite Inhibition of Aerobic Phosphate Uptake
... some of PAOs can that, the inhibitory effect of nitrite will be reduced Hence, the purpose of this study is to examine the effect of anoxic activity of PAOs on reduction of inhibitory effect of ... Cycle Operations of SBRs for Cultivation of the Enriched PAOs - 66 - Journal of Water and Environment Technology, Vol 6, No.1, 2008 Table - Composition of Synthetic Wastewater Methods of nitrite inhibition ... presence of nitrite was 13 mgP.gVSS-1.h-1 and the % activity of phosphate uptake was 39% On the other hands, in the case of AA with 1.9 mgN/gVSS of initial nitrite concentration, the size of inhibition...
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Transmission mechanisms of monetary policy the evidence
... cycle soon followed Transmission Mechanisms of Monetary Policy Traditional Interest-Rate Channels: expansionary monetary policy ir ↓, I ↑, Y↑ The interest rate channel of monetary transmission applies ... price for it relative to the cost of the facilities and equipment they are buying I ↑ because firms can buy a lot of new investment goods with only a small issue of stock The transmission mechanism ... which raises the desire of consumers to hold durable goods or housing, thus ↑ spending on them Expansionary monetary policy Pe ↑, value of financial assets ↑, likelihood of financial distress ↓,...
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Tài liệu Women''''s attitudes towards mechanisms of action of family planning methods: survey in primary health centres in Pamplona, Spain doc
... of action of some FP methods We did not state the mechanism of action of any FP methods and thus asked women to express their beliefs independently of their actual choices and independently of ... hypothetical method of FP In further sections women were asked about their knowledge of the mechanism of action of specific FP methods and if doctors or providers should explain the details of how a method ... attitudes for postfertilization effects The purpose of our study was to assess the attitudes about the mechanisms of action of FP in terms of whether these may influence a woman's decision to...
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Tài liệu Báo cáo khoa học: Mechanisms of amyloid fibril formation – focus on domain-swapping doc
... blocks only after partial unfolding of the a-helix from the body of the b-sheet (Fig 2C) Possible role of domain-swapping in the ‘off-pathway folding’ (OFF) model The OFF model for amyloid formation ... understanding of the importance of different parts of the molecule and their flexibility in the process of amyloid fibril formation often results more from a structural analysis of the amyloid ... absence of structural restraints is considered to drive the assembly of susceptible proteins into amyloid fibrils [19] The structure of amyloid fibrils reflects the aggregation of strands of b-pleated...
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Tài liệu Báo cáo khoa học: Survival mechanisms of pathogenic Mycobacterium tuberculosis H37Rv ppt
... Proton ATPasePump Inhibition of acidification of phagosome harbouring Mycobacteria Expression of virulence proteins of PE-PGRS family C O2– Fig Key factors of the survival mechanisms involved in the ... of digested material by exocytosis Fig Detailed structure of a macrophage showing a typical process of phagocytosis Engulfed material A D Phagosome TACO Fusion Lysosome Inhibition of fusion of ... proteins of mycobacteria have a profound influence on its pathogenicity It was found that the disruption of an erp gene of M tuberculosis encoding a secretory protein effects the survival of M tuberculosis...
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Tài liệu Báo cáo khoa học: Mechanisms of obesity and related pathologies: Androgen deficiency and endothelial dysfunction may be the link between obesity and erectile dysfunction pptx
... with an increased risk of T2DM, hypertension and CVD; however, the exact underlying pathophysiological mechanisms by which obesity increases the risk of VD remains the subject of intensive investigation ... pathophysiological mechanisms of obesity-induced androgen deficiency and hypogonadism-induced obesity remain the subject of intense investigation Several hypotheses have discussed the relationship of androgen ... organic ED, in which approximately 43% of men with MetS had ED and the severity of ED increased with the components of the MetS [84] Interestingly, the severity of ED was positively associated with...
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Tài liệu Báo cáo khoa học: Reaction mechanisms of thiamin diphosphate enzymes: redox reactions pdf
... deprotonation of C2a-OH of HEThDP and protonation of FAD at N5 and N1) The tight and rigid binding of both cofactors excludes a direct carbanion mechanism with covalent linkage between C2a of the HEThDP ... cluster [28] Rapid depletion of the thiamin radical and reduction of all clusters is only achieved after addition of CoA What is the special role of CoA for propagation of the second electron and ... radical An additional intricacy of this mechanism is the necessity of a structural rearrangement of CoA in the course of catalysis: initially, the reactive thiol group of CoA must be positioned proximal...
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Tài liệu Báo cáo khoa học: Models and mechanisms of O-O bond activation by cytochrome P450 A critical assessment of the potential role of multiple active intermediates in oxidative catalysis doc
... of the active species [76] Further support in favour of the idea of the involvement of a high-valent iron-oxene in P450 catalysis came from experiments with metalloporphyrin models [5,6,77] Of ... of the crystal structure of NDO as well as spectroscopic data provide a rationale for the catalytic mechanism of this class of enzymes Naphthalene 1,2dioxygenase is a heterohexamer composed of ... reect ring opening of an epoxide intermediate at either of its two C-O bonds [219,220] The sum of these ndings strongly invokes the notion of oxygen activation during redox cycling of the diverse...
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Motivating Better Hygiene Behaviour: Importance for Public Health Mechanisms of Change doc
... shortage of water often goes hand in hand with a high incidence of skin and eye diseases It was not the diseases, but the scarcity of drinking water and the long distances that were the first need of ... move from the increase of knowledge to the demonstrated improvement of hygiene conditions and practices professionalism of hygiene educators and adaption of a team approach ofengineers, health staff ... Health Mechanisms of Change Motivating Better Hygiene Behaviour: Importance for Public Health Mechanisms of Change Each year millions of children suffer from diarrhoea and other diseases Many of...
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Báo cáo khoa học: Molecular mechanisms of the phospho-dependent prolyl cis ⁄ trans isomerase Pin1 docx
... Molecular mechanisms of Pin1 tPro213 Fig NOESY spectrum of the triply phosphorylated SRSRpT212PpS214LPpT217PPTR peptide of Tau The cis conformation for the Pro219 is below the limit of detection ... FEBS 5215 Molecular mechanisms of Pin1 G Lippens et al populations, as one of the forms would continuously disappear from the pool of free peptides Structural characterization of the MPM-2 antibody ... examined in great detail the structure of both cis and trans conformers of the same peptide by NMR spectroscopy [31] The local structure of the cis conformer of this peptide is characterized by...
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Báo cáo khoa học: Two L-amino acid oxidase isoenzymes from Russell’s viper (Daboia russelli russelli) venom with different mechanisms of inhibition by substrate analogs pdf
... features of the dissociated cofactor were similar to those of FAD The shifting of absorption maxima of the enzyme-bound avin was due to its microenvironment The RP-HPLC proles of the cofactor ... level of glycosylation and homogeneity of the glycosydic part, as has been reported in the case of Ca rhodostoma LAAO [23], might be the cause of the chromatofocusing features for both the isoforms ... that the presence of 0.1% SDS did not affect the spectrum of FAD Identication of cofactor The absorption spectra between 300 and 600 nm of holo-LAAO from the active fractions of Sephadex G100...
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Báo cáo khoa học: Mechanisms of accumulation of arachidonate in phosphatidylinositol in yellowtail A comparative study of acylation systems of phospholipids in rat and the fish species Seriola quinqueradiata pot
... is composed mainly of 1-stearoyl-2-arachidonoyl species also applies to tissues of yellowtail Accumulation of arachidonic acid in PtdIns in the presence of the large amounts of docosahexaenoic ... concentration of 50 lM, the level of acylation of docosahexaenoic acid to lysoPtdIns was 19.4 nmol per 10 per mg protein, which was about one-fifth of that obtained with the same concentration of arachidonic ... to clarify the involvement of the PtdIns cycle in the accumulation of arachidonic acid in PtdIns of fish Fig Effects of docosahexaenoic acid (DHA) on the incorporation of [14C]arachidonic acid (*AA)...
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Báo cáo khoa học: Kinetic mechanisms of glycine oxidase fromBacillus subtilis docx
... of the corresponding oxidases [8–10], particularly in light of the data presented here, will considerably expand our understanding of the evolution and the mode of functioning of this class of ... result of anaerobic titration of fully reduced glycine oxidase (obtained by anaerobic reaction with a twofold excess of glycine) using increasing concentrations of glyoxylate in the presence of 400 ... the spectrum of a similar amount of reduced glycine oxidase after addition of 92 mM glycine, 400 mM ammonium chloride, and 44 mM glyoxylate Inset: Effect of glyoxylate concentration of the absorbance...
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Báo cáo Y học: Protein methylation as a marker of aspartate damage in glucose-6-phosphate dehydrogenase-deficient erythrocytes docx
... glycosylation of haemoglobin (glycation) has been shown to increase in the course of mismanaged hyperglycaemia in diabetes [27] Haemoglobin is a useful protein marker of this kind of damage, although ... the presence of the C563T point mutation A group of patients and age/sex-matched normal controls were selected Patients gave informed consent and were made aware of the outcomes of the study ... digestion of PCR amplified fragments, yielding additional bands of 317 and 100 bp, respectively Evaluation of lipid peroxidation Lipid peroxidation was evaluated by detecting the amount of TBARS,...
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Báo cáo khoa học: Modeling hydration mechanisms of enzymes in nonpolar and polar organic solvents potx
... precise picture of water at the surface of the protein, we looked at the number of water molecules within a specific layer of 0.25 nm from the surface of the protein (Fig 3), and the ratio of Fig Average ... probability density A key aspect of this work is the analysis of the localization of water at the enzyme surface We have successfully identified regions of high density of water in close contact with ... of water that optimizes the structural and dynamic properties of the enzyme depends on the polarity of the organic solvent used [7] Each replicate of cutinase hydrated with a specific amount of...
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